公开(公告)号：JP2009143924A

公开(公告)日：2009-07-02

申请号：JP2008327771

申请日：2008-12-24

Applicant: Abbott Lab ,  アボット・ラボラトリーズAbbott Laboratories

Inventor： HOLLADAY MARK W ,  ARNERIC STEPHEN P ,  BAI HAO ,  DART MICHAEL J ,  LIN NAN-HORNG ,  LYNCH JOHN K ,  OR YAT SUN ,  RYTHER KEITH B ,  SULLIVAN JAMES P ,  WASICAK JAMES T ,  EHRLICH PAUL P

IPC: A61P25/04 ,  C07D401/12 ,  A61K31/4427 ,  A61K31/443 ,  A61K31/4439 ,  A61K31/485 ,  A61P9/10 ,  A61P25/28 ,  A61P29/00 ,  A61P43/00 ,  C07D205/04 ,  C07D401/14 ,  C07D405/14

CPC classification number: C07D401/12 ,  A61K31/4427 ,  A61K31/485 ,  C07D205/04 ,  Y02P20/55 ,  A61K2300/00

Abstract: PROBLEM TO BE SOLVED: To provide a new 3-pyridyl enantiomer. SOLUTION: The present invention relates to a method of controlling pain in mammals, including humans, comprising administering selected compounds of formula I or a pharmaceutically acceptable salt thereof to a mammal or patient in need of treatment thereof. The invention further relates to selected (R) and (S) compounds of formula I which are useful as analgesics as well as neuronal cell death preventors and anti-inflammatory agents. COPYRIGHT: (C)2009,JPO&INPIT

Abstract translation: 要解决的问题：提供新的3-吡啶基对映异构体。 解决方案：本发明涉及一种控制包括人在内的哺乳动物疼痛的方法，其包括给选择的式I化合物或其药学上可接受的盐施用于需要治疗的哺乳动物或患者。 本发明还涉及可用作止痛剂的选择的（R）和（S）化合物，以及神经元细胞死亡预防剂和抗炎剂。 版权所有（C）2009，JPO＆INPIT

公开(公告)号：JP2007269811A

公开(公告)日：2007-10-18

申请号：JP2007153768

申请日：2007-06-11

Applicant: Abbott Lab ,  アボット・ラボラトリーズAbbott Laboratories

Inventor： ELLIOTT RICHARD L ,  RYTHER KEITH B ,  HOLLADAY MARK W ,  WASICAK JAMES T ,  DAANEN JEROME F

IPC: C07D491/048 ,  A61K31/00 ,  A61K31/435 ,  A61K31/4353 ,  A61K31/4355 ,  A61P9/00 ,  A61P25/00 ,  A61P25/04 ,  A61P25/16 ,  A61P25/28 ,  A61P25/30 ,  A61P25/32 ,  A61P25/34 ,  A61P43/00 ,  C07D471/04 ,  C07D487/04 ,  C07D491/04 ,  C07D491/044 ,  C07D495/04 ,  C07D519/00

CPC classification number: C07D471/04 ,  A61K31/4355 ,  C07D487/04 ,  C07D491/04 ,  C07D495/04

Abstract: PROBLEM TO BE SOLVED: To provide furopyridine, thienopyridine, pyrrolopyridine, and related pyrimidine, pyridazine and triazine compounds controlling chemical synaptic transmission; to provide medicinal compositions of the compounds effective for therapy; and to provide these compositions for selectively controlling the synaptic transmission. SOLUTION: The novel heterocyclic ether compound is represented by formula (I) (wherein, A, m, R, X, Y 1 , Y 2 and Y 3 are specifically defined). The medicinal composition thereof is effective for the therapy. The compositions are used for selectively controlling the synaptic transmission in mammals. COPYRIGHT: (C)2008,JPO&INPIT

Abstract translation: 要解决的问题：提供控制化学突触传播的呋喃啶，噻吩并吡啶，吡咯并吡啶和相关的嘧啶，哒嗪和三嗪化合物; 提供有效治疗的化合物的药物组合物; 并提供这些组合物以选择性地控制突触传递。 解决方案：新型杂环醚化合物由式（I）表示（其中，A，m，R，X，Y 1 ，Y 2， SP> 3 是特别定义的）。 其药物组合物对于治疗是有效的。 组合物用于选择性地控制哺乳动物的突触传递。 版权所有（C）2008，JPO＆INPIT

公开(公告)号：EP0663912A4

公开(公告)日：1995-02-17

申请号：EP93923826

申请日：1993-10-08

Applicant: ABBOTT LAB

Inventor： ABREO MELWYN A ,  GUNN DAVID E ,  LIN NAN-HORNG ,  ELLIOTT RICHARD L ,  GARVEY DAVID S ,  LEBOLD SUZANNE A ,  WASICAK JAMES T

IPC: A61K31/427 ,  A61K31/439 ,  A61K31/44 ,  A61K31/4427 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/4545 ,  A61K31/47 ,  A61K31/4709 ,  A61K31/497 ,  A61K31/501 ,  A61P25/00 ,  A61P25/28 ,  C07D401/12 ,  C07D403/12 ,  C07D411/12 ,  C07D417/12 ,  C07D471/08 ,  C07D487/04 ,  A61K31/425 ,  A61K31/445 ,  A61K31/495 ,  A61K31/50 ,  A61K31/505 ,  C07D453/02

CPC classification number: C07D401/12 ,  C07D403/12 ,  C07D417/12

公开(公告)号：CA2273917C

公开(公告)日：2010-05-25

申请号：CA2273917

申请日：1997-12-10

Applicant: ABBOTT LAB

Inventor： HOLLADAY MARK W ,  ARNERIC STEPHEN P ,  BAI HAO ,  DART MICHAEL J ,  LIN NAN-HORNG ,  LYNCH JOHN K ,  OR YAT SUN ,  RYTHER KEITH B ,  SULLIVAN JAMES P ,  WASICAK JAMES T ,  EHRLICH PAUL P

IPC: A61P25/04 ,  C07D401/12 ,  A61K31/4427 ,  A61K31/443 ,  A61K31/4439 ,  A61K31/485 ,  A61P25/28 ,  A61P29/00 ,  C07D205/04 ,  C07D401/14 ,  C07D405/14

Abstract: The present invention relates to a method of controlling pain in mammals, including humans, comprising administering to a mammal or patient in need of treatment thereof selected compounds of formula (I) or a pharmaceutically acceptable salt thereof. The invention further relates to selected (R) and (S) compounds of formula (I) which are useful as analgesics as well as neuronal cell death preventors and anti-inflammatories.

公开(公告)号：CA2285263C

公开(公告)日：2009-03-10

申请号：CA2285263

申请日：1998-04-10

Applicant: ABBOTT LAB

Inventor： DAANEN JEROME F ,  LI YIHONG ,  RYTHER KEITH B ,  HOLLADAY MARK W ,  ELLIOTT RICHARD L ,  LIN NAN-HORNG ,  WASICAK JAMES T ,  DART MICHAEL J ,  HE YUN

IPC: C07D491/048 ,  A61K31/4355 ,  A61K31/4365 ,  A61P25/00 ,  A61P43/00 ,  C07D491/04 ,  C07D495/04 ,  C07D519/00

Abstract: Novel heterocyclic ether compounds having formula (I) wherein A, m, R, X, Y1 , Y2 and Y3 are specifically defined, which are useful in selectively controlling chemical synaptic transmission; therapeutically- effective pharmaceutical compositions thereof; and use of said compositions to selectively control synaptic transmission in mammals.

公开(公告)号：CA2227695C

公开(公告)日：2008-02-12

申请号：CA2227695

申请日：1996-07-25

Applicant: ABBOTT LAB

Inventor： RYTHER KEITH B ,  ELLIOTT RICHARD L ,  DAANEN JEROME F ,  WASICAK JAMES T ,  HOLLADAY MARK W ,  DART MICHAEL J

IPC: C07D491/048 ,  A61K31/00 ,  A61K31/435 ,  A61K31/4353 ,  A61K31/4355 ,  A61K31/495 ,  A61K31/53 ,  A61P9/00 ,  A61P25/00 ,  A61P25/30 ,  C07D471/04 ,  C07D487/04 ,  C07D491/04 ,  C07D491/044 ,  C07D495/04 ,  C07D519/00

Abstract: Novel heterocyclic ether compounds having the formula (I) wherein A, m, R, X , Y1, Y2 and Y3 are specifically defined, which are useful in selectively controlling chemical synaptic transmission; therapeutically-effective pharmaceutical compositions thereof; and use of said compositions to selectively control synaptic transmission in mammals.

公开(公告)号：DK0970083T3

公开(公告)日：2003-08-11

申请号：DK98907359

申请日：1998-02-05

Applicant: ABBOTT LAB

Inventor： WASICAK JAMES T ,  GARVEY DAVID S ,  HOLLADAY MARK W ,  RYTHER KEITH B ,  LIN NAN-HORNG

IPC: A61P25/04 ,  A61K31/422 ,  A61K31/4439 ,  A61K31/4725 ,  A61P25/00 ,  A61P43/00 ,  C07D487/04 ,  A61K31/44

Abstract: 7a-Substituted hexahydro-1H-pyrrolizine compounds having the formula wherein A is a defined heterocycle moiety, pharmaceutical compositions of these compounds, and use of said compositions to selectively control synaptic transmission in mammals.

公开(公告)号：DK0950057T3

公开(公告)日：2003-03-10

申请号：DK97952392

申请日：1997-12-10

Applicant: ABBOTT LAB

Inventor： HOLLADAY MARK W ,  ARNERIC STEPHEN P ,  BAI HAO ,  DART MICHAEL J ,  LYNCH JOHN K ,  OR YAT SUN ,  RYTHER KEITH B ,  SULLIVAN JAMES P ,  WASICAK JAMES T ,  EHRLICH PAUL P ,  LIN NAN-HORNG

IPC: A61P25/04 ,  A61K31/4427 ,  A61K31/443 ,  A61K31/4439 ,  A61K31/485 ,  A61P25/28 ,  A61P29/00 ,  C07D205/04 ,  C07D401/12 ,  C07D401/14 ,  C07D405/14 ,  A61K31/44

Abstract: The present invention relates to a method of controlling pain in mammals, including humans, comprising administering to a mammal or patient in need of treatment thereof selected compounds of formula (I) or a pharmaceutically acceptable salt thereof. The invention further relates to selected (R) and (S) compounds of formula (I) which are useful as analgesics as well as neuronal cell death preventors and anti-inflammatories.

公开(公告)号：CA2285263A1

公开(公告)日：1998-10-22

申请号：CA2285263

申请日：1998-04-10

Applicant: ABBOTT LAB

Inventor： RYTHER KEITH B ,  HOLLADAY MARK W ,  WASICAK JAMES T ,  LI YIHONG ,  LIN NAN-HORNG ,  DAANEN JEROME F ,  ELLIOTT RICHARD L ,  DART MICHAEL J ,  HE YUN

IPC: A61K31/4355 ,  A61K31/4365 ,  A61P25/00 ,  A61P43/00 ,  C07D491/04 ,  C07D491/048 ,  C07D495/04 ,  C07D519/00 ,  A61K31/435

Abstract: Novel heterocyclic ether compounds having formula (I) wherein A, m, R, X, Y1, Y2 and Y3 are specifically defined, which are useful in selectively controlling chemical synaptic transmission; therapeutically-effective pharmaceutical compositions thereof; and use of said compositions to selectively control synaptic transmission in mammals.

公开(公告)号：ZA981301B

公开(公告)日：1998-08-28

申请号：ZA981301

申请日：1998-02-17

Applicant: ABBOTT LAB

Inventor： WASICAK JAMES T ,  GARVEY DAVID S ,  HOLLADAY MARK W ,  LIN NAN-HORNG ,  RYTHER KEITH B

IPC: A61P25/04 ,  A61K31/422 ,  A61K31/4439 ,  A61K31/4725 ,  A61P25/00 ,  A61P43/00 ,  C07D487/04 ,  C07D ,  A61K

Abstract: 7a-Substituted hexahydro-1H-pyrrolizine compounds having the formula wherein A is a defined heterocycle moiety, pharmaceutical compositions of these compounds, and use of said compositions to selectively control synaptic transmission in mammals.