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公开(公告)号：JP2009143924A
公开(公告)日：2009-07-02
申请号：JP2008327771
申请日：2008-12-24
Applicant: Abbott Lab , アボット・ラボラトリーズAbbott Laboratories
Inventor： HOLLADAY MARK W , ARNERIC STEPHEN P , BAI HAO , DART MICHAEL J , LIN NAN-HORNG , LYNCH JOHN K , OR YAT SUN , RYTHER KEITH B , SULLIVAN JAMES P , WASICAK JAMES T , EHRLICH PAUL P
IPC: A61P25/04 , C07D401/12 , A61K31/4427 , A61K31/443 , A61K31/4439 , A61K31/485 , A61P9/10 , A61P25/28 , A61P29/00 , A61P43/00 , C07D205/04 , C07D401/14 , C07D405/14
CPC classification number: C07D401/12 , A61K31/4427 , A61K31/485 , C07D205/04 , Y02P20/55 , A61K2300/00
Abstract: PROBLEM TO BE SOLVED: To provide a new 3-pyridyl enantiomer. SOLUTION: The present invention relates to a method of controlling pain in mammals, including humans, comprising administering selected compounds of formula I or a pharmaceutically acceptable salt thereof to a mammal or patient in need of treatment thereof. The invention further relates to selected (R) and (S) compounds of formula I which are useful as analgesics as well as neuronal cell death preventors and anti-inflammatory agents. COPYRIGHT: (C)2009,JPO&INPIT
Abstract translation: 要解决的问题：提供新的3-吡啶基对映异构体。 解决方案：本发明涉及一种控制包括人在内的哺乳动物疼痛的方法，其包括给选择的式I化合物或其药学上可接受的盐施用于需要治疗的哺乳动物或患者。 本发明还涉及可用作止痛剂的选择的（R）和（S）化合物，以及神经元细胞死亡预防剂和抗炎剂。 版权所有（C）2009，JPO＆INPIT
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公开(公告)号：ES2189003T3
公开(公告)日：2003-07-01
申请号：ES97952392
申请日：1997-12-10
Applicant: ABBOTT LAB
Inventor： HOLLADAY MARK W , ARNERIC STEPHEN P , BAI HAO , DART MICHAEL J , LIN NAN-HORNG , LYNCH JOHN K
IPC: A61P25/04 , A61K31/4427 , A61K31/443 , A61K31/4439 , A61K31/485 , A61P25/28 , A61P29/00 , C07D205/04 , C07D401/12 , C07D401/14 , C07D405/14 , A61K31/44
Abstract: The present invention relates to a method of controlling pain in mammals, including humans, comprising administering to a mammal or patient in need of treatment thereof selected compounds of formula (I) or a pharmaceutically acceptable salt thereof. The invention further relates to selected (R) and (S) compounds of formula (I) which are useful as analgesics as well as neuronal cell death preventors and anti-inflammatories.
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公开(公告)号：AU733881B2
公开(公告)日：2001-05-31
申请号：AU5601098
申请日：1997-12-10
Applicant: ABBOTT LAB
Inventor： HOLLADAY MARK W , ARNERIC STEPHEN P , BAI HAO , DART MICHAEL J , LIN NAN-HORNG , LYNCH JOHN K , OR YAT SUN , RYTHER KEITH B , SULLIVAN JAMES P , WASICAK JAMES T , EHRLICH PAUL P
IPC: A61P25/04 , A61K31/4427 , A61K31/443 , A61K31/4439 , A61K31/485 , A61P25/28 , A61P29/00 , C07D205/04 , C07D401/12 , C07D401/14 , C07D405/14 , A61K31/44
Abstract: The present invention relates to a method of controlling pain in mammals, including humans, comprising administering to a mammal or patient in need of treatment thereof selected compounds of formula (I) or a pharmaceutically acceptable salt thereof. The invention further relates to selected (R) and (S) compounds of formula (I) which are useful as analgesics as well as neuronal cell death preventors and anti-inflammatories.
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公开(公告)号：GR3035285T3
公开(公告)日：2001-04-30
申请号：GR20010400099
申请日：2001-01-24
Applicant: ABBOTT LAB
Inventor： GARVEY DAVID S , CARRERA GEORGE M JR , ARNERIC STEPHEN P , SHUE YOUE-KONG , LIN NAN-HORNG , HE YUN
IPC: A61K31/40 , A61K31/415 , A61K31/42 , A61K31/422 , A61K31/425 , A61K31/427 , A61K31/44 , A61P25/00 , A61P25/22 , A61P25/28 , C07D401/14 , C07D403/04 , C07D403/14 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/14
Abstract: Novel isoxazole isothiazole and pyrazole compounds of the formula: wherein A, R1, and R2 are specifically defined, or pharmaceutical salts thereof, are selective and potent cholinergic ligands at neuronal nicotinic receptors, useful in the treatment of cognitive, neurological and mental disorders characterized by decreased cholinergic function, as well as in the treatment of alcohol intoxication and petit real absence epilepsy.
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公开(公告)号：AU5601098A
公开(公告)日：1998-07-03
申请号：AU5601098
申请日：1997-12-10
Applicant: ABBOTT LAB
Inventor： HOLLADAY MARK W , ARNERIC STEPHEN P , BAI HAO , DART MICHAEL J , LIN NAN-HORNG , LYNCH JOHN K , OR YAT SUN , RYTHER KEITH B , SULLIVAN JAMES P , WASICAK JAMES T , EHRLICH PAUL P
IPC: A61P25/04 , A61K31/4427 , A61K31/443 , A61K31/4439 , A61K31/485 , A61P25/28 , A61P29/00 , C07D205/04 , C07D401/12 , C07D401/14 , C07D405/14 , A61K31/44
Abstract: The present invention relates to a method of controlling pain in mammals, including humans, comprising administering to a mammal or patient in need of treatment thereof selected compounds of formula (I) or a pharmaceutically acceptable salt thereof. The invention further relates to selected (R) and (S) compounds of formula (I) which are useful as analgesics as well as neuronal cell death preventors and anti-inflammatories.
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Patent Agency Ranking
公开(公告)号：CA2109585A1
公开(公告)日：1992-12-10
申请号：CA2109585
申请日：1992-05-28
Applicant: ABBOTT LAB
Inventor： GARVEY DAVID S , CARRERA GEORGE M JR , ARNERIC STEPHEN P , SHUE YOUE-KONG , LIN NAN-HORNG , HE YUN
IPC: A61K31/40 , A61K31/415 , A61K31/42 , A61K31/422 , A61K31/425 , A61K31/427 , A61K31/44 , A61P25/00 , A61P25/22 , A61P25/28 , C07D401/14 , C07D403/04 , C07D403/14 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/14 , A61K31/41
Abstract: Novel isoxazole isothiazole and pyrazole compounds of the formula: wherein A, R1, and R2 are specifically defined, or pharmaceutical salts thereof, are selective and potent cholinergic ligands at neuronal nicotinic receptors, useful in the treatment of cognitive, neurological and mental disorders characterized by decreased cholinergic function, as well as in the treatment of alcohol intoxication and petit real absence epilepsy.
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公开(公告)号：IE921690A1
公开(公告)日：1992-12-02
申请号：IE921690
申请日：1992-07-01
Applicant: ABBOTT LAB
Inventor： GARVEY DAVID S , ARNERIC STEPHEN P , LIN NAN-HORNG , JR GEORGE M CARRERA , SHUE YOUE-KONG , HE YUN
IPC: A61K31/40 , A61K31/415 , A61K31/42 , A61K31/422 , A61K31/425 , A61K31/427 , A61K31/44 , A61P25/00 , A61P25/22 , A61P25/28 , C07D401/14 , C07D403/04 , C07D403/14 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/14
Abstract: Novel isoxazole isothiazole and pyrazole compounds of the formula: wherein A, R1, and R2 are specifically defined, or pharmaceutical salts thereof, are selective and potent cholinergic ligands at neuronal nicotinic receptors, useful in the treatment of cognitive, neurological and mental disorders characterized by decreased cholinergic function, as well as in the treatment of alcohol intoxication and petit real absence epilepsy.
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公开(公告)号：CA2273917C
公开(公告)日：2010-05-25
申请号：CA2273917
申请日：1997-12-10
Applicant: ABBOTT LAB
Inventor： HOLLADAY MARK W , ARNERIC STEPHEN P , BAI HAO , DART MICHAEL J , LIN NAN-HORNG , LYNCH JOHN K , OR YAT SUN , RYTHER KEITH B , SULLIVAN JAMES P , WASICAK JAMES T , EHRLICH PAUL P
IPC: A61P25/04 , C07D401/12 , A61K31/4427 , A61K31/443 , A61K31/4439 , A61K31/485 , A61P25/28 , A61P29/00 , C07D205/04 , C07D401/14 , C07D405/14
Abstract: The present invention relates to a method of controlling pain in mammals, including humans, comprising administering to a mammal or patient in need of treatment thereof selected compounds of formula (I) or a pharmaceutically acceptable salt thereof. The invention further relates to selected (R) and (S) compounds of formula (I) which are useful as analgesics as well as neuronal cell death preventors and anti-inflammatories.
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公开(公告)号：DK0950057T3
公开(公告)日：2003-03-10
申请号：DK97952392
申请日：1997-12-10
Applicant: ABBOTT LAB
Inventor： HOLLADAY MARK W , ARNERIC STEPHEN P , BAI HAO , DART MICHAEL J , LYNCH JOHN K , OR YAT SUN , RYTHER KEITH B , SULLIVAN JAMES P , WASICAK JAMES T , EHRLICH PAUL P , LIN NAN-HORNG
IPC: A61P25/04 , A61K31/4427 , A61K31/443 , A61K31/4439 , A61K31/485 , A61P25/28 , A61P29/00 , C07D205/04 , C07D401/12 , C07D401/14 , C07D405/14 , A61K31/44
Abstract: The present invention relates to a method of controlling pain in mammals, including humans, comprising administering to a mammal or patient in need of treatment thereof selected compounds of formula (I) or a pharmaceutically acceptable salt thereof. The invention further relates to selected (R) and (S) compounds of formula (I) which are useful as analgesics as well as neuronal cell death preventors and anti-inflammatories.
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公开(公告)号：DE69231557T2
公开(公告)日：2001-06-21
申请号：DE69231557
申请日：1992-05-28
Applicant: ABBOTT LAB
Inventor： GARVEY DAVID S , CARRERA JR , ARNERIC STEPHEN P , SHUE YOUE-KONG , LIN NAN-HORNG , HE YUN
IPC: A61K31/40 , A61K31/415 , A61K31/42 , A61K31/422 , A61K31/425 , A61K31/427 , A61K31/44 , A61P25/00 , A61P25/22 , A61P25/28 , C07D401/14 , C07D403/04 , C07D403/14 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/14
Abstract: Novel isoxazole isothiazole and pyrazole compounds of the formula: wherein A, R1, and R2 are specifically defined, or pharmaceutical salts thereof, are selective and potent cholinergic ligands at neuronal nicotinic receptors, useful in the treatment of cognitive, neurological and mental disorders characterized by decreased cholinergic function, as well as in the treatment of alcohol intoxication and petit real absence epilepsy.
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