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公开(公告)号：JP2009143924A
公开(公告)日：2009-07-02
申请号：JP2008327771
申请日：2008-12-24
Applicant: Abbott Lab , アボット・ラボラトリーズAbbott Laboratories
Inventor： HOLLADAY MARK W , ARNERIC STEPHEN P , BAI HAO , DART MICHAEL J , LIN NAN-HORNG , LYNCH JOHN K , OR YAT SUN , RYTHER KEITH B , SULLIVAN JAMES P , WASICAK JAMES T , EHRLICH PAUL P
IPC: A61P25/04 , C07D401/12 , A61K31/4427 , A61K31/443 , A61K31/4439 , A61K31/485 , A61P9/10 , A61P25/28 , A61P29/00 , A61P43/00 , C07D205/04 , C07D401/14 , C07D405/14
CPC classification number: C07D401/12 , A61K31/4427 , A61K31/485 , C07D205/04 , Y02P20/55 , A61K2300/00
Abstract: PROBLEM TO BE SOLVED: To provide a new 3-pyridyl enantiomer. SOLUTION: The present invention relates to a method of controlling pain in mammals, including humans, comprising administering selected compounds of formula I or a pharmaceutically acceptable salt thereof to a mammal or patient in need of treatment thereof. The invention further relates to selected (R) and (S) compounds of formula I which are useful as analgesics as well as neuronal cell death preventors and anti-inflammatory agents. COPYRIGHT: (C)2009,JPO&INPIT
Abstract translation: 要解决的问题：提供新的3-吡啶基对映异构体。 解决方案：本发明涉及一种控制包括人在内的哺乳动物疼痛的方法，其包括给选择的式I化合物或其药学上可接受的盐施用于需要治疗的哺乳动物或患者。 本发明还涉及可用作止痛剂的选择的（R）和（S）化合物，以及神经元细胞死亡预防剂和抗炎剂。 版权所有（C）2009，JPO＆INPIT
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公开(公告)号：WO2007137107A3
公开(公告)日：2008-01-10
申请号：PCT/US2007069112
申请日：2007-05-17
Applicant: ABBOTT LAB , IYENGAR RAJESH R , ZHAO GANG , FREEMAN JENNIFER C , GAO JU , JUDD ANDREW S , KYM PHILIP R , LYNCH JOHN K , MULHERN MATHEW M , SOUERS ANDREW J
Inventor： IYENGAR RAJESH R , ZHAO GANG , FREEMAN JENNIFER C , GAO JU , JUDD ANDREW S , KYM PHILIP R , LYNCH JOHN K , MULHERN MATHEW M , SOUERS ANDREW J
IPC: C07C211/22 , A61K31/155 , A61K31/17 , A61K31/381 , A61K31/4164 , A61K31/435 , A61P3/04 , C07C275/30 , C07C279/18 , C07C335/16 , C07D213/55 , C07D213/75 , C07D277/28 , C07D333/36
CPC classification number: C07C335/22 , C07C229/46 , C07C275/30 , C07C275/32 , C07C275/38 , C07C279/28 , C07C2601/08 , C07C2601/14 , C07D213/55 , C07D213/75 , C07D277/30 , C07D333/22 , C07D333/36 , C07D401/04 , C07D401/12 , C07D409/12 , C07D409/14
Abstract: The present invention relates to compounds of formula (I) wherein R 1 , R 3 , X, Q, Z, A, D, m, and n are defined herein. Pharmaceutical compositions and methods for treating DGAT-1 related diseases or conditions are also disclosed.
Abstract translation: 本发明涉及式（I）化合物，其中R 1，R 3，X，Q，Z，A，D，m和n如本文所定义。 还公开了治疗DGAT-1相关疾病或病症的药物组合物和方法。
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公开(公告)号：WO02062762A3
公开(公告)日：2003-07-31
申请号：PCT/US0205252
申请日：2002-01-17
Applicant: ABBOTT LAB
Inventor： ALTENBACH ROBERT J , BAI HAO , BRIONI JORGE D , CARROLL WILLIAM A , GOPALAKRISHNAN MURALI , GREGG ROBERT J , HOLLADAY MARK W , HUANG PEGGY P , KINCAID JOHN F , KORT MICHAEL E , KYM PHILIP R , LYNCH JOHN K , PEREZ-MEDRANO ARTURO , ZHANG HENRY Q
IPC: A61K31/17 , A61K31/275 , A61K31/4164 , A61K31/4406 , A61K31/455 , A61K31/47 , A61K31/505 , A61P1/00 , A61P9/00 , A61P9/04 , A61P9/10 , A61P11/00 , A61P11/06 , A61P13/00 , A61P13/08 , A61P13/10 , A61P15/00 , A61P15/06 , A61P15/10 , A61P17/00 , A61P17/14 , A61P25/00 , A61P25/04 , A61P25/06 , A61P25/08 , A61P25/18 , A61P25/28 , A61P43/00 , C07C233/36 , C07C233/78 , C07C233/83 , C07C255/61 , C07C271/22 , C07C275/28 , C07C275/30 , C07C279/28 , C07C279/36 , C07C335/16 , C07C335/18 , C07C335/20 , C07D209/08 , C07D209/30 , C07D213/40 , C07D213/74 , C07D213/75 , C07D213/82 , C07D215/38 , C07D233/42 , C07D233/84 , C07D235/06 , C07D239/42 , C07D333/20 , C07D401/04 , C07D401/12 , C07D405/12 , C07D409/12
CPC classification number: C07D213/40 , A61K31/17 , A61K31/275 , A61K31/4406 , C07C233/78 , C07C233/83 , C07C271/22 , C07C275/28 , C07C275/30 , C07C279/28 , C07C279/36 , C07C335/16 , C07C335/18 , C07D209/08 , C07D213/74 , C07D213/75 , C07D213/82 , C07D215/38 , C07D233/42 , C07D233/84 , C07D235/06 , C07D239/42 , C07D333/20 , C07D401/04 , C07D401/12 , C07D405/12 , C07D409/12
Abstract: Compounds of formula (I) are useful in treating diseases prevented by or ameliorated with potassium channel openers. Also disclosed are potassium channel opening compositions and a method of opening potassium channels in a mammal.
Abstract translation: 式（I）化合物可用于治疗用钾通道开放剂预防或改善的疾病。 还公开了钾通道开放组合物和在哺乳动物中开放钾通道的方法。
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公开(公告)号：WO0109096A3
公开(公告)日：2001-08-16
申请号：PCT/US0021054
申请日：2000-08-02
Applicant: ABBOTT LAB
Inventor： ALTENBACH ROBERT J , BAI HAO , BRIONI JORGE D , CARROLL WILLIAM A , GOPALAKRISHNAN MURALI , GREGG ROBERT J , HOLLADAY MARK W , HUANG PEGGY P , KINCAID JOHN F , KORT MICHAEL E , KYM PHILIP R , LYNCH JOHN K , PEREZ-MEDRANO ARTURO , ZHANG HENRY Q
IPC: C07D249/18 , A61K31/166 , A61K31/17 , A61K31/417 , A61K31/4192 , A61K31/44 , A61K31/4406 , A61K31/47 , A61P1/00 , A61P9/00 , A61P9/10 , A61P11/06 , A61P13/02 , A61P13/08 , A61P13/10 , A61P15/00 , A61P15/10 , A61P17/14 , A61P25/00 , A61P25/02 , A61P25/06 , A61P25/08 , C07C233/78 , C07C233/83 , C07C271/22 , C07C275/28 , C07C275/30 , C07C275/54 , C07C279/22 , C07C279/28 , C07C279/36 , C07C335/16 , C07C335/18 , C07C335/26 , C07D209/08 , C07D213/74 , C07D213/75 , C07D215/38 , C07D233/02 , C07D233/42 , C07D235/06 , C07D239/42 , C07D401/04 , C07D401/12 , C07D405/12 , C07D407/12 , A61K31/155 , C07C279/30
CPC classification number: C07D213/74 , A61K31/17 , C07C233/78 , C07C233/83 , C07C271/22 , C07C275/28 , C07C275/30 , C07C279/28 , C07C279/36 , C07C335/16 , C07C335/18 , C07D209/08 , C07D215/38 , C07D233/42 , C07D235/06 , C07D239/42 , C07D401/04 , C07D401/12 , C07D405/12
Abstract: Compounds of formula (I), are useful in treating diseases prevented by or ameliorated with potassium channel openers. Also disclosed are potassium channel opening compositions and a method of opening potassium channels in a mammal.
Abstract translation: 式（I）化合物可用于治疗钾通道开放剂所预防或改善的疾病。 还公开了钾通道开放组合物和在哺乳动物中打开钾通道的方法。
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5.发明申请
公开(公告)号：WO0039081A3
公开(公告)日：2001-05-25
申请号：PCT/US9931162
申请日：1999-12-29
Applicant: ABBOTT LAB
Inventor： LINK JAMES , LIU GANG , PEI ZHONGHUA , VON GELDERN TOM , WINN MARTIN , XIN ZHILI , BOYD STEVEN A , JAE HWAN-SOO , LYNCH JOHN K , ZHU GUI-DONG , FREEMAN JENNIFER C , GUNAWARDANA INDRANI W , STAEGER MICHAEL A
IPC: C07D295/12 , A61K31/16 , A61K31/164 , A61K31/165 , A61K31/167 , A61K31/40 , A61K31/4015 , A61K31/404 , A61K31/407 , A61K31/417 , A61K31/438 , A61K31/44 , A61K31/443 , A61K31/445 , A61K31/4465 , A61K31/4468 , A61K31/45 , A61K31/453 , A61K31/454 , A61K31/472 , A61K31/495 , A61K31/496 , A61K31/506 , A61K31/5375 , A61K31/5377 , A61K31/54 , A61K31/541 , A61P29/00 , A61P37/02 , C07C323/00 , C07C323/62 , C07C323/63 , C07D207/08 , C07D207/09 , C07D207/12 , C07D207/14 , C07D207/20 , C07D207/22 , C07D207/26 , C07D207/263 , C07D207/27 , C07D207/273 , C07D207/34 , C07D207/36 , C07D209/08 , C07D209/12 , C07D209/14 , C07D209/18 , C07D211/22 , C07D211/26 , C07D211/42 , C07D211/44 , C07D211/46 , C07D211/54 , C07D211/60 , C07D211/62 , C07D211/66 , C07D211/74 , C07D213/74 , C07D213/75 , C07D213/81 , C07D213/82 , C07D215/04 , C07D215/36 , C07D217/06 , C07D233/61 , C07D235/26 , C07D239/42 , C07D241/04 , C07D241/18 , C07D241/24 , C07D243/08 , C07D265/30 , C07D295/13 , C07D295/16 , C07D295/18 , C07D295/185 , C07D295/205 , C07D295/215 , C07D295/26 , C07D295/32 , C07D307/52 , C07D307/68 , C07D317/58 , C07D317/62 , C07D319/18 , C07D319/20 , C07D401/04 , C07D401/06 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/06 , C07D405/12 , C07D405/14 , C07D411/04 , C07D413/04 , C07D413/12 , C07D413/14 , C07D417/12 , C07D471/10 , C07D487/08 , C07D491/10 , A61K31/10 , A61K31/33 , C07D295/20
CPC classification number: C07D207/27 , C07C323/62 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07D207/09 , C07D207/14 , C07D207/20 , C07D207/22 , C07D207/26 , C07D209/08 , C07D209/18 , C07D211/22 , C07D211/26 , C07D211/42 , C07D211/46 , C07D211/54 , C07D211/60 , C07D211/62 , C07D211/74 , C07D213/74 , C07D213/75 , C07D213/81 , C07D215/36 , C07D217/06 , C07D235/26 , C07D239/42 , C07D241/04 , C07D241/24 , C07D243/08 , C07D265/30 , C07D295/13 , C07D295/185 , C07D295/205 , C07D295/215 , C07D295/26 , C07D295/32 , C07D307/52 , C07D307/68 , C07D317/58 , C07D317/62 , C07D319/18 , C07D319/20 , C07D401/04 , C07D401/06 , C07D401/12 , C07D403/12 , C07D405/12 , C07D405/14 , C07D413/04 , C07D413/14 , C07D471/10 , C07D487/08 , C07D491/10
Abstract: The present invention relates to novel cinnamide compounds that are useful for treating inflammatory and immune diseases, to pharmaceutical compositions containing these compounds, and to methods of inhibiting inflammation or suppressing immune response in a mammal.
Abstract translation: 本发明涉及可用于治疗炎症和免疫疾病的新颖的肉桂酰胺化合物，含有这些化合物的药物组合物，以及抑制哺乳动物炎症或抑制免疫反应的方法。
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Patent Agency Ranking
公开(公告)号：DE60227662D1
公开(公告)日：2008-08-28
申请号：DE60227662
申请日：2002-01-17
Applicant: ABBOTT LAB
Inventor： ALTENBACH ROBERT J , BAI HAO , BRIONI JORGE D , CARROL WILLIAM A , GOPALAKRISHNAN MURALI , HOLLADAY MARK W , HUANG PEGGY P , KINCAID JOHN F , KORT MICHAEL E , KYM PHILIP R , LYNCH JOHN K , PEREZ-MEDRANO ARTURO , ZHANG HENRY Q , GREGG ROBERT J
IPC: C07D213/75 , A61K31/17 , A61K31/275 , A61K31/4164 , A61K31/4406 , A61K31/455 , A61K31/47 , A61K31/505 , A61P1/00 , A61P9/00 , A61P9/04 , A61P9/10 , A61P11/00 , A61P11/06 , A61P13/00 , A61P13/08 , A61P13/10 , A61P15/00 , A61P15/06 , A61P15/10 , A61P17/00 , A61P17/14 , A61P25/00 , A61P25/04 , A61P25/06 , A61P25/08 , A61P25/18 , A61P25/28 , A61P43/00 , C07C233/36 , C07C233/78 , C07C233/83 , C07C255/61 , C07C271/22 , C07C275/28 , C07C275/30 , C07C279/28 , C07C279/36 , C07C335/16 , C07C335/18 , C07C335/20 , C07D209/08 , C07D209/30 , C07D213/40 , C07D213/74 , C07D213/82 , C07D215/38 , C07D233/42 , C07D233/84 , C07D235/06 , C07D239/42 , C07D333/20 , C07D401/04 , C07D401/12 , C07D405/12 , C07D409/12
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公开(公告)号：HRP20010776A2
公开(公告)日：2002-12-31
申请号：HRP20010776
申请日：2001-10-23
Applicant: ABBOTT LAB
Inventor： LINK JAMES , LIU GANG , PEI ZHONGHUA , GELDERN THOMAS W VON , WINN MARTIN , XIN ZHILI , WANG SHELDON , BOYD STEVEN A , ZHU GUI-DONG , FREEMAN JENNIFER C , GUNAWARDANA INDRANI W , STAEGER MICHAEL A , JAE HWAN-SOO , LYNCH JOHN K
IPC: C07D243/08 , A61K20060101 , A61K31/10 , A61K31/165 , A61K31/33 , A61K31/40 , A61K31/4015 , A61K31/41 , A61K31/417 , A61K31/438 , A61K31/44 , A61K31/4427 , A61K31/445 , A61K31/4468 , A61K31/451 , A61K31/453 , A61K31/454 , A61K31/4545 , A61K31/472 , A61K31/496 , A61K31/4965 , A61K31/506 , A61K31/5375 , A61K31/5377 , A61K31/54 , A61K31/541 , A61K31/55 , A61K31/551 , A61P20060101 , A61P29/00 , A61P37/06 , C07C20060101 , C07C323/60 , C07C323/62 , C07D20060101 , C07D205/04 , C07D207/09 , C07D207/12 , C07D207/14 , C07D207/16 , C07D207/26 , C07D207/27 , C07D207/273 , C07D209/08 , C07D209/12 , C07D211/20 , C07D211/22 , C07D211/46 , C07D211/60 , C07D211/62 , C07D211/64 , C07D211/66 , C07D211/70 , C07D213/40 , C07D213/74 , C07D213/81 , C07D215/24 , C07D217/02 , C07D217/04 , C07D217/06 , C07D233/61 , C07D239/42 , C07D241/04 , C07D241/24 , C07D257/04 , C07D279/12 , C07D295/18 , C07D295/185 , C07D295/20 , C07D295/205 , C07D295/22 , C07D295/26 , C07D307/24 , C07D307/52 , C07D307/68 , C07D317/58 , C07D317/66 , C07D319/18 , C07D401/04 , C07D401/12 , C07D405/12 , C07D417/12 , C07D471/20 , C07D487/04 , C07D491/113 , C07D521/00
Abstract: The present invention relates to cinnamide compounds of formula (I), in which at least one of R1 to R5 is a "cis-cinnamide" (a) or a "trans-cinnamide" (b) and the other variables are as defined in the claims, that are useful for treating inflammatory and immune diseases, to pharmaceutical compositions containing these compounds and to methods of inhibiting inflammation or suppressing immune response in a mammal.
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公开(公告)号：HU0200222A2
公开(公告)日：2002-06-29
申请号：HU0200222
申请日：1999-12-29
Applicant: ABBOTT LAB
Inventor： BOYD STEVEN A , FREEMAN JENNIFER C , VON GELDERN TOM , GUNAWARDANA INDRANI W , JAE HWAN-SOO , LINK JAMES , LIU GANG , LYNCH JOHN K , PEI ZHONGHUA , STAEGER MICHAEL A , WINN MARTIN , XIN ZHILI , ZHU GUI-DONG
IPC: C07D295/12 , A61K31/16 , A61K31/164 , A61K31/165 , A61K31/167 , A61K31/40 , A61K31/4015 , A61K31/404 , A61K31/407 , A61K31/417 , A61K31/438 , A61K31/44 , A61K31/443 , A61K31/445 , A61K31/4465 , A61K31/4468 , A61K31/45 , A61K31/453 , A61K31/454 , A61K31/472 , A61K31/495 , A61K31/496 , A61K31/506 , A61K31/5375 , A61K31/5377 , A61K31/54 , A61K31/541 , A61P29/00 , A61P37/02 , C07C323/00 , C07C323/62 , C07C323/63 , C07D207/08 , C07D207/09 , C07D207/12 , C07D207/14 , C07D207/20 , C07D207/22 , C07D207/26 , C07D207/263 , C07D207/27 , C07D207/273 , C07D207/34 , C07D207/36 , C07D209/08 , C07D209/12 , C07D209/14 , C07D209/18 , C07D211/22 , C07D211/26 , C07D211/42 , C07D211/44 , C07D211/46 , C07D211/54 , C07D211/60 , C07D211/62 , C07D211/66 , C07D211/74 , C07D213/74 , C07D213/75 , C07D213/81 , C07D213/82 , C07D215/04 , C07D215/36 , C07D217/06 , C07D233/61 , C07D235/26 , C07D239/42 , C07D241/04 , C07D241/18 , C07D241/24 , C07D243/08 , C07D265/30 , C07D295/13 , C07D295/16 , C07D295/18 , C07D295/185 , C07D295/205 , C07D295/215 , C07D295/26 , C07D295/32 , C07D307/52 , C07D307/68 , C07D317/58 , C07D317/62 , C07D319/18 , C07D319/20 , C07D401/04 , C07D401/06 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/06 , C07D405/12 , C07D405/14 , C07D411/04 , C07D413/04 , C07D413/12 , C07D413/14 , C07D417/12 , C07D471/10 , C07D487/08 , C07D491/10
Abstract: The present invention relates to novel cinnamide compounds that are useful for treating inflammatory and immune diseases, to pharmaceutical compositions comprising these compounds, and to methods of inhibiting inflammation or suppressing immune response in a mammal.
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公开(公告)号：HK1040985A1
公开(公告)日：2002-06-28
申请号：HK02102655
申请日：2002-04-09
Applicant: ABBOTT LAB
Inventor： LINK JAMES , LIU GANG , PEI ZHONGHUA , GELDERN VON THOMAS W , WINN MARTIN , XIN ZHILI , WANG SHELDON , BOYD STEVEN A , ZHU GUI-DONG , FREEMAN JENNIFER C , GUNAWARDANA INDRANI W , STAEGER MICHAEL A , JAE HWAN-SOO , LYNCH JOHN K
IPC: C07D243/08 , A61K20060101 , A61K31/10 , A61K31/165 , A61K31/33 , A61K31/40 , A61K31/4015 , A61K31/41 , A61K31/417 , A61K31/438 , A61K31/44 , A61K31/4427 , A61K31/445 , A61K31/4468 , A61K31/451 , A61K31/453 , A61K31/454 , A61K31/4545 , A61K31/472 , A61K31/496 , A61K31/4965 , A61K31/506 , A61K31/5375 , A61K31/5377 , A61K31/54 , A61K31/541 , A61K31/55 , A61K31/551 , A61P20060101 , A61P29/00 , A61P37/06 , C07C20060101 , C07C323/60 , C07C323/62 , C07D20060101 , C07D205/04 , C07D207/09 , C07D207/12 , C07D207/14 , C07D207/16 , C07D207/26 , C07D207/27 , C07D207/273 , C07D209/08 , C07D209/12 , C07D211/20 , C07D211/22 , C07D211/46 , C07D211/60 , C07D211/62 , C07D211/64 , C07D211/66 , C07D211/70 , C07D213/40 , C07D213/74 , C07D213/81 , C07D215/24 , C07D217/02 , C07D217/04 , C07D217/06 , C07D233/61 , C07D239/42 , C07D241/04 , C07D241/24 , C07D257/04 , C07D279/12 , C07D295/18 , C07D295/185 , C07D295/20 , C07D295/205 , C07D295/22 , C07D295/26 , C07D307/24 , C07D307/52 , C07D307/68 , C07D317/58 , C07D317/66 , C07D319/18 , C07D401/04 , C07D401/12 , C07D405/12 , C07D417/12 , C07D471/20 , C07D487/04 , C07D491/113 , C07D521/00 , C07C , C07D , A61K , A61P
Abstract: The present invention relates to cinnamide compounds of formula (I), in which at least one of R1 to R5 is a "cis-cinnamide" (a) or a "trans-cinnamide" (b) and the other variables are as defined in the claims, that are useful for treating inflammatory and immune diseases, to pharmaceutical compositions containing these compounds and to methods of inhibiting inflammation or suppressing immune response in a mammal.
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公开(公告)号：CA2378936A1
公开(公告)日：2001-02-08
申请号：CA2378936
申请日：2000-08-02
Applicant: ABBOTT LAB
Inventor： PEREZ-MEDRANO ARTURO , HOLLADAY MARK W , ZHANG HENRY Q , CARROLL WILLIAM A , HUANG PEGGY P , LYNCH JOHN K , GREGG ROBERT J , GOPALAKRISHNAN MURALI , KINCAID JOHN F , ALTENBACH ROBERT J , KORT MICHAEL E , KYM PHILIP R , BAI HAO , BRIONI JORGE D
IPC: C07D249/18 , A61K31/166 , A61K31/17 , A61K31/417 , A61K31/4192 , A61K31/44 , A61K31/4406 , A61K31/47 , A61P1/00 , A61P9/00 , A61P9/10 , A61P11/06 , A61P13/02 , A61P13/08 , A61P13/10 , A61P15/00 , A61P15/10 , A61P17/14 , A61P25/00 , A61P25/02 , A61P25/06 , A61P25/08 , C07C233/78 , C07C233/83 , C07C271/22 , C07C275/28 , C07C275/30 , C07C275/54 , C07C279/22 , C07C279/28 , C07C279/36 , C07C335/16 , C07C335/18 , C07C335/26 , C07D209/08 , C07D213/74 , C07D213/75 , C07D215/38 , C07D233/02 , C07D233/42 , C07D235/06 , C07D239/42 , C07D401/04 , C07D401/12 , C07D405/12 , C07D407/12 , A61K31/155 , C07C279/30
Abstract: Compounds of formula (I), are useful in treating diseases prevented by or ameliorated with potassium channel openers. Also disclosed are potassium channel opening compositions and a method of opening potassium channels in a mammal.
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