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公开(公告)号：EP0663912A4
公开(公告)日：1995-02-17
申请号：EP93923826
申请日：1993-10-08
Applicant: ABBOTT LAB
Inventor： ABREO MELWYN A , GUNN DAVID E , LIN NAN-HORNG , ELLIOTT RICHARD L , GARVEY DAVID S , LEBOLD SUZANNE A , WASICAK JAMES T
IPC: A61K31/427 , A61K31/439 , A61K31/44 , A61K31/4427 , A61K31/4439 , A61K31/444 , A61K31/4545 , A61K31/47 , A61K31/4709 , A61K31/497 , A61K31/501 , A61P25/00 , A61P25/28 , C07D401/12 , C07D403/12 , C07D411/12 , C07D417/12 , C07D471/08 , C07D487/04 , A61K31/425 , A61K31/445 , A61K31/495 , A61K31/50 , A61K31/505 , C07D453/02
CPC classification number: C07D401/12 , C07D403/12 , C07D417/12
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公开(公告)号：AT262519T
公开(公告)日：2004-04-15
申请号：AT98964167
申请日：1998-12-18
Applicant: ABBOTT LAB
Inventor： HOLLADAY MARK W , ABREO MELWYN A , GUNN DAVID E , LIN NAN-HORNG , GARVEY DAVID S , RYTHER KEITH , LEBOLD SUZANNE A , ELLIOTT RICHARD L , HE YUN , WASIAK JAMES T , BAI HAO , DART MICHAEL J , EHRLICH PAUL P , LI YIHONG , KINCAID JOHN F , SCHKERYANTZ JEFFREY M , LYNCH JOHN K
IPC: A61K31/427 , A61K31/4427 , A61K31/4439 , A61K31/4545 , A61K31/4709 , A61K31/4725 , A61K31/497 , A61K31/501 , A61K31/506 , A61P25/00 , A61P25/22 , A61P25/28 , A61P25/30 , A61P43/00 , C07D401/12 , C07D403/12 , C07D417/12 , C07D455/02 , C07D487/04 , A61K31/40 , A61K31/425 , A61K31/44
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公开(公告)号：DK0805812T3
公开(公告)日：2001-09-17
申请号：DK96903364
申请日：1996-01-11
Applicant: ABBOTT LAB
Inventor： BASHA FATIMA Z , TIETJE KARIN R , MEYER MICHAEL D , ALTENBACH ROBERT J , CARROLL WILLIAM A , DRIZIN IRENE , KERWIN JAMES F JR , LEBOLD SUZANNE A , LEE EDMUND L , PRATT JOHN K , YAMAMOTO DIANE M , SIPPY KEVIN B
IPC: A61K31/505 , A61K31/519 , A61P13/02 , A61P15/00 , A61P25/02 , C07D401/06 , C07D403/06 , C07D471/04 , C07D473/04 , C07D475/02 , C07D487/04 , C07D491/04 , C07D491/056 , C07D495/04 , C07D498/04 , C07D487/02 , C07D487/00 , C07D495/02
Abstract: The present invention relates to a compound of the formula and the pharmaceutically acceptable salts thereof wherein W is a bicyclic heterocyclic ring system. The compounds are alpha -1 adrenergic antagonists and are useful in the treatment of BPH; also disclosed are alpha -1 antagonist compositions and a method for antagonizing alpha -1 receptors and treating BPH.
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公开(公告)号：AT194141T
公开(公告)日：2000-07-15
申请号：AT96903340
申请日：1996-01-11
Applicant: ABBOTT LAB
Inventor： MEYER MICHAEL D , ALTENBACH ROBERT J , BASHA FATIMA Z , CARROLL WILLIAM A , DRIZIN IRENE , KERWIN JAMES F JR , LEBOLD SUZANNE A , LEE EDMUND L , ELMORE STEVEN W , SIPPY KEVIN B , TIETJE KARIN R , WENDT MICHAEL D , YAMAMOTO DIANE M
IPC: A61K31/437 , A61K31/519 , A61P13/00 , A61P13/08 , A61P43/00 , C07D403/06 , C07D471/04 , C07D471/14 , C07D487/04 , C07D487/14 , C07D491/04 , C07D491/048 , C07D491/14 , C07D491/147 , C07D495/04 , C07D495/14 , C07D487/16
Abstract: The present invention relates to a compound of the formula and the pharmaceutically acceptable salts thereof wherein W is a tricyclic heterocyclic ring system; which is an alpha -1 adrenergic antagonist and is useful in the treatment of BPH; also disclosed are alpha -1 antagonist compositions and a method for antagonizing alpha -1 receptors and treating BPH.
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5.发明专利
公开(公告)号：CA2315117C
公开(公告)日：2011-03-15
申请号：CA2315117
申请日：1998-12-18
Applicant: ABBOTT LAB
Inventor： HOLLADAY MARK W , ABREO MELWYN A , GUNN DAVID E , LIN NAN-HORNG , GARVEY DAVID S , RYTHER KEITH , LEBOLD SUZANNE A , ELLIOTT RICHARD L , HE YUN , WASICAK JAMES T , BAI HAO , DART MICHAEL J , EHRLICH PAUL P , LI YIHONG , KINCAID JOHN F , SCHKERYANTZ JEFFREY M , LYNCH JOHN K
IPC: C07D401/12 , A61K31/40 , A61K31/425 , A61K31/427 , A61K31/44 , A61K31/4427 , A61K31/4439 , A61K31/4545 , A61K31/47 , A61K31/4709 , A61K31/4725 , A61K31/497 , A61K31/50 , A61K31/501 , A61K31/505 , A61K31/506 , A61P25/00 , A61P25/22 , A61P25/28 , A61P25/30 , A61P43/00 , C07D403/12 , C07D417/12 , C07D455/02 , C07D487/04
Abstract: Novel compounds having formulas (I), (II) or (III) or pharmaceutically-acceptable salts or prodrugs thereof, which are useful for controlling synaptic transmission; to therapeutically-effective pharmaceutical compositions of these compounds; and to the use of said compositions to controlling synaptic transmission in human or veterinary patients.
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Patent Agency Ranking
公开(公告)号：ES2169727T3
公开(公告)日：2002-07-16
申请号：ES93923826
申请日：1993-10-08
Applicant: ABBOTT LAB
Inventor： ABREO MELWYN A , GUNN DAVID E , LIN NAN-HORNG , ELLIOTT RICHARD L , GARVEY DAVID S , LEBOLD SUZANNE A
IPC: A61K31/427 , A61K31/439 , A61K31/44 , A61K31/4427 , A61K31/4439 , A61K31/444 , A61K31/4545 , A61K31/47 , A61K31/4709 , A61K31/497 , A61K31/501 , A61P25/00 , A61P25/28 , C07D401/12 , C07D403/12 , C07D411/12 , C07D417/12 , C07D471/08 , C07D487/04 , A61K31/425 , A61K31/445 , A61K31/495 , A61K31/50 , A61K31/505 , C07D453/02
Abstract: Novel heterocyclic ether compounds of formula (I), wherein A, B and R are specifically defined, or pharmaceutically-acceptable salts or prodrugs thereof, which are selective and potent ligands at cholinergic channel receptors, useful in the treatment of cognitive, neurological and mental disorders characterized by decreased cholinergic function.
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公开(公告)号：PT808318E
公开(公告)日：2000-12-29
申请号：PT96903340
申请日：1996-01-11
Applicant: ABBOTT LAB
Inventor： BASHA FATIMA Z , ALTENBACH ROBERT J , CARROLL WILLIAM A , DRIZIN IRENE , KERWIN JAMES F , WENDT MICHAEL D , MEYER MICHAEL D , LEBOLD SUZANNE A , LEE EDMUND L , ELMORE STEVEN W , SIPPY KEVIN B , TIETJE KARIN R , YAMAMOTO DIANE M
IPC: A61K31/437 , A61K31/519 , A61P13/00 , A61P13/08 , A61P43/00 , C07D403/06 , C07D471/04 , C07D471/14 , C07D487/04 , C07D487/14 , C07D491/04 , C07D491/048 , C07D491/14 , C07D491/147 , C07D495/04 , C07D495/14 , C07D487/16 , A61K31/395
Abstract: The present invention relates to a compound of the formula and the pharmaceutically acceptable salts thereof wherein W is a tricyclic heterocyclic ring system; which is an alpha -1 adrenergic antagonist and is useful in the treatment of BPH; also disclosed are alpha -1 antagonist compositions and a method for antagonizing alpha -1 receptors and treating BPH.
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8.发明专利
公开(公告)号：CA2315117A1
公开(公告)日：1999-07-01
申请号：CA2315117
申请日：1998-12-18
Applicant: ABBOTT LAB
Inventor： HE YUN , LEBOLD SUZANNE A , ELLIOTT RICHARD L , BAI HAO , DART MICHAEL J , WASICAK JAMES T , KINCAID JOHN F , GARVEY DAVID S , LI YIHONG , RYTHER KEITH , HOLLADAY MARK W , EHRLICH PAUL P , ABREO MELWYN A , GUNN DAVID E , LIN NAN-HORNG , SCHKERYANTZ JEFFREY M , LYNCH JOHN K
IPC: A61K31/427 , A61K31/4427 , A61K31/4439 , A61K31/4545 , A61K31/4709 , A61K31/4725 , A61K31/497 , A61K31/501 , A61K31/506 , A61P25/00 , A61P25/22 , A61P25/28 , A61P25/30 , A61P43/00 , C07D401/12 , C07D403/12 , C07D417/12 , C07D455/02 , C07D487/04 , A61K31/40 , A61K31/425 , A61K31/44 , A61K31/47 , A61K31/50 , A61K31/505
Abstract: Novel compounds having formulas (I), (II) or (III) or pharmaceuticallyacceptable salts or prodrugs thereof, which are useful for controlling synaptic transmission; to therapeutically-effective pharmaceutical compositions of these compounds; and to the use of said compositions to controlling synaptic transmission in human or veterinary patients.
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公开(公告)号：MX9705675A
公开(公告)日：1997-10-31
申请号：MX9705675
申请日：1996-01-11
Applicant: ABBOTT LAB
Inventor： MEYER MICHAEL D , ALTENBACH ROBERT J , BASHA FATIMA J , CARROLL WILLIAM A , DRIZIN IRENE , KERWIN JAMES F JR , LEBOLD SUZANNE A , LEE EDMUND L , PRATY JOHN K
IPC: A61K31/505 , A61K31/519 , A61P13/02 , A61P15/00 , A61P25/02 , C07D401/06 , C07D403/06 , C07D471/04 , C07D473/04 , C07D475/02 , C07D487/04 , C07D491/04 , C07D491/056 , C07D495/04 , C07D498/04 , C07D487/02 , C07D495/02 , C07D487/00 , C07D239/00 , C07D209/00 , C07D333/00
Abstract: La presente invencion se refiere a un compuesto de la Formula (I), y a las sales farmacéuticamente aceptables del mismo, en donde W es un sistema de anillo heterocíclico bicíclico. Los compuestos son antagonistas adrenérgicos alfa-1, y son utiles en el tratamiento de hiperplasia prostática benigna; también se describen composiciones antagonistas de alfa-1, y un método para antagonizar receptores de alfa-1, y para el tratamiento de hiperplasia prostática benigna.
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公开(公告)号：CA2136075C
公开(公告)日：2004-12-14
申请号：CA2136075
申请日：1993-10-08
Applicant: ABBOTT LAB
Inventor： ABREO MELWYN A , GUNN DAVID E , LIN NAN-HORNG , ELLIOTT RICHARD L , GARVEY DAVID S , LEBOLD SUZANNE A , WASICAK JAMES T
IPC: A61K31/427 , A61K31/439 , A61K31/44 , A61K31/4427 , A61K31/4439 , A61K31/444 , A61K31/4545 , A61K31/47 , A61K31/4709 , A61K31/497 , A61K31/501 , A61P25/00 , A61P25/28 , C07D401/12 , C07D403/12 , C07D411/12 , C07D417/12 , C07D471/08 , C07D487/04 , C07D453/02 , A61K31/425 , A61K31/435 , A61K31/495
Abstract: Novel heterocyclic ether compounds of formula (I), wherein A, B and R2 are specifically defined, or pharmaceutically- acceptable salts or prodrugs thereof, which are selective and potent ligands at cholinergic channel receptors, useful in the treatment of cognitive, neurological and mental disorders characterized by decreased cholinergic function.
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