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公开(公告)号：EP1638941B1
公开(公告)日：2010-06-02
申请号：EP04776083.0
申请日：2004-05-21
Applicant: ABBOTT LABORATORIES
Inventor： DAI, Yujia , DAVIDSEN, Steven, K. , ERICSSON, Anna, M. , HARTANDI, Kresna , JI, Zhiqin , MICHAELIDES, Michael, R.
IPC: C07D231/56 , C07D403/12 , C07D261/20 , C07D401/12 , C07D403/04 , C07D401/04 , C07D409/04 , C07D275/04 , C07D405/12 , A61K31/423 , A61K31/428 , A61P35/00 , A61K31/416
CPC classification number: C07D231/56 , C07D261/20 , C07D275/04 , C07D401/04 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/12 , C07D409/04 , Y02P20/582
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12.发明公开APOPTOSIS-INDUCING AGENTS FOR THE TREATMENT OF CANCER AND IMMUNE AND AUTOIMMUNE DISEASES 有权APOPTOSE-INDUZIERENDE MITTEL ZUR BEHANDLUNG VON KREBS UND INMMUN- UND AUTOIMMUNKRANKHEITEN
公开(公告)号：EP2376197A2
公开(公告)日：2011-10-19
申请号：EP09768289.2
申请日：2009-12-04
Applicant: Abbott Laboratories
Inventor： BRUNCKO, Milan , DAI, Yujia , DING, Hong , DOHERTY, George, A. , ELMORE, Steven, W. , HASVOLD, Lisa , HEXAMER, Laura , KUNZER, Aaron, R. , MANTEI, Robert, A. , MCCLELLAN, William, J. , PARK, Chang, H. , PARK, Cheol-Min , PETROS, Andrew, M. , SONG, Xiaohong , SOUERS, Andrew, J. , SULLIVAN, Gerard, M. , TAO, Zhi-Fu , WANG, Gary, T. , WANG, Le , WANG, Xilu , WENDT, Michael, D.
IPC: A61P35/00 , A61K31/496 , C07D403/12
CPC classification number: C07D405/12 , C07D209/08 , C07D211/58 , C07D213/74 , C07D213/84 , C07D231/56 , C07D235/06 , C07D277/24 , C07D295/30 , C07D309/04 , C07D401/14 , C07D405/14 , C07D413/12 , C07D417/12 , C07D471/04
Abstract: Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-2 protein.
Abstract translation: 公开了抑制抗凋亡Bcl-2蛋白活性的化合物，含有化合物的组合物和治疗其中表达抗凋亡Bcl-2蛋白的疾病的方法。
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13.发明公开
公开(公告)号：EP1968979A2
公开(公告)日：2008-09-17
申请号：EP06839265.3
申请日：2006-12-08
Applicant: ABBOTT LABORATORIES
Inventor： MICHAELIDES, Michael, R. , MCCLELLAN, William, J. , FREY, Robin, R. , CURTIN, Michael, L. , STEINMAN, Douglas, H. , DAI, Yujia , HOLMS, James, H.
IPC: C07D487/04 , C07D495/04 , A61K31/519 , A61P35/00
CPC classification number: C07F9/6561 , C07D487/04 , C07D495/04
Abstract: Compounds that inhibit protein kinases, compositions containing the compounds and methods of treating cancer using the compounds are disclosed.
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公开(公告)号：EP1807424A2
公开(公告)日：2007-07-18
申请号：EP05815246.3
申请日：2005-10-28
Applicant: ABBOTT LABORATORIES
Inventor： DAI, Yujia , HARTANDI, Kresna , MICHAELIDES, Michael, M.
IPC: C07D471/04 , A61K31/437 , A61P35/00
CPC classification number: C07D471/04 , C07D487/04
Abstract: Compounds having the formula (I) are useful for inhibiting protein tyrosine kinases. The present invention also discloses methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.
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Patent Agency Ranking
公开(公告)号：EP1147101B1
公开(公告)日：2002-11-20
申请号：EP00905758.9
申请日：2000-01-27
Applicant: ABBOTT LABORATORIES
Inventor： CURTIN, Michael, L. , DAI, Yujia , DAVIDSEN, Steven, K. , HEYMAN, Howard, R. , HOLMES, James, H. , MICHAELIDES, Michael, R. , STEINMAN, Douglas, H.
IPC: C07D317/28 , C07D307/14 , C07D207/48 , C07D207/09 , C07D263/04 , A61K31/335 , A61P35/04
CPC classification number: C07D263/04 , C07D207/09 , C07D207/48 , C07D307/14 , C07D317/28
Abstract: Compounds having formula (I) are matric metalloproteinase inhibitors. Also disclosed are matrix metalloproteinase-inhibiting compositions and methods of inhibiting matrix metalloproteinase in a mammal.
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16.发明公开APOPTOSIS-INDUCING AGENTS FOR THE TREATMENT OF CANCER AND IMMUNE AND AUTOIMMUNE DISEASES 有权细胞凋亡诱导剂治疗癌症和免疫及自身免疫疾病
公开(公告)号：EP2507211A1
公开(公告)日：2012-10-10
申请号：EP10722500.5
申请日：2010-06-01
Applicant: Abbott Laboratories
Inventor： BRUNCKO, Milan , DAI, Yujia , DING, Hong , DOHERTY, George A. , ELMORE, Steven W. , HASVOLD, Lisa , HEXAMER, Laura , KUNZER, Aaron , MANTEI, Robert A. , McCLELLAN, William J. , PARK, Chang H. , PARK, Cheol-Min , PETROS, Andrew M. , SONG, Xiaohong , SOUERS, Andrew J. , SULLIVAN, Gerard M. , TAO, Zhi-Fu , WANG, Gary T. , WANG, Le , WANG, Xilu , WENDT, Michael D. , HANSEN, Todd M.
IPC: C07D209/08 , C07D211/58 , C07D213/74 , C07D213/84 , C07D231/56 , C07D235/06 , C07D277/24 , C07D309/04 , C07D401/14 , C07D403/12 , C07D405/12 , C07D405/14 , C07D413/12 , C07D417/12 , C07D471/04
CPC classification number: C07D209/08 , A61K31/635 , C07D211/58 , C07D213/74 , C07D213/84 , C07D231/56 , C07D235/06 , C07D277/24 , C07D295/30 , C07D309/04 , C07D309/08 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D405/14 , C07D413/12 , C07D417/12 , C07D471/04
Abstract: Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-2 protein.
Abstract translation: 公开了抑制抗凋亡Bcl-2蛋白活性的化合物，含有该化合物的组合物和治疗表达抗凋亡Bcl-2蛋白的疾病的方法。
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公开(公告)号：EP1807424B1
公开(公告)日：2012-04-18
申请号：EP05815246.3
申请日：2005-10-28
Applicant: ABBOTT LABORATORIES
Inventor： DAI, Yujia , HARTANDI, Kresna , MICHAELIDES, Michael, M.
IPC: C07D471/04 , A61K31/437 , A61P35/00
CPC classification number: C07D471/04 , C07D487/04
Abstract: Compounds having the formula (I) are useful for inhibiting protein tyrosine kinases. The present invention also discloses methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.
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18.发明公开INDAZOLES, BENZISOXAZOLES AND BENZISOTHIAZOLES AS INHIBITORS OF PROTEIN KINASES 有权吲唑，异恶唑和异噻唑作为蛋白激酶的抑制剂
公开(公告)号：EP2170834A1
公开(公告)日：2010-04-07
申请号：EP08781893.6
申请日：2008-07-16
Applicant: Abbott Laboratories
Inventor： DAI, Yujia , ZHIQIN, Ji , MICHAELIDES, Michael R.
IPC: C07D231/56 , C07D261/20 , C07D275/04 , A61K31/416 , A61K31/423 , A61K31/428 , A61P35/00
CPC classification number: C07D231/56 , C07D261/20 , C07D275/04
Abstract: Compounds that inhibit Aurora-kinases, compositions containing the compounds and methods of treating diseases using the compounds are disclosed.
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19.发明公开INDAZOLE, BENZISOXAZOLE, AND BENZISOTHIAZOLE KINASE INHIBITORS 有权INDAZOL-，BENZISOXAZOL- UND BENZISOTHIAZOL-KINASEINHIBITOREN
公开(公告)号：EP1638941A1
公开(公告)日：2006-03-29
申请号：EP04776083.0
申请日：2004-05-21
Applicant: ABBOTT LABORATORIES
Inventor： DAI, Yujia , DAVIDSEN, Steven, K. , ERICSSON, Anna, M. , HARTANDI, Kresna , JI, Zhiqin , MICHAELIDES, Michael, R.
IPC: C07D231/56 , C07D403/12 , C07D261/20 , C07D401/12 , C07D403/04 , C07D401/04 , C07D409/04 , C07D275/04 , C07D405/12 , A61K31/423 , A61K31/428 , A61P35/00 , A61K31/416
CPC classification number: C07D231/56 , C07D261/20 , C07D275/04 , C07D401/04 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/12 , C07D409/04 , Y02P20/582
Abstract: Compounds having the formula (I) are useful for inhibiting protein tyrosine kinases. The present invention also discloses methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.
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