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    CONTROLLED GLYCEMIC RESPONSE SWEETENED CEREAL PRODUCT
    11.
    发明申请
    CONTROLLED GLYCEMIC RESPONSE SWEETENED CEREAL PRODUCT 审中-公开
    控制性糖果反应性谷物产品

    公开(公告)号：WO2008030998A2

    公开(公告)日：2008-03-13

    申请号：PCT/US2007/077824

    申请日：2007-09-07

    Applicant: ABBOTT LABORATORIES ,  ATKINSON, Judith, R. ,  EDENS, Neile ,  DEWILLE, Normanella, T. ,  MAZER, Terry ,  YOSICK, Kelley, J. ,  OGILVIE, Allison ,  WEARLY, Douglas

    Inventor： ATKINSON, Judith, R. ,  EDENS, Neile ,  DEWILLE, Normanella, T. ,  MAZER, Terry ,  YOSICK, Kelley, J. ,  OGILVIE, Allison ,  WEARLY, Douglas

    IPC: A23L1/29 ,  A23L1/00 ,  A23L1/164

    CPC classification number: A23L7/126 ,  A23L7/122 ,  A23P20/12 ,  A23P20/18 ,  A23P20/20 ,  A23V2002/00 ,  A23V2200/22 ,  A23V2200/328 ,  A23V2250/606

    Abstract: The present invention provides a food product comprising: a formed reduced glycemic response cereal component; and a non-sticky reduced glyccmic response sweetener coating over the formed cereal component, the sweetener coating comprising: a first sticky layer comprising at least about 30% fructose (of the total sweetener coating); a second less sticky layer having a DE value of about 60 or less and comprising up to about 17% fructose and at least about 1% non-fructose carbohydrates (of the total sweetener coating); and third layer comprising crystalline fructose. The present invention also provides a process for forming the sweetener coating over the formed cereal component comprising the following steps: (a) providing a formed cereal component having thereon a first sticky layer comprising fructose; (b) forming over the first sticky layer a less sticky second layer comprising non- fructose carbohydrates and optionally fructose; and (c) applying crystalline fructose over the second layer.

    Abstract translation: 本发明提供一种食品，其包含：形成的降低的血糖反应谷物成分; 并且所述甜味剂涂层包含：包含至少约30％的果糖（总甜味剂涂层的）的第一粘性层;以及在所形成的谷物组分上的非粘性减少的糖应答甜味剂涂层。 DE值为约60或更小的第二较低粘性层，包含高达约17％的果糖和至少约1％的非果糖碳水化合物（总甜味剂涂层）; 和包含结晶果糖的第三层。 本发明还提供了一种用于在所形成的谷物成分上形成甜味剂涂层的方法，包括以下步骤：（a）提供形成有谷物成分的谷物成分，其上含有果糖的第一粘性层; （b）在第一粘性层上形成较少粘性的第二层，其包含非果糖碳水化合物和任选的果糖; 和（c）在第二层上施加结晶果糖。

    TREATMENT OF INSULIN RESISTANCE ASSOCIATED WITH PROLONGED PHYSICAL INACTIVITY
    13.
    发明申请
    TREATMENT OF INSULIN RESISTANCE ASSOCIATED WITH PROLONGED PHYSICAL INACTIVITY 审中-公开
    与广泛的物理活动相关的胰岛素抵抗的治疗

    公开(公告)号：WO2014152606A2

    公开(公告)日：2014-09-25

    申请号：PCT/US2014/027524

    申请日：2014-03-14

    Applicant: ABBOTT LABORATORIES

    Inventor： LUO, Menghua ,  PEREIRA, Suzette ,  EDENS, Neile ,  DAVIS, Gerard ,  GAWEL, Susan ,  CHANDRAN, Raj

    IPC: A61K31/19

    CPC classification number: A61K31/19 ,  G01N33/6893 ,  G01N2333/47 ,  G01N2333/4704 ,  G01N2333/575 ,  G01N2800/52

    Abstract: Insulin resistance biomarkers and related methods of using the biomarkers are provided. The biomarkers may be blood biomarkers and include C-peptide, Insulin-Like Growth Factor- Binding Protein 2 (IGFBP-2), and Leptin. Also provided is a method of reducing the effect of prolonged physical inactivity on insulin resistance in a subject who is experiencing prolonged physical inactivity, or who is expected to experience prolonged physical inactivity in the near future.

    Abstract translation: 提供了使用生物标志物的胰岛素抵抗生物标志物和相关方法。 生物标志物可以是血液生物标志物，包括C肽，胰岛素样生长因子结合蛋白2（IGFBP-2）和瘦蛋白。 还提供了一种减少长期身体不活动对经历长时间身体不活动的受试者或预期在不久的将来会经历长时间身体不活动的受试者的胰岛素抵抗的影响的方法。

    LOW GLYCEMIC INDEX NUTRITIONAL COMPOSITIONS FOR PRESERVING MUSCLE MASS AND IMPROVING BODY COMPOSITION IN DIABETICS
    15.
    发明申请
    LOW GLYCEMIC INDEX NUTRITIONAL COMPOSITIONS FOR PRESERVING MUSCLE MASS AND IMPROVING BODY COMPOSITION IN DIABETICS 审中-公开
    用于保存肌肉质量和改善身体组成的低糖果指数营养成分

    公开(公告)号：WO2014028607A1

    公开(公告)日：2014-02-20

    申请号：PCT/US2013/054925

    申请日：2013-08-14

    Applicant: ABBOTT LABORATORIES

    Inventor： PEREIRA, Suzette ,  KRISHNAN DESAI, Padmavathy ,  EDENS, Neile

    IPC: A61K31/122 ,  A61P3/02 ,  A61K36/00

    CPC classification number: A61K31/12 ,  A61K36/9066 ,  A61K31/353 ,  A61K2300/00

    Abstract: Nutritional compositions that include a combination of Curcumin and epigallocatechin gallate (EGCg) are provided. The nutritional compositions may be formulated as low glycemic index nutritional compositions. The nutritional compositions may be administered to an individual, particularly an insulin resistant, pre-diabetic, or diabetic individual, to preserve muscle mass and decrease fat deposition, thereby improving overall body composition leading to increased strength and functionality as well as improved blood glucose control and insulin sensitivity.

    Abstract translation: 提供了包含姜黄素和表没食子儿茶素没食子酸酯（EGCg）的组合的营养组合物。 营养组合物可以配制成低血糖指数营养组合物。 营养组合物可以施用于个体，特别是胰岛素抵抗，糖尿病前期或糖尿病个体，以保持肌肉质量并减少脂肪沉积，从而改善整体身体组成，从而提高强度和功能，以及改善血糖控制 和胰岛素敏感性。

    METHODS OF MAINTAINING AND IMPROVING MUSCLE FUNCTION
    19.
    发明公开
    METHODS OF MAINTAINING AND IMPROVING MUSCLE FUNCTION 审中-公开
    VERFAHREN ZUR BEWAHRUNG UND VERBESSERUNG DER MUSKELFUNKTION

    公开(公告)号：EP2986158A1

    公开(公告)日：2016-02-24

    申请号：EP14719586.1

    申请日：2014-03-14

    Applicant: ABBOTT LABORATORIES

    Inventor： GARVEY, Sean ,  PEREIRA, Suzette ,  EDENS, Neile

    IPC: A23L33/10 ,  A23L2/50

    CPC classification number: A61K31/353 ,  A23L2/50 ,  A23L33/105 ,  A23V2002/00 ,  A23V2200/316 ,  A61K9/0053 ,  A23V2250/214

    Abstract: Methods of decreasing muscle function decline and improving muscle function in a subject are provided. The methods utilize an effective amount of epigallocatechin-3-gallate (EGCg) to increase the level of muscle vascular endothelial growth factor A (VEGF), to decrease myostatin levels, or both, and thereby decrease muscle function decline or improve muscle function. The EGCg may be provided as part of a nutritional composition.

    Abstract translation: 提供减少肌肉功能下降和改善受试者肌肉功能的方法。 该方法利用有效量的表没食子儿茶素-3-没食子酸酯（EGCg）来增加肌肉血管内皮生长因子A（VEGF）的水平，降低肌生成抑制素水平或两者，从而减少肌肉功能下降或改善肌肉功能。 EGCg可以作为营养组合物的一部分提供。

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