公开(公告)号：WO2005074603A3

公开(公告)日：2005-08-18

申请号：PCT/US2005/003196

申请日：2005-02-03

Applicant: ABBOTT LABORATORIES ,  WISHART, Neil ,  FRIEDMAN, Michael ,  ARNOLD, Lee, D. ,  YANG, Bryant ,  FIX-STENZEL, Shannon, R. ,  ERICSSON, Anna ,  MICHAELIDES, Michael R., ,  QIAN, Xiao-dong ,  HOLMES, James, H. ,  STEINMAN, Douglas, H. ,  TIAN, Zhengping ,  WITTENBERGER, Steven, J.

Inventor： WISHART, Neil ,  FRIEDMAN, Michael ,  ARNOLD, Lee, D. ,  YANG, Bryant ,  FIX-STENZEL, Shannon, R. ,  ERICSSON, Anna ,  MICHAELIDES, Michael R., ,  QIAN, Xiao-dong ,  HOLMES, James, H. ,  STEINMAN, Douglas, H. ,  TIAN, Zhengping ,  WITTENBERGER, Steven, J.

IPC: C07D487/04 ,  C07D513/06 ,  C07D295/03 ,  C07D239/70 ,  C07D263/54 ,  A61K31/519 ,  A61K31/5377 ,  A61K31/381

Abstract: A compound of Formula (I), wherein the substituents are as defined herein, which are useful as kinase inhibitors.

公开(公告)号：WO2003080064A1

公开(公告)日：2003-10-02

申请号：PCT/US2003/008950

申请日：2003-03-21

Applicant: ABBOTT LABORATORIES ,  HIRST, Gavin, C. ,  ARNOLD, Lee, D. ,  BURCHAT, Andrew ,  WISHART, Neil ,  CALDERWOOD, David ,  WADA, Carol, K. ,  MICHAELIDES, Michael, R. ,  JI, Zhiqin ,  MUCKEY, Melanie

Inventor： HIRST, Gavin, C. ,  ARNOLD, Lee, D. ,  BURCHAT, Andrew ,  WISHART, Neil ,  CALDERWOOD, David ,  WADA, Carol, K. ,  MICHAELIDES, Michael, R. ,  JI, Zhiqin ,  MUCKEY, Melanie

IPC: A61K31/519

CPC classification number: C07D487/04 ,  C07D491/04

Abstract: The present application is directed to pyrazolopyrimidine and furopyrimidine analogs of the formula (I), wherein the substituents are as defined herein, which are useful as kinase inhibitors.

Abstract translation: 本申请涉及式（I）的吡唑并嘧啶和呋喃嘧啶类似物，其中取代基如本文所定义，其可用作激酶抑制剂。

公开(公告)号：EP2299821A1

公开(公告)日：2011-03-30

申请号：EP09763424.0

申请日：2009-06-09

Applicant: Abbott Laboratories

Inventor： WISHART, Neil ,  ARGIRIADI, Maria, A. ,  CALDERWOOD, David, J. ,  ERICSSON, Anna, M. ,  FIAMENGO, Bryan, A. ,  FRANK, Kristine, E. ,  FRIEDMAN, Michael ,  GEORGE, Dawn, M. ,  GOEDKEN, Eric, R. ,  JOSEPHSOHN, Nathan, S. ,  LI, Biqin, C. ,  MORYTKO, Michael, J. ,  STEWART, Kent, D. ,  VOSS, Jeffrey, W. ,  WALLACE, Grier, A. ,  WANG, Lu ,  WOLLER, Kevin, R.

IPC: A01N43/42

CPC classification number: C07D487/14 ,  C07D498/14 ,  C07D513/14

Abstract: The invention provides a compound of Formula (I), pharmaceutically acceptable salts, pro-drugs, biologically active metabolites, stereoisomers and isomers thereof wherein the variable are defined herein. The compounds of the invention are useful for treating immunological and oncological conditions.

公开(公告)号：EP1753428A2

公开(公告)日：2007-02-21

申请号：EP05778736.8

申请日：2005-05-13

Applicant: ABBOTT LABORATORIES

Inventor： CUSACK, Kevin ,  SALMERON-GARCIA, Jose-Andres ,  GORDON, Thomas D. ,  BARBERIS, Claude E. ,  ALLEN, Hamish J. ,  BISCHOFF, Agnieszka K. ,  ERICSSON, Anna M. ,  FRIEDMAN, Michael M. ,  GEORGE, Dawn M. ,  ROTH, Gregory P. ,  TALANIAN, Robert V. ,  THOMAS, Christine ,  WALLACE, Grier A. ,  WISHART, Neil ,  YU, Zhengtian

IPC: A61K31/4743 ,  C07D498/02

CPC classification number: C07D471/04 ,  A61K31/4743 ,  C07D487/04 ,  C07D491/04 ,  C07D495/04 ,  Y02A50/481

Abstract: A compound or pharmaceutically acceptable salts thereof of Formula (I) wherein the substituents are as defined herein, which are useful as kinase inhibitors.

公开(公告)号：EP2099454A2

公开(公告)日：2009-09-16

申请号：EP07867491.8

申请日：2007-11-16

Applicant: ABBOTT LABORATORIES

Inventor： GEORGE, Dawn M. ,  DIXON, Richard W. ,  FRIEDMAN, Michael ,  HOBSON, Adrian ,  LI, Biqin ,  WANG, Lu ,  WU, Xiaoyun ,  WISHART, Neil

IPC: A61K31/445 ,  C07D211/00

CPC classification number: A61K31/454 ,  A61K31/437 ,  A61K31/438 ,  A61K31/4545 ,  A61K31/4709 ,  A61K31/4747 ,  A61K31/506 ,  A61K31/517 ,  A61K31/5377 ,  A61K31/55 ,  A61K31/553 ,  C07D207/14 ,  C07D401/04 ,  C07D401/14 ,  C07D403/12 ,  C07D405/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04 ,  C07D471/10 ,  C07D487/04 ,  C07D487/10 ,  C07D487/14

Abstract: The present invention is directed to novel aminopyrrolidines of formula (I), pharmaceutically acceptable salts thereof, metabolites thereof, isomers thereof, stereoisomers thereof or pro-drugs thereof, wherein the variables are as defined herein. The compounds of formula (I) are useful as chemokine receptor antagonists and as such would be useful in treating certain conditions and diseases, especially inflammatory conditions and diseases and proliferative disorders and conditions, for example, cancers.

公开(公告)号：EP2506716A1

公开(公告)日：2012-10-10

申请号：EP10835061.2

申请日：2010-12-01

Applicant: Abbott Laboratories

Inventor： WISHART, Neil ,  ARGIRIADI, Maria, A. ,  CALDERWOOD, David, J. ,  ERICSSON, Anna, M. ,  FIAMENGO, Bryan, A. ,  FRANK, Kristine, E. ,  FRIEDMAN, Michael ,  GEORGE, Dawn, M. ,  GOEDKEN, Eric, R. ,  JOSEPHSOHN, Nathan, S. ,  LI, Biqin, C. ,  MORYTKO, Michael, J. ,  STEWART, Kent, D. ,  VOSS, Jeffrey, W. ,  WALLACE, Grier, A. ,  WANG, Lu ,  WOLLER, Kevin, R.

IPC: A01N43/58

CPC classification number: C07D487/14 ,  A61K31/437 ,  A61K31/4985 ,  A61K45/06 ,  C07D471/14 ,  C07D498/14 ,  C07D513/14

Abstract: The invention provides compounds of Formula (I) and Formula (II), pharmaceutically acceptable salts, pro-drugs, biologically active metabolites, stereoisomers and isomers thereof wherein the variable are defined herein. The compounds of the invention are useful for treating immunological and oncological conditions.

公开(公告)号：EP2506713A1

公开(公告)日：2012-10-10

申请号：EP10835075.2

申请日：2010-12-01

Applicant: Abbott Laboratories

Inventor： WISHART, Neil ,  ARGIRIADI, Maria, A. ,  BREINLINGER, Eric, C. ,  CALDERWOOD, David, J. ,  ERICSSON, Anna, M. ,  FIAMENGO, Bryan, A. ,  FRANK, Kristine, E. ,  FRIEDMAN, Michael ,  GEORGE, Dawn, M. ,  GOEDKEN, Eric, R. ,  JOSEPHSOHN, Nathan, S. ,  LI, Biqin, C. ,  MORYTKO, Michael, J. ,  MULLEN, Kelly, D. ,  SOMAL, Gagandeep ,  STEWART, Kent, D. ,  VOSS, Jeffrey, W. ,  WALLACE, Grier, A. ,  WANG, Lu ,  WOLLER, Kevin, R. ,  HOEMANN, Michael, Z.

IPC: A01N43/42 ,  A61K31/44

CPC classification number: C07F9/06 ,  C07D471/14 ,  C07D487/14 ,  C07D498/14 ,  C07D513/14

Abstract: The invention provides a compound of Formula (Ia), (Ib), (Ic), (Id), (Ie), (If), (Ig), (Ih), (Ii), (Ij), (Ik), or (Il) as defined herein, pharmaceutically acceptable salts, pro-drugs, biologically active metabolites, stereoisomers and isomers thereof wherein the variable are defined herein. The compounds of the invention are useful for treating immunological and oncological conditions.

Abstract translation: 本发明提供了式（Ia），（Ib），（Ic），（Id），（Ie），（If），（Ig），（Ih），（Ii）， 或（II）化合物，其药学上可接受的盐，前药，生物活性代谢物，立体异构体和异构体，其中变量如本文所定义。 本发明的化合物可用于治疗免疫学和肿瘤学病症。

公开(公告)号：EP1730148A2

公开(公告)日：2006-12-13

申请号：EP05722668.0

申请日：2005-02-03

Applicant: ABBOTT LABORATORIES

Inventor： WISHART, Neil ,  FRIEDMAN, Michael ,  ARNOLD, Lee, D. ,  YANG, Bryant ,  FIX-STENZEL, Shannon, R. ,  ERICSSON, Anna ,  MICHAELIDES, Michael R., ,  QIAN, Xiao-dong ,  HOLMES, James, H. ,  STEINMAN, Douglas, H. ,  TIAN, Zhengping ,  WITTENBERGER, Steven, J.

IPC: C07D487/04

CPC classification number: C07D487/04

Abstract: A compound of Formula (I), wherein the substituents are as defined herein, which are useful as kinase inhibitors.

公开(公告)号：EP1496910A1

公开(公告)日：2005-01-19

申请号：EP03718039.5

申请日：2003-03-21

Applicant: Abbott Laboratories

Inventor： HIRST, Gavin, C. ,  ARNOLD, Lee, D. ,  BURCHAT, Andrew ,  WISHART, Neil ,  CALDERWOOD, David ,  WADA, Carol, K. ,  MICHAELIDES, Michael, R. ,  JI, Zhiqin ,  MUCKEY, Melanie

IPC: A61K31/519 ,  C07D487/02 ,  C07D473/00 ,  C07D471/00 ,  C07D487/00 ,  C07D491/00

CPC classification number: C07D487/04 ,  C07D491/04

Abstract: The present application is directed to pyrazolopyrimidine and furopyrimidine analogs of the formula (I), wherein the substituents are as defined herein, which are useful as kinase inhibitors.

Abstract translation: 本申请涉及吡唑并嘧啶和式（I），其中取代基如本文所定义的furopyrimidine类似物，其是作为激酶抑制剂是有用的。

公开(公告)号：EP2001480A2

公开(公告)日：2008-12-17

申请号：EP07754773.5

申请日：2007-04-02

Applicant: ABBOTT LABORATORIES

Inventor： ERICSSON, Anna M. ,  BURCHAT, Andrew ,  FRANK, Kristine E. ,  CALDERWOOD, David J. ,  ABBOTT, Lily K. ,  ARGIRIADI, Maria A. ,  BORHANI, David W. ,  CUSACK, Kevin P. ,  DIXON, Richard W. ,  GORDON, Thomas D. ,  MULLEN, Kelly D. ,  TALANIAN, Robert V. ,  WU, Xiaoyun ,  ZHANG, Xiaolei ,  WANG, Lu X. ,  LI, Biqin ,  BARBERIS, Claude E. ,  WISHART, Neil

IPC: A61K31/5377

CPC classification number: C07D487/04 ,  C07D403/12 ,  C07D403/14 ,  C07D409/04 ,  C07D409/14

Abstract: Novel compounds of Formula (I) or pharmaceutically acceptable salts, prodrugs and biologically active metabolites thereof of Formula (I) wherein the substituents are as defined herein, which are useful as therapeutic agents.

Abstract translation: 式（I）的新化合物或其式（I）的药用盐，前药和生物活性代谢物，其中取代基如本文所定义，其可用作治疗剂。