公开(公告)号：CH599190A5

公开(公告)日：1978-05-12

申请号：CH1237474

申请日：1974-09-11

Applicant: BASF AG

Inventor： AMANN AUGUST DR MED ,  BOLZ GERHARD DR ,  WIERSDORFF WALTER-WIELANT DR ,  GIERTZ HUBERT PROF DR MED ,  WILSMANN KLAUS DR MED

IPC: C07D307/77 ,  A61K20060101 ,  A61K31/27 ,  A61K31/34 ,  A61K31/365 ,  C07D20060101 ,  C07D307/89 ,  C07D307/93

公开(公告)号：DE2346305A1

公开(公告)日：1975-04-03

申请号：DE2346305

申请日：1973-09-14

Applicant: BASF AG

Inventor： AMANN AUGUST DR MED ,  BOLZ GERHARD DIPL CHEM DR ,  WIERSDORFF WALTER-WIELANT DIPL ,  GIERTZ HUBERT PROF DR MED ,  WILSMANN KLAUS DR MED

IPC: C07D307/77 ,  A61K20060101 ,  A61K31/27 ,  A61K31/34 ,  A61K31/365 ,  C07D20060101 ,  C07D307/89 ,  C07D307/93

公开(公告)号：DE2310140A1

公开(公告)日：1974-09-12

申请号：DE2310140

申请日：1973-03-01

Applicant: BASF AG

Inventor： AMANN AUGUST DR MED ,  THIEME PETER C DIPL CHEM DR ,  GIERTZ HUBERT PROF DR MED ,  KOENIG HORST DIPL-CHEM DR

IPC: C07C45/75 ,  C07D319/08 ,  C07C91/24 ,  A61K27/00

Abstract: Cpds. of formula (I) (where R1 is H or 1-4C alkyl; R2 is 1-6C alkyl; or R1 + R2 is -(CH2)n- in which n is 3, 4, 5 or 6; and m is 0 or 1) and their pharmacologically tolerable salts, which are useful as bronchodilators, are prepd. by reacting an epoxide of formula (II) (where R3 and R4 are H or 1-4C alkyl or R3 + R4 is -(CH2)n- in which n is 3, 4 or 5) with an amine H2N-CR1R2-(CH2)m-C CH and hydrolysing the reaction prod.

公开(公告)号：DE2215606A1

公开(公告)日：1973-10-11

申请号：DE2215606

申请日：1972-03-30

Applicant: BASF AG

Inventor： HAGEN HELMUT DR ING ,  AMANN AUGUST DR MED ,  GIERTZ HUBERT PROF DR MED

IPC: A61K31/55 ,  A61P9/08 ,  A61P9/10 ,  A61P25/04 ,  A61P29/00 ,  C07D233/20 ,  C07D495/10 ,  C07D513/04 ,  C07D93/40

Abstract: Biologically active imidazolino-[1,2-d]-benzo-1,4-thiazepines, their production and their acid addition salts. These compounds, especially as the pharmacologically compatible salts, are useful to dilate coronary vessels of guinea pigs and rabbits and exhibit analgesic, spasmolytic and blood pressure changing properties.

公开(公告)号：CH331373A

公开(公告)日：1958-07-15

申请号：CH331373D

申请日：1954-08-21

Applicant: BASF AG

Inventor： REPPE WALTER DR ,  SCHLICHTING OTTO DR ,  WESTPHAL FRANZ DR ,  AMANN AUGUST DR MED ,  OETTEL HEINZ DR MED

公开(公告)号：DE3144138A1

公开(公告)日：1983-05-19

申请号：DE3144138

申请日：1981-11-06

Applicant: BASF AG

Inventor： KROPP RUDOLF ,  THYES MARCO DR ,  SCHLECKER RAINER DR ,  FRANKE ALBRECHT DR ,  REICHENEDER FRANZ DR ,  AMANN AUGUST DR MED ,  TESCHENDORF HANS-JUERGEN DR ME ,  KRETZSCHMAR ROLF PROF DR MED ,  TRAUT MARTIN DR ,  GRIES JOSEF DR MED

IPC: A61K31/50 ,  A61P9/02 ,  A61P25/00 ,  A61P25/24 ,  A61P25/26 ,  C07D237/20 ,  C07D237/22

公开(公告)号：DE2456958A1

公开(公告)日：1976-06-16

申请号：DE2456958

申请日：1974-12-03

Applicant: BASF AG

Inventor： AMANN AUGUST DR MED ,  VILHUBER HEINZ GEORG DIPL CHEM ,  KUNZE JOHANNES DR MED ,  GIERTZ HUBERT PROF DR MED ,  FRAKE ALBRECHT DIPL CHEM DR

IPC: A61K31/275 ,  C07C29/147 ,  C07C67/00 ,  C07C253/00 ,  C07C255/32 ,  C07C255/33 ,  C07C121/66

公开(公告)号：DE2441350A1

公开(公告)日：1976-03-18

申请号：DE2441350

申请日：1974-08-29

Applicant: BASF AG

Inventor： AMANN AUGUST DR MED ,  ZEEH BERND DIPL CHEM ,  KOENIG KARL-HEINZ DIPL CHEM DR ,  GIERTZ HUBERT PROF DR MED ,  RENTZEA COSTIN DIPL ING DR ,  WEIFENBACH HARALD DR

IPC: C07D265/30 ,  C07D295/13

Abstract: Carbamates or formamides of formula (I) (where R1 is H or 1-8C alkoxy; X1 is H, Cl or Br; X2 and X3 are Cl or Br; Y is O or S; R is 1-4C alkyl and/or phenyl; and n is 1,2 or 3; provided that when n is 2 the two R's are not both methyl or both phenyl, or the two R's are methyl in the 2,2-, 2,5- or 2,6-position), e.g. N-(1-formamido-2,2,2-trichloroethyl)-2,6-dimethylmorpholine or N-(1-ethoxycarbonylamino-2,2,2-trichloroethyl)-2,6-dimethylmorpho- line, and their pharmacologically tolerable salts are new cpds. (I) have sedative, hypnotic, narcotic and anticonvulsant activity and can be used e.g. in the treatment of sleep disorders; dosage is 100-200 mg. Results of pharmacological tests are given in the specification; thus, 4-(1-formamido-2,2,2-trichloroethyl)2-methyl-morpholine in a dosage of 46.4, 100 or 215mg/kg p. o gives a lowering of rat body temperature of 1.82, 2.00 or 3.07 degrees C, resp. (lowering of body temp. is a measure of sedative and narcotic activity).

公开(公告)号：DE2310142A1

公开(公告)日：1974-09-12

申请号：DE2310142

申请日：1973-03-01

Applicant: BASF AG

Inventor： AMANN AUGUST DR MED ,  KOENIG HORST DIPL CHEM DR ,  THIEME PETER C DIPL CHEM DR ,  GIERTZ HUBERT PROF DR MED

IPC: C07C45/75 ,  C07C47/56 ,  C07D319/08 ,  C07D15/08 ,  A61K27/00

Abstract: New cpds. of formula (I) (where R1 is H, opt. substd. 1-8 C alkyl, opt. alkyl-substd. 3-6C cyclo-alkyl, or -CR4R5-(CH2)m -C triple bond CH; R4 is H or 1-4C alkyl and R5 is 1-6C alkyl, or R4+R5 is (CH2)p; p = 3-6; m = 0 or 1;R2 and R3 are 1-4C alkyl or R2+R3 is (CH2)n; n = 3-5) are pref. prepd. by reacting a cpd. (II) with R1NH2.

公开(公告)号：DE2219841A1

公开(公告)日：1973-10-25

申请号：DE2219841

申请日：1972-04-22

Applicant: BASF AG

Inventor： HAGEN HELMUT DR ING ,  AMANN AUGUST DR MED ,  GIERTZ HUBERT PROF DR MED

IPC: A01N43/48 ,  C07D233/20 ,  C07D239/06 ,  C07D271/06 ,  C07D271/10 ,  C07D49/34