公开(公告)号：DE3882589D1

公开(公告)日：1993-09-02

申请号：DE3882589

申请日：1988-05-13

Applicant: BASF AG

Inventor： STEINER GERD DR ,  PFISTER JUERGEN DR ,  TESCHENDORF HANS-JUERGEN DR ,  UNGER LILIANE DR ,  BINDER RUDOLF DR

IPC: A61K31/55 ,  A61P21/02 ,  A61P25/00 ,  A61P25/02 ,  A61P25/20 ,  C07D487/04

Abstract: 4-Amino-10-cyanomethylene -pyrrolo (3,4-c) benz(b)azepine derivs. of formula (I) and their acid-addn. salts are new: In (I), R1 = H, halogen, 1-3C alkyl, CF3 or 1-3C alkoxy; R2 and R3 = H or halogen; R4 = H, 1-3C alkyl, or aryl (1-3C) alkyl opt. ring-substd. by halogen, 1-3C alkyl or OMe; A = NR3R6 or NHR7; NR5R6 is a satd. 5- to 7-membered ring opt. contg. O, NR or NR-O; R = H, 1-3C alkyl, 2-3C hydroxyalkyl, 2-3C alkoxyalkyl, 3-7C cycloalkyl, (3-7C cycloalkyl)methyl or 2-5C alkynyl; R7 = 2-7C aminoalkyl in which the amine N is opt. substd. by a 1-5C alkyl gp. or forms part of a satd. 5- to 7-membered ring opt. contg. O or NR"; R" = H, 1-3C alkyl or 2-3C hydroxyalkyl. 10-Cyanomethylene-4- (4-methyl-1-piperazinyl)- pyrrolo (3,4-c) benz(b)azepine and its 7-chloro deriv. are specifically claimed.

公开(公告)号：DE4032766A1

公开(公告)日：1992-04-30

申请号：DE4032766

申请日：1990-10-16

Applicant: BASF AG

Inventor： LUBISCH WILFRIED DR ,  SCHULT SABINE DR ,  BINDER RUDOLF DR ,  RASCHACK MANFRED DR ,  REINHARDT ROLAND DR ,  SEEMANN DIETMAR DR

IPC: A61K31/445 ,  A61K31/4427 ,  A61K31/4468 ,  A61P9/00 ,  C07D211/58 ,  C07D401/12

Abstract: Phenylpiperidylamines of the formula I I R1 is H, NO2, R4SO2NH, N=C, CF3, CF3O, F, Cl, Br, C1-C4-alkyl, R3O, CO2R3, CHO, CH=NOR3, CH3OR3 and R2 is H, F, Cl, Br, C1-C4-alkyl or R4O, where R1 and R2 are not both H, R3 is H or R4, R4 is C1-C4-alkyl or phenyl, n is 1, 2, 3 or 4 and Ar is and the physiologically tolerated salts thereof, are used as active ingredients in drugs.

公开(公告)号：CZ9503008A3

公开(公告)日：1996-02-14

申请号：CZ300895

申请日：1994-05-09

Applicant: BASF AG

Inventor： GRABOWSKI SVEN DR ,  MUELLER WINFRIED DR ,  ROSENBERG JOERG DR ,  BINDER RUDOLF DR ,  SANNER AXEL DR

IPC: A61K47/32 ,  A61K9/14 ,  A61K31/37 ,  A61K31/41 ,  A61K31/425 ,  A61K31/433 ,  A61K47/38

CPC classification number: A61K9/146 ,  A61K31/37 ,  A61K31/41 ,  A61K31/425 ,  A61K31/433

公开(公告)号：DE59106082D1

公开(公告)日：1995-08-31

申请号：DE59106082

申请日：1991-10-02

Applicant: BASF AG

Inventor： LUBISCH WILFRIED DR ,  SCHULT SABINE DR ,  BINDER RUDOLF DR ,  RASCHACK MANFRED DR ,  REINHARDT ROLAND DR ,  SEEMANN DIETMAR DR

IPC: A61K31/445 ,  A61K31/4468 ,  A61P9/00 ,  C07D211/58

Abstract: Phenylpiperidinylamines of the formula I I where R1 is -NHSO2R4 or R2 and R3 are each, independently of one another, H or C1-C4-alkyl or together are a (CH2)n chain with n=4 or 5, and R4 is C1-C4-alkyl or phenyl, and the physiologically tolerated salts thereof, and pharmaceutical compositions containing these are described.

公开(公告)号：AT125531T

公开(公告)日：1995-08-15

申请号：AT91116812

申请日：1991-10-02

Applicant: BASF AG

Inventor： LUBISCH WILFRIED DR ,  SCHULT SABINE DR ,  BINDER RUDOLF DR ,  RASCHACK MANFRED DR ,  REINHARDT ROLAND DR ,  SEEMANN DIETMAR DR

IPC: A61K31/445 ,  A61K31/4468 ,  A61P9/00 ,  C07D211/58

Abstract: Phenylpiperidinylamines of the formula I I where R1 is -NHSO2R4 or R2 and R3 are each, independently of one another, H or C1-C4-alkyl or together are a (CH2)n chain with n=4 or 5, and R4 is C1-C4-alkyl or phenyl, and the physiologically tolerated salts thereof, and pharmaceutical compositions containing these are described.

公开(公告)号：AT92069T

公开(公告)日：1993-08-15

申请号：AT88107762

申请日：1988-05-13

Applicant: BASF AG

Inventor： STEINER GERD DR ,  PFISTER JUERGEN DR ,  TESCHENDORF HANS-JUERGEN DR ,  UNGER LILIANE DR ,  BINDER RUDOLF DR

IPC: A61K31/55 ,  A61P21/02 ,  A61P25/00 ,  A61P25/02 ,  A61P25/20 ,  C07D487/04

公开(公告)号：DE4032767A1

公开(公告)日：1992-04-30

申请号：DE4032767

申请日：1990-10-16

Applicant: BASF AG

Inventor： LUBISCH WILFRIED DR ,  SCHULT SABINE DR ,  BINDER RUDOLF DR ,  RASCHACK MANFRED DR ,  REINHARDT ROLAND DR ,  SEEMANN DIETMAR DR

IPC: A61K31/445 ,  A61K31/4468 ,  A61P9/00 ,  C07D211/58

Abstract: Phenylpiperidinylamines of the formula I I where R1 is -NHSO2R4 or R2 and R3 are each, independently of one another, H or C1-C4-alkyl or together are a (CH2)n chain with n=4 or 5, and R4 is C1-C4-alkyl or phenyl, and the physiologically tolerated salts thereof, and pharmaceutical compositions containing these are described.

公开(公告)号：DE3717069A1

公开(公告)日：1988-12-08

申请号：DE3717069

申请日：1987-05-21

Applicant: BASF AG

Inventor： STEINER GERD DR ,  TESCHENDORF HANS-JUERGEN DR ME ,  UNGER LILIANE DR ,  BINDER RUDOLF DR

IPC: A61K31/55 ,  A61P21/02 ,  A61P25/00 ,  A61P25/20 ,  C07D495/04

Abstract: Compounds of the formula I where R1, R2, R3 and A have the meanings stated in the specification, as well as the use thereof for controlling diseases, are described.