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    11.
    发明专利
    未知

    公开(公告)号：DE3867183D1

    公开(公告)日：1992-02-06

    申请号：DE3867183

    申请日：1988-09-03

    Applicant: BASF AG

    Inventor： KOEHLER HERMANN DR ,  DOCKNER TONI DR ,  KARN HELMUT

    IPC: C07D233/90

    Abstract: In the prodn. of 1-alkyl-imidazole-5-carboxylic acid derivs. of formula (I), a corresp. 1-unsubstd. cpd. of formula (II) is reacted with a dialkyl sulphate of formula (R1O)2SO2 (III) at elevated temp. in the presence of a carboxylic acid and/or carboxylic acid anhydride. In formulae, R1 is alkyl, R2,R3 are H, alkyl, (ar)alkyl or alkylaryl, R4 is COOH, COOR5, CONH2 or CN; and R5 is 1-8C alkyl. The reaction is pref. carried out in the presence of a 1-8C carboxylic acid of 4-16C carboxylic acid anhydride, pref. used in an amt. of 40-2000 ml. per mol. (II).

    12.
    发明专利
    未知

    公开(公告)号：DE2908212A1

    公开(公告)日：1980-09-11

    申请号：DE2908212

    申请日：1979-03-02

    Applicant: BASF AG

    Inventor： KEMPE UWE DIPL CHEM DR ,  DOCKNER TONI DIPL CHEM DR ,  FRANK ANTON ,  KARN HELMUT

    IPC: C07D233/54 ,  C07D233/64

    Abstract: A process for the manufacture of 5-hydroxymethylimidazoles by reaction of an imidazole with formaldehyde or an oligomer of formaldehyde in aqueous hydrochloric acid solution containing from 5 to 18% by weight of hydrogen chloride, at from 80 DEG to 160 DEG C., if desired in a closed system under pressure, followed by isolation in the form of its hydrochloride of the 5-hydroxymethylimidazole obtained.

    Opt-2-substd. imidazoles prepn - by reacting aldehydes with glyoxal and ammonia
    14.
    发明专利
    Opt-2-substd. imidazoles prepn - by reacting aldehydes with glyoxal and ammonia 未知

    公开(公告)号：DE2360175A1

    公开(公告)日：1975-06-05

    申请号：DE2360175

    申请日：1973-12-03

    Applicant: BASF AG

    Inventor： FRANK ANTON ,  KARN HELMUT ,  SPAENIG HERMANN DIPL CHEM DR

    IPC: C07D233/54 ,  C07D233/58 ,  C07D233/90 ,  C07D233/04

    Abstract: 2-Substd. imidazoles of formula (I): (where R1 is H, an aliphatic, araliphatic, cycloaliphatic or aromatic residue, or a group -CO-OR2 in which R2 is an aliphatic, araliphatic, cycloaliphatic, or aromatic residue), e.g. 2-octyl-imidazole, are prepd. by reacting glyoxal with ammonia and aldehydes of the formula R1-CHO (II) in the presence of 100-2000 wt. % (based on (II) of an inert solvent for a reaction time of is not >250 seconds. (I) are useful as catalysts for polymerisation and condensation reactings; intermediates for dyes, textile and insecticides; and intermediates for di-, tri- or tetra-substituted imidazoles, esp. the pharmaceutically important 2-alkyl-4(5)-nitro-imidazoles. Process is simple and economical giving (I) in (in some cases) improved overall yields, improved space-time yields and improved purity.

    16.
    发明专利
    未知

    公开(公告)号：DE2232352A1

    公开(公告)日：1974-01-17

    申请号：DE2232352

    申请日：1972-07-01

    Applicant: BASF AG

    Inventor： SPAENIG HERMANN DR ,  DOCKNER TONI DR ,  KARN HELMUT

    IPC: C07C51/42 ,  C07C59/153 ,  C07C59/30

    Abstract: A process for the recovery of glyoxylic acid as a byproduct in the synthesis of glyoxal by elution of the ion exchanger used for purifying the glyoxal and crystallization of sodium glyoxylate at a pH of from 3 to 6 from the aqueous eluate.

    PREPARATION OF 5-HYDROXYMETHYLIMIDAZOLES
    19.
    发明专利
    PREPARATION OF 5-HYDROXYMETHYLIMIDAZOLES 未知

    公开(公告)号：CA1134839A

    公开(公告)日：1982-11-02

    申请号：CA346104

    申请日：1980-02-19

    Applicant: BASF AG

    Inventor： KEMPE UWE ,  DOCKNER TONI ,  FRANK ANTON ,  KARN HELMUT

    IPC: C07D233/54 ,  C07D233/64

    Abstract: The invention is concerned with a process for the preparation of a 5-hydroxymethylimidazole of the formula 1 1 where R1 is hydrogen or alkyl of 1 to 18 carbon atoms, phenyl, benzyl or .beta.-phenylethyl, and R2 is alkyl of 1 to 18 carbon atoms or phenyl, wherein an imdazole of the formula 2 2 where R1 and R2 have the meanings given for formula 1, is reacted with formaldehyde or an oligomer of formaldehyde is aqueous hydrochloric acid solution, containing from 5 to 18% by weight of hydrogen chloride, at from 80.degree. to 160.degree.C, if appropriate in a closed system under pressure, the resulting 5hydroxymethylimidazole is isolated in the form of its hydrochloride and the ratio of imidazole to hydrogen chloride being from 1:1.5 to 1:5. The process according to the present invention is particularly usable to prepare 5-hydroxymethylimidazoles in a very simple manner, and in a form free from by-products, on an industrial scale.

    PROCESS FOR PREPARING 5-(HYDROXYMETHYL)IMIDAZOLES
    20.
    发明专利
    PROCESS FOR PREPARING 5-(HYDROXYMETHYL)IMIDAZOLES 未知

    公开(公告)号：DE3060433D1

    公开(公告)日：1982-07-08

    申请号：DE3060433

    申请日：1980-02-29

    Applicant: BASF AG

    Inventor： KEMPE UWE DR ,  DOCKNER TONI DR ,  FRANK ANTON ,  KARN HELMUT

    IPC: C07D233/54 ,  C07D233/64

    Abstract: A process for the manufacture of 5-hydroxymethylimidazoles by reaction of an imidazole with formaldehyde or an oligomer of formaldehyde in aqueous hydrochloric acid solution containing from 5 to 18% by weight of hydrogen chloride, at from 80 DEG to 160 DEG C., if desired in a closed system under pressure, followed by isolation in the form of its hydrochloride of the 5-hydroxymethylimidazole obtained.

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