公开(公告)号：ZA838760B

公开(公告)日：1984-08-29

申请号：ZA838760

申请日：1983-11-24

Applicant: BASF AG

Inventor： SEITZ WERNER ,  TESCHENDORF HANS-JUERGEN ,  ALFRED MICHEL ,  TRAUT MARTIN ,  HOFMANN HANS PETER ,  KREISKOTT HORST

IPC: C07C225/18 ,  A61K31/135 ,  A61K31/205 ,  A61K31/395 ,  A61P25/24 ,  A61P25/26 ,  C07D207/08 ,  C07D211/32 ,  C07D295/10 ,  C07D295/116 ,  C07D295/12 ,  C07D295/145 ,  A61K ,  C07D

Abstract: 1-Oxo-2-phenyl-2-(2-alkylaminoethyl)-1,2,3,4-tetrahydronaphthalenes of the formula I I where R1 and R2 are identical or different and are each hydrogen, halogen, trifluoromethyl, C1-C4-alkyl or C1-C4-alkoxy, R3 is C1-C6-alkyl and R4 is hydrogen, C1-C6-alkyl or benzyl, or R3 and R4 together may furthermore be a C2-C5-alkylene chain, and their salts with physiologically tolerated acids, and their preparation, are described. The novel compounds are useful active compounds for treating disorders.

公开(公告)号：AU536527B2

公开(公告)日：1984-05-10

申请号：AU6813981

申请日：1981-03-06

Applicant: BASF AG

Inventor： STEINER GERD ,  HOFMANN HANS PETER ,  KREISKOTT HORST ,  TESCHENDORF HANS-JUERGEN ,  LENKE DIETER

IPC: C07D295/14 ,  A61K31/275 ,  A61K31/395 ,  A61K31/50 ,  A61K31/55 ,  A61P25/20 ,  C07C67/00 ,  C07C253/00 ,  C07C255/37 ,  C07C255/42 ,  C07D243/08 ,  C07D295/08 ,  C07D295/155 ,  A61K31/505 ,  C07C121/78 ,  C07D211/22 ,  C07D295/22

Abstract: 10-Substituted 5-cyanomethylene-dibenzo[a,d]-cycloheptenes, their pure cis- and trans-isomers, their N-oxides and their pharmaceutically tolerated addition salts with acids, processes for their preparation, therapeutic agents containing these compounds and their use as drugs, especially as sedatives, hypnotics or tranquilizers.

公开(公告)号：CA1148946A

公开(公告)日：1983-06-28

申请号：CA350809

申请日：1980-04-28

Applicant: BASF AG

Inventor： STEINER GERD ,  FRANKE ALBRECHT ,  LENKE DIETER ,  TESCHENDORF HANS-JUERGEN ,  WORSTMANN WOLFGANG ,  KREISKOTT HORST

IPC: A61K31/55 ,  A61P25/18 ,  C07D223/20 ,  C07D401/06 ,  C07D403/04

Abstract: 6-Substituted 11-alkylene-morphanthridines, also referred to as 11-alkylene-di-benzo¢b,e!-azepines, their pure cis- and trans-isomers, processes for their preparation, and therapeutic agents containing these compounds, which may be used as drugs, in particular neuroleptics, sedatives, hypnotics, analgesics, antidepressants or agents for treating Parkinson's syndrome.

公开(公告)号：ZA8106927B

公开(公告)日：1982-10-27

申请号：ZA8106927

申请日：1981-10-07

Applicant: BASF AG

Inventor： STEINER GERD ,  TESCHENDORF HANS JUERGEN ,  KREISKOTT HORST ,  HOFMANN HANS PETER

IPC: A61K31/55 ,  A61P25/00 ,  A61P25/08 ,  A61P25/20 ,  C07D495/14 ,  C07D

CPC classification number: C07D495/14

公开(公告)号：FI781872A

公开(公告)日：1978-12-14

申请号：FI781872

申请日：1978-06-12

Applicant: BASF AG

Inventor： BINNIG FRITZ ,  FRIEDRICH LUDWIG ,  HOFMANN HANS PETER ,  KREISKOTT HORST ,  MUELLER CLAUS ,  RASCHACK MANFRED

IPC: A61K31/435 ,  A61K31/445 ,  A61P9/06 ,  C07D221/00 ,  C07D471/08 ,  C07D

Abstract: Bispidine derivatives of the formula where R1 is H or C6H5, R2 is H, Cl or CF3, R3 is H, F or Cl and X is 0 or 1, and drugs which contain these compounds. The compounds are prepared by condensing N-monobenzylbispidine with appropriately substituted phenylethyl halides or by a Mannich reaction of N-benzylpiperid-4-one with appropriately substituted phenylalkylamines, followed by reduction. They exhibit mainly anti-arrhythmic action.

公开(公告)号：FI79526B

公开(公告)日：1989-09-29

申请号：FI844645

申请日：1984-11-27

Applicant: BASF AG

Inventor： RASCHACK MANFRED ,  KREISKOTT HORST ,  SEITZ WERNER

IPC: C07B57/00 ,  A61K20060101 ,  A61K31/275 ,  A61P9/00 ,  C07B31/00 ,  C07C20060101 ,  C07C67/00 ,  C07C253/00 ,  C07C255/32 ,  C07C255/42 ,  C07C255/58 ,  C07D20060101 ,  C07C121/66

Abstract: 1,7-diphenyl-3-methylaza-7-cyano-8-methylnonane and its antipodes and salts are used for the treatment of diseases.

公开(公告)号：DK152289B

公开(公告)日：1988-02-15

申请号：DK443881

申请日：1981-10-07

Applicant: BASF AG

Inventor： STEINER GERD ,  TESCHENDORF HANS-JUERGEN ,  KREISKOTT HORST ,  HOFMANN HANS PETER

IPC: A61K31/55 ,  A61P25/00 ,  A61P25/08 ,  A61P25/20 ,  C07D223/00 ,  C07D333/00 ,  C07D495/14

公开(公告)号：CA1226291A

公开(公告)日：1987-09-01

申请号：CA441471

申请日：1983-11-18

Applicant: BASF AG

Inventor： TREIBER HANS J ,  HOFMANN HANS P ,  KREISKOTT HORST ,  TESCHENDORF HANS-JUERGEN ,  TRAUT MARTIN

IPC: A61K31/13 ,  A61K31/135 ,  A61K31/215 ,  A61K31/265 ,  A61P25/24 ,  A61P25/26 ,  C07C47/00 ,  C07C67/00 ,  C07C213/00 ,  C07C217/30 ,  C07C217/48 ,  C07C219/22 ,  C07C239/00 ,  C07C271/10 ,  C07C313/00 ,  C07C319/20 ,  C07C323/12 ,  C07C323/25 ,  C07D295/08 ,  C07D295/084 ,  C07D295/10 ,  C07D295/104 ,  C07C91/16 ,  C07C149/42 ,  C07D295/04

Abstract: Phenylpropanolamines of the formula I I where R1 is hydrogen or halogen, R2 is hydrogen, a saturated or unsaturated hydrocarbon radical of not more than 15 carbon atoms or phenyl, R3 is hydrogen, a saturated or unsaturated hydrocarbon radical of not more than 3 carbon atoms, C1-C4-acyl, benzoyl, C2-C4-carbalkoxy or a carboxamido group -CO-NHR6, where R6 is C1-C4-alkyl, R4 is hydrogen or halogen, R5 is dimethylamino, piperidino or pyrrolidino and X is oxygen or sulfur, their salts with physiologically tolerated acids and their preparation are described. These compounds are useful for treating psychological illnesses, especially depression.

公开(公告)号：FI71132C

公开(公告)日：1986-11-24

申请号：FI801228

申请日：1980-04-17

Applicant: BASF AG

Inventor： STEINER GERD ,  FRANKE ALBRECHT ,  LENKE DIETER ,  TESCHENDORF HANS-JUERGEN ,  WORSTMANN WOLFGANG ,  KREISKOTT HORST

IPC: A61K31/55 ,  A61P25/18 ,  C07D223/20 ,  C07D401/06 ,  C07D403/04 ,  C07D401/04

Abstract: 6-Substituted 11-alkylene-morphanthridines, also referred to as 11-alkylene-dibenzo[b,e]-azepines, their pure cis- and trans-isomers, processes for their preparation, and therapeutic agents containing these compounds, which may be used as drugs, in particular neuroleptics, sedatives, hypnotics, analgesics, antidepressants or agents for treating Parkinson's syndrome.

公开(公告)号：DK585984A

公开(公告)日：1985-06-11

申请号：DK585984

申请日：1984-12-07

Applicant: BASF AG

Inventor： RASCHACK MANFRED ,  KREISKOTT HORST ,  SEITZ WERNER

IPC: C07B57/00 ,  A61K20060101 ,  A61K31/275 ,  A61P9/00 ,  C07B31/00 ,  C07C20060101 ,  C07C67/00 ,  C07C253/00 ,  C07C255/32 ,  C07C255/42 ,  C07C255/58 ,  C07D20060101 ,  C07D

Abstract: 1,7-diphenyl-3-methylaza-7-cyano-8-methylnonane and its antipodes and salts are used for the treatment of diseases.