公开(公告)号：ES2053677T3

公开(公告)日：1994-08-01

申请号：ES88117889

申请日：1988-10-27

Applicant: BASF AG

Inventor： URBAN DIETER DR ,  LADNER WOLFGANG DR ,  PAUL AXEL DR

IPC: C12N11/08 ,  C12P41/00

Abstract: A biocatalyst is produced by mixing… a) an insoluble, only slightly swellable copolymer of an N-vinyllactam with a cyclic amide which contains at least two ethylenically unsaturated copolymerisable groups, of which at least one is bonded directly to the amide nitrogen,… b) crude pig pancreatic lipase,… c) at least one water-soluble dihydric to hexahydric alcohol with 2 to 6 carbon atoms and… d) an aqueous buffer solution of pH 5 to 9… at 0 to 40 DEG C, filtering after 1 minute to 3 days and washing the filter cake, and is used for resolving esters of racemic alcohols.

公开(公告)号：DE4220241A1

公开(公告)日：1993-12-23

申请号：DE4220241

申请日：1992-06-20

Applicant: BASF AG

Inventor： STAUDENMAIER HORST RALF DR ,  HAUER BERNHARD DR ,  LADNER WOLFGANG DR ,  MUELLER URSULA DR ,  PRESSLER UWE DR ,  MEYER JOACHIM DR

IPC: C12P7/42 ,  C12P7/54 ,  C12R1/645 ,  C07C59/52

Abstract: The invention concerns a method for the preparation of 3-hydroxyphenylacetic acid by cultivating a microorganism of the species Rhizoctonia, Ceratobasidium or Pellicularia in the presence of a phenyl compound of general formula (I), in which X = COOR, CH2OH, CH2NH2 or (II) and R = methyl, ethyl, hydrogen, sodium, potassium or ammonium.

公开(公告)号：DE3877143D1

公开(公告)日：1993-02-11

申请号：DE3877143

申请日：1988-10-27

Applicant: BASF AG

Inventor： URBAN DIETER DR ,  LADNER WOLFGANG DR ,  PAUL AXEL DR

IPC: C12N11/08 ,  C12P41/00

Abstract: Prodn. of biocatalysts is effected by (a) mixing a carrier with crude porcine pancreatic lipase (PPL), an aq. buffer soln. (pH 5-9) and a water-soluble 2-6C polyol contg. 2-6 OH gps., at 0-40 deg.C, (b) filtering the mixt. after 1 min. to 3 days and (c) washing the filter cake. The carrier is a powdered, insoluble, only slightly swellable copolymer of (i) an N-vinyl 4-6C lactam and (ii) a cyclic amide contg. at least two ethylenically unsatd. copolymerisable gps..

公开(公告)号：ES2100759T3

公开(公告)日：1997-06-16

申请号：ES95108695

申请日：1995-06-07

Applicant: BASF AG

Inventor： STAUDENMAIER HORST RALF DR ,  HAUER BERNHARD DR ,  BALKENHOHL FRIEDHELM DR ,  LADNER WOLFGANG DR ,  SCHNELL URSULA DR ,  PRESSLER UWE DR

IPC: C12P17/10 ,  C12P41/00 ,  C12R1/01 ,  C12R1/38

Abstract: Prodn. of enantiomeric lactams of formula (I) comprises reacting a racemate (I) with a biocatalyst which reacts with one enantiomer and isolating the unreacted enantiomer from the mixt. obtd. R1, R2 = 1-4C alkyl, 2-4C alkenyl or aryl (all opt. substd.), H or (CH2)n-COOH; n = 0-3; x = 1-5. Pref. the biocatalyst is a microorganism, esp. from Pseudomonas or Rhodococcus.

公开(公告)号：DE59500222D1

公开(公告)日：1997-06-12

申请号：DE59500222

申请日：1995-06-07

Applicant: BASF AG

Inventor： STAUDENMAIER HORST RALF DR ,  HAUER BERNHARD DR ,  BALKENHOHL FRIEDHELM DR ,  LADNER WOLFGANG DR ,  SCHNELL URSULA DR ,  PRESSLER UWE DR

IPC: C12P17/10 ,  C12P41/00 ,  C12R1/01 ,  C12R1/38

Abstract: Prodn. of enantiomeric lactams of formula (I) comprises reacting a racemate (I) with a biocatalyst which reacts with one enantiomer and isolating the unreacted enantiomer from the mixt. obtd. R1, R2 = 1-4C alkyl, 2-4C alkenyl or aryl (all opt. substd.), H or (CH2)n-COOH; n = 0-3; x = 1-5. Pref. the biocatalyst is a microorganism, esp. from Pseudomonas or Rhodococcus.

公开(公告)号：DE19534208A1

公开(公告)日：1997-03-20

申请号：DE19534208

申请日：1995-09-15

Applicant: BASF AG

Inventor： DITRICH KLAUS DR ,  BALKENHOHL FRIEDHELM DR ,  LADNER WOLFGANG DR

IPC: C12M1/40 ,  B01J23/04 ,  C07B53/00 ,  C07B61/00 ,  C07C69/708 ,  C07C209/62 ,  C07C211/27 ,  C07C235/06 ,  C07C231/02 ,  C07C231/18 ,  C07C31/20

Abstract: The invention concerns a method of separating optically active amides to form carboxylic acids and optically active amines such thatsthe centre of chirality is maintained. The method is characterized in that the amides are hydrolyzed in the presence of a polyol or an aminoalcohol and an alkali or alkaline earth hydroxide.

公开(公告)号：DE4414548A1

公开(公告)日：1995-11-02

申请号：DE4414548

申请日：1994-04-26

Applicant: BASF AG

Inventor： DINGLER CHRISTOPH DR ,  LADNER WOLFGANG DR ,  KREI GEORG ARNOLD

IPC: C12P7/42 ,  C12P1/00 ,  C12P7/40 ,  C12P7/62 ,  C12R1/645 ,  C07C59/68

Abstract: A process for the biotransformation of carboxylic acids in the presence of a microorganism in which the best possible concentration of undissociated carboxylic acid for biotransformation is set by controlling the pH throughout the biotransformation process.

公开(公告)号：DE4344211A1

公开(公告)日：1995-06-29

申请号：DE4344211

申请日：1993-12-23

Applicant: BASF AG

Inventor： BAKLENHOHL FRIEDHELM DR ,  HAUER BERNHARD DR ,  LADNER WOLFGANG DR ,  PRESSLER UWE DR ,  RETTENMAIER HANSJOERG DR ,  ADAM GEO DR

IPC: C12N9/20 ,  C12N9/96 ,  C07B41/12 ,  C07C53/126 ,  C07C69/22 ,  C12N9/14 ,  C12N9/18

公开(公告)号：DE3910024A1

公开(公告)日：1990-10-11

申请号：DE3910024

申请日：1989-03-28

Applicant: BASF AG

Inventor： COOPER BRYAN DR ,  LADNER WOLFGANG DR ,  HAUER BERNHARD DR ,  SIEGEL HARDO DR

IPC: C12P7/42 ,  C12P7/52 ,  C12R1/465 ,  C12R1/48 ,  C12R1/55 ,  C12R1/645 ,  C12R1/66 ,  C12R1/685 ,  C12R1/79

Abstract: Process for oxidizing 2-(phenoxy-)propionic acid to 2-(4-hydroxyphenoxy-)propionic acid using microorganisms.

公开(公告)号：DE3815722A1

公开(公告)日：1989-11-16

申请号：DE3815722

申请日：1988-05-07

Applicant: BASF AG

Inventor： LADNER WOLFGANG DR ,  SIEGEL HARDO DR

IPC: C12P7/40 ,  C12P41/00

Abstract: The selective hydrolysis of compounds of the formula in which R to R have the meaning specified in the description, is described.