公开(公告)号：DE19648793A1

公开(公告)日：1998-05-28

申请号：DE19648793

申请日：1996-11-26

Applicant: BASF AG

Inventor： LUBISCH WILFRIED DR ,  MOELLER ACHIM DR ,  TREIBER HANS-JOERG DR

IPC: A61K31/16 ,  A61K31/166 ,  A61K31/18 ,  A61K31/4045 ,  A61K31/435 ,  A61K31/4402 ,  A61K31/4406 ,  A61K31/4409 ,  A61K31/47 ,  A61P9/10 ,  A61P21/00 ,  A61P25/00 ,  A61P25/08 ,  A61P25/28 ,  A61P27/00 ,  A61P35/00 ,  A61P35/04 ,  A61P43/00 ,  C07C233/76 ,  C07C235/42 ,  C07C235/46 ,  C07C235/58 ,  C07C235/60 ,  C07C235/84 ,  C07C237/42 ,  C07C311/08 ,  C07C311/21 ,  C07C317/44 ,  C07C323/42 ,  C07C323/60 ,  C07D209/14 ,  C07D209/16 ,  C07D213/30 ,  C07D213/56 ,  C07D213/71 ,  C07D213/82 ,  C07D215/36 ,  C07C233/42 ,  C07C323/56 ,  C07C323/25 ,  C12N9/99

Abstract: The invention relates to compounds of the formula (I) in which R , R , R , X and n have the meaning given in the description. The compounds are suitable for combating diseases.

公开(公告)号：AT69953T

公开(公告)日：1991-12-15

申请号：AT88120960

申请日：1988-12-15

Applicant: BASF AG

Inventor： HERR DIETER DR ,  DOERPER THOMAS DR ,  DAUM LOTHAR DR ,  GEISS KARL-HEINZ DR ,  MOELLER ACHIM DR

IPC: C08B37/10 ,  A61K20060101 ,  A61K31/715 ,  A61P31/12 ,  A61K31/725

公开(公告)号：DE3839639A1

公开(公告)日：1990-05-31

申请号：DE3839639

申请日：1988-11-24

Applicant: BASF AG

Inventor： MOELLER ACHIM DR ,  KAPP ALEXANDER DR

IPC: A61K38/00 ,  A61K38/19 ,  A61P17/00

Abstract: The use of TNF in the treatment of inflammatory skin diseases is described.

公开(公告)号：DE3744119A1

公开(公告)日：1989-07-06

申请号：DE3744119

申请日：1987-12-24

Applicant: BASF AG

Inventor： HERR DIETER DR ,  DOERPER THOMAS DR ,  DAUM LOTHAR DR ,  GEISS KARL-HEINZ DR ,  MOELLER ACHIM DR

IPC: C08B37/10 ,  A61K20060101 ,  A61K31/715 ,  A61P31/12

公开(公告)号：DE3620656A1

公开(公告)日：1987-12-23

申请号：DE3620656

申请日：1986-06-20

Applicant: BASF AG

Inventor： SCHOLLMEIER KLAUS DR ,  MOELLER ACHIM DR ,  KOERWER WOLFGANG DR ,  DOERPER THOMAS DR

IPC: C07K14/52 ,  A61K38/00 ,  A61P35/00 ,  C07K14/00 ,  C07K14/525 ,  C12N15/00 ,  C12N15/09 ,  C12P21/02 ,  C12R1/19 ,  C12N1/20 ,  A61K37/02 ,  A61K45/05 ,  C07K15/04 ,  C07K15/12 ,  C12P19/34 ,  C12P21/00

公开(公告)号：DE19718251A1

公开(公告)日：1998-11-05

申请号：DE19718251

申请日：1997-04-30

Applicant: BASF AG

Inventor： AMMERMANN EBERHARD DR ,  BUTTERFIELD EARLE DR ,  LERCHL JENS DR ,  LORENZ GISELA DR ,  MOELLER ACHIM DR ,  RABE UDO DR ,  SCHMIDT RALF-MICHAEL DR ,  CONRAD UDO DR

IPC: A01H5/00 ,  C07K14/00 ,  C07K16/44 ,  C12N15/09 ,  C12N15/13 ,  C12N15/82 ,  C12P21/02 ,  A01H1/00 ,  C07K16/00

Abstract: The invention relates to a method for producing fungicide-tolerant plants by expressing a fungicide-binding antibody therein.

公开(公告)号：ES2052513T3

公开(公告)日：1994-07-16

申请号：ES87108847

申请日：1987-06-20

Applicant: BASF AG

Inventor： SCHOLLMEIER KLAUS DR ,  MOELLER ACHIM DR ,  KOERWER WOLFGANG DR ,  DOERPER THOMAS DR ,  HILLEN HEINZ DR ,  DAUM LOTHAR DR ,  EMLING FRANZ DR ,  KEILHAUER GERHARD DR

IPC: C07K14/52 ,  A61K38/00 ,  A61P35/00 ,  C07K14/00 ,  C07K14/525 ,  C12N15/00 ,  C12N15/09 ,  C12P21/02 ,  C12R1/19 ,  A61K37/02 ,  C07K15/00

公开(公告)号：DE3866686D1

公开(公告)日：1992-01-16

申请号：DE3866686

申请日：1988-12-15

Applicant: BASF AG

Inventor： HERR DIETER DR ,  DOERPER THOMAS DR ,  DAUM LOTHAR DR ,  GEISS KARL-HEINZ DR ,  MOELLER ACHIM DR

IPC: C08B37/10 ,  A61K20060101 ,  A61K31/715 ,  A61P31/12 ,  A61K31/725

Abstract: Polysulphated heparins (I) are used to prepare medicaments for prophylaxis and therapy of diseases caused by retroviruses. (I) have an S content of 13-15% and a molecular wt. of 2000-20,000 (esp. 2000-9000 for oral admin). They may be prepd. by converting heparin to the pyridinium salt and reacting this with ClSO3H in pyridine. The medicaments may be formulated for oral or parenteral admin., or as sprays. The daily dose is 10-1000 mg/kg oral or 0.1-10 mg/kg parenteral.

公开(公告)号：DE3925183A1

公开(公告)日：1991-02-07

申请号：DE3925183

申请日：1989-07-29

Applicant: BASF AG

Inventor： DOERPER THOMAS DR ,  HILLEN HEINZ DR ,  EMLING FRANZ DR ,  DAUM LOTHAR DR ,  MOELLER ACHIM DR

IPC: A61K38/00 ,  A61P29/00 ,  A61P31/04 ,  A61P37/06 ,  C07K14/47 ,  C07K14/52 ,  C07K14/525 ,  C07K19/00 ,  C12N1/21 ,  C12N5/24 ,  C12N15/09 ,  C12P21/02 ,  C12R1/19

Abstract: The invention relates to derivatives of the tumour necrosis factor (TNF) produced by joining partial sequences of the heavy leukokinine chain to the terminal amino of the mature human TNF. These proteins are suitable for use in drugs. A process for obtaining them is also described.

公开(公告)号：DE3843534A1

公开(公告)日：1990-07-12

申请号：DE3843534

申请日：1988-12-23

Applicant: BASF AG

Inventor： DAUM LOTHAR DR ,  DOERPER THOAMS DR ,  HILLEN HEINZ DR ,  MOELLER ACHIM DR ,  SCHOLLMEIER KLAUS DR ,  WALKER NIGEL DR ,  KEILHAUER GERHARD DR

IPC: A61K38/00 ,  C07K14/525 ,  C12N1/21 ,  C12N15/28

Abstract: Polypeptides derived from tumour necrosis factors (TNF) differ from natural TNF by the substitution and/or deletion of amino acids. These novel polypeptides are useful therapeutic agents.