公开(公告)号：CA2208539C

公开(公告)日：2004-04-20

申请号：CA2208539

申请日：1995-12-22

Applicant: BASF AG

Inventor： MAIER WERNER ,  ROSENBERG JOERG ,  FRICKE HELMUT ,  BREITENBACH JORG

IPC: A61J3/10 ,  A61K9/20 ,  B30B11/16

Abstract: the present invention concerns a method of producing divisible tablets by me lt calendering: two form cylinders are combined, one of the cylinders having at least one recess with at least one ridge which extends as far as the surface line of the cylinder and forms a break groove.

公开(公告)号：NO313735B1

公开(公告)日：2002-11-25

申请号：NO964410

申请日：1996-10-17

Applicant: BASF AG

Inventor： GRABOWSKI SVEN ,  ROSENBERG JOERG ,  SANNER AXEL

IPC: A61K9/16 ,  A61K9/22

Abstract: Slow-release matrix pellets with a spherical or lenticular shape and uniform maximum diameters in the range from 0.5 to 4 mm, composed ofa) 0.1-87% by weight of at least one biologically active compound,b) 5-50% by weight of at least one water-insoluble polymer,c) 5-45% by weight of at least one lipophilic component as plasticizer for polymer b),d) 3-40% by weight of a natural or semisynthetic gel former,e) 0-50% by weight of one or more conventional formulation aids.

公开(公告)号：DE59609451D1

公开(公告)日：2002-08-22

申请号：DE59609451

申请日：1996-02-01

Applicant: BASF AG

Inventor： GRABOWSKI SVEN ,  BREITENBACH JOERG ,  ROSENBERG JOERG ,  SANNER AXEL

IPC: A61K9/22 ,  A61K9/20

Abstract: PCT No. PCT/EP96/00417 Sec. 371 Date Jul. 30, 1997 Sec. 102(e) Date Jul. 30, 1997 PCT Filed Feb. 1, 1996 PCT Pub. No. WO96/25151 PCT Pub. Date Aug. 22, 1996Solid preparations are obtainable by melt extrusion of A) at least one active compound, B) a mixture of B1) from 10 to 90% by weight of a water-soluble, thermoplastic polymer, and B2) from 10 to 90% by weight of a low-substituted hydroxypropylcellulose, and C) from 0 to 50% by weight, based on the total amount of the preparation, of customary pharmaceutical auxiliaries.

公开(公告)号：AT216224T

公开(公告)日：2002-05-15

申请号：AT96937214

申请日：1996-10-23

Applicant: BASF AG

Inventor： BREITENBACH JOERG ,  HAERTL AXEL PAUL ,  HOFMANN JUERGEN ,  ROSENBERG JOERG ,  SCHIESSL MICHAEL ,  ZETTLER HANS DIETER

IPC: A61J3/10 ,  A61K9/20 ,  A61K9/24 ,  A61K9/28 ,  A61K31/07 ,  A61K31/167 ,  A61K31/192 ,  A61K31/277 ,  A61K31/355 ,  A61K31/375 ,  A61K31/401 ,  A61K31/4422 ,  A61K31/52 ,  A61K31/522 ,  A61K31/60

Abstract: PCT No. PCT/EP96/04601 Sec. 371 Date Apr. 15, 1998 Sec. 102(e) Date Apr. 15, 1998 PCT Filed Oct. 23, 1996 PCT Pub. No. WO97/15293 PCT Pub. Date May 1, 1997The present invention relates to a process for producing multilayer, solid drug forms for oral or rectal administration, which comprises coextrusion of at least two compositions which in each case comprise a thermoplastic, pharmacologically acceptable polymeric binder which is soluble or swellable in a physiological environment, and at least one of which contains a pharmaceutical active ingredient, and shaping the coextruded multilayer material to the required drug form.

公开(公告)号：DK0845982T3

公开(公告)日：2002-03-25

申请号：DK96929292

申请日：1996-08-21

Applicant: BASF AG

Inventor： ROSENBERG JOERG ,  BREITENBACH JOERG

IPC: A61K9/20

Abstract: Lipids are used as aids in the production of solid drug forms by melt extrusion.

公开(公告)号：DK0814781T3

公开(公告)日：2002-03-18

申请号：DK96907412

申请日：1996-03-09

Applicant: BASF AG

Inventor： SANNER AXEL ,  ROSENBERG JOERG ,  BREITENBACH JOERG ,  RIEGER JENS

IPC: A61K9/20 ,  A61K9/16 ,  A61K47/30

公开(公告)号：PT876141E

公开(公告)日：2002-02-28

申请号：PT97901537

申请日：1997-01-17

Applicant: BASF AG

Inventor： ROSENBERG JOERG ,  BREITENBACH JORG

IPC: A61K9/20 ,  A61K31/00 ,  A61K47/04 ,  A61K31/19 ,  A61K31/192 ,  A61K45/00 ,  A61K47/32 ,  A61P25/00 ,  A61P29/00

Abstract: Preparations of non-steroidal analgesics with antipyretic and antiinflammatory effect are obtainable by extrusion and shaping of a melt, comprising, besides one or more active ingredients, a mixture ofa) 40-99.5% by weight of a homopolymer of N-vinylpyrrolidone with a Fikentscher K value of 30,b) 0.25-59.75% by weight of a water-soluble copolymer of N-vinylpyrrolidone, andc) 0.25-10% by weight of one or more physiologically acceptable salts of sodium or potassium,where the stated amounts are based on the total of components a), b) and c).

公开(公告)号：HRP960483B1

公开(公告)日：2002-02-28

申请号：HRP960483

申请日：1996-10-22

Applicant: BASF AG

Inventor： BREITENBACH JOERG ,  HAERTEL AXEL PAUL ,  HOFFMAN JUERGEN ,  ROSENBERG JOERG ,  SCHIESSL MICHAEL ,  ZETTLER HANS DIETER

IPC: A61J3/10 ,  A61K9/20 ,  A61K9/24 ,  A61K9/28 ,  A61K31/07 ,  A61K31/167 ,  A61K31/192 ,  A61K31/277 ,  A61K31/355 ,  A61K31/375 ,  A61K31/401 ,  A61K31/4422 ,  A61K31/52 ,  A61K31/522 ,  A61K31/60

Abstract: PCT No. PCT/EP96/04601 Sec. 371 Date Apr. 15, 1998 Sec. 102(e) Date Apr. 15, 1998 PCT Filed Oct. 23, 1996 PCT Pub. No. WO97/15293 PCT Pub. Date May 1, 1997The present invention relates to a process for producing multilayer, solid drug forms for oral or rectal administration, which comprises coextrusion of at least two compositions which in each case comprise a thermoplastic, pharmacologically acceptable polymeric binder which is soluble or swellable in a physiological environment, and at least one of which contains a pharmaceutical active ingredient, and shaping the coextruded multilayer material to the required drug form.

公开(公告)号：ES2162635T3

公开(公告)日：2002-01-01

申请号：ES95915844

申请日：1995-04-05

Applicant: BASF AG

Inventor： GRABOWSKI SVEN ,  ROSENBERG JOERG ,  SANNER AXEL

IPC: A61K9/16 ,  A61K9/22

Abstract: Slow-release matrix pellets with a spherical or lenticular shape and uniform maximum diameters in the range from 0.5 to 4 mm, composed ofa) 0.1-87% by weight of at least one biologically active compound,b) 5-50% by weight of at least one water-insoluble polymer,c) 5-45% by weight of at least one lipophilic component as plasticizer for polymer b),d) 3-40% by weight of a natural or semisynthetic gel former,e) 0-50% by weight of one or more conventional formulation aids.

公开(公告)号：ES2162237T3

公开(公告)日：2001-12-16

申请号：ES97901537

申请日：1997-01-17

Applicant: BASF AG

Inventor： BREITENBACH JORG ,  ROSENBERG JOERG

IPC: A61K9/20 ,  A61K47/04 ,  A61K31/00 ,  A61K31/19 ,  A61K31/192 ,  A61K45/00 ,  A61K47/32 ,  A61P25/00 ,  A61P29/00

Abstract: Preparations of non-steroidal analgesics with antipyretic and antiinflammatory effect are obtainable by extrusion and shaping of a melt, comprising, besides one or more active ingredients, a mixture ofa) 40-99.5% by weight of a homopolymer of N-vinylpyrrolidone with a Fikentscher K value of 30,b) 0.25-59.75% by weight of a water-soluble copolymer of N-vinylpyrrolidone, andc) 0.25-10% by weight of one or more physiologically acceptable salts of sodium or potassium,where the stated amounts are based on the total of components a), b) and c).