公开(公告)号：CA2409828C

公开(公告)日：2010-08-03

申请号：CA2409828

申请日：2001-05-29

Applicant: BASF AG

Inventor： ROSENBERG JORG ,  BREITENBACH JORG ,  HERR DIETER ,  LAUX VOLKER ,  HEGER ROBERT

IPC: A61K9/16 ,  A61K47/12 ,  A61K9/48 ,  A61K31/726 ,  A61K31/727 ,  A61K47/14 ,  A61K47/30 ,  A61K47/32 ,  A61K47/34 ,  A61K47/38 ,  A61K47/44 ,  A61P1/04 ,  A61P7/02 ,  A61P9/00 ,  A61P9/06 ,  A61P9/10 ,  A61P11/00 ,  A61P13/12 ,  A61P19/02 ,  A61P27/02 ,  A61P29/00 ,  A61P35/00 ,  A61P35/04 ,  A61P37/06

Abstract: The invention relates to formulations based on at least one heparin, one glycosaminoglycan or on one heparinoid, and to a formulation base with a lipid constituent and a polymer constituent. The invention also relates to the use of this formulation as a medicament for orally administering at least one heparin, one glycosaminoglycan or one heparinoid, and to a method for preparing the formulations by mixing the formulation constituents while forming a plastic mixture and, optionally, while preparing the formulations as a medicament while, advantageously, using melt extrusion. The lipid constituent advantageously comprises active substance-promoting properties, whereas the polymer constituent is soluble or is capable of swelling. The invention provides that at least portions of the lipid constituent are embedded in a polymer matrix, preferably in molecularly dispersed form. The formulations can form emulsions in water or in aqueous fluids.

公开(公告)号：NO318236B1

公开(公告)日：2005-02-21

申请号：NO974338

申请日：1997-09-19

Applicant: BASF AG

Inventor： SANNER AXEL ,  ROSENBERG JORG ,  BREITENBACH JORG

IPC: A61K9/00 ,  A61K9/20 ,  A61K31/19 ,  A61K31/192 ,  A61K47/30

Abstract: PCT No. PCT/EP96/01021 Sec. 371 Date Sep. 16, 1997 Sec. 102(e) Date Sep. 16, 1997 PCT Filed Mar. 9, 1996 PCT Pub. No. WO96/29053 PCT Pub. Date Sep. 26, 1996Transparent rapid release active substance compositions obtainable by extrusion of melts, containing non-steroidal analgesics, homopolymers of N-vinylpyrrolidone, saccharides or sugar alcohols and sodium or potassium salts.

公开(公告)号：CA2408915A1

公开(公告)日：2002-11-13

申请号：CA2408915

申请日：2001-05-29

Applicant: BASF AG

Inventor： BERNDL GUNTHER ,  HEGER ROBERT ,  WILKE PETER ,  STADLER MICHAEL ,  BREITENBACH JORG ,  ROSENBERG JORG

IPC: A61F13/53 ,  A23P1/02 ,  A23P1/08 ,  A61F13/49 ,  A61K9/107 ,  A61K9/16 ,  A61K47/00 ,  A61K47/10 ,  A61K47/12 ,  A61K47/14 ,  A61K47/26 ,  A61K47/32 ,  A61K47/34 ,  A61K47/38

Abstract: The present invention relates to self-emulsifying formulations based on an active ingredient component and a formulation base with a lipid component and with a binder component and to the use of this formulation as dosage form in the life science sector. The invention also describes a process for producing self-emulsifying formulations by mixing the formulation components to form a plastic mixture and, where appropriate, to manufacture the formulations as dosage form advantageously by use of melt extrusion. The formulations spontaneously form emulsions in water or aqueous media.

公开(公告)号：ES2125062T3

公开(公告)日：1999-02-16

申请号：ES95943202

申请日：1995-12-22

Applicant: BASF AG

Inventor： ROSENBERG JORG ,  MAIER WERNER ,  FRICKE HELMUT ,  BREITENBACH JORG

IPC: A61J3/10 ,  A61K9/20 ,  B30B11/16

Abstract: PCT No. PCT/EP95/05117 Sec. 371 Date Jun. 18, 1997 Sec. 102(e) Date Jun. 18, 1997 PCT Filed Dec. 22, 1995 PCT Pub. No. WO96/19962 PCT Pub. Date Jul. 4, 1996A process for the production of divisible tablets by melt calendering in which two molding rolls are combined together, at least one of which has depressions with at least one bar which extends up to the surface line of the molding roll and forms a score.

公开(公告)号：AU7963101A

公开(公告)日：2001-12-11

申请号：AU7963101

申请日：2001-05-29

Applicant: BASF AG

Inventor： BERNDL GUNTHER ,  BREITENBACH JORG ,  HEGER ROBERT ,  STADLER MICHAEL ,  WILKE PETER ,  ROSENBERG JORG

IPC: A61F13/53 ,  A23P1/02 ,  A23P1/08 ,  A61F13/49 ,  A61K9/107 ,  A61K9/16 ,  A61K47/00 ,  A61K47/10 ,  A61K47/12 ,  A61K47/14 ,  A61K47/26 ,  A61K47/32 ,  A61K47/34 ,  A61K47/38

Abstract: The present invention relates to self-emulsifying formulations based on an active ingredient component and a formulation base with a lipid component and with a binder component and to the use of this formulation as dosage form in the life science sector. The invention also describes a process for producing self-emulsifying formulations by mixing the formulation components to form a plastic mixture and, where appropriate, to manufacture the formulations as dosage form advantageously by use of melt extrusion. The formulations spontaneously form emulsions in water or aqueous media.

公开(公告)号：CA2409828A1

公开(公告)日：2001-12-06

申请号：CA2409828

申请日：2001-05-29

Applicant: BASF AG

Inventor： LAUX VOLKER ,  BREITENBACH JORG ,  HERR DIETER ,  HEGER ROBERT ,  ROSENBERG JORG

IPC: A61K47/12 ,  A61K9/16 ,  A61K31/726 ,  A61K31/727 ,  A61K47/14 ,  A61K47/30 ,  A61K47/32 ,  A61K47/34 ,  A61K47/38 ,  A61K47/44 ,  A61P1/04 ,  A61P7/02 ,  A61P9/00 ,  A61P9/06 ,  A61P9/10 ,  A61P11/00 ,  A61P13/12 ,  A61P19/02 ,  A61P27/02 ,  A61P29/00 ,  A61P35/00 ,  A61P35/04 ,  A61P37/06 ,  A61K9/48

公开(公告)号：CA2322629A1

公开(公告)日：1999-09-10

申请号：CA2322629

申请日：1999-02-26

Applicant: BASF AG

Inventor： KLEINKE ANDREAS ,  KESSLER THOMAS ,  ROSENBERG JORG ,  KRULL HARALD ,  BERNDL GUNTHER ,  MAIER WERNER ,  BREITENBACH JORG

IPC: A61K9/16 ,  A61K31/135 ,  A61K31/192

Abstract: The invention relates to a method for producing solid, spherical forms containing at least one pharmaceutical active agent homogeneously dispersed in an auxiliary matrix. According to this method, the constituents are mixed to form a melt which is then shaped. The invention is characterised in that at least one pharmaceutical active agent is processed with at least one thermoplastically processable matrix auxiliary to form a homogeneous melt with a viscosity of less than 5000 mPas and in that this melt is shaped into drops using a rotating perforated roll. These drops are then cooled so that they solidify.

公开(公告)号：AU699971B2

公开(公告)日：1998-12-17

申请号：AU4434196

申请日：1995-12-22

Applicant: BASF AG

Inventor： ROSENBERG JORG ,  MAIER WERNER ,  FRICKE HELMUT ,  BREITENBACH JORG

IPC: A61J3/10 ,  A61K9/20 ,  B30B11/16

Abstract: PCT No. PCT/EP95/05117 Sec. 371 Date Jun. 18, 1997 Sec. 102(e) Date Jun. 18, 1997 PCT Filed Dec. 22, 1995 PCT Pub. No. WO96/19962 PCT Pub. Date Jul. 4, 1996A process for the production of divisible tablets by melt calendering in which two molding rolls are combined together, at least one of which has depressions with at least one bar which extends up to the surface line of the molding roll and forms a score.