公开(公告)号：AT133668T

公开(公告)日：1996-02-15

申请号：AT91118954

申请日：1991-11-07

Applicant: BASF AG

Inventor： LUBISCH WILFRIED DR ,  VON PHILIPSBORN GERDA DR ,  SCHULT SABINE DR ,  KIRCHENGAST MICHAEL DR

IPC: A61K31/165 ,  A61K31/00 ,  A61K31/16 ,  A61K31/167 ,  A61K31/40 ,  A61K31/445 ,  A61K31/4453 ,  A61P9/00 ,  A61P9/06 ,  C07C233/29 ,  C07C235/38 ,  C07D295/08 ,  C07D295/088 ,  C07D295/092

Abstract: Substituted anilides of the formula I I (where R1 is C1-C4-alkyl, C1-C4-haloalkyl, C1-C4-alkoxy, halogen, cyano, nitro, C2-C4-alkenyl, C2-C4-alkynyl; X is methylene, ethylene, vinylene; R2 and R3 are each C1-C4-alkyl, C3-C6-cycloalkyl or together are tetra- or pentamethylene; R4 is C1-C4-alkyl, methoxy; n is 2, 3 or 4), and the physiologically tolerated acid addition salts thereof, the pharmaceutical use thereof, drugs produced therefrom and the use thereof for treating cardiac arrhythmias and/or for lowering the heart rate, are described.

公开(公告)号：DE4132013A1

公开(公告)日：1993-04-01

申请号：DE4132013

申请日：1991-09-26

Applicant: BASF AG

Inventor： LUBISCH WILFRIED DR ,  SCHULT SABINE DR ,  BINDER RUDOLF DR ,  RASCHACK MANFRED DR ,  REINHARDT ROLAND DR ,  SEEMANN DIETMAR DR

IPC: A61K31/165 ,  A61K31/18 ,  A61K31/415 ,  A61K31/44 ,  A61K31/4409 ,  A61K31/4418 ,  A61P9/06 ,  C07C217/58 ,  C07C233/80 ,  C07C255/54 ,  C07C255/57 ,  C07C311/08 ,  C07C311/21 ,  C07D213/30 ,  C07D213/38 ,  C07D213/71 ,  C07D213/81 ,  C07D233/60 ,  C07D233/61 ,  C07D295/096 ,  C07D295/135

公开(公告)号：DE3939797A1

公开(公告)日：1991-06-06

申请号：DE3939797

申请日：1989-12-01

Applicant: BASF AG

Inventor： ZECHEL JOHANN-CHRISTIAN DR ,  SCHULT SABINE DR ,  UNGER LILIANE DR

IPC: A61K38/00 ,  C07K14/575

Abstract: The description relates to peptides of the formula: Z-Ak-Bl-Cm-Dn-Eo-Fp-Gq-H-Thr-I-Gln-J-K-NH2, where A - K, Z and k - q have the meaning given in the description, and their production. The peptides are suitable for combatting diseases.

公开(公告)号：DE19614542A1

公开(公告)日：1997-10-16

申请号：DE19614542

申请日：1996-04-12

Applicant: BASF AG

Inventor： AMBERG WILHELM DR ,  KLING ANDREAS DR ,  KLINGE DAGMAR DR ,  RIECHERS HARTMUT DR ,  BAUMANN ERNST DR ,  UNGER LILIANE DR ,  RASCHACK MANFRED DR ,  HERGENROEDER STEFAN ,  SCHULT SABINE DR

IPC: A61K31/00 ,  A61K31/47 ,  A61K31/505 ,  A61P9/00 ,  A61P9/12 ,  A61P13/00 ,  A61P13/12 ,  C07D215/22 ,  C07D215/227 ,  C07D239/34 ,  C07D239/60 ,  C07D401/12 ,  C07D403/12 ,  C07D239/32 ,  C07D213/60 ,  C07C215/16 ,  C07C217/22 ,  C07D227/08 ,  C07D247/02 ,  A61K31/44

Abstract: The present invention relates to carboxylic acid derivatives of formula (I) in which the radicals have the meaning given in the description, and the production of these substances and their use as medicaments.

公开(公告)号：DE59204456D1

公开(公告)日：1996-01-11

申请号：DE59204456

申请日：1992-02-29

Applicant: BASF AG

Inventor： LUBISCH WILFRIED DR ,  SCHULT SABINE DR ,  BEHL BERTHOLD DR ,  KIRCHENGAST MICHAEL DR

IPC: A61K31/445 ,  A61K31/4427 ,  A61K31/4465 ,  A61K31/4468 ,  A61K31/451 ,  A61K31/495 ,  A61K31/496 ,  A61P9/06 ,  C07D211/26 ,  C07D211/56 ,  C07D211/58 ,  C07D401/04 ,  C07D401/06

公开(公告)号：DE59106082D1

公开(公告)日：1995-08-31

申请号：DE59106082

申请日：1991-10-02

Applicant: BASF AG

Inventor： LUBISCH WILFRIED DR ,  SCHULT SABINE DR ,  BINDER RUDOLF DR ,  RASCHACK MANFRED DR ,  REINHARDT ROLAND DR ,  SEEMANN DIETMAR DR

IPC: A61K31/445 ,  A61K31/4468 ,  A61P9/00 ,  C07D211/58

Abstract: Phenylpiperidinylamines of the formula I I where R1 is -NHSO2R4 or R2 and R3 are each, independently of one another, H or C1-C4-alkyl or together are a (CH2)n chain with n=4 or 5, and R4 is C1-C4-alkyl or phenyl, and the physiologically tolerated salts thereof, and pharmaceutical compositions containing these are described.

公开(公告)号：AT125531T

公开(公告)日：1995-08-15

申请号：AT91116812

申请日：1991-10-02

Applicant: BASF AG

Inventor： LUBISCH WILFRIED DR ,  SCHULT SABINE DR ,  BINDER RUDOLF DR ,  RASCHACK MANFRED DR ,  REINHARDT ROLAND DR ,  SEEMANN DIETMAR DR

IPC: A61K31/445 ,  A61K31/4468 ,  A61P9/00 ,  C07D211/58

Abstract: Phenylpiperidinylamines of the formula I I where R1 is -NHSO2R4 or R2 and R3 are each, independently of one another, H or C1-C4-alkyl or together are a (CH2)n chain with n=4 or 5, and R4 is C1-C4-alkyl or phenyl, and the physiologically tolerated salts thereof, and pharmaceutical compositions containing these are described.

公开(公告)号：DE4117904A1

公开(公告)日：1992-12-03

申请号：DE4117904

申请日：1991-05-31

Applicant: BASF AG

Inventor： LUBISCH WILFRIED DR ,  SCHULT SABINE DR ,  BEHL BERTHOLD DR ,  KIRCHENGAST MICHAEL DR

IPC: C07D211/26 ,  C07D211/56 ,  C07D211/58 ,  C07D401/04

Abstract: Substituted N-phenylpiperidines I (* CHEMICAL STRUCTURE *) I (R1=H, NO2, CN, halogen, C1-C4-alkyl, CF3, OCF3, OH, CH2OH, COOH, CHO, NH-CHO, NH2, CO-NH2, 5-tetrazinyl, R4-O-, R4-O-CH2-, R4O-CO-, R4-CO-, R4-NH-CO, R4-CO-NH-, R4-SO2-NH-; R2=H, NO2, halogen, C1-C4-alkyl or R4-O-; (* CHEMICAL STRUCTURE *) (* CHEMICAL STRUCTURE *) (* CHEMICAL STRUCTURE *) (* CHEMICAL STRUCTURE *) (* CHEMICAL STRUCTURE *) R4=C1-C4-alkyl or phenyl which can carry one of the R2 radicals; R5, R6=H or one of the R4 radicals; R7 =one of the R1 radicals; n=0 or 1; m=1 or 2; with the proviso that R3 is (* CHEMICAL STRUCTURE *) only when n is 1, and the optical isomers in the case of optical isomerism, and the physiologically tolerated acid addition salts, are suitable as drugs.

公开(公告)号：DE4032767A1

公开(公告)日：1992-04-30

申请号：DE4032767

申请日：1990-10-16

Applicant: BASF AG

Inventor： LUBISCH WILFRIED DR ,  SCHULT SABINE DR ,  BINDER RUDOLF DR ,  RASCHACK MANFRED DR ,  REINHARDT ROLAND DR ,  SEEMANN DIETMAR DR

IPC: A61K31/445 ,  A61K31/4468 ,  A61P9/00 ,  C07D211/58

Abstract: Phenylpiperidinylamines of the formula I I where R1 is -NHSO2R4 or R2 and R3 are each, independently of one another, H or C1-C4-alkyl or together are a (CH2)n chain with n=4 or 5, and R4 is C1-C4-alkyl or phenyl, and the physiologically tolerated salts thereof, and pharmaceutical compositions containing these are described.

公开(公告)号：DE19533025A1

公开(公告)日：1997-03-13

申请号：DE19533025

申请日：1995-09-07

Applicant: BASF AG

Inventor： AMBERG WILHELM DR ,  KLING ANDREAS DR ,  KLINGE DAGMAR DR ,  RIECHERS HARTMUT DR ,  UNGER LILIANE DR ,  RASCHACK MANFRED DR ,  HERGENROEDER STEFAN ,  ELGER BERND ,  SCHULT SABINE DR

IPC: C07D317/02 ,  A61K31/00 ,  A61K31/19 ,  A61K31/192 ,  A61K31/34 ,  A61K31/341 ,  A61K31/343 ,  A61K31/35 ,  A61K31/352 ,  A61K31/357 ,  A61K31/36 ,  A61K31/435 ,  A61K31/44 ,  A61K31/505 ,  A61P9/00 ,  A61P9/08 ,  C07C53/134 ,  C07C57/30 ,  C07C57/32 ,  C07C57/38 ,  C07C59/64 ,  C07C69/616 ,  C07C69/734 ,  C07C255/00 ,  C07D213/55 ,  C07D213/64 ,  C07D221/04 ,  C07D239/26 ,  C07D239/34 ,  C07D239/52 ,  C07D239/70 ,  C07D257/04 ,  C07D307/79 ,  C07D317/50 ,  C07D317/60 ,  C07D319/02 ,  C07D319/18 ,  C07D317/64 ,  C07D213/54 ,  C07D239/24 ,  C07D221/00 ,  C07D213/63 ,  C07C59/66

Abstract: Described are carboxylic acid derivatives of formula (I) in which R is a tetrazole or nitrile group, a COOH group or a group which can be hydrolysed to COOH, and the other substituents are as defined in the description.