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公开(公告)号:AT296102T
公开(公告)日:2005-06-15
申请号:AT01945258
申请日:2001-06-06
Applicant: BASF AG
Inventor: GENESTE HERVE , KLING ANDREAS , LANGE UDO , SEITZ WERNER , GRAEF CLAUDIA ISABELLA , SUBKOWSKI THOMAS , HORNBERGER WILFRIED , LAUTERBACH ARNULF
IPC: C07D223/10 , A61K31/55 , A61K31/5513 , A61K45/00 , A61K45/06 , A61P3/10 , A61P5/18 , A61P7/00 , A61P7/02 , A61P9/00 , A61P9/10 , A61P9/12 , A61P13/12 , A61P17/00 , A61P17/02 , A61P17/06 , A61P19/00 , A61P19/02 , A61P29/00 , A61P31/00 , A61P31/12 , A61P33/00 , A61P35/00 , A61P43/00 , C07D263/48 , C07D277/08 , C07D307/68 , C07D333/38 , C07D401/12 , C07D401/14 , C07D403/12 , C07D409/12 , C07D409/14 , C07D413/12 , C07D417/12 , C07D417/14 , C07D471/04 , C07D495/04 , C07K5/023
Abstract: The invention relates to the use of cyclic compounds as ligands of integrin receptors, in particular as ligands of the alpha V beta 3 integrin receptor, the novel compounds themselves, their use, and pharmaceutical preparations comprising these compounds.
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公开(公告)号:AU2003251447A1
公开(公告)日:2004-02-09
申请号:AU2003251447
申请日:2003-07-22
Applicant: BASF AG
Inventor: HAMPRECHT GERHARD , REINHARD ROBERT , SAGASSER INGO , SEITZ WERNER , ZAGAR CYRILL , WITSCHEL MATTHIAS , LANDES ANDREAS , PUHL MICHAEL
IPC: A01N25/30 , A01N43/38 , A01N43/40 , A01N43/54 , A01N43/56 , A01N43/58 , A01N43/64 , A01N43/653 , A01N43/90 , C07D213/61 , C07D213/65 , C07D231/16 , C07D231/18 , C07D237/14 , C07D237/22 , C07D239/54 , C07D251/38 , C07D401/12 , C07D403/12 , A01N43/84
Abstract: Disclosed are 3-heterocyclyl substituted benzoic acid derivatives of general formula (I), in which the variables R1 to R8 and X have the meanings indicated in claim 1, and the use thereof as herbicides or for desiccating/defoliating plants.
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公开(公告)号:PL351441A1
公开(公告)日:2003-04-22
申请号:PL35144100
申请日:2000-03-28
Applicant: BASF AG
Inventor: HILLEN HEINZ , SCHMIDT MARTIN , MACK HELMUT , SEITZ WERNER , HAUPT ANDREAS , ZECHEL JOHANN-CHRISTIAN , KLING ANDREAS
IPC: A61K38/00 , A61K38/55 , A61P1/04 , A61P1/18 , A61P5/14 , A61P7/02 , A61P9/00 , A61P9/10 , C12N9/99 , A61P11/00 , A61P11/06 , A61P13/12 , A61P15/00 , A61P17/02 , A61P19/02 , A61P21/04 , A61P25/00 , A61P25/28 , A61P29/00 , A61P37/02 , C07B43/00 , C07D401/12 , C07D409/12 , C07K5/06 , C07K5/062 , C07K5/065 , C07K5/068 , C07K5/072 , C07K5/078 , A61K38/05
Abstract: Peptide substances, their preparation and their use as complement inhibitors are described. These are in particular substances having a guanidine or amidine radical as a terminal group. In particular, inhibitors of the complement proteases C1s and C1r are described.
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公开(公告)号:AU751111B2
公开(公告)日:2002-08-08
申请号:AU2829799
申请日:1999-01-23
Applicant: BASF AG
Inventor: BAUCKE DORIT , LANGE UDO , MACK HELMUT , SEITZ WERNER , HOFFKEN HANS WOLFGANG , HORNBERGER WILFRIED
IPC: A61K38/00 , A61P1/18 , A61P7/02 , A61P11/06 , A61P17/04 , A61P19/02 , A61P27/16 , A61P29/00 , C07K5/06 , C07K5/065 , A61K38/05
Abstract: Novel five-membered heterocyclic amidines, their preparation and use as competitive inhibitors of trypsin-like serine proteases, especially thrombin and kininogenases such as kallikrein. Pharmaceutical compositions which contain the compounds as active ingredients, and use of the compounds as thrombin inhibitors, anticoagulants and antiinflammatory agents.
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公开(公告)号:TR200102912T2
公开(公告)日:2002-03-21
申请号:TR200102912
申请日:2000-04-05
Applicant: BASF AG
Inventor: BAUKE DORIT , MACK HELMUT , SEITZ WERNER , BACKFISCH GISELA , DELZER JUERGEN , HORNBERGER WILFRIED
IPC: C12N9/99 , A61K38/00 , A61K38/55 , A61P7/02 , A61P9/06 , A61P9/10 , A61P25/00 , A61P25/28 , A61P29/00 , A61P35/00 , A61P35/04 , A61P43/00 , C07B43/00 , C07K5/02 , C07K5/062 , C07K5/065 , A61K38/05
Abstract: The present invention relates to prodrugs of pharmacologically active five-membered heterocyclic amidines from which are produced in vivo compounds which are competitive inhibitors of trypsin-like serine proteases, in particular thrombin and kininogenases such as kallikrein, to the preparation thereof and to the use thereof as medicines. The invention also relates to pharmaceutical compositions which comprise the prodrugs of the active compounds as ingredients, and to the use of the compounds as thrombin inhibitors, anticoagulants and as antiinflammatory agents.
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公开(公告)号:BR0009674A
公开(公告)日:2002-01-15
申请号:BR0009674
申请日:2000-04-05
Applicant: BASF AG
Inventor: BAUKE DORIT , MACK HELMUT , SEITZ WERNER , HORNBERGER WILFRIED , BACKFISCH GISELA , DELZER JUERGEN
IPC: C12N9/99 , A61K38/00 , A61K38/55 , A61P7/02 , A61P9/06 , A61P9/10 , A61P25/00 , A61P25/28 , A61P29/00 , A61P35/00 , A61P35/04 , A61P43/00 , C07B43/00 , C07K5/02 , C07K5/062 , C07K5/065 , C07K5/06
Abstract: The present invention relates to prodrugs of pharmacologically active five-membered heterocyclic amidines from which are produced in vivo compounds which are competitive inhibitors of trypsin-like serine proteases, in particular thrombin and kininogenases such as kallikrein, to the preparation thereof and to the use thereof as medicines. The invention also relates to pharmaceutical compositions which comprise the prodrugs of the active compounds as ingredients, and to the use of the compounds as thrombin inhibitors, anticoagulants and as antiinflammatory agents.
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公开(公告)号:NO20014876A
公开(公告)日:2001-12-04
申请号:NO20014876
申请日:2001-10-08
Applicant: BASF AG
Inventor: HILLEN HEINZ , SCHMIDT MARTIN , MACK HELMUT , SEITZ WERNER , HAUPT ANDREAS , ZECHEL JOHANN-CHRISTIAN , KLING ANDREAS
IPC: C12N9/99 , A61K38/00 , A61P1/04 , A61P1/18 , A61P5/14 , A61P7/02 , A61P9/00 , A61P9/10 , A61P11/00 , A61P11/06 , A61P13/12 , A61P15/00 , A61P17/02 , A61P19/02 , A61P21/04 , A61P25/00 , A61P25/28 , A61P29/00 , A61P37/02 , C07B43/00 , C07D401/12 , C07K5/06 , C07K5/065 , A61K38/05
CPC classification number: C07D401/12 , A61K38/00 , C07B43/00 , C07K5/06078
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公开(公告)号:PL181405B1
公开(公告)日:2001-07-31
申请号:PL31798995
申请日:1995-06-06
Applicant: BASF AG
Inventor: BOEHM HANS-JOACHIM , KOSER STEFAN , MACK HELMUT , PFEIFFER THOMAS , SEITZ WERNER , HOEFFKEN HANS W , HORNBERGER WILFRIED
IPC: A61K31/40 , A61K38/00 , A61K38/05 , A61K38/55 , A61K47/48 , A61P7/02 , C07C279/00 , C07D205/04 , C07D207/06 , C07D207/16 , C07D207/48 , C07D211/60 , C07K5/06 , C07K5/065 , C07K5/072 , C07K5/078
Abstract: Compounds of the formula and the salts thereof with physiologically tolerated acids and the stereoisomers thereof, in which the substituents have the meanings stated in the description, are described. Also disclosed are intermediates for their preparation. The compounds are suitable for controlling diseases.
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19.
公开(公告)号:HU0100082A2
公开(公告)日:2001-06-28
申请号:HU0100082
申请日:1999-01-23
Applicant: BASF AG
Inventor: BAUCKE DORIT , HORNBERGER WILFRIED , HOEFFKEN HANS WOLFGANG , LANGE UDO , MACK HELMUT , SEITZ WERNER
IPC: A61K38/00 , A61P1/18 , A61P7/02 , A61P11/06 , A61P17/04 , A61P19/02 , A61P27/16 , A61P29/00 , C07K5/06 , C07K5/065
Abstract: Novel five-membered heterocyclic amidines, their preparation and use as competitive inhibitors of trypsin-like serine proteases, especially thrombin and kininogenases such as kallikrein. Pharmaceutical compositions which contain the compounds as active ingredients, and use of the compounds as thrombin inhibitors, anticoagulants and antiinflammatory agents.
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公开(公告)号:AU3659200A
公开(公告)日:2000-11-14
申请号:AU3659200
申请日:2000-04-05
Applicant: BASF AG
Inventor: BAUCKE DORIT , MACK HELMUT , SEITZ WERNER , HORNBERGER WILFRIED , BACKFISCH GISELA , DELZER JURGEN
IPC: C12N9/99 , A61K38/00 , A61K38/55 , A61K47/48 , A61P7/02 , A61P43/00 , C07B43/00 , C07D401/12 , C07K5/062 , C07K5/065 , A61K31/4427
Abstract: The present invention relates to prodrugs of general formula (I). The meaning of said formula is given in the description. Disclosed are the prodrugs of pharmaceutically active, heterocyclic amidines. In vivo compounds which are competitive inhibitors of trypsin-like serine proteases, especially thrombin, are produced from the amidines. The invention also relates to the production and use of the prodrugs as medicaments.
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