公开(公告)号：CA2731184C

公开(公告)日：2017-03-21

申请号：CA2731184

申请日：2009-08-21

Applicant: BAXTER INT ,  BAXTER HEALTHCARE SA

Inventor： YANG GUOHAN ,  HAI TON THAT ,  MELNICK BENNETT ,  SANDERS PAUL ,  JIANG CONG ,  QUINN CATHERINE ,  LI JIE ,  AMBROISE AROUNAGUIRY ,  BROWN LARRY R

IPC: C07C69/708 ,  A61P7/00 ,  C07C69/63 ,  C08G65/333

Abstract: The present invention relates to polymeric derivatives, which can be conjugated to an amino-containing drug to improve its in vivo properties. The polymeric derivative can subsequently be released to yield the drug in its native form. Methods of preparing and using these polymeric derivatives and drug conjugates are described. Examples of drug conjugates described include conjugates of Formula II: (see formula II)

公开(公告)号：BRPI0917819A2

公开(公告)日：2015-11-24

申请号：BRPI0917819

申请日：2009-08-21

Applicant: BAXTER HEALTHCARE SA ,  BAXTER INT

Inventor： AMBROISE AROUNAGUIRY ,  MELNICK BENNETT ,  QUINN CATHERINE ,  JIANG CONG ,  YANG GUOHAN ,  LI JIE ,  BROWN LARRY R ,  SANDERS PAUL ,  HAI TON THAT

IPC: A61K47/48 ,  A61P7/00

公开(公告)号：AU2013215167A1

公开(公告)日：2014-08-21

申请号：AU2013215167

申请日：2013-01-30

Applicant: BAXTER INT ,  BAXTER HEALTHCARE SA

Inventor： DOCKAL MICHAEL ,  SCHEIFLINGER FRITZ ,  KNAPPE SABINE ,  TILL SUSANNE ,  HAI TON ,  SANDERS PAUL

IPC: A61K31/795 ,  A61P7/04

Abstract: The present invention provides pharmaceutical formulations including a non-anticoagulant, non-saccharide polymer that with at least one sulfate or sulfonate moiety. The pharmaceutical formulations of the invention are of use to improve blood clotting in a subject. Also provided are useful analytical methods utilizing these polymers to query the dynamics of blood clotting in vitro.

公开(公告)号：CA2861077A1

公开(公告)日：2013-08-08

申请号：CA2861077

申请日：2013-01-30

Applicant: BAXTER INT ,  BAXTER HEALTHCARE SA

Inventor： DOCKAL MICHAEL ,  SCHEIFLINGER FRITZ ,  KNAPPE SABINE ,  TILL SUSANNE ,  HAI TON ,  SANDERS PAUL ,  DANDE PRASAD ,  JIANG CONG

IPC: A61K31/715 ,  A61P7/04

Abstract: The present invention provides non-anticoagulant sulfated or sulfonated polysaccharides (NASPs), which accelerate the blood clotting process. Also provided are pharmaceutical formulations comprising a NASP of the invention in conjunction with a pharmaceutically acceptable excipient and, in various embodiments, these formulations are unit dosage formulations. The invention provides a NASP formulation, which is orally bioavailable. Also provided are methods for utilizing the compounds and formulations of the invention to promote blood clotting in vivo as therapeutic and prophylactic agents and in vitro as an aid to studies of the blood clotting process.

公开(公告)号：CA2731184A1

公开(公告)日：2010-02-25

申请号：CA2731184

申请日：2009-08-21

Applicant: BAXTER INT ,  BAXTER HEALTHCARE SA

Inventor： YANG GUOHAN ,  HAI TON THAT ,  MELNICK BENNETT ,  SANDERS PAUL ,  JIANG CONG ,  QUINN CATHERINE ,  LI JIE ,  AMBROISE AROUNAGUIRY ,  BROWN LARRY R

IPC: A61K47/48 ,  A61P7/00

Abstract: The present invention relates to polymeric derivatives, which can be conjugated to an amino-containing drug to improve its in vivo properties. The polymeric derivative can subsequently be released to yield the drug in its native form. Methods of preparing and using these polymeric derivatives and drug conjugates are described.

公开(公告)号：AU2015364375A1

公开(公告)日：2017-06-08

申请号：AU2015364375

申请日：2015-12-18

Applicant: BAXTER HEALTHCARE SA ,  BAXTER INT

Inventor： SANDERS PAUL ,  FULGHUM TIMOTHY MICHAEL ,  BARRY JOHN J

IPC: A61L26/00 ,  A61K31/718

Abstract: The present disclosure relates, in general, to hemostatic compositions comprising polysaccharide based polymers, such as amylopectins, amylose, dextrins, maltodextrins and icodextrin and modified forms thereof, cross-linked with a cross-linking agent that are useful as a hemostatic composition. Also provided are methods of treating injury and slowing or stopping bleeding using a hemostatic composition disclosed herein.

公开(公告)号：SG184305A1

公开(公告)日：2012-11-29

申请号：SG2012071858

申请日：2011-04-08

Applicant: BAXTER INT ,  BAXTER HEALTHCARE SA

Inventor： BUI TUAN ,  HAI TON THAT ,  NORDHAUS MARK ,  SANDERS PAUL ,  JIANG CONG ,  LAMB DAVID ,  YARDIMCI OZLEM

公开(公告)号：AU2011240879A1

公开(公告)日：2012-10-25

申请号：AU2011240879

申请日：2011-04-08

Applicant: BAXTER HEALTHCARE SA ,  BAXTER INT

Inventor： BUI TUAN ,  HAI TON THAT ,  NORDHAUS MARK ,  SANDERS PAUL ,  JIANG CONG ,  LAMB DAVID ,  YARDIMCI OZLEM

IPC: A61L27/50 ,  A61L27/54 ,  A61L29/14 ,  A61L29/16 ,  A61L31/14 ,  A61L31/16 ,  A61M39/02 ,  A61M39/16

Abstract: A method for immobilizing dyes and antimicrobial agents on a polymeric cover or housing for a medical device is disclosed and described. The surface may be that of a catheter, a connector, a drug vial spike, a bag spike, a prosthetic device, an endoscope, a surface of an infusion pump, a key pad, a touch screen or a handle. The surfaces may also be one or more of those associated with a infusion of a medicament or dialysis treatment, such as peritoneal dialysis or hemodialysis, where it is important that the working surface for the dialysis fluid be sterile. These surfaces include connectors for peritoneal dialysis sets or for hemodialysis sets, bag spikes, dialysis catheters, and so forth. A method for determining whether a surface has been sterilized, and a dye useful in so indicating, is also disclosed.

公开(公告)号：MX2011001887A

公开(公告)日：2011-04-04

申请号：MX2011001887

申请日：2009-08-21

Applicant: BAXTER INT

Inventor： HAI TON THAT ,  SANDERS PAUL ,  JIANG CONG ,  BROWN LARRY R ,  YANG GUOHAN ,  MELNICK BENNETT ,  QUINN CATHERINE ,  LI JIE ,  AMBROISE AROUNAGUIRY

IPC: A61K47/48 ,  A61P7/00

Abstract: La presente invención se refiere a derivados poliméricos, los cuales pueden ser conjugados a un medicamento conteniendo amino para mejorar sus propiedades in vivo. El derivado polimérico puede ser liberado subsecuentemente para producir el medicamento en su forma natural. Se describen métodos para preparar y usar estos derivados poliméricos y conjugados de medicamento.

公开(公告)号：DE60227189D1

公开(公告)日：2008-07-31

申请号：DE60227189

申请日：2002-10-01

Applicant: BAXTER INT

Inventor： KAROOR SUJATHA ,  DONOVAN BRIAN ,  HAI TON THAT ,  KATADA MARI ,  LU LUIS ,  MARTIS LEO ,  MORTI STAVROULA ,  MUJAIS SALIM ,  SANDERS PAUL ,  SOLTYS PAUL ,  TANDON RAHUL

IPC: A61M1/16 ,  A61M1/36 ,  A61M1/28 ,  A61M1/34 ,  B01D15/00 ,  B01J20/02 ,  B01J20/06 ,  B01J20/20 ,  B01J20/22 ,  B01J39/10 ,  B01J41/10

Abstract: The invention provides a device (32) for removing uremic toxins in a dialysis procedure comprising a body having an inlet (42) and an outlet (44) and defining an interior. The interior includes a layer comprising urease, a layer comprising zirconium oxide, a layer comprising zirconium phosphate, and a layer comprising carbon. The device is constructed and arranged so that a fluid entering the device contacts the zirconium phosphate layer before contacting the urease layer and before contacting the zirconium oxide layer.