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公开(公告)号：AU755755B2
公开(公告)日：2002-12-19
申请号：AU1322800
申请日：1999-10-25
Applicant: DELSYS PHARMACEUTICAL CORP
Inventor： CHRAI SUGGY S , MCGINN JOSEPH THOMAS , SINGH BAWA
Abstract: A dry powder, for example, a medicament for an inhaler, comprises elongated particles with an aspect ratio sufficient to cause the particles to be bound to a preferably metal or non-metallic sheet material substrate at the particle tips by electrostatic deposition and for aligning a plurality of particles with their major axes aligned normal to the substrate and oriented tip-to-tip. Particles deposited form a low density, high relative void deposition to minimize attractive forces between the particles. This minimizes agglomeration and bonding forces to the substrate facilitating the release of a powdered medicament in an inhaler. Medicament dosages in a substrate pocket are covered by a sealing layer. An embodiment of a drug dosage inhaler substrate and inhaler is disclosed.
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公开(公告)号：AU1251701A
公开(公告)日：2001-04-10
申请号：AU1251701
申请日：2000-09-11
Applicant: DELSYS PHARMACEUTICAL CORP
Inventor： SUN HOI CHEONG , SINGH BAWA , RIVENBURG HOWARD CHRISTOPHER
Abstract: Provided is a method of moving a charged particle from a first position at which it is retained by a first electrode to a second position at which it is retained by a second electrode, the method comprising: applying a potential to the second electrode to attract the particle; and applying a potential to a guide electrode offset from the particle at the first position, wherein the applied potential is effective to reduce the attraction of the particle to the first position sufficiently to allow the potential applied at the second electrode to be effective to move the particle from the first position to the second position.
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公开(公告)号：CA2347978A1
公开(公告)日：2000-05-18
申请号：CA2347978
申请日：1999-10-25
Applicant: DELSYS PHARMACEUTICAL CORP
Inventor： CHRAI SUGGY S , MCGINN JOSEPH THOMAS , SINGH BAWA
Abstract: A dry powder, for example, a medicament for an inhaler, comprises elongated particles with an aspect ratio sufficient to cause the particles to be bound to a preferably metal or non-metallic sheet material substrate at the partic le tips by electrostatic deposition and for aligning a plurality of particles with their major axes aligned normal to the substrate and oriented tip-to-ti p. Particles deposited form a low density, high relative void deposition to minimize attractive forces between the particles. This minimizes agglomerati on and bonding forces to the substrate facilitating the release of a powdered medicament in an inhaler. Medicament dosages in a substrate pocket are cover ed by a sealing layer. An embodiment of a drug dosage inhaler substrate and inhaler is disclosed.
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公开(公告)号：PT1126891E
公开(公告)日：2004-03-31
申请号：PT99956676
申请日：1999-10-25
Applicant: DELSYS PHARMACEUTICAL CORP
Inventor： SINGH BAWA , CHRAI SUGGY S , MCGINN JOSEPH THOMAS
Abstract: A dry powder, for example, a medicament for an inhaler, comprises elongated particles with an aspect ratio sufficient to cause the particles to be bound to a preferably metal or non-metallic sheet material substrate at the particle tips by electrostatic deposition and for aligning a plurality of particles with their major axes aligned normal to the substrate and oriented tip-to-tip. Particles deposited form a low density, high relative void deposition to minimize attractive forces between the particles. This minimizes agglomeration and bonding forces to the substrate facilitating the release of a powdered medicament in an inhaler. Medicament dosages in a substrate pocket are covered by a sealing layer. An embodiment of a drug dosage inhaler substrate and inhaler is disclosed.
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公开(公告)号：AT256482T
公开(公告)日：2004-01-15
申请号：AT99956676
申请日：1999-10-25
Applicant: DELSYS PHARMACEUTICAL CORP
Inventor： CHRAI SUGGY S , MCGINN JOSEPH THOMAS , SINGH BAWA
Abstract: A dry powder, for example, a medicament for an inhaler, comprises elongated particles with an aspect ratio sufficient to cause the particles to be bound to a preferably metal or non-metallic sheet material substrate at the particle tips by electrostatic deposition and for aligning a plurality of particles with their major axes aligned normal to the substrate and oriented tip-to-tip. Particles deposited form a low density, high relative void deposition to minimize attractive forces between the particles. This minimizes agglomeration and bonding forces to the substrate facilitating the release of a powdered medicament in an inhaler. Medicament dosages in a substrate pocket are covered by a sealing layer. An embodiment of a drug dosage inhaler substrate and inhaler is disclosed.
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Patent Agency Ranking
公开(公告)号：HU0102753A2
公开(公告)日：2001-11-28
申请号：HU0102753
申请日：1999-06-08
Applicant: DELSYS PHARMACEUTICAL CORP
Inventor： CHEN JEN-CHI , CHRAI SUGGY S , DESAI NITIN VITHALBHAI , HAMMER LAWRENCE HARRISON , KELLER DAVID , KUMAR NALIN , LAL PRINCE , LEVINE AARON WILLIAM , MURARI RAMASWAMY , O'MARA KERRY DENNIS , POLINIAK EUGENE SAMUEL , RIVENBURG HOWARD CHRISTOPHER , ROACH WILLIAM RONALD , ROSATI DOMINIC STEPHEN , SINGH BAWA , SOUTHGATE PETER DAVID , SUN HOI CHEONG , ZANZUCCHI PETER JOHN
IPC: A61K9/14 , A61J1/03 , A61J3/00 , A61K9/16 , A61K9/51 , A61K9/70 , B05B5/025 , B05B5/08 , B05B5/16 , B65B1/04 , B65B1/30 , B65B11/50
Abstract: The present invention provides a product (1) that includes a pharmaceutical unit dosage or diagnostic form (6) that includes at least one active ingredient that is present in an amount that advantageously does not vary by more than about five percent from a predetermined target amount. In one embodiment, the unit form comprises a substrate (8), a deposit (14) that is disposed on the substrate and a cover layer (9) that overlies the deposit and is joined to the substrate by a bond that encircles that deposit, thereby encapsulating it between the substrate and cover substrates. The deposit comprises a powder, at least some of which includes the at least one active ingredient. The unit form is created via a dry powder deposition apparatus that electrostatically deposits the powder on the substrate utilizing an electrostatic chuck and charged powder delivery apparatus.
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公开(公告)号：AU734279B2
公开(公告)日：2001-06-07
申请号：AU3222597
申请日：1997-06-10
Applicant: DELSYS PHARMACEUTICAL CORP
Inventor： SUN HOI CHEONG STEVE , SINGH BAWA , RIVENBURG HOWARD CHRISTOPHER , DATTA PABITRA
IPC: A61M15/00
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公开(公告)号：CA2383893A1
公开(公告)日：2001-03-15
申请号：CA2383893
申请日：2000-09-11
Applicant: DELSYS PHARMACEUTICAL CORP
Inventor： RIVENBURG HOWARD CHRISTOPHER , SINGH BAWA , SUN HOI CHEONG
Abstract: A charged particle (Bead) is moved from a first electrode (9) to a second electrode (10) also with the aid of a guide electrode (Guide Electrode).
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19.发明专利
公开(公告)号：NZ332865A
公开(公告)日：2000-08-25
申请号：NZ33286597
申请日：1997-06-10
Applicant: DELSYS PHARMACEUTICAL CORP
Inventor： SUN HOI CHEONG STEVE , SINGH BAWA , RIVENBURG HOWARD CHRISTOPHER , DATTA PABITRA
IPC: A61M15/00
Abstract: An inhaler includes a medicament 107 deposited on a substrate that consists of a dielectric layer above a conductive layer. The dispensing of the medicament may be electrostatically assisted by providing a voltage between the conductive layer and a mesh 109 above the medicament. The voltage source is activated when the user inhales.
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公开(公告)号：CA2333130A1
公开(公告)日：1999-12-16
申请号：CA2333130
申请日：1999-06-08
Applicant: DELSYS PHARMACEUTICAL CORP
Inventor： ROSATI DOMINIC STEOHEN , SUN HOI CHEONG , POLINIAK EUGENE SAMUEL , DESAI NITIN VITHALBHAI , SINGH BAWA
Abstract: AC waveforms biasing of bead transporter chucks and their accumulated charge sensing circuits tailored for low resistivity substrates and beads where if traditional DC quasi-static biasing potentials were used, the bead attractio n potentials of the chuck would undergo rapid RC decay and cause the bead transporter chuck to stop working. Methods for selecting AC waveforms are given, including those that maximize the time average of the bead attraction potential at the bead collection zone of the bead contact surface.
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