公开(公告)号：AU3234501A

公开(公告)日：2001-09-03

申请号：AU3234501

申请日：2001-02-20

Applicant: FUSO PHARMACEUTICAL IND

Inventor： ARAKI HIROMASA ,  KAWABATA ATSUFUMI ,  KURODA RYOTARO ,  KAKEHI KAZUAKI ,  TANAKA SHUICHI ,  KAWAI KENZO ,  NISHIMURA SACHIYO ,  NISHIKAWA HIROYUKI

IPC: A61K9/00 ,  A61K38/00 ,  A61K38/08 ,  A61K38/17 ,  A61K38/46 ,  A61K38/55 ,  A61K45/00 ,  A61K45/06 ,  A61P1/04 ,  A61P1/12 ,  A61K38/48

Abstract: The present invention provides a composition for safely and effectively preventing and treating digestive organs diseases, particularly, gastric ulcer, duodenal ulcer, gastritis, diarrhea, enteritis and the like. There is also provided a composition having a novel mechanism of action in order to solve the problems which was difficult to be solved by the side effect previously known mechanisms of action. More particularly, there is provided a pharmaceutical composition containing an ingredient which activates PAR-2 as an essential ingredient, which is useful for inhibiting gastric acid secretion, promoting digestive tract mucus secretion, protecting digestive tract mucosa, repairing tissue of digestive organs, and preventing and treating digestive organs diseases.

公开(公告)号：CA2400650A1

公开(公告)日：2001-08-30

申请号：CA2400650

申请日：2001-02-20

Applicant: FUSO PHARMACEUTICAL IND

Inventor： NISHIKAWA HIROYUKI ,  NISHIMURA SACHIYO ,  TANAKA SHUICHI ,  KAWAI KENZO ,  KURODA RYOTARO ,  KAKEHI KAZUAKI ,  KAWABATA ATSUFUMI ,  ARAKI HIROMASA

IPC: A61K9/00 ,  A61K38/00 ,  A61K38/08 ,  A61K38/17 ,  A61K38/46 ,  A61K38/55 ,  A61K45/00 ,  A61K45/06 ,  A61P1/04 ,  A61P1/12 ,  A61K38/48

Abstract: Compositions for safely and effectively preventing and treating digestive diseases, in particular, gastric ulcer, duodenal ulcer, gastritis, diarrhea, enteritis, etc. Compositions having a novel function mechanism for solving t he problem of side effects which can be hardly overcome by the publicly known function mechanisms. More particularly speaking, medicinal compositions essentially containing a component activating PAR-2 which are useful in controlling gastric hydrochloric acid secretion, promoting digestive mucous secretion, protecting gastric mucosae, repairing gastric tissues and preventing and treating gastric diseases.

公开(公告)号：AT428444T

公开(公告)日：2009-05-15

申请号：AT01904557

申请日：2001-02-20

Applicant: FUSO PHARMACEUTICAL IND

Inventor： ARAKI HIROMASA ,  KAWABATA ATSUFUMI ,  KURODA RYOTARO ,  KAKEHI KAZUAKI ,  TANAKA SHUICHI ,  KAWAI KENZO ,  NISHIMURA SACHIYO ,  NISHIKAWA HIROYUKI

IPC: A61K9/00 ,  A61K45/00 ,  A61K38/00 ,  A61K38/08 ,  A61K38/17 ,  A61K38/46 ,  A61K38/48 ,  A61K38/55 ,  A61K45/06 ,  A61P1/04 ,  A61P1/12

Abstract: The present invention provides a composition for safely and effectively preventing and treating digestive organs diseases, particularly, gastric ulcer, duodenal ulcer, gastritis, diarrhea, enteritis and the like. There is also provided a composition having a novel mechanism of action in order to solve the problems which was difficult to be solved by the side effect previously known mechanisms of action. More particularly, there is provided a pharmaceutical composition containing an ingredient which activates PAR-2 as an essential ingredient, which is useful for inhibiting gastric acid secretion, promoting digestive tract mucus secretion, protecting digestive tract mucosa, repairing tissue of digestive organs, and preventing and treating digestive organs diseases.

公开(公告)号：DE60041658D1

公开(公告)日：2009-04-09

申请号：DE60041658

申请日：2000-12-08

Applicant: FUSO PHARMACEUTICAL IND

Inventor： ARAKI HIROMASA ,  KAWABATA ATSUFUMI ,  TANAKA SHUICHI ,  KAWAI KENZO ,  NISHIMURA SACHIYO ,  NISHIKAWA HIROYUKI

IPC: A61K45/00 ,  G02C7/04 ,  A61F9/00 ,  A61K9/06 ,  A61K9/08 ,  A61K9/10 ,  A61K38/00 ,  A61K38/08 ,  A61K38/17 ,  A61K38/48 ,  A61K38/55 ,  A61K45/06 ,  A61L27/22 ,  A61P27/02 ,  A61P43/00 ,  C07K7/06 ,  C12N9/76 ,  C12N9/99 ,  G02B1/04 ,  G02C13/00

Abstract: A composition for promoting lacrimal secretion, comprising a protease-activated receptor (PAR)-2 agonist, is new. Independent claims are also included for the following: (1) drug delivery systems comprising the above composition; and (2) contact lenses coated in and/or containing the above composition. ACTIVITY : Ophthalmological. In tests Ser-Leu-ILe-Gly-Leu-NH 2administered to Wistar rats at 5 Micromol/kg by tail vein injection significantly (p is less than 0.01) increased lacrimal secretion. MECHANISM OF ACTION : Protease-agonist.

公开(公告)号：AU777262B2

公开(公告)日：2004-10-07

申请号：AU1734201

申请日：2000-12-08

Applicant: FUSO PHARMACEUTICAL IND

Inventor： ARAKI HIROMASA ,  KAWABATA ATSUFUMI ,  TANAKA SHUICHI ,  KAWAI KENZO ,  NISHIMURA SACHIYO ,  NISHIKAWA HIROYUKI

IPC: G02C7/04 ,  A61F9/00 ,  A61K9/06 ,  A61K9/08 ,  A61K9/10 ,  A61K38/00 ,  A61K38/17 ,  A61K38/48 ,  A61K45/00 ,  A61K45/06 ,  A61L27/22 ,  A61P27/02 ,  A61P43/00 ,  C07K7/06 ,  C12N9/76 ,  C12N9/99 ,  G02B1/04 ,  G02C13/00 ,  A61K38/08

Abstract: A composition for promoting lacrimal secretion, comprising a protease-activated receptor (PAR)-2 agonist, is new. Independent claims are also included for the following: (1) drug delivery systems comprising the above composition; and (2) contact lenses coated in and/or containing the above composition. ACTIVITY : Ophthalmological. In tests Ser-Leu-ILe-Gly-Leu-NH 2administered to Wistar rats at 5 Micromol/kg by tail vein injection significantly (p is less than 0.01) increased lacrimal secretion. MECHANISM OF ACTION : Protease-agonist.

公开(公告)号：JP2001240607A

公开(公告)日：2001-09-04

申请号：JP2000053475

申请日：2000-02-29

Applicant: FUSO PHARMACEUTICAL IND

Inventor： ARAKI HIROMASA ,  KAWAI KENZO ,  TANAKA SHUICHI ,  NISHIMURA KOUYO ,  OTANI HIRONARI ,  NISHIKAWA HIROYUKI ,  TAKEDA SEIICHI ,  SHIMADA CHIAKI ,  KITAGAWA CHIZUKO ,  ABE TOMOYUKI

IPC: A61K31/727 ,  A61P7/02 ,  A61P13/12 ,  A61P39/06 ,  C08B37/10

Abstract: PROBLEM TO BE SOLVED: To provide a method for depolymerizing a heparin, to obtain a new depolymerized heparin prepared by the method for depolymerization and its amidated derivative and further a pharmaceutical composition comprising the depolymerized heparin and its amidated derivative as active ingredients. SOLUTION: This method for depolymerizing the heparin is characterized by using a reducing metal and a metal oxide and the method for depolymerizing the heparin comprises the step. The depolymerized heparin is obtained by the method for depolymerization. Furthermore, the amidated depolymerized heparin is obtained and an anticoagulant, a therapeutic agent for renal diseases, a platelet aggregation inhibitor, a radical scavenger, a mesangium cell proliferation inhibitor and a complement activity inhibitor comprise the depolymerized heparin or the amidated depolymerized heparin derivative.

公开(公告)号：JP2001181208A

公开(公告)日：2001-07-03

申请号：JP36999699

申请日：1999-12-27

Applicant: FUSO PHARMACEUTICAL IND

Inventor： ARAKI HIROMASA ,  KAWABATA ATSUSHI ,  TANAKA SHUICHI ,  KAWAI KENZO ,  NISHIMURA KOUYO ,  NISHIKAWA HIROYUKI

IPC: G02C7/04 ,  A61F9/00 ,  A61K9/06 ,  A61K9/08 ,  A61K9/10 ,  A61K38/00 ,  A61K38/17 ,  A61K38/48 ,  A61K45/00 ,  A61K45/06 ,  A61L27/22 ,  A61P27/02 ,  A61P43/00 ,  C07K7/06 ,  C12N9/76 ,  C12N9/99 ,  G02B1/04 ,  G02C13/00

Abstract: PROBLEM TO BE SOLVED: To provide a lachrymal fluid secretion-stimulating composition which can safely and effectively be used, not in a conventional lachrymal fluid ingredient-supplementing therapy but in a lachrymal fluid secretion-stimulating therapy. SOLUTION: This lachrymal fluid secretion-stimulating composition characterized by containing an ingredient for activating PAR-2, and a contact lens holding and/or containing the composition.

公开(公告)号：JPH09286803A

公开(公告)日：1997-11-04

申请号：JP3015097

申请日：1997-02-14

Applicant: FUSO PHARMACEUTICAL IND

Inventor： ARAKI HIROMASA ,  NISHIKAWA HIROYUKI ,  TANAKA SHUICHI ,  NAKAMURA KAZUMOTO ,  OTANI HIRONARI ,  NISHIMURA YUKIHIRO ,  SHIMADA CHIAKI ,  TAKEDA SEIICHI ,  KAWAI KENZO ,  KITAGAWA CHIZUKO ,  KUWABARA MASAAKI ,  ABE TOMOYUKI

IPC: C08B37/10 ,  A61K31/715 ,  A61P7/02 ,  A61P9/08 ,  A61P9/10 ,  A61P11/00 ,  A61P13/02 ,  A61P15/00 ,  A61P35/00 ,  A61P37/08 ,  A61K31/725

Abstract: PROBLEM TO BE SOLVED: To obtain medium-molecular heparin which gives an amino acid deriv. effectively usable for various diseases reduced in bleeding tendency by depolymerizing heparin to a specified average mol.wt. SOLUTION: This medium-molecular heparin has an average mol.wt. of 8,500-9,500 and, when converted into an amino acid deriv., gives a medium- molecular heparinylamino acid deriv., more specifically a medium-molecular heparinylamino acid or its lower alkyl ester. The deriv. is used as the active component for compsns. for coagulation inhibition, nephric mesangial cell proliferation inhibition, cancer metastasis inhibition, complement activation inhibition, pulmonary inhibition, nephric disease inhibition, radical scavenging, allergic disease prevention, and a remedial medicine.

公开(公告)号：JP2001233790A

公开(公告)日：2001-08-28

申请号：JP2000047515

申请日：2000-02-24

Applicant: FUSO PHARMACEUTICAL IND

Inventor： ARAKI HIROMASA ,  KAWABATA ATSUSHI ,  KURODA RYOTARO ,  KAKEHI KAZUAKI ,  TANAKA SHUICHI ,  KAWAI KENZO ,  NISHIMURA KOUYO ,  NISHIKAWA HIROYUKI

IPC: A61K9/00 ,  A61K38/00 ,  A61K38/08 ,  A61K38/17 ,  A61K38/46 ,  A61K38/55 ,  A61K45/00 ,  A61K45/06 ,  A61P1/04 ,  A61P1/12

Abstract: PROBLEM TO BE SOLVED: To provide a safe and effective composition for the prophylaxis and/or therapy of digestive diseases, especially for the prophylaxis and/or therapy of gastric ulcer, duodenal ulcer, gastritis, diarrhea, enteritis, etc., and also to provide a composition having a new action mechanism in order to resolve the problem of a side effect which has been difficult to be resolved by an action mechanism already known. SOLUTION: This medicinal composition useful for gastric-acid secretion control, digestive tract mucus secretion promotion, alimentary canal mucosa protection and digestive tract organization repair and for the prophylaxis and/or therapy of digestive diseases includes a component for activating PAR-2 as an essential component.

公开(公告)号：JP2001064203A

公开(公告)日：2001-03-13

申请号：JP24139499

申请日：1999-08-27

Applicant: FUSO PHARMACEUTICAL IND

Inventor： KAWABATA ATSUSHI ,  KURODA RYOTARO ,  ARAKI HIROMASA ,  KAWAI KENZO ,  NISHIKAWA HIROYUKI

IPC: A23G3/34 ,  A23G3/00 ,  A23G4/00 ,  A61K8/00 ,  A61K8/11 ,  A61K8/64 ,  A61K8/66 ,  A61K31/405 ,  A61K31/439 ,  A61K38/00 ,  A61K38/46 ,  A61K38/48 ,  A61K45/00 ,  A61P1/14 ,  A61Q11/00 ,  C07K7/06 ,  C12N9/48 ,  C12N9/76 ,  C12N9/99 ,  C12N15/09 ,  C12Q1/40 ,  C12Q1/68 ,  A61K7/16

Abstract: PROBLEM TO BE SOLVED: To obtain the subject composition capable of exhibiting excellent saliva secretion-promoting activities, and useful as a therapeutic agent for dryness of the mouth caused by a side effect, or the like, of a medicine by including an agonist of a protease-activated receptor(PAR)-2 which is one of the PAR. SOLUTION: This composition contains a component for activating PAR-2. The component is preferably a peptide, and preferably selected from the group consisting of Ser-Leu-Ile-Gly-Arg-Leu-NH2, Ser-Leu-Ile-Gly-Arg-Leu-OH and trans-cinnamoyl-Leu-Ile-Gly-Arg-Leu-ornithine-NH2. The component is also a protein, preferably trypsin and/or tryptase. A material (preferably amastatin) inhibiting the deactivation or decomposition of the component is used in combination with and/or formulated with the composition.