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公开(公告)号：EP1258251A4
公开(公告)日：2003-04-09
申请号：EP01904557
申请日：2001-02-20
Applicant: FUSO PHARMACEUTICAL IND
Inventor： ARAKI HIROMASA , KAWABATA ATSUFUMI , KURODA RYOTARO , KAKEHI KAZUAKI , TANAKA SHUICHI , KAWAI KENZO , NISHIMURA SACHIYO , NISHIKAWA HIROYUKI
IPC: A61K9/00 , A61K38/00 , A61K38/08 , A61K38/17 , A61K38/46 , A61K38/55 , A61K45/00 , A61K45/06 , A61P1/04 , A61P1/12 , A61K38/48
CPC classification number: A61K38/08 , A61K38/06 , A61K38/482 , A61K38/4826 , A61K2300/00
Abstract: The present invention provides a composition for safely and effectively preventing and treating digestive organs diseases, particularly, gastric ulcer, duodenal ulcer, gastritis, diarrhea, enteritis and the like. There is also provided a composition having a novel mechanism of action in order to solve the problems which was difficult to be solved by the side effect previously known mechanisms of action. More particularly, there is provided a pharmaceutical composition containing an ingredient which activates PAR-2 as an essential ingredient, which is useful for inhibiting gastric acid secretion, promoting digestive tract mucus secretion, protecting digestive tract mucosa, repairing tissue of digestive organs, and preventing and treating digestive organs diseases.
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公开(公告)号：EP1247532A4
公开(公告)日：2005-01-19
申请号：EP00979995
申请日：2000-12-08
Applicant: FUSO PHARMACEUTICAL IND
Inventor： ARAKI HIROMASA , KAWABATA ATSUFUMI , TANAKA SHUICHI , KAWAI KENZO , NISHIMURA SACHIYO , NISHIKAWA HIROYUKI
IPC: G02C7/04 , A61F9/00 , A61K9/06 , A61K9/08 , A61K9/10 , A61K38/00 , A61K38/17 , A61K38/48 , A61K45/00 , A61K45/06 , A61L27/22 , A61P27/02 , A61P43/00 , C07K7/06 , C12N9/76 , C12N9/99 , G02B1/04 , G02C13/00 , A61K38/08 , A61K38/55
CPC classification number: G02B1/043 , A61K38/06 , A61K38/08 , A61K38/177 , A61K38/482 , A61K38/4826 , A61L27/227
Abstract: A composition promoting lacrimal secretion which can be safely and efficaciously used in the treatment of promoting lacrimal secretion different from the conventional treatment of supplying lacrimal components. This composition is characterized by containing a component activating PAR-2. Also, contact lenses carrying and/or containing this composition are provided.
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3.发明专利
公开(公告)号：CA2726161A1
公开(公告)日：2009-12-23
申请号：CA2726161
申请日：2009-06-15
Applicant: UNIV KINKI , FUSO PHARMACEUTICAL IND
Inventor： KAWABATA ATSUFUMI , NISHIKAWA HIROYUKI , KAWAI KENZO
Abstract: Disclosed is a composition for promoting the secretion of a tear, which can be used safely and effectively in tear secretion promotion therapies rather than conventional therapies for supplementing a tear component, and can exhibit its effect for a long period. Specifically disclosed are: a composition for promoting the secretion of a tear, which is characterized by comprising a peptide derivative represented by formula (I); and a contact lens retaining and/or containing the composition.
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公开(公告)号：CA2396542A1
公开(公告)日：2001-07-05
申请号：CA2396542
申请日：2000-12-08
Applicant: FUSO PHARMACEUTICAL IND
Inventor： KAWAI KENZO , NISHIMURA SACHIYO , TANAKA SHUICHI , NISHIKAWA HIROYUKI , KAWABATA ATSUFUMI , ARAKI HIROMASA
IPC: G02C7/04 , A61F9/00 , A61K9/06 , A61K9/08 , A61K9/10 , A61K38/00 , A61K38/17 , A61K38/48 , A61K45/00 , A61K45/06 , A61L27/22 , A61P27/02 , A61P43/00 , C07K7/06 , C12N9/76 , C12N9/99 , G02B1/04 , G02C13/00 , A61K38/08
Abstract: A composition promoting lacrimal secretion which can be safely and efficaciously used in the treatment of promoting lacrimal secretion differen t from the conventional treatment of supplying lacrimal components. This composition is characterized by containing a component activating PAR-2. Als o, contact lenses carrying and/or containing this composition are provided.
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5.发明专利
公开(公告)号：CA2726161C
公开(公告)日：2015-09-08
申请号：CA2726161
申请日：2009-06-15
Applicant: UNIV KINKI , FUSO PHARMACEUTICAL IND
Inventor： KAWABATA ATSUFUMI , NISHIKAWA HIROYUKI , KAWAI KENZO
Abstract: A composition for promoting lacrimal secretion which can be used safely and effectively in the lacrimal secretion promoting therapy, not in the conventional supplemental therapy of lacrimal fluid components is provided. The composition for promoting lacrimal secretion comprising a peptide derivative represented by the formula (I): (see above formula I) and a contact lens which retains and/or contains the composition are provided.
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Patent Agency Ranking
公开(公告)号：DE60138366D1
公开(公告)日：2009-05-28
申请号：DE60138366
申请日：2001-02-20
Applicant: FUSO PHARMACEUTICAL IND
Inventor： ARAKI HIROMASA , KAWABATA ATSUFUMI , KURODA RYOTARO , KAKEHI KAZUAKI , TANAKA SHUICHI , KAWAI KENZO , NISHIMURA SACHIYO , NISHIKAWA HIROYUKI
IPC: A61K9/00 , A61K45/00 , A61K38/00 , A61K38/08 , A61K38/17 , A61K38/46 , A61K38/48 , A61K38/55 , A61K45/06 , A61P1/04 , A61P1/12
Abstract: The present invention provides a composition for safely and effectively preventing and treating digestive organs diseases, particularly, gastric ulcer, duodenal ulcer, gastritis, diarrhea, enteritis and the like. There is also provided a composition having a novel mechanism of action in order to solve the problems which was difficult to be solved by the side effect previously known mechanisms of action. More particularly, there is provided a pharmaceutical composition containing an ingredient which activates PAR-2 as an essential ingredient, which is useful for inhibiting gastric acid secretion, promoting digestive tract mucus secretion, protecting digestive tract mucosa, repairing tissue of digestive organs, and preventing and treating digestive organs diseases.
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公开(公告)号：AT423572T
公开(公告)日：2009-03-15
申请号：AT00979995
申请日：2000-12-08
Applicant: FUSO PHARMACEUTICAL IND
Inventor： ARAKI HIROMASA , KAWABATA ATSUFUMI , TANAKA SHUICHI , KAWAI KENZO , NISHIMURA SACHIYO , NISHIKAWA HIROYUKI
IPC: A61K45/00 , G02C7/04 , A61F9/00 , A61K9/06 , A61K9/08 , A61K9/10 , A61K38/00 , A61K38/08 , A61K38/17 , A61K38/48 , A61K38/55 , A61K45/06 , A61L27/22 , A61P27/02 , A61P43/00 , C07K7/06 , C12N9/76 , C12N9/99 , G02B1/04 , G02C13/00
Abstract: A composition for promoting lacrimal secretion, comprising a protease-activated receptor (PAR)-2 agonist, is new. Independent claims are also included for the following: (1) drug delivery systems comprising the above composition; and (2) contact lenses coated in and/or containing the above composition. ACTIVITY : Ophthalmological. In tests Ser-Leu-ILe-Gly-Leu-NH 2administered to Wistar rats at 5 Micromol/kg by tail vein injection significantly (p is less than 0.01) increased lacrimal secretion. MECHANISM OF ACTION : Protease-agonist.
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公开(公告)号：CA2396542C
公开(公告)日：2011-04-12
申请号：CA2396542
申请日：2000-12-08
Applicant: FUSO PHARMACEUTICAL IND
Inventor： ARAKI HIROMASA , KAWABATA ATSUFUMI , TANAKA SHUICHI , KAWAI KENZO , NISHIMURA SACHIYO , NISHIKAWA HIROYUKI
IPC: A61K38/55 , G02C7/04 , A61F9/00 , A61K9/06 , A61K9/08 , A61K9/10 , A61K38/00 , A61K38/08 , A61K38/17 , A61K38/48 , A61K45/00 , A61K45/06 , A61L12/08 , A61L27/22 , A61P27/02 , A61P43/00 , C07K7/06 , C12N9/76 , C12N9/99 , G02B1/04 , G02C13/00
Abstract: T he present invention is directed to a composition for promoting lacrimal secretion which can be used safely and effectively in lacrimal secretion promoting therapy, not in conventional supplemental therapy of lacrimal fluid components. The composition comprises a component which activates PAR-2. Also, a contact lens which retains and/or contains said composition for promoting lacrimal secretion is provided.
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公开(公告)号：CA2400650C
公开(公告)日：2010-10-19
申请号：CA2400650
申请日：2001-02-20
Applicant: FUSO PHARMACEUTICAL IND
Inventor： ARAKI HIROMASA , KAWABATA ATSUFUMI , KURODA RYOTARO , KAKEHI KAZUAKI , TANAKA SHUICHI , KAWAI KENZO , NISHIMURA SACHIYO , NISHIKAWA HIROYUKI
IPC: A61K9/00 , A61K38/55 , A61K38/00 , A61K38/08 , A61K38/17 , A61K38/46 , A61K38/48 , A61K45/00 , A61K45/06 , A61P1/00 , A61P1/04 , A61P1/12
Abstract: The present invention provides a composition for safely and effectively preventing and treating digestive organs diseases, particularly, gastric ulcer, duodenal ulcer, gastritis, diarrhea, enteritis and the like. There is also provided a composition having a novel mechanism of action in order to solve problems that were difficult to solve by the side effects of previously known mechanisms of action. More particularly, there is provided a pharmaceutical composition containing an ingredient which activates PAR-2 as an essential ingredient, which is useful for inhibiting gastric acid secretion, promoting digestive tract mucus secretion, protecting digestive tract mucosa, repairing tissue of digestive organs, and preventing and treating digestive organs diseases.
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公开(公告)号：AU2009261285A1
公开(公告)日：2009-12-23
申请号：AU2009261285
申请日：2009-06-15
Applicant: UNIV KINKI , FUSO PHARMACEUTICAL IND
Inventor： KAWAI KENZO , KAWABATA ATSUFUMI , NISHIKAWA HIROYUKI
Abstract: A composition for promoting lacrimal secretion which can be used safely and effectively in the lacrimal secretion promoting therapy, not in the conventional supplemental therapy of lacrimal fluid components is provided. The composition for promoting lacrimal secretion comprising a peptide derivative represented by the formula (I): and a contact lens which retains and/or contains the composition are provided.
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