公开(公告)号：EP1258251A4

公开(公告)日：2003-04-09

申请号：EP01904557

申请日：2001-02-20

Applicant: FUSO PHARMACEUTICAL IND

Inventor： ARAKI HIROMASA ,  KAWABATA ATSUFUMI ,  KURODA RYOTARO ,  KAKEHI KAZUAKI ,  TANAKA SHUICHI ,  KAWAI KENZO ,  NISHIMURA SACHIYO ,  NISHIKAWA HIROYUKI

IPC: A61K9/00 ,  A61K38/00 ,  A61K38/08 ,  A61K38/17 ,  A61K38/46 ,  A61K38/55 ,  A61K45/00 ,  A61K45/06 ,  A61P1/04 ,  A61P1/12 ,  A61K38/48

CPC classification number: A61K38/08 ,  A61K38/06 ,  A61K38/482 ,  A61K38/4826 ,  A61K2300/00

Abstract: The present invention provides a composition for safely and effectively preventing and treating digestive organs diseases, particularly, gastric ulcer, duodenal ulcer, gastritis, diarrhea, enteritis and the like. There is also provided a composition having a novel mechanism of action in order to solve the problems which was difficult to be solved by the side effect previously known mechanisms of action. More particularly, there is provided a pharmaceutical composition containing an ingredient which activates PAR-2 as an essential ingredient, which is useful for inhibiting gastric acid secretion, promoting digestive tract mucus secretion, protecting digestive tract mucosa, repairing tissue of digestive organs, and preventing and treating digestive organs diseases.

公开(公告)号：DE60138366D1

公开(公告)日：2009-05-28

申请号：DE60138366

申请日：2001-02-20

Applicant: FUSO PHARMACEUTICAL IND

Inventor： ARAKI HIROMASA ,  KAWABATA ATSUFUMI ,  KURODA RYOTARO ,  KAKEHI KAZUAKI ,  TANAKA SHUICHI ,  KAWAI KENZO ,  NISHIMURA SACHIYO ,  NISHIKAWA HIROYUKI

IPC: A61K9/00 ,  A61K45/00 ,  A61K38/00 ,  A61K38/08 ,  A61K38/17 ,  A61K38/46 ,  A61K38/48 ,  A61K38/55 ,  A61K45/06 ,  A61P1/04 ,  A61P1/12

Abstract: The present invention provides a composition for safely and effectively preventing and treating digestive organs diseases, particularly, gastric ulcer, duodenal ulcer, gastritis, diarrhea, enteritis and the like. There is also provided a composition having a novel mechanism of action in order to solve the problems which was difficult to be solved by the side effect previously known mechanisms of action. More particularly, there is provided a pharmaceutical composition containing an ingredient which activates PAR-2 as an essential ingredient, which is useful for inhibiting gastric acid secretion, promoting digestive tract mucus secretion, protecting digestive tract mucosa, repairing tissue of digestive organs, and preventing and treating digestive organs diseases.

公开(公告)号：CA2400650C

公开(公告)日：2010-10-19

申请号：CA2400650

申请日：2001-02-20

Applicant: FUSO PHARMACEUTICAL IND

Inventor： ARAKI HIROMASA ,  KAWABATA ATSUFUMI ,  KURODA RYOTARO ,  KAKEHI KAZUAKI ,  TANAKA SHUICHI ,  KAWAI KENZO ,  NISHIMURA SACHIYO ,  NISHIKAWA HIROYUKI

IPC: A61K9/00 ,  A61K38/55 ,  A61K38/00 ,  A61K38/08 ,  A61K38/17 ,  A61K38/46 ,  A61K38/48 ,  A61K45/00 ,  A61K45/06 ,  A61P1/00 ,  A61P1/04 ,  A61P1/12

Abstract: The present invention provides a composition for safely and effectively preventing and treating digestive organs diseases, particularly, gastric ulcer, duodenal ulcer, gastritis, diarrhea, enteritis and the like. There is also provided a composition having a novel mechanism of action in order to solve problems that were difficult to solve by the side effects of previously known mechanisms of action. More particularly, there is provided a pharmaceutical composition containing an ingredient which activates PAR-2 as an essential ingredient, which is useful for inhibiting gastric acid secretion, promoting digestive tract mucus secretion, protecting digestive tract mucosa, repairing tissue of digestive organs, and preventing and treating digestive organs diseases.

公开(公告)号：AU3234501A

公开(公告)日：2001-09-03

申请号：AU3234501

申请日：2001-02-20

Applicant: FUSO PHARMACEUTICAL IND

Inventor： ARAKI HIROMASA ,  KAWABATA ATSUFUMI ,  KURODA RYOTARO ,  KAKEHI KAZUAKI ,  TANAKA SHUICHI ,  KAWAI KENZO ,  NISHIMURA SACHIYO ,  NISHIKAWA HIROYUKI

IPC: A61K9/00 ,  A61K38/00 ,  A61K38/08 ,  A61K38/17 ,  A61K38/46 ,  A61K38/55 ,  A61K45/00 ,  A61K45/06 ,  A61P1/04 ,  A61P1/12 ,  A61K38/48

Abstract: The present invention provides a composition for safely and effectively preventing and treating digestive organs diseases, particularly, gastric ulcer, duodenal ulcer, gastritis, diarrhea, enteritis and the like. There is also provided a composition having a novel mechanism of action in order to solve the problems which was difficult to be solved by the side effect previously known mechanisms of action. More particularly, there is provided a pharmaceutical composition containing an ingredient which activates PAR-2 as an essential ingredient, which is useful for inhibiting gastric acid secretion, promoting digestive tract mucus secretion, protecting digestive tract mucosa, repairing tissue of digestive organs, and preventing and treating digestive organs diseases.

公开(公告)号：CA2400650A1

公开(公告)日：2001-08-30

申请号：CA2400650

申请日：2001-02-20

Applicant: FUSO PHARMACEUTICAL IND

Inventor： NISHIKAWA HIROYUKI ,  NISHIMURA SACHIYO ,  TANAKA SHUICHI ,  KAWAI KENZO ,  KURODA RYOTARO ,  KAKEHI KAZUAKI ,  KAWABATA ATSUFUMI ,  ARAKI HIROMASA

IPC: A61K9/00 ,  A61K38/00 ,  A61K38/08 ,  A61K38/17 ,  A61K38/46 ,  A61K38/55 ,  A61K45/00 ,  A61K45/06 ,  A61P1/04 ,  A61P1/12 ,  A61K38/48

Abstract: Compositions for safely and effectively preventing and treating digestive diseases, in particular, gastric ulcer, duodenal ulcer, gastritis, diarrhea, enteritis, etc. Compositions having a novel function mechanism for solving t he problem of side effects which can be hardly overcome by the publicly known function mechanisms. More particularly speaking, medicinal compositions essentially containing a component activating PAR-2 which are useful in controlling gastric hydrochloric acid secretion, promoting digestive mucous secretion, protecting gastric mucosae, repairing gastric tissues and preventing and treating gastric diseases.

公开(公告)号：AT428444T

公开(公告)日：2009-05-15

申请号：AT01904557

申请日：2001-02-20

Applicant: FUSO PHARMACEUTICAL IND

Inventor： ARAKI HIROMASA ,  KAWABATA ATSUFUMI ,  KURODA RYOTARO ,  KAKEHI KAZUAKI ,  TANAKA SHUICHI ,  KAWAI KENZO ,  NISHIMURA SACHIYO ,  NISHIKAWA HIROYUKI

IPC: A61K9/00 ,  A61K45/00 ,  A61K38/00 ,  A61K38/08 ,  A61K38/17 ,  A61K38/46 ,  A61K38/48 ,  A61K38/55 ,  A61K45/06 ,  A61P1/04 ,  A61P1/12

Abstract: The present invention provides a composition for safely and effectively preventing and treating digestive organs diseases, particularly, gastric ulcer, duodenal ulcer, gastritis, diarrhea, enteritis and the like. There is also provided a composition having a novel mechanism of action in order to solve the problems which was difficult to be solved by the side effect previously known mechanisms of action. More particularly, there is provided a pharmaceutical composition containing an ingredient which activates PAR-2 as an essential ingredient, which is useful for inhibiting gastric acid secretion, promoting digestive tract mucus secretion, protecting digestive tract mucosa, repairing tissue of digestive organs, and preventing and treating digestive organs diseases.

公开(公告)号：JP2001233790A

公开(公告)日：2001-08-28

申请号：JP2000047515

申请日：2000-02-24

Applicant: FUSO PHARMACEUTICAL IND

Inventor： ARAKI HIROMASA ,  KAWABATA ATSUSHI ,  KURODA RYOTARO ,  KAKEHI KAZUAKI ,  TANAKA SHUICHI ,  KAWAI KENZO ,  NISHIMURA KOUYO ,  NISHIKAWA HIROYUKI

IPC: A61K9/00 ,  A61K38/00 ,  A61K38/08 ,  A61K38/17 ,  A61K38/46 ,  A61K38/55 ,  A61K45/00 ,  A61K45/06 ,  A61P1/04 ,  A61P1/12

Abstract: PROBLEM TO BE SOLVED: To provide a safe and effective composition for the prophylaxis and/or therapy of digestive diseases, especially for the prophylaxis and/or therapy of gastric ulcer, duodenal ulcer, gastritis, diarrhea, enteritis, etc., and also to provide a composition having a new action mechanism in order to resolve the problem of a side effect which has been difficult to be resolved by an action mechanism already known. SOLUTION: This medicinal composition useful for gastric-acid secretion control, digestive tract mucus secretion promotion, alimentary canal mucosa protection and digestive tract organization repair and for the prophylaxis and/or therapy of digestive diseases includes a component for activating PAR-2 as an essential component.

公开(公告)号：JP2001064203A

公开(公告)日：2001-03-13

申请号：JP24139499

申请日：1999-08-27

Applicant: FUSO PHARMACEUTICAL IND

Inventor： KAWABATA ATSUSHI ,  KURODA RYOTARO ,  ARAKI HIROMASA ,  KAWAI KENZO ,  NISHIKAWA HIROYUKI

IPC: A23G3/34 ,  A23G3/00 ,  A23G4/00 ,  A61K8/00 ,  A61K8/11 ,  A61K8/64 ,  A61K8/66 ,  A61K31/405 ,  A61K31/439 ,  A61K38/00 ,  A61K38/46 ,  A61K38/48 ,  A61K45/00 ,  A61P1/14 ,  A61Q11/00 ,  C07K7/06 ,  C12N9/48 ,  C12N9/76 ,  C12N9/99 ,  C12N15/09 ,  C12Q1/40 ,  C12Q1/68 ,  A61K7/16

Abstract: PROBLEM TO BE SOLVED: To obtain the subject composition capable of exhibiting excellent saliva secretion-promoting activities, and useful as a therapeutic agent for dryness of the mouth caused by a side effect, or the like, of a medicine by including an agonist of a protease-activated receptor(PAR)-2 which is one of the PAR. SOLUTION: This composition contains a component for activating PAR-2. The component is preferably a peptide, and preferably selected from the group consisting of Ser-Leu-Ile-Gly-Arg-Leu-NH2, Ser-Leu-Ile-Gly-Arg-Leu-OH and trans-cinnamoyl-Leu-Ile-Gly-Arg-Leu-ornithine-NH2. The component is also a protein, preferably trypsin and/or tryptase. A material (preferably amastatin) inhibiting the deactivation or decomposition of the component is used in combination with and/or formulated with the composition.