公开(公告)号：WO2005117993A3

公开(公告)日：2006-06-15

申请号：PCT/US2005019630

申请日：2005-06-03

Applicant: GENVEC INC ,  FUSO PHARMACEUTICAL IND ,  WICKHAM THOMAS J ,  AKIYAMA MASAKI ,  MURGESAN SELVA ,  EINFELD DAVID ,  ABE TOMOYUKI ,  YOSHIDA HIROSHI ,  YAMADA OSAMU ,  ARAKI HIROMASA

Inventor： WICKHAM THOMAS J ,  AKIYAMA MASAKI ,  MURGESAN SELVA ,  EINFELD DAVID ,  ABE TOMOYUKI ,  YOSHIDA HIROSHI ,  YAMADA OSAMU ,  ARAKI HIROMASA

IPC: A61K48/00 ,  C07K14/525 ,  C12N15/861

CPC classification number: C12N15/86 ,  A61K48/00 ,  A61K48/0075 ,  C07K14/525 ,  C12N7/00 ,  C12N2710/10332 ,  C12N2710/10343 ,  C12N2710/10345 ,  C12N2810/405 ,  C12N2830/008

Abstract: The invention provides a method of destroying tumor cells in the peritoneal cavity of a mammal. The method comprises administering to the mammal intraperitoneally a dose of replication-deficient adenoviral vector comprising (a) an exogenous nucleic acid sequence encoding a human TNF-a which is operably linked to a tumor cell-selective promoter, (b) a fiber protein wherein a native CAR-binding site is disrupted, and (c) and a penton base protein wherein a native integrin-binding site is disrupted.

Abstract translation: 本发明提供一种破坏哺乳动物腹膜腔中的肿瘤细胞的方法。 该方法包括给予哺乳动物腹膜内一定剂量的复制缺陷型腺病毒载体，其包含（a）编码与肿瘤细胞选择性启动子有效连接的人TNF-α的外源核酸序列，（b）纤维蛋白，其中 天然CAR结合位点被破坏，和（c）和其中天然整联蛋白结合位点被破坏的五邻体蛋白质。

公开(公告)号：EP0872180A4

公开(公告)日：2001-08-01

申请号：EP96929521

申请日：1996-09-04

Applicant: FUSO PHARMACEUTICAL IND

Inventor： NAKAZAWA TERUKI ,  ARAKI HIROMASA ,  KISHI YUICHIRO ,  SHINODA SANJI ,  YAMADA MORIYUKI ,  OHASHI KAZUTOMO

IPC: A01K67/02 ,  A01K67/027 ,  C12N5/02 ,  C12N5/073 ,  C12N5/00

CPC classification number: A01K67/027 ,  C12N5/0604 ,  C12N2500/32

Abstract: Object: to provide a medium composition for external fertilization, in particular, one to be used in the incubation of an ovum or an early embryo, i.e., a fertilized ovum or in the pretreatment of an ovum or sperms. Means for solution: a medium composition for external fertilization which comprises as the essential components L-phenylalanine, L-tryptophan, L-lysine, L-threonine, L-valine, L-methionine, L-isoleucine, L-leucine, L-proline, glycine, L-alanine, L-tyrosine, L-histidine, L-arginine, L-taurine, L-aspartic acid, L-serine, L-asparagine, L-glutamic acid, L-glutamine and L-cystine.

公开(公告)号：EP1403369A4

公开(公告)日：2005-06-15

申请号：EP02778910

申请日：2002-05-27

Applicant: FUSO PHARMACEUTICAL IND

Inventor： OHNO TSUNEYA ,  MATSUHISA AKIO ,  KESHI HIROYUKI ,  ABE KANAKO ,  SUGIMOTO NORIHIKO ,  UEYAMA HIROSHI ,  EDA SOJI ,  UEHARA HIROTSUGU ,  IWAMI TAKAHISA ,  YAMAMOTO SEIJI ,  ARAKI HIROMASA

IPC: C12Q1/68 ,  G01N33/50 ,  C12N15/09 ,  C12N5/06 ,  C12N5/10 ,  G01N33/53

CPC classification number: G01N33/5047 ,  C12Q1/6841 ,  C12Q1/689 ,  G01N33/5005

Abstract: Phagocytes having taken a foreign microorganism which are prepared by bringing phagocytes into contact with the microorganism and then isolating the phagocytes; a process for producing the same; and a method and a kit with the use of the same. An experimental model whereby the phagocytosis function of phagocytes can be evaluated in vitro .

公开(公告)号：EP1258251A4

公开(公告)日：2003-04-09

申请号：EP01904557

申请日：2001-02-20

Applicant: FUSO PHARMACEUTICAL IND

Inventor： ARAKI HIROMASA ,  KAWABATA ATSUFUMI ,  KURODA RYOTARO ,  KAKEHI KAZUAKI ,  TANAKA SHUICHI ,  KAWAI KENZO ,  NISHIMURA SACHIYO ,  NISHIKAWA HIROYUKI

IPC: A61K9/00 ,  A61K38/00 ,  A61K38/08 ,  A61K38/17 ,  A61K38/46 ,  A61K38/55 ,  A61K45/00 ,  A61K45/06 ,  A61P1/04 ,  A61P1/12 ,  A61K38/48

CPC classification number: A61K38/08 ,  A61K38/06 ,  A61K38/482 ,  A61K38/4826 ,  A61K2300/00

Abstract: The present invention provides a composition for safely and effectively preventing and treating digestive organs diseases, particularly, gastric ulcer, duodenal ulcer, gastritis, diarrhea, enteritis and the like. There is also provided a composition having a novel mechanism of action in order to solve the problems which was difficult to be solved by the side effect previously known mechanisms of action. More particularly, there is provided a pharmaceutical composition containing an ingredient which activates PAR-2 as an essential ingredient, which is useful for inhibiting gastric acid secretion, promoting digestive tract mucus secretion, protecting digestive tract mucosa, repairing tissue of digestive organs, and preventing and treating digestive organs diseases.

公开(公告)号：EP2130539A4

公开(公告)日：2010-05-19

申请号：EP08722191

申请日：2008-03-14

Applicant: TOYO BOSEKI ,  FUSO PHARMACEUTICAL IND

Inventor： FUKUNO TAKUJI ,  TACHIMORI HIROSHI ,  MUKUNOKI FUMINORI ,  MIYASAKA TADAYO ,  ARAKI HIROMASA ,  TANAKA SHUICHI ,  DOI SHINGO ,  KAWAZOE SHOICHI

IPC: A61K31/485 ,  A61K9/24 ,  A61K47/02 ,  A61K47/10 ,  A61K47/32 ,  A61P25/04

CPC classification number: C07D489/02 ,  A61K9/209 ,  A61K31/485

公开(公告)号：EP1233026A4

公开(公告)日：2005-08-17

申请号：EP00969985

申请日：2000-10-23

Applicant: FUSO PHARMACEUTICAL IND

Inventor： KUWAHARA YOSHIHIRO ,  HASEGAWA MICHINORI ,  ISAKA KIYOTSUGU ,  ARAKI HIROMASA

IPC: C07K16/18 ,  C12N5/20 ,  C12N15/06 ,  C12P21/08 ,  G01N33/577 ,  G01N33/68 ,  C12N5/10 ,  G01N33/15 ,  G01N33/53

CPC classification number: C07K16/18 ,  G01N33/689 ,  G01N2800/367 ,  Y10S435/806 ,  Y10S435/975

Abstract: An antibody binding specifically to rat postacrosome reaction sperm is produced and hybridomas (FARS-91 and FARS-92 strains) capable of stably proliferating are obtained by fusing mouse spleen cells having a high antibody titer against rat postacrosome reaction sperm with mouse-origin myeloma cells and screening fused cells reacting strongly with rat postacrosome reaction sperm. From these hybridomas, monoclonal antibodies selectively binding to rat postacrosome reaction sperm can be obtained. Thus, a diagnostic method for evaluating rat fertility is presented.

公开(公告)号：EP1247532A4

公开(公告)日：2005-01-19

申请号：EP00979995

申请日：2000-12-08

Applicant: FUSO PHARMACEUTICAL IND

Inventor： ARAKI HIROMASA ,  KAWABATA ATSUFUMI ,  TANAKA SHUICHI ,  KAWAI KENZO ,  NISHIMURA SACHIYO ,  NISHIKAWA HIROYUKI

IPC: G02C7/04 ,  A61F9/00 ,  A61K9/06 ,  A61K9/08 ,  A61K9/10 ,  A61K38/00 ,  A61K38/17 ,  A61K38/48 ,  A61K45/00 ,  A61K45/06 ,  A61L27/22 ,  A61P27/02 ,  A61P43/00 ,  C07K7/06 ,  C12N9/76 ,  C12N9/99 ,  G02B1/04 ,  G02C13/00 ,  A61K38/08 ,  A61K38/55

CPC classification number: G02B1/043 ,  A61K38/06 ,  A61K38/08 ,  A61K38/177 ,  A61K38/482 ,  A61K38/4826 ,  A61L27/227

Abstract: A composition promoting lacrimal secretion which can be safely and efficaciously used in the treatment of promoting lacrimal secretion different from the conventional treatment of supplying lacrimal components. This composition is characterized by containing a component activating PAR-2. Also, contact lenses carrying and/or containing this composition are provided.

公开(公告)号：DE60138366D1

公开(公告)日：2009-05-28

申请号：DE60138366

申请日：2001-02-20

Applicant: FUSO PHARMACEUTICAL IND

Inventor： ARAKI HIROMASA ,  KAWABATA ATSUFUMI ,  KURODA RYOTARO ,  KAKEHI KAZUAKI ,  TANAKA SHUICHI ,  KAWAI KENZO ,  NISHIMURA SACHIYO ,  NISHIKAWA HIROYUKI

IPC: A61K9/00 ,  A61K45/00 ,  A61K38/00 ,  A61K38/08 ,  A61K38/17 ,  A61K38/46 ,  A61K38/48 ,  A61K38/55 ,  A61K45/06 ,  A61P1/04 ,  A61P1/12

Abstract: The present invention provides a composition for safely and effectively preventing and treating digestive organs diseases, particularly, gastric ulcer, duodenal ulcer, gastritis, diarrhea, enteritis and the like. There is also provided a composition having a novel mechanism of action in order to solve the problems which was difficult to be solved by the side effect previously known mechanisms of action. More particularly, there is provided a pharmaceutical composition containing an ingredient which activates PAR-2 as an essential ingredient, which is useful for inhibiting gastric acid secretion, promoting digestive tract mucus secretion, protecting digestive tract mucosa, repairing tissue of digestive organs, and preventing and treating digestive organs diseases.

公开(公告)号：AT423572T

公开(公告)日：2009-03-15

申请号：AT00979995

申请日：2000-12-08

Applicant: FUSO PHARMACEUTICAL IND

Inventor： ARAKI HIROMASA ,  KAWABATA ATSUFUMI ,  TANAKA SHUICHI ,  KAWAI KENZO ,  NISHIMURA SACHIYO ,  NISHIKAWA HIROYUKI

IPC: A61K45/00 ,  G02C7/04 ,  A61F9/00 ,  A61K9/06 ,  A61K9/08 ,  A61K9/10 ,  A61K38/00 ,  A61K38/08 ,  A61K38/17 ,  A61K38/48 ,  A61K38/55 ,  A61K45/06 ,  A61L27/22 ,  A61P27/02 ,  A61P43/00 ,  C07K7/06 ,  C12N9/76 ,  C12N9/99 ,  G02B1/04 ,  G02C13/00

Abstract: A composition for promoting lacrimal secretion, comprising a protease-activated receptor (PAR)-2 agonist, is new. Independent claims are also included for the following: (1) drug delivery systems comprising the above composition; and (2) contact lenses coated in and/or containing the above composition. ACTIVITY : Ophthalmological. In tests Ser-Leu-ILe-Gly-Leu-NH 2administered to Wistar rats at 5 Micromol/kg by tail vein injection significantly (p is less than 0.01) increased lacrimal secretion. MECHANISM OF ACTION : Protease-agonist.

公开(公告)号：DK0872180T3

公开(公告)日：2003-08-11

申请号：DK96929521

申请日：1996-09-04

Applicant: FUSO PHARMACEUTICAL IND

Inventor： NAKAZAWA TERUKI ,  ARAKI HIROMASA ,  KISHI YUICHIRO ,  SHINODA SANJI ,  YAMADA MORIYUKI ,  OHASHI KAZUTOMO

IPC: A01K67/02 ,  A01K67/027 ,  C12N5/02 ,  C12N5/073 ,  C12N5/00

Abstract: The present invention aims to provide a medium composition for in vitro fertilization, in particular, a composition usable in the culture of ova or early embryos which are fertilized eggs, the preparation or culture of sperm, and the pre-treatment of ova or sperm. The composition comprises, as its essential components, L-phenylalanine, L-tryptophan, L-lysine, L-threonine, L-valine, L-methionine, L-isoleucine, L-leucine, L-proline, glycine, L-alanine, L-tyrosine, L-histidine, L-arginine, L-taurine, L-aspartic acid, L-serine, L-asparagine, L-glutamic acid, L-glutamine and L-cystine, provided that at least a part of the L-cystine may be replaced by L-cysteine.