公开(公告)号：NO950889A

公开(公告)日：1995-09-11

申请号：NO950889

申请日：1995-03-08

Applicant: HOECHST AG

Inventor： AHLERS MICHAEL ,  WALCH AXEL ,  SEIPKE GERHARD ,  RUSSELL-JONES GREGORY JOHN

IPC: A61K47/34 ,  A61K9/51 ,  A61K47/48 ,  A61P3/00 ,  C08G69/40

CPC classification number: A61K9/5146 ,  A61K47/6933 ,  B82Y5/00 ,  Y10S514/808 ,  Y10S514/951 ,  Y10S977/773 ,  Y10S977/90 ,  Y10S977/915

公开(公告)号：CA2144216A1

公开(公告)日：1995-09-10

申请号：CA2144216

申请日：1995-03-08

Applicant: HOECHST AG

Inventor： AHLERS MICHAEL ,  WALCH AXEL ,  SEIPKE GERHARD ,  RUSSEL-JONES GREGORY

IPC: A61K47/34 ,  A61K9/51 ,  A61K47/48 ,  A61P3/00 ,  B01J13/02

Abstract: Nanoparticles containing an active substance and a ketalized polytartramidic acid, process for their preparation, and use thereof Nanoparticles containing an active substance and a ketalized polytartramidic acid are suitable as vehicles for active substances, in particular for peptides and proteins. Processes for the preparation of the nanoparticles are described.

公开(公告)号：HUT67045A

公开(公告)日：1995-01-30

申请号：HU9303538

申请日：1993-12-10

Applicant: HOECHST AG

Inventor： SCHLEYERBACH RUDOLF ,  GRABLEY SUSANNE ,  WALCH AXEL ,  STAHL WILHELM ,  AHLERS MICHAEL ,  BARTNIK ECKHART ,  KRETZSCHMAR GERHARD

IPC: A61K31/715 ,  A61K31/765 ,  A61K31/785 ,  A61K31/80 ,  A61K47/48 ,  A61K49/00 ,  A61P29/00 ,  A61P31/04 ,  A61P31/12 ,  A61P35/00 ,  A61P43/00 ,  C07H15/04 ,  C07H15/203 ,  C08B37/00 ,  C08G63/00 ,  C08G63/06 ,  C08G64/00 ,  C08G64/42 ,  C08G65/16 ,  C08G67/04 ,  C08G69/00 ,  C08G69/10 ,  C08G73/16 ,  C07H5/06 ,  A61K31/70

Abstract: The invention relates to physiologically compatible and physiologically degradable polymer-based carbohydrate receptor blocker with an HLB of 10 to 20, containing: carbohydrate portion - bifunctional spacer - hydrophilic biodegradable polymer - potentiator, where the carbohydrate portion consists of 1 to 20 naturally occurring, identical or different, monosaccharide units and is coupled via one or more bifunctional spacers, which is a natural or synthetic molecule, to a hydrophilic biodegradable polymer, and the polymer in turn is the carrier of one or more spacers and the hydrophilic biodegradable polymer is additionally linked to the potentiator which is a crosslinker, one or more groups with hydrophobic, hydrophilic or ionic properties or a solubility improver, to a method for the preparation and to its use in vivo for blocking carbohydrate-recognising receptors. The carbohydrate receptor blocker induces no incompatibility reaction in vivo either in its totality or in the form of breakdown products.

公开(公告)号：CA2111129A1

公开(公告)日：1994-06-12

申请号：CA2111129

申请日：1993-12-10

Applicant: HOECHST AG

Inventor： STAHL WILHELM ,  AHLERS MICHAEL ,  WALCH AXEL ,  BARTNIK ECKHART ,  KRETZSCHMAR GERHARD ,  GRABLEY SUSANNE ,  SCHLEYERBACH RUDOLF

IPC: A61K31/715 ,  A61K31/765 ,  A61K31/785 ,  A61K31/80 ,  A61K47/48 ,  A61K49/00 ,  A61P29/00 ,  A61P31/04 ,  A61P31/12 ,  A61P35/00 ,  A61P43/00 ,  C07H15/04 ,  C07H15/203 ,  C08B37/00 ,  C08G63/00 ,  C08G63/06 ,  C08G64/00 ,  C08G64/42 ,  C08G65/16 ,  C08G67/04 ,  C08G69/00 ,  C08G69/10 ,  C08G73/16 ,  C08B31/00 ,  C08G73/10 ,  A61K39/385 ,  G01N33/53 ,  A61K31/70

Abstract: The invention relates to physiologically tolerated and physiologically degradable polymer-based carbohydrate receptor blockers with an HLB* of 10 to 20 containing: carbohydrate portion - bifunctional spacer - hydrophilic, biodegradable polymer - potentiator, where the carbohydrate portion which is composed of 1 to 20 naturally occurring, identical or different, monosaccharide units is coupled via one or more bifunctional spacers, which is a natural or synthetic molecule, to a hydrophilic, biodegradable polymer, where the polymer in turn is the carrier of one or more spacers, and the hydrophilic, biodegradable polymer is additionally linked to the potentiator which is a crosslinker, one or more groups with hydrophobic, hydrophilic or ionic properties or a solubility improver, to a process for the preparation and to their use in vivo for blocking carbohydrate-recognizing receptors. The carbohydrate receptor blocker causes no intolerance reaction in vivo either in its entirety or in the form of degradation products.

公开(公告)号：FI933274A

公开(公告)日：1994-01-23

申请号：FI933274

申请日：1993-07-20

Applicant: HOECHST AG

Inventor： AHLERS MICHAEL ,  GLOMBIK HEINER ,  MUELLNER STEFAN ,  WALCH AXEL

IPC: A61K31/785 ,  A61P3/06 ,  C08F8/12 ,  C08F26/00 ,  C08F26/02

Abstract: The invention relates to crosslinked, nitrogen-containing vinyl copolymers containing units of the formula I and the physiologically acceptable salts thereof, where, in formula I, A1, A2, R, w, x, y and z are as defined, to a process for their preparation, and to the use of the compounds as medicaments (drugs, pharmaceuticals), active compound (active ingredient) carriers and as foodstuff auxiliaries.

公开(公告)号：NO932635D0

公开(公告)日：1993-07-21

申请号：NO932635

申请日：1993-07-21

Applicant: HOECHST AG

Inventor： AHLERS MICHAEL ,  GLOMBIK HEINER ,  MUELLNER STEFAN ,  WALCH AXEL

IPC: A61P3/06 ,  A61K31/785 ,  C08F8/12 ,  C08F26/00 ,  C08F26/02 ,  C08F

Abstract: The invention relates to crosslinked, nitrogen-containing vinyl copolymers containing units of the formula I and the physiologically acceptable salts thereof, where, in formula I, A1, A2, R, w, x, y and z are as defined, to a process for their preparation, and to the use of the compounds as medicaments (drugs, pharmaceuticals), active compound (active ingredient) carriers and as foodstuff auxiliaries.

公开(公告)号：NO307422B1

公开(公告)日：2000-04-03

申请号：NO950889

申请日：1995-03-08

Applicant: HOECHST AG

Inventor： AHLERS MICHAEL ,  WALCH AXEL ,  SEIPKE GERHARD ,  RUSSELL-JONES GREGORY JOHN

IPC: A61K47/34 ,  A61K9/51 ,  A61K47/48 ,  A61P3/00 ,  C08G69/40

Abstract: Nanoparticles contg. an active ingredient (A) and a poly (ketal tartaric acid amide) (B) with at least 95 mole% of repeating units of formula (I) are new: X = NH; R2 = alkyl or cycloalkyl, opt. with 1 or more inert substits.

公开(公告)号：DE59503469D1

公开(公告)日：1998-10-08

申请号：DE59503469

申请日：1995-06-13

Applicant: HOECHST AG

Inventor： HOERSCH BRIGITTE ,  AHLERS MICHAEL ,  KRETZSCHMAR GERHARD ,  BARTNIK ECKART ,  SEIFFGE DIRK

IPC: C12P19/14 ,  A61K31/70 ,  C07H1/00 ,  C07H3/06 ,  C12P19/00 ,  C12P19/18 ,  C12P19/26 ,  C12P19/44

公开(公告)号：AT170567T

公开(公告)日：1998-09-15

申请号：AT95923321

申请日：1995-06-13

Applicant: HOECHST AG

Inventor： HOERSCH BRIGITTE ,  AHLERS MICHAEL ,  KRETZSCHMAR GERHARD ,  BARTNIK ECKART ,  SEIFFGE DIRK

IPC: C12P19/14 ,  A61K31/70 ,  C07H1/00 ,  C07H3/06 ,  C12P19/00 ,  C12P19/18 ,  C12P19/26 ,  C12P19/44

公开(公告)号：NO301427B1

公开(公告)日：1997-10-27

申请号：NO932634

申请日：1993-07-21

Applicant: HOECHST AG

Inventor： AHLERS MICHAEL ,  GLOMBIK HEINER ,  GRABLEY SUSANNE ,  GRANZER ERNOLD ,  MUELLNER STEFAN ,  WALCH AXEL ,  XU GUAN-YU

IPC: A23L33/00 ,  A61K31/785 ,  A61K47/30 ,  A61P3/06 ,  A61P3/12 ,  C08F8/12 ,  C08F26/00 ,  C08F226/02 ,  C08F26/02 ,  A23L1/058

Abstract: The invention relates to polyvinylamine derivatives containing hydrophilic centres, of the formula I in which R , R , R , X, w, x, y and z are as defined, and to a process for their preparation, and to the use of these compounds as medicaments (drugs, pharmaceuticals), active compound (active ingredient) carriers and as foodstuff auxiliaries. The preparation starts, in particular, from highly pure polyvinylamines containing the recurring unit of the formula Ia whose preparation is likewise described.a