公开(公告)号：CZ9700742A3

公开(公告)日：1997-09-17

申请号：CZ74297

申请日：1997-03-11

Applicant: HOECHST AG

Inventor： BOSSLET KLAUS ,  CZECH JOERG ,  GERKEN MANFRED ,  STRAUB RAINER ,  MONNERET CLAUDE ,  FLORENT JEAN CLAUDE ,  SCHMIDT FREDERIC

IPC: C07H15/203 ,  A61K31/70 ,  A61K31/7012 ,  A61K31/7028 ,  A61K31/7034 ,  A61K47/48 ,  A61P29/00 ,  A61P35/00 ,  A61P37/00 ,  A61P43/00 ,  C07H15/26

CPC classification number: A61K47/549 ,  A61K47/54

公开(公告)号：BRPI9701248B1

公开(公告)日：2022-01-18

申请号：BR9701248

申请日：1997-03-11

Applicant: AVENTIS PHARMA DEUTSCHLAND GMBH ,  HOECHST AG ,  SANOFI AVENTIS DEUTSCHLAND

Inventor： MONNERET CLAUDE ,  SCHMIDT FREDERIC ,  FLORENT JEAN-CLAUDE ,  CZECH JOERG ,  BOSSLET KLAUS ,  GERKEN MANFRED ,  STRAUB RAINER

IPC: A61K47/54 ,  C07H15/203 ,  A61K31/70 ,  A61K31/7012 ,  A61K31/7028 ,  A61K31/7034 ,  A61K47/48 ,  A61P29/00 ,  A61P35/00 ,  A61P37/00 ,  A61P43/00 ,  C07H15/26

Abstract: patente de invenção: "novos pró-medicamentos para a terapia de tumores e distúrbios inflamatórios" . novos pró-medicamentos para a terapia de tumores e distúrbios inflamatórios. são descritos compostos da fórmula i: glocosil-y[-c(=y)x-]~ p~-w(r)~ n~-z-c(=y)-composto ativo que são adequados para o tratamento de doenças carcinomatosas, doenças auto-imunes e doenças inflamatórias crônicas, tais como a artrite reumatóide.

公开(公告)号：RO120951B1

公开(公告)日：2006-10-30

申请号：RO9700402

申请日：1997-03-03

Applicant: HOECHST AG

Inventor： BOSSLET KLAUS ,  CZECH JOERG ,  GERKEN MANFRED ,  STRAUB RAINER ,  MONNERET CLAUDE ,  FLORENT JEAN CLAUDE ,  SCHMIDT FREDERIC

IPC: A61K47/48 ,  A61K31/70 ,  C07H15/203 ,  A61K31/7012 ,  A61K31/7028 ,  A61K31/7034 ,  A61P29/00 ,  A61P35/00 ,  A61P37/00 ,  A61P43/00 ,  C07H15/26

Abstract: Prezenta invenţie se referă la un compus cu activitate antitumoralăşi antiinflamatoare, la un procedeu pentru producerea acestui compus, la o compoziţie farmaceuticăşi la utilizarea acestui compus pentru fabricarea unui medicament pentru profilaxia şi tratamentul bolilor carcinomatoase, bolilor autoimune şi al bolilor inflamatoare cronice.

公开(公告)号：AT193326T

公开(公告)日：2000-06-15

申请号：AT92102197

申请日：1992-02-10

Applicant: HOECHST AG

Inventor： SEEMANN GERHARD ,  BOSSLET KLAUS ,  CZECH JOERG ,  KOLAR CENEK ,  HOFFMANN DIETER ,  SEDLACEK HANS-HARALD

IPC: C12N15/09 ,  A61K38/00 ,  A61K39/395 ,  A61K47/48 ,  A61P35/00 ,  C07K1/113 ,  C07K16/00 ,  C07K16/30 ,  C07K19/00 ,  C12N1/15 ,  C12N9/24 ,  C12N15/56 ,  C12N15/62 ,  C12P21/02 ,  C12P21/08 ,  C12R1/91

公开(公告)号：DE59310018D1

公开(公告)日：2000-05-31

申请号：DE59310018

申请日：1993-09-24

Applicant: HOECHST AG

Inventor： GEHRMANN MATHIAS ,  SEEMANN GERHARD ,  BOSSLET KLAUS ,  CZECH JOERG

IPC: A01K67/027 ,  A61K38/00 ,  A61P35/00 ,  C07K14/00 ,  C07K14/705 ,  C07K16/00 ,  C07K16/18 ,  C07K19/00 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N9/00 ,  C12N9/24 ,  C12N15/09 ,  C12N15/62 ,  C12N15/81 ,  C12P21/02 ,  C12R1/865 ,  G01N33/53 ,  G01N33/68

Abstract: The invention relates to compounds which contain an antigen binding region which is bound to at least one enzyme which is able to metabolise a compound which has little or no cytotoxicity (prodrug) into a cytotoxic compound (drug), where the antigen binding region consists of a single polypeptide chain. Covalently bonded carbohydrates are advantageously present on the polypeptide chain.

公开(公告)号：PL326336A1

公开(公告)日：1998-11-23

申请号：PL32633698

申请日：1998-05-15

Applicant: HOECHST AG

Inventor： BOSLET KLAUS ,  CZECH JOERG ,  GERKEN MANFRED ,  STRAUB RAINER ,  BLUMRICH MATTHIAS

IPC: C07H15/20 ,  A61K9/20 ,  A61K9/48 ,  A61K31/047 ,  A61K31/70 ,  A61K31/7004 ,  A61K31/7028 ,  A61K31/7034 ,  A61K31/704 ,  A61K31/715 ,  A61K47/10 ,  A61K47/26 ,  A61K47/36 ,  A61K47/48 ,  A61P29/00 ,  A61P35/00 ,  A61P37/00 ,  A61P43/00 ,  C07H5/06 ,  C07H15/244 ,  C07H15/252

Abstract: Compositions containing a glycosylated drug derivative of formula (I) and/or its salts, a carrier and optionally divalent ions, is new. G-Y-(C(=Y)-X)p-W(R)n-X-C(=Y)-A (I) Also claimed is the production of the preparation by processing the ingredients into a pharmaceutical dosage form. G = enzymatically cleavable poly-, oligo- or monosaccharide residue; W = aromatic or heteroaromatic residue, aliphatic residue containing conjugated double bonds or amino acid residue which cyclises after cleavage of G; R = H, Me, OMe, COOH, CN, COOMe, OH, NO2, F, Cl, Br, sulphonyl, sulphonamide or (1-4C alkyl)-sulphonamide; p = 0 or 1; n = integer; X = O, NH, methyleneoxy, methyleneamino or methylene-(1-4C) alkylamino; Y = O or NH; and A = biologically active agent bonded via a hydroxy, amino or imino group.

公开(公告)号：AU3241997A

公开(公告)日：1998-02-12

申请号：AU3241997

申请日：1997-07-31

Applicant: HOECHST AG

Inventor： BOSSLET KLAUS ,  CZECH JOERG ,  VASELLA ANDREA ,  HOOS ROLAND

IPC: C07D309/28 ,  A61K31/35 ,  A61K31/351 ,  A61P29/00 ,  A61P35/00 ,  A61P43/00 ,  C07D211/74 ,  C07D211/78 ,  C07D309/30 ,  C07D335/02 ,  C07F9/59 ,  C07F9/655 ,  C07F9/6553

Abstract: Trihydroxyheterocyclylamino compounds of formula (I) and their salts are new. Y = COOH, PO3H2, P(O)(OR6)(OH), P(O)R6(OH), tetrazole or SO3H; R6 = 1-4C alkyl; X = NH, O or S; R = H or CONH-C6(R7)5; and R7 = H, OH, halo, COOH, PO3H2 or SO3H.

公开(公告)号：HU9700579D0

公开(公告)日：1997-04-28

申请号：HU9700579

申请日：1997-03-12

Applicant: HOECHST AG

Inventor： BOSSLET KLAUS ,  CZECH JOERG ,  FLORENT JEAN-CLAUDE ,  GERKEN MANFRED ,  MONNERET CLAUDE ,  SCHMIDT FREDERIC ,  STRAUB RAINER

IPC: C07H15/203 ,  A61K31/70 ,  A61K31/7012 ,  A61K31/7028 ,  A61K31/7034 ,  A61K47/48 ,  A61P29/00 ,  A61P35/00 ,  A61P37/00 ,  A61P43/00 ,  C07H15/26

Abstract: Glycosyl derivatives of formula Glycosyl-YÄ-C(=Y)-X-Üp-W(R)n-Z-C(=Y)-active agent (I) and their salts are new: glycosyl = enzymatically cleavable poly-, oligo- or mono-saccharide; W = 5-14 membered aryl, naphthyl, indenyl, anthryl, phenanthryl, 5-14 membered heterocyclyl (containing 1-4 O, N or S), 1-6C alkyl, 2-6C alkenyl, 3-6C cycloalkyl or phenyl; R = H, 1-4C alkyl, phenyl, methoxy, carboxy, methyloxycarbonyl, CN, OH, NO2, F, Cl, Br, sulphonyl, sulphonamide or 1-4C sulphonalkylamide; p = 0-1; n = 0-3; X = O, NH, methyleneoxy, methyleneamino, methylene-1-4C alkylamino, 1-4C alkylamino, 3-6C cycloalkylamino; Y = O or NH; Z = 1-4C alkylamino, NCH3, C(CH3)2NH, CH(CH3)NH, C(CH3)2N(R ) or NH if W = 1-6C alkyl; R = 1-4C alkyl; and active agent = a compound with biological effect bonded via an oxygen, primary or secondary amine or an imino group.

公开(公告)号：NO971116D0

公开(公告)日：1997-03-11

申请号：NO971116

申请日：1997-03-11

Applicant: HOECHST AG

Inventor： BOSSLET KLAUS ,  CZECH JOERG ,  GERKEN MANFRED ,  STRAUB RAINER ,  MONNERET CLAUDE ,  FLORENT JEAN-CLAUDE ,  SCHMIDT FREDOERIC

IPC: A61K31/70 ,  A61K31/7012 ,  A61K31/7028 ,  C07H15/203 ,  A61K31/7034 ,  A61K47/48 ,  A61P29/00 ,  A61P35/00 ,  A61P37/00 ,  A61P43/00 ,  C07H15/26 ,  A61K47/26

Abstract: Glycosyl derivatives of formula Glycosyl-YÄ-C(=Y)-X-Üp-W(R)n-Z-C(=Y)-active agent (I) and their salts are new: glycosyl = enzymatically cleavable poly-, oligo- or mono-saccharide; W = 5-14 membered aryl, naphthyl, indenyl, anthryl, phenanthryl, 5-14 membered heterocyclyl (containing 1-4 O, N or S), 1-6C alkyl, 2-6C alkenyl, 3-6C cycloalkyl or phenyl; R = H, 1-4C alkyl, phenyl, methoxy, carboxy, methyloxycarbonyl, CN, OH, NO2, F, Cl, Br, sulphonyl, sulphonamide or 1-4C sulphonalkylamide; p = 0-1; n = 0-3; X = O, NH, methyleneoxy, methyleneamino, methylene-1-4C alkylamino, 1-4C alkylamino, 3-6C cycloalkylamino; Y = O or NH; Z = 1-4C alkylamino, NCH3, C(CH3)2NH, CH(CH3)NH, C(CH3)2N(R ) or NH if W = 1-6C alkyl; R = 1-4C alkyl; and active agent = a compound with biological effect bonded via an oxygen, primary or secondary amine or an imino group.

公开(公告)号：DK537289D0

公开(公告)日：1989-10-27

申请号：DK537289

申请日：1989-10-27

Applicant: HOECHST AG

Inventor： NAIK RAMCHANDRA GANAPATI ,  LAL BANSI ,  RUPP RICHARD HELMUT ,  SEDLACEK HANS HARALD ,  DICKNEITE GERHARD ,  CZECH JOERG

IPC: A61K31/35 ,  A61K31/40 ,  A61K31/443 ,  A61K31/4433 ,  A61K31/445 ,  A61K31/55 ,  A61P35/00 ,  C07D405/04 ,  C07D405/14 ,  C07D409/14 ,  C12N9/99

Abstract: Compounds of the formula I in which the substituents R1-R5 and n and m have the said meanings, are suitable for controlling tumours. The present invention relates to the use of 4H-1-benzopyran-4-one derivatives, to 4H-1-benzopyran-4-one derivatives and to medicines containing same. Benzopyran derivatives have already been disclosed in European Patent No. 0137193 and German Offenlegungsschrift 36 12 337. In the latter, compounds of the formula a) are disclosed.