公开(公告)号：NZ225611A

公开(公告)日：1991-09-25

申请号：NZ22561188

申请日：1988-07-29

Applicant: HOECHST AG

Inventor： SCHRINNER ELMAR ,  WINKLER IRVIN ,  MEICHSNER CHRISTOPH ,  HELSBERG MATTHIAS

IPC: C07D473/06 ,  A61K20060101 ,  A61K31/52 ,  A61K31/70 ,  A61K31/715 ,  A61P31/12 ,  C07D20060101 ,  C07D473/04 ,  C08B20060101 ,  C08B37/00 ,  A61K31/72 ,  A61K31/735

Abstract: The preparation contains or consists of… a) at least one sulphated polysaccharide and… b) at least one xanthine derivative. The preparation is suitable for the control and prophylaxis of viral diseases, especially those caused by retroviruses.

公开(公告)号：AU597068B2

公开(公告)日：1990-05-24

申请号：AU7379587

申请日：1987-06-03

Applicant: HOECHST AG

Inventor： LIMBERT MICHAEL ,  SCHRINNER ELMAR ,  SEIBERT GERHARD

IPC: A61K31/545 ,  A61P31/04 ,  A61K31/54

Abstract: Pharmaceutical preparation having a synergistic, antibacterial activity and containing a) a cephalosporin derivative or physiologically acceptable salts or esters thereof, and b) a penem antibiotic of the basic structure (B) or physiologically acceptable salts or esters thereof, process for manufacturing such a preparation, and its use in the treatment of bacterial infections.

公开(公告)号：PT84996B

公开(公告)日：1990-03-08

申请号：PT8499687

申请日：1987-06-03

Applicant: HOECHST AG

Inventor： SEIBERT GERHARD ,  SCHRINNER ELMAR ,  LIMBERT MICHAEL

IPC: A61K31/545 ,  A61P31/04 ,  A61K31/43

Abstract: Pharmaceutical preparation having a synergistic, antibacterial activity and containing a) a cephalosporin derivative or physiologically acceptable salts or esters thereof, and b) a penem antibiotic of the basic structure (B) or physiologically acceptable salts or esters thereof, process for manufacturing such a preparation, and its use in the treatment of bacterial infections.

公开(公告)号：PT91103A

公开(公告)日：1990-02-08

申请号：PT9110389

申请日：1989-07-07

Applicant: HOECHST AG

Inventor： SCHRINNER ELMAR ,  MEICHSNER CHRISTOPH ,  WINKLER IRVIN ,  HELSBERG MATTHIAS ,  KLOSA JOSEF ,  HANS-KROGER

IPC: A61K31/52 ,  A61P31/12 ,  C07D473/38

公开(公告)号：ZA885577B

公开(公告)日：1989-04-26

申请号：ZA885577

申请日：1988-07-29

Applicant: HOECHST AG

Inventor： SCHRINNER ELMAR ,  ELMAR SCHRINNER ,  HELSBERG MATTHIAS ,  MATTHIAS HELSBERG ,  WINKLER IRVIN ,  IRVIN WINKLER ,  MEICHSNER CHRISTOPH ,  CHRISTOPH MEICHSNER

IPC: C07D473/06 ,  A61K20060101 ,  A61K31/52 ,  A61K31/70 ,  A61K31/715 ,  A61P31/12 ,  C07D20060101 ,  C07D473/04 ,  C08B20060101 ,  C08B37/00 ,  A61K ,  C08B ,  C07D

Abstract: The preparation contains or consists of… a) at least one sulphated polysaccharide and… b) at least one xanthine derivative. The preparation is suitable for the control and prophylaxis of viral diseases, especially those caused by retroviruses.

公开(公告)号：ZA875803B

公开(公告)日：1988-03-30

申请号：ZA875803

申请日：1987-08-06

Applicant: HOECHST AG

Inventor： SEIBERT GERHARD ,  GERHARD SEIBERT ,  SCHRINNER ELMAR ,  ELMAR SCHRINNER

IPC: A61L15/58 ,  A61B20060101 ,  A61K31/47 ,  A61L20060101 ,  A61P31/04 ,  C09J20060101 ,  A61L ,  A61B ,  C09J

公开(公告)号：FI70221C

公开(公告)日：1986-09-15

申请号：FI780966

申请日：1978-03-30

Applicant: HOECHST AG

Inventor： DUERCKHEIMER WALTER ,  BORMANN DIETER ,  EHLERS EBERHARD ,  SCHRINNER ELMAR ,  HEYMES RENE

IPC: A61K31/397 ,  A61K31/435 ,  A61K31/505 ,  A61K31/535 ,  A61K31/545 ,  A61K31/546 ,  A61P31/04 ,  B25J15/08 ,  C07D205/08 ,  C07D277/20 ,  C07D277/40 ,  C07D277/42 ,  C07D277/50 ,  C07D463/00 ,  C07D471/04 ,  C07D487/04 ,  C07D498/04 ,  C07D501/20 ,  C07D501/24 ,  C07D501/36 ,  C07D505/00 ,  C07D519/06 ,  C07F9/6561

Abstract: Cephem derivatives of the general formula in which the R2O group is in the syn-position, a process for their manufacture and pharmaceutical formulations which are active against bacterial infections and contain these compounds.

公开(公告)号：HU184680B

公开(公告)日：1984-09-28

申请号：HUHO002061

申请日：1978-03-31

Applicant: HOECHST AG

Inventor： DUERCKHEIMER WALTER ,  BORMANN DIETER ,  EHLERS EBERHARD ,  SCHRINNER ELMAR ,  HEYMES RENE

IPC: C07D501/36 ,  A61K31/545 ,  A61K31/546 ,  A61P31/04 ,  C07D501/20 ,  C07D501/46

公开(公告)号：FI66188B

公开(公告)日：1984-05-31

申请号：FI781131

申请日：1978-04-13

Applicant: HOECHST AG

Inventor： DUERCKHEIMER WALTER ,  EHLERS EBERHARD ,  SELINGER HUBERT ,  SCHRINNER ELMAR

IPC: A61K20060101 ,  A61K31/545 ,  A61K31/546 ,  A61K31/675 ,  A61K31/695 ,  A61P31/04 ,  B23K1/18 ,  B23Q5/033 ,  C07D20060101 ,  C07D277/20 ,  C07D277/40 ,  C07D501/00 ,  C07D501/20 ,  C07D501/24 ,  C07D501/34 ,  C07D501/36 ,  C07D501/46 ,  C07D501/59 ,  C07D501/60 ,  C07D519/06

Abstract: What are disclosed are cephem compounds of the formula in which R1 denotes hydrogen, an optionally substituted alkyl, acyl, arylsulfonyl or alkylsulfonyl group or an amino-protective group which is known from peptide chemistry, R2 denotes hydrogen or an optionally substituted alkyl, alkenyl, alkinyl, cycloalkyl, aralkyl, acyl, aryl, arylsulfonyl, alkylsulfonyl or heterocyclic group, R3 denotes hydrogen, an ester group or a cation, R4 denotes hydrogen, a lower alkoxy group or a group which can be converted to this, X denotes a SO group in the R or S configuration or a SO2 group and A denotes hydrogen, an optionally substituted alkoxy or alkenyloxy group, halogen or a group -CH2Y, in which Y represents hydrogen, halogen or the radical of a nucleophilic compound, and in which the R2O group is in the syn-position, which compounds are valuable chemotherapeutic agents having a very powerful antimicrobial action against Gram-positive and Gram-negative bacteria and an unexpectedly good action against penicillinase-forming Staphilococci.

公开(公告)号：FI791649A

公开(公告)日：1979-11-27

申请号：FI791649

申请日：1979-05-24

Applicant: HOECHST AG

Inventor： BORMANN DIETER ,  DUERCKHEIMER WALTER ,  SCHRINNER ELMAR

IPC: C07D501/22 ,  A61K31/545 ,  A61K31/546 ,  A61P31/04 ,  C07D277/24 ,  C07D277/28 ,  C07D277/32 ,  C07D501/20 ,  C07D501/34 ,  C07D