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    SYSTEM FOR IN-VIVO MEASUREMENT OF AN ANALYTE CONCENTRATION
    11.
    发明专利
    SYSTEM FOR IN-VIVO MEASUREMENT OF AN ANALYTE CONCENTRATION 未知

    公开(公告)号：CA2625911A1

    公开(公告)日：2008-09-20

    申请号：CA2625911

    申请日：2008-03-17

    Applicant: HOFFMANN LA ROCHE

    Inventor： SCHWIND KARIN ,  LINDEGGER STEFAN ,  MURI MARTIN ,  ROESICKE BERND ,  NIEDERHAUSER SANDRO ,  SCHOEMAKER MICHAEL ,  MENKE ANDREAS ,  OBERMAIER KARIN ,  SCHERWR JORG ,  BAINCZYK GREGOR ,  GAA OTTO ,  MARQUANT MICHAEL

    IPC: A61B5/00

    Abstract: The invention relates to a system for in-vivo measurement of an analyte concentration in a human or animal body having at least one implantable sens or (3) for generating measuring signals that are correlated to the analyte concentration to be measured, a base station (2) that can be coupled to the sensor (3) and contains an electronic analytical unit (47) for analysis of measuring signals of a sensor (3) connected to it, and a transmitter (31) for wireless transmission of analytical results, and a display device (4) that has a receiver for receiving the analytical results transmitted by the base station (2) and a display facility (29) for displayi ng analyte concentration values. The invention provides the sensor (3) to be part of a replaceable sensor carrier unit (10) that has a closed housing (12) inside o f which the sensor (3) is disposed, and provides the housing (12) of the sensor carrier unit (10) to catch onto the base station (2) in order to couple the sensor (3) to the base station (2).

    15.
    发明专利
    未知

    公开(公告)号：ES2193123T3

    公开(公告)日：2003-11-01

    申请号：ES01119090

    申请日：2001-08-08

    Applicant: HOFFMANN LA ROCHE

    Inventor： GAA OTTO ,  ALBRECHT GERTRUD ,  LOCH-LEROUX DIETER

    IPC: G01N31/22 ,  G01N21/78 ,  G01N33/52 ,  G01N33/66 ,  G01N33/96

    Abstract: Test strips to control the usefulness of analysis (1), and the like, comprises initially, a reference value measurement takes a standard reference value at a reference control agent (4) as a standardized reference value for the control parameter. To control the usefulness of analysis test strips, and the like, the control parameter of the new test strip is determined as a control value to give a quotient with the first standard reference value as a control quotient. Any deviation between the control quotient and the first reference quotient is measured, and the test strip is rejected if the difference is outside a given tolerance range. The deviation is registered by a relative difference between the control quotient and the first reference quotient, or the actual difference. The new test strip is rejected if the control quotient is smaller than the first reference quotient by a given percentage or a given difference value. The tolerance range is specific to the actual charge of the test strip. The initial test strip and the further test strip are taken from the same package or dispenser, within a long-life packing, where they are each protected by separate wrappings. The test is made when a new package is used, when the first test strip is taken from the pack or on opening a long-life packing. The test stages are repeated if it is shown by the control measurement that test readings or the values measured by an analysis apparatus would be potentially affected. When a given deviation is noted, the control value for the second strip is taken as a new control reference value to give a new reference quotient for the control of further test strips. A new reference quotient is formed if the control quotient is greater than the reference quotient by more than a set threshold value, related to the actual charge of the test strip. One or more of the test stages can be automated. The reference control agent gives a higher measured value for the control parameter. The test strip has a test field (3) and a reference control agent for the measurement of the control reference value or control value. The control parameter is an optical measured value and especially a remission value.

    Sistema para la medición in vivo de una concentración de analitos
    16.
    发明专利
    Sistema para la medición in vivo de una concentración de analitos 未知

    公开(公告)号：ES2588605T3

    公开(公告)日：2016-11-03

    申请号：ES07024174

    申请日：2007-12-13

    Applicant: HOFFMANN LA ROCHE

    Inventor： ROESICKE BERND ,  OBERMAIER KARIN ,  LINDEGGER STEFAN ,  MENKE ANDREAS ,  SCHERER JÖRG ,  SCHWIND KARIN ,  GAA OTTO ,  BAINCZYK GREGOR ,  MARQUANT MICHAEL ,  NIEDERHÄUSER SANDRO ,  SCHOEMAKER MICHAEL ,  MÜRI MARTIN

    IPC: A61B5/00

    Abstract: Sistema para la medición in vivo de una concentración de analitos en un cuerpo humano o animal que comprende al menos un sensor implantable (3) para generar señales de medición que son equivalentes a la concentración de analitos que va a medirse, una estación base (2) que puede conectarse al sensor (3) y contiene una unidad analítica electrónica (47) para el análisis de señales de medición de un sensor (3) conectado a ella, y un transmisor (31) para la transmisión inalámbrica de resultados analíticos, y un dispositivo de visualización (4) que tiene un receptor para recibir los resultados analíticos transmitidos por la estación base (2) y una unidad de visualización (29) para visualizar valores de concentración de analitos, caracterizado por que en funcionamiento la unidad analítica (47) de la estación base (2) somete las señales de medición facilitadas por un sensor (3) como datos brutos al análisis estadístico y genera, a partir de los datos brutos, datos de medición condensados que el transmisor (31) transmite al dispositivo de visualización (4), y por que el dispositivo de visualización (4) contiene una unidad analítica electrónica que, en funcionamiento, determina un valor de concentración de analitos mediante el análisis de los datos de medición condensados, en el que en la estación base (2) se determina un valor de señal de medición para los primeros intervalos de tiempo, y se generan datos de medición condensados para los segundos intervalos de tiempo a partir de los valores de señales de medición de múltiples primeros intervalos de tiempo de forma que haya disponible un valor de los datos de medición condensados para los segundos intervalos de tiempo, y en el que la unidad analítica (47) de la estación base (2) en funcionamiento evalúa datos brutos (33) estadísticamente proporcionados por un sensor conectado (3) y genera datos de medición condensados (36), en el que la unidad analítica (47) en la evaluación estadística para generar los datos de medición condensados (36) realiza un método en el que se forman pares de valores de señales de medición a partir de las señales de medición (32) que se generan en un intervalo de tiempo, después se determina una pendiente de una línea que conecta los dos valores del par de valores para cada par de valores de señales de medición, después se calcula un valor mediano de las pendientes determinadas de ese modo, y después se calcula un valor de datos de medición condensados para dicho intervalo de tiempo a partir del valor mediano de la pendiente y el valor de datos de medición condensados del intervalo de tiempo anterior.

    18.
    发明专利
    未知

    公开(公告)号：AT235059T

    公开(公告)日：2003-04-15

    申请号：AT01119090

    申请日：2001-08-08

    Applicant: HOFFMANN LA ROCHE

    Inventor： GAA OTTO ,  ALBRECHT GERTRUD ,  LOCH-LEROUX DIETER

    IPC: G01N31/22 ,  G01N21/78 ,  G01N33/52 ,  G01N33/66 ,  G01N33/96

    Abstract: Test strips to control the usefulness of analysis (1), and the like, comprises initially, a reference value measurement takes a standard reference value at a reference control agent (4) as a standardized reference value for the control parameter. To control the usefulness of analysis test strips, and the like, the control parameter of the new test strip is determined as a control value to give a quotient with the first standard reference value as a control quotient. Any deviation between the control quotient and the first reference quotient is measured, and the test strip is rejected if the difference is outside a given tolerance range. The deviation is registered by a relative difference between the control quotient and the first reference quotient, or the actual difference. The new test strip is rejected if the control quotient is smaller than the first reference quotient by a given percentage or a given difference value. The tolerance range is specific to the actual charge of the test strip. The initial test strip and the further test strip are taken from the same package or dispenser, within a long-life packing, where they are each protected by separate wrappings. The test is made when a new package is used, when the first test strip is taken from the pack or on opening a long-life packing. The test stages are repeated if it is shown by the control measurement that test readings or the values measured by an analysis apparatus would be potentially affected. When a given deviation is noted, the control value for the second strip is taken as a new control reference value to give a new reference quotient for the control of further test strips. A new reference quotient is formed if the control quotient is greater than the reference quotient by more than a set threshold value, related to the actual charge of the test strip. One or more of the test stages can be automated. The reference control agent gives a higher measured value for the control parameter. The test strip has a test field (3) and a reference control agent for the measurement of the control reference value or control value. The control parameter is an optical measured value and especially a remission value.

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