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公开(公告)号：WO1997040679A1
公开(公告)日：1997-11-06
申请号：PCT/US1997007237
申请日：1997-04-30
Applicant: IMARX PHARMACEUTICAL CORP.
Inventor： IMARX PHARMACEUTICAL CORP. , UNGER, Evan, C.
IPC: A01N43/04
CPC classification number: A61K48/00 , A61K9/1272 , A61K41/0028 , C12N15/87 , C12N15/88
Abstract: The present invention is directed, inter alia, to a method for delivering a compound into a cell comprising administering to the cell the compound to be delivered, an organic halide, and/or a carrier. Ultrasound may also be applied, if desired.
Abstract translation: 本发明尤其涉及将化合物递送到细胞中的方法，包括向细胞施用待递送的化合物，有机卤化物和/或载体。 如果需要，也可以应用超声波。
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12.发明申请
公开(公告)号：WO1996028090A1
公开(公告)日：1996-09-19
申请号：PCT/US1996003054
申请日：1996-03-06
Applicant: IMARX PHARMACEUTICAL CORP.
Inventor： IMARX PHARMACEUTICAL CORP. , UNGER, Evan, C.
IPC: A61B05/055
CPC classification number: G01R33/5601 , A61K9/127 , A61K9/1277 , A61K9/1278 , A61K41/0028 , A61K41/0052 , A61K47/6911 , A61K47/6913 , A61K47/6925 , A61K49/103 , A61K49/16 , A61K49/1806 , A61K49/1839 , A61K49/1863 , A61K49/1866 , A61K49/1878 , A61K49/22 , A61K49/223 , A61K49/227 , A61M5/3145 , B82Y5/00 , G01R33/56308
Abstract: A novel method of magnetic resonance focused surgical ultrasound by administering to a patient a magnetic resonance imaging (MRI) contrast medium comprising gas filled vesicles, then scanning the patient with MRI techniques, and then applying ultrasound to effect surgery. These methods may also use an MRI contrast medium comprising gaseous precursor filled vesicles which undergo a phase transition from a liquid to gas in vivo after administration. Additionally, the MRI contrast medium may comprise a therapeutic compound.
Abstract translation: 通过向患者施用包含充满气体的囊泡的磁共振成像（MRI）造影剂，然后用MRI技术扫描患者，然后施加超声波以进行手术，来实现磁共振聚焦手术超声的新方法。 这些方法还可以使用包含气体前体填充的囊泡的MRI造影剂，其在给药后在体内经历从液体到气体的相变。 另外，MRI造影剂可以包含治疗化合物。
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13.发明申请
公开(公告)号：WO1995032005A1
公开(公告)日：1995-11-30
申请号：PCT/US1995006491
申请日：1995-05-22
Applicant: IMARx PHARMACEUTICAL CORP.
Inventor： IMARx PHARMACEUTICAL CORP. , UNGER, Evan, C.
IPC: A61K49/04
CPC classification number: A61K49/1806 , A61K49/0419
Abstract: Novel stabilized suspensions of a gas as diagnostic contrast agents, including computed tomography (CT) and magnetic resonance (MR) contrast agents. In preferred embodiments, the suspensions comprise stabilized gas-filled microspheres. Also in some preferred embodiments, at least a portion of the gas is derived from a gaseous precursor.
Abstract translation: 新型稳定的气体悬浮液作为诊断造影剂，包括计算机断层扫描（CT）和磁共振（MR）造影剂。 在优选的实施方案中，悬浮液包含稳定的充气微球。 同样在一些优选的实施方案中，至少一部分气体来自气态前体。
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公开(公告)号：EP1037673B1
公开(公告)日：2006-08-23
申请号：EP98906695.6
申请日：1998-02-25
Applicant: IMARX PHARMACEUTICAL CORP.
Inventor： UNGER, Evan, C.
CPC classification number: A61K49/223 , A61K9/1271 , A61K41/0028 , A61K47/544 , Y10T428/2984
Abstract: The present invention is directed to charged lipids, compositions comprising charged lipids, and the use of these compositions in drug delivery, targeted drug delivery, therapeutic imaging and diagnostic imaging, as well as their use as contrast agents.
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15.发明授权
公开(公告)号：EP0840570B1
公开(公告)日：2003-08-13
申请号：EP96938613.5
申请日：1996-06-06
Applicant: IMARx PHARMACEUTICAL CORP.
Inventor： UNGER, Evan, C. , McCREERY, Thomas , YELLOWHAIR, David , BARRETTE, Terrence, R.
CPC classification number: A61K49/22 , A61J3/00 , A61K9/127 , A61K9/1277 , A61K9/1278 , A61K41/0028 , A61K41/0052 , A61K49/1815 , A61K49/223 , A61K49/227 , A61K2800/87 , A61M5/3145 , B01F3/04099 , B01F11/0025 , B01F13/0033 , B01F15/00435 , Y10S366/605
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Patent Agency Ranking
公开(公告)号：EP0839125A1
公开(公告)日：1998-05-06
申请号：EP96905351.0
申请日：1996-01-29
Applicant: IMARX PHARMACEUTICAL CORP.
Inventor： UNGER, Evan, C. , SHEN, Dekang , WU, Guanli
CPC classification number: C07K14/005 , A61K9/1272 , A61K38/00 , A61K48/00 , C07C237/10 , C07C2601/14 , C07F9/10 , C07K14/501 , C12N15/88 , C12N2760/18522 , Y10S436/829 , Y10S977/797 , Y10S977/798 , Y10S977/80 , Y10S977/801 , Y10S977/907
Abstract: Cationic lipid compounds which comprise at least two cationic groups. The cationic lipid compounds are particularly suitable for use as carriers in the intracellular delivery of bioactive agents, including pharmaceuticals and genetic material. Compositions of the present cationic lipid compounds include suspensions, emulsions, micelles and liposomes.
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17.发明授权IMPROVED METHODS FOR DIAGNOSTIC IMAGING BY REGULATING THE ADMINISTRATION RATE OF A CONTRAST AGENT 失效用于诊断成像过程改进，通过控制对比部件的速度
公开(公告)号：EP0930844B1
公开(公告)日：2008-09-03
申请号：EP97928998.0
申请日：1997-06-16
Applicant: IMARX PHARMACEUTICAL CORP.
Inventor： UNGER, Evan, C. , MATSUNAGA, Terry, O. , FRITZ, Thomas, A. , RAMASWAMI, Varada, Rajan
IPC: A61B5/055
CPC classification number: A61K49/223 , Y10S977/801 , Y10S977/927 , Y10S977/928 , Y10S977/929 , Y10S977/93
Abstract: Methods for providing an image of an internal region of a patient. Embodiments of the methods involve administering to the patient a contrast agent which comprises a vesicle composition comprising, in an aqueous carrier, a gas or gaseous precursor and vesicles comprising lipids, proteins or polymers. The patient is scanned using diagnostic imaging, such as ultrasound, to obtain a visible image of the region. The contrast agent is administered to the patient at a rate to substantially eliminate diagnostic artifacts in the image. The methods are particularly useful for diagnosing the presence of any diseased tissue in the patient.
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公开(公告)号：EP1039834A1
公开(公告)日：2000-10-04
申请号：EP98964127.9
申请日：1998-12-17
Applicant: IMARX PHARMACEUTICAL CORP.
Inventor： UNGER, Evan, C. , WU, Yunqiu
CPC classification number: A61K49/0002
Abstract: The present invention generally relates to optoacoustic contrast agents and methods of diagnostic and therapeutic imaging using optoacoustic contrast agents.
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19.发明公开IMPROVED METHODS FOR DIAGNOSTIC IMAGING INVOLVING THE USE OF A CONTRAST AGENT AND A CORONARY VASODILATOR 失效用于诊断成像方法的改进使用造影剂和冠状动脉扩张剂
公开(公告)号：EP1017425A1
公开(公告)日：2000-07-12
申请号：EP97938609.1
申请日：1997-08-26
Applicant: IMARx PHARMACEUTICAL CORP.
Inventor： UNGER, Evan, C.
CPC classification number: A61B5/411 , A61B5/201 , A61K49/223 , A61K49/227
Abstract: Improved method for providing an image of an internal region of a patient, especially the cardiovascular region. Embodiments of the invention involve the administration to the patient of a contrast agent which comprises a vesicle composition comprising lipid or polymer vesicles and a gas or gaseous precursor, in combinationwith a coronary vasodilator. The patient is scanned using diagnostic imaging, such as ultrasound, to obtain a visible image of the region. The methods are particularly useful for diagnosing the presence of diseased tissue in the cardiovascular region of a patient, as well as for measuring blood flow in the cardiovascular region of a patient.
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公开(公告)号：EP0935415A1
公开(公告)日：1999-08-18
申请号：EP97921460.0
申请日：1997-04-30
Applicant: IMARX PHARMACEUTICAL CORP.
Inventor： UNGER, Evan, C. , McCREERY, Thomas
IPC: C12N15 , A61K9 , A61K41 , A61K45 , A61K47 , A61K48 , A61P3 , A61P7 , A61P9 , A61P11 , A61P21 , A61P31 , A61P35 , C12N5 , C12P21
CPC classification number: A61K48/00 , A61K9/1272 , A61K41/0028 , C12N15/87 , C12N15/88
Abstract: The present invention is directed, inter alia, to a method for delivering a compound into a cell comprising administering to the cell the compound to be delivered, an organic halide, and/or a carrier. Ultrasound may also be applied, if desired.
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