公开(公告)号：WO1997048337A1

公开(公告)日：1997-12-24

申请号：PCT/US1997010510

申请日：1997-06-16

Applicant: IMARX PHARMACEUTICAL CORP.

Inventor： IMARX PHARMACEUTICAL CORP. ,  UNGER, Evan, C. ,  MATSUNAGA, Terry, O. ,  FRITZ, Thomas, A. ,  RAMASWAMI, Varada, Rajan

IPC: A61B05/055

CPC classification number: A61K49/223 ,  Y10S977/801 ,  Y10S977/927 ,  Y10S977/928 ,  Y10S977/929 ,  Y10S977/93

Abstract: Methods for providing an image of an internal region of a patient. Embodiments of the methods involve administering to the patient a contrast agent which comprises a vesicle composition comprising, in an aqueous carrier, a gas or gaseous precursor and vesicles comprising lipids, proteins or polymers. The patient is scanned using diagnostic imaging, such as ultrasound, to obtain a visible image of the region. The contrast agent is administered to the patient at a rate to substantially eliminate diagnostic artifacts in the image. The methods are particularly useful for diagnosing the presence of any diseased tissue in the patient.

Abstract translation: 提供患者内部区域的图像的方法。 该方法的实施方案涉及向患者施用造影剂，其包含囊泡组合物，所述囊泡组合物在水性载体中包含气体或气体前体和包含脂质，蛋白质或聚合物的囊泡。 使用诸如超声波之类的诊断成像扫描患者，以获得该区域的可见图像。 将造影剂以基本上消除图像中的诊断伪像的速率施用于患者。 该方法对于诊断患者中任何患病组织的存在特别有用。

公开(公告)号：WO1996008234A1

公开(公告)日：1996-03-21

申请号：PCT/US1995009392

申请日：1995-07-26

Applicant: IMARx PHARMACEUTICAL CORP.

Inventor： IMARx PHARMACEUTICAL CORP. ,  UNGER, Evan, C. ,  MATSUNAGA, Terry, O. ,  YELLOWHAIR, David

IPC: A61K09/127

CPC classification number: A61K49/227 ,  A61K8/046 ,  A61K8/14 ,  A61K8/70 ,  A61K9/127 ,  A61K9/1277 ,  A61K9/1278 ,  A61K41/0028 ,  A61K41/0052 ,  A61K47/51 ,  A61K47/6925 ,  A61K49/1815 ,  A61K49/22 ,  A61K49/223 ,  A61K2800/87 ,  A61M5/3145 ,  A61Q19/00 ,  G01R33/5601 ,  Y10T428/2984

Abstract: A container comprising an aqueous lipid suspension and a gaseous phase substantially separate from the aqueous stabilizing phase, useful in diagnostic imaging such as ultrasound and magnetic resonance imaging and in therapeutic applications, is disclosed.

Abstract translation: 公开了一种容器，其包含水性脂质悬浮液和基本上与水稳定相分离的气相，其用于诸如超声和磁共振成像以及治疗应用的诊断成像。

公开(公告)号：EP0930844B1

公开(公告)日：2008-09-03

申请号：EP97928998.0

申请日：1997-06-16

Applicant: IMARX PHARMACEUTICAL CORP.

Inventor： UNGER, Evan, C. ,  MATSUNAGA, Terry, O. ,  FRITZ, Thomas, A. ,  RAMASWAMI, Varada, Rajan

IPC: A61B5/055

CPC classification number: A61K49/223 ,  Y10S977/801 ,  Y10S977/927 ,  Y10S977/928 ,  Y10S977/929 ,  Y10S977/93

Abstract: Methods for providing an image of an internal region of a patient. Embodiments of the methods involve administering to the patient a contrast agent which comprises a vesicle composition comprising, in an aqueous carrier, a gas or gaseous precursor and vesicles comprising lipids, proteins or polymers. The patient is scanned using diagnostic imaging, such as ultrasound, to obtain a visible image of the region. The contrast agent is administered to the patient at a rate to substantially eliminate diagnostic artifacts in the image. The methods are particularly useful for diagnosing the presence of any diseased tissue in the patient.

公开(公告)号：EP0788348B1

公开(公告)日：2004-07-14

申请号：EP95927429.1

申请日：1995-07-26

Applicant: IMARX PHARMACEUTICAL CORP.

Inventor： UNGER, Evan, C. ,  MATSUNAGA, Terry, O. ,  YELLOWHAIR, David

IPC: A61K9/127 ,  A61K49/00

CPC classification number: A61K49/227 ,  A61K8/046 ,  A61K8/14 ,  A61K8/70 ,  A61K9/127 ,  A61K9/1277 ,  A61K9/1278 ,  A61K41/0028 ,  A61K41/0052 ,  A61K47/51 ,  A61K47/6925 ,  A61K49/1815 ,  A61K49/22 ,  A61K49/223 ,  A61K2800/87 ,  A61M5/3145 ,  A61Q19/00 ,  G01R33/5601 ,  Y10T428/2984

公开(公告)号：EP0930844A1

公开(公告)日：1999-07-28

申请号：EP97928998.0

申请日：1997-06-16

Applicant: IMARX PHARMACEUTICAL CORP.

Inventor： UNGER, Evan, C. ,  MATSUNAGA, Terry, O. ,  FRITZ, Thomas, A. ,  RAMASWAMI, Varada, Rajan

IPC: A61M5 ,  A61B8 ,  A61K49 ,  A61K51

CPC classification number: A61K49/223 ,  Y10S977/801 ,  Y10S977/927 ,  Y10S977/928 ,  Y10S977/929 ,  Y10S977/93

Abstract: Methods for providing an image of an internal region of a patient. Embodiments of the methods involve administering to the patient a contrast agent which comprises a vesicle composition comprising, in an aqueous carrier, a gas or gaseous precursor and vesicles comprising lipids, proteins or polymers. The patient is scanned using diagnostic imaging, such as ultrasound, to obtain a visible image of the region. The contrast agent is administered to the patient at a rate to substantially eliminate diagnostic artifacts in the image. The methods are particularly useful for diagnosing the presence of any diseased tissue in the patient.

公开(公告)号：EP0788348A1

公开(公告)日：1997-08-13

申请号：EP95927429.0

申请日：1995-07-26

Applicant: IMARX PHARMACEUTICAL CORP.

Inventor： UNGER, Evan, C. ,  MATSUNAGA, Terry, O. ,  YELLOWHAIR, David

IPC: G01R33 ,  A61B5 ,  A61J1 ,  A61K8 ,  A61K9 ,  A61K41 ,  A61K47 ,  A61K49 ,  A61Q19 ,  B65D81 ,  A61M5

CPC classification number: A61K49/227 ,  A61K8/046 ,  A61K8/14 ,  A61K8/70 ,  A61K9/127 ,  A61K9/1277 ,  A61K9/1278 ,  A61K41/0028 ,  A61K41/0052 ,  A61K47/51 ,  A61K47/6925 ,  A61K49/1815 ,  A61K49/22 ,  A61K49/223 ,  A61K2800/87 ,  A61M5/3145 ,  A61Q19/00 ,  G01R33/5601 ,  Y10T428/2984

Abstract: A container comprising an aqueous lipid suspension and a gaseous phase substantially separate from the aqueous stabilizing phase, useful in diagnostic imaging such as ultrasound and magnetic resonance imaging and in therapeutic applications, is disclosed.