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    IMPROVED METHODS FOR DIAGNOSTIC IMAGING USING A CONTRAST AGENT AND A VASODILATOR
    1.
    发明申请
    IMPROVED METHODS FOR DIAGNOSTIC IMAGING USING A CONTRAST AGENT AND A VASODILATOR 审中-公开
    改进的使用对比剂和血管扩张剂进行诊断成像的方法

    公开(公告)号：WO1998010798A1

    公开(公告)日：1998-03-19

    申请号：PCT/US1997014957

    申请日：1997-08-26

    Applicant: IMARX PHARMACEUTICAL CORP.

    Inventor： IMARX PHARMACEUTICAL CORP. ,  UNGER, Evan, C.

    IPC: A61K49/00

    CPC classification number: A61B5/411 ,  A61B5/201 ,  A61K49/223 ,  A61K49/227

    Abstract: A method for providing an image of an internal region of a patient has been developed. The method reduces imaging artifacts by providing enhanced contrast between tissue and blood during imaging. The method comprises administering to a patient a contrast agent in combination with a renal vasodilator and performing ultrasound imaging of the region. Renal disease, including renal arterial stenosis, may be diagnosed using the method.

    Abstract translation: 已经开发了用于提供患者的内部区域的图像的方法。 该方法通过在成像期间通过提供组织和血液之间的增强的对比来减少成像伪像。 该方法包括向患者施用与肾血管扩张剂组合的造影剂并对该区域进行超声成像。 可以使用该方法诊断肾脏疾病，包括肾动脉狭窄。

    NOVEL SILICON AMPHIPHILIC COMPOUNDS AND THE USE THEREOF
    2.
    发明申请
    NOVEL SILICON AMPHIPHILIC COMPOUNDS AND THE USE THEREOF 审中-公开
    新型硅酮化合物及其用途

    公开(公告)号：WO1998009600A2

    公开(公告)日：1998-03-12

    申请号：PCT/US1997015033

    申请日：1997-08-26

    Applicant: IMARX PHARMACEUTICAL CORP.

    Inventor： IMARX PHARMACEUTICAL CORP. ,  UNGER, Evan, C. ,  SHEN, DeKANG ,  WU, Guanli

    IPC: A61K00/00

    CPC classification number: A61K51/1227 ,  A61K49/1806 ,  A61K49/223 ,  C07F7/0838

    Abstract: Novel silicon amphiphilic compounds which comprise a silicon residue. The silicon amphiphilic compounds are particularly suitable for use in compositions for diagnostic imaging, such as ultrasound. Compositions of the silicon amphiphilic compounds comprise a gas or gaseous precursor, and may take the form of vesicle compositions, such as micelles or liposomes.

    Abstract translation: 包含硅残渣的新型硅两亲化合物。 硅两亲化合物特别适用于用于诊断成像的组合物，例如超声波。 硅两亲化合物的组合物包含气体或气体前体，并且可以采取囊泡组合物的形式，例如胶束或脂质体。

    IMPROVED METHODS FOR DIAGNOSTIC IMAGING BY REGULATING THE ADMINISTRATION RATE OF A CONTRAST AGENT
    4.
    发明申请
    IMPROVED METHODS FOR DIAGNOSTIC IMAGING BY REGULATING THE ADMINISTRATION RATE OF A CONTRAST AGENT 审中-公开
    通过调整对比剂的行政率进行诊断成像的改进方法

    公开(公告)号：WO1997048337A1

    公开(公告)日：1997-12-24

    申请号：PCT/US1997010510

    申请日：1997-06-16

    Applicant: IMARX PHARMACEUTICAL CORP.

    Inventor： IMARX PHARMACEUTICAL CORP. ,  UNGER, Evan, C. ,  MATSUNAGA, Terry, O. ,  FRITZ, Thomas, A. ,  RAMASWAMI, Varada, Rajan

    IPC: A61B05/055

    CPC classification number: A61K49/223 ,  Y10S977/801 ,  Y10S977/927 ,  Y10S977/928 ,  Y10S977/929 ,  Y10S977/93

    Abstract: Methods for providing an image of an internal region of a patient. Embodiments of the methods involve administering to the patient a contrast agent which comprises a vesicle composition comprising, in an aqueous carrier, a gas or gaseous precursor and vesicles comprising lipids, proteins or polymers. The patient is scanned using diagnostic imaging, such as ultrasound, to obtain a visible image of the region. The contrast agent is administered to the patient at a rate to substantially eliminate diagnostic artifacts in the image. The methods are particularly useful for diagnosing the presence of any diseased tissue in the patient.

    Abstract translation: 提供患者内部区域的图像的方法。 该方法的实施方案涉及向患者施用造影剂，其包含囊泡组合物，所述囊泡组合物在水性载体中包含气体或气体前体和包含脂质，蛋白质或聚合物的囊泡。 使用诸如超声波之类的诊断成像扫描患者，以获得该区域的可见图像。 将造影剂以基本上消除图像中的诊断伪像的速率施用于患者。 该方法对于诊断患者中任何患病组织的存在特别有用。

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