公开(公告)号：EP1852412B1

公开(公告)日：2011-03-16

申请号：EP06712459.4

申请日：2006-01-27

Applicant: Japan Science and Technology Agency

Inventor： KOBAYASHI, Shu ,  MANABE, Kei

IPC: C07C45/75 ,  B01J31/22 ,  C07B53/00 ,  C07C49/497 ,  C07C49/513 ,  C07C49/82 ,  C07B61/00

CPC classification number: B01J31/2213 ,  B01J31/1815 ,  B01J2231/321 ,  B01J2531/0252 ,  B01J2531/54 ,  C07B53/00 ,  C07B2200/07 ,  C07C45/511 ,  C07C49/497 ,  C07C49/747 ,  C07C49/82 ,  C07C49/84

Abstract: [PROBLEMS] To provide a process for producing optically active hydroxymethylated compounds in high yields at high stereoselectivity with broad substrate generality, and a catalyst for the production. [MEANS FOR SOLVING PROBLEMS] The process comprises reacting a silicon enolate represented by the general formula (1) with formaldehyde in either an aqueous solution or a mixed solvent of water and an organic solvent in the presence of a catalyst obtained by mixing a ligand consisting of a chiral bipyridine or an antipode thereof with Bi(OTf)3: (1) wherein R5 to R7 are each hydrogen, an aliphatic hydrocarbon group, an aliphatic mono- or poly-cyclic hydrocarbon group, a mono- or poly-cyclic aromatic or araliphatic hydrocarbon group, or a heterocyclic group with the proviso that R5 and R7 are different from each other and R6 is not hydrogen; and R8's may be the same or different and are each methyl, ethyl, or isopropyl.

公开(公告)号：EP1577328B1

公开(公告)日：2010-08-11

申请号：EP03780853.2

申请日：2003-12-17

Applicant: Japan Science and Technology Agency

Inventor： KOBAYASHI, Shu

IPC: C08F8/30 ,  B01J31/06 ,  C07C29/40 ,  C07C33/30 ,  C07C241/02 ,  C07C243/38

CPC classification number: C08F8/30 ,  B01J31/0237 ,  B01J31/0247 ,  B01J31/06 ,  B01J31/4007 ,  B01J2231/341 ,  C07C29/38 ,  C07C243/38 ,  C07C2601/16 ,  Y02P20/584 ,  C07C33/20

Abstract: Polymer-immobilized formamides characterized by being represented by the general formula: (wherein R1 is an optionally substituted hydrocarbon chain which may have a cyclic moiety or a heteroatom; R2 is an optionally substituted hydrocarbon group or an optionally substituted hydrocarbon chain which is bonded to R1 to form a ring; and the solid circle represents a polymer); novel organic catalysts containing the same, which catalysts are free from metallic catalyst components and very easy of recovery from reaction mixtures of synthesis and reuse; polymer-immobilized organic compounds useful as intermediates for synthesis; catalysts containing the same as the active ingredient; and a process for the allylation of aldehydes or hydrazones by the use of these catalysts.

公开(公告)号：EP1386663B1

公开(公告)日：2009-04-15

申请号：EP02701554.4

申请日：2002-02-15

Applicant: Japan Science and Technology Agency

Inventor： KOBAYASHI, Shu

IPC: B01J13/06 ,  B01J31/24

CPC classification number: C07C67/343 ,  B01J13/06 ,  B01J13/14 ,  B01J23/44 ,  B01J31/165 ,  B01J31/2404 ,  B01J2231/4205 ,  B01J2231/44 ,  B01J2531/821 ,  B01J2531/822 ,  B01J2531/824 ,  B01J2531/827 ,  B01J2531/828 ,  C07C69/73 ,  C07C69/738 ,  C07C69/618 ,  C07C69/757

Abstract: A microencapsulated Group VIII metal catalyst which is stable even in air, easy to recover, and reutilizable. It comprises a polymer having side chains each comprising an aromatic substituent and, encapsulated in the polymer, a metal catalyst comprising a Group VIII metal.

公开(公告)号：EP1069127B1

公开(公告)日：2007-08-08

申请号：EP99903915.9

申请日：1999-02-12

Applicant: Japan Science and Technology Agency

Inventor： KOBAYASHI, Shu

IPC: C07F5/00 ,  B01J13/02 ,  C07C225/16 ,  C07C69/732 ,  C07C69/738 ,  C07C49/84 ,  C07C33/30 ,  C07C255/31 ,  C07C255/42 ,  C07C211/45 ,  C07D491/048 ,  C07D263/26

CPC classification number: B01J31/4015 ,  B01J13/08 ,  B01J13/20 ,  B01J31/0227 ,  B01J31/06 ,  B01J31/165 ,  B01J31/2256 ,  B01J2231/326 ,  B01J2231/328 ,  B01J2231/343 ,  B01J2231/346 ,  B01J2231/348 ,  B01J2231/4205 ,  B01J2231/44 ,  B01J2531/35 ,  B01J2531/36 ,  B01J2531/37 ,  B01J2531/38 ,  C07C29/40 ,  C07C45/46 ,  C07C211/48 ,  C07C225/16 ,  C07C255/31 ,  C07C255/42 ,  Y02P20/584 ,  Y10T428/2984 ,  Y10T428/2985 ,  Y10T428/2989 ,  Y10T428/2991 ,  Y10T428/31525 ,  C07C33/30

Abstract: A microencapsulated Lewis acid characterized in that the Lewis acid has been supported through coordinate bonds on microcapsules of an organic polymer. The acid is a novel polymer-supported Lewis acid which exceeds the technical limit to conventional polymer-supported catalysts and eliminates the problems in Lewis acid catalysts, which are significantly industrially useful, concerning preparation of a reaction system, catalyst separation from a reaction product, and catalyst recovery.

Abstract translation: 微囊包封的路易斯酸，其特征在于路易斯酸通过配位键被支撑在有机聚合物的微胶囊上。 该酸是一种新型聚合物负载的路易斯酸，其超过了常规负载型聚合物催化剂的技术限制，并且消除了在反应体系的制备，从反应产物中分离催化剂等在工业上非常有用的路易斯酸催化剂中的问题， 和催化剂回收。

公开(公告)号：EP1738824A1

公开(公告)日：2007-01-03

申请号：EP05720221.0

申请日：2005-03-08

Applicant: Japan Science and Technology Agency

Inventor： KOBAYASHI, Shu ,  AKIYAMA, Ryo ,  KAWAI, Nobuyuki ,  TAKEUCHI, Masahiro

IPC: B01J31/26 ,  B01J31/28 ,  C07C45/72 ,  C07C49/245 ,  C07C49/255 ,  C07C49/507 ,  C07C49/76 ,  C07C49/83

CPC classification number: C07C67/347 ,  B01J13/14 ,  B01J31/165 ,  B01J31/2239 ,  B01J31/226 ,  B01J31/4015 ,  B01J2231/326 ,  B01J2231/346 ,  B01J2231/348 ,  B01J2231/4205 ,  B01J2231/44 ,  B01J2531/16 ,  B01J2531/26 ,  B01J2531/35 ,  B01J2531/37 ,  B01J2531/38 ,  B01J2531/842 ,  B01J2540/22 ,  C07C45/46 ,  C07C45/511 ,  C07C45/72 ,  C07C45/73 ,  C07C49/245 ,  C07C49/573 ,  C07C49/76 ,  C07C49/83 ,  C07C67/00 ,  C07C227/12 ,  C07C327/22 ,  C07C2601/08 ,  C07C2602/08 ,  C07C2602/10 ,  Y02P20/584 ,  C07C69/732 ,  C07C69/738 ,  C07C69/757 ,  C07C229/34

Abstract: The objective is to incarcerate a Lewis acid metal in a polymer and to make this catalyst recoverable while maintaining its function as a Lewis acid metal catalyst.
The present invention is a polymer-incarcerated Lewis acid metal catalyst in which a Lewis acid metal is incarcerated in a crosslinked polymer and the crosslinked polymer is crosslinked using the crosslinking groups contained in a crosslinkable polymer. The polymer incarcerated Lewis acid metal catalyst is characterized by the crosslinkable polymer containing at least one type of monomer unit containing hydrophobic substituents and hydrophilic substituents containing crosslinking groups, and the hydrophobic substituents contain aromatic substituents. This crosslinkable polymer preferably comprises at least one type of monomer unit containing hydrophobic substituents and hydrophilic substituents containing crosslinking groups and a monomer unit containing hydrophobic substituents. This catalyst can be obtained by subjecting a polymer micelle incarcerated Lewis acid metal obtained by mixing an organic solution containing a crosslinkable polymer and a Lewis acid metal with a bad solvent to a crosslinking reaction. This catalyst is useful as a catalyst in aldol reactions, cyanolation reactions, allylation reactions, Michael reactions, Mannich reactions, Diels Alder reactions and Friedel Crafts reactions.

公开(公告)号：EP1151987B1

公开(公告)日：2006-10-25

申请号：EP00976327.7

申请日：2000-11-17

Applicant: Japan Science and Technology Agency

Inventor： KOBAYASHI, Shu ,  ISHITANI, Haruro

IPC: C07C39/38 ,  B01J31/02 ,  B01J31/26

CPC classification number: C07C251/24 ,  B01J21/06 ,  B01J21/066 ,  B01J31/0211 ,  B01J31/0231 ,  B01J31/223 ,  B01J2231/348 ,  B01J2531/0266 ,  B01J2531/30 ,  B01J2531/48 ,  B01J2540/22 ,  C07B53/00 ,  C07B2200/07 ,  C07C6/04 ,  C07C39/38 ,  C07C249/02

Abstract: A novel optically active binaphthol derivative with which a higher reaction yield and a higher optical yield (selectivity) can be attained in asymmetric synthesis and which is useful as an asymmetric catalyst, etc.; an asymmetric catalyst comprising the derivative; and a method of asymmetric synthesis. The optically active fluorinated binaphthol derivative is represented by formula (I) wherein R1 and R2 each represents a fluorohydrocarbon group.

公开(公告)号：EP1495806A1

公开(公告)日：2005-01-12

申请号：EP03710298.5

申请日：2003-03-11

Applicant: Japan Science and Technology Agency

Inventor： KOBAYASHI, Shu

IPC: B01J31/38 ,  C07C227/12 ,  C07C229/34 ,  C07C327/22 ,  C07D307/52 ,  C07B61/00

CPC classification number: C07D307/54 ,  B01J29/061 ,  B01J29/7053 ,  B01J31/1616 ,  B01J31/223 ,  B01J31/4015 ,  B01J2229/186 ,  B01J2229/34 ,  B01J2231/346 ,  B01J2531/0266 ,  B01J2531/48 ,  B01J2540/22 ,  C07B53/00 ,  C07B2200/07 ,  C07C227/32 ,  C07C327/22 ,  Y02P20/584 ,  Y02P20/588 ,  C07C229/18 ,  C07C229/34

Abstract: A practical chiral zirconium catalyst that can maintain its high catalytic activity even after long-term storage, which is stable in air and storable for a long period of time, and recoverable and reusable after reaction, is provided.

Abstract translation: 提供即使在长期储存后也能保持其高催化活性的实用的手性锆催化剂，其在空气中稳定并且可长期储存，并且在反应后可回收和可重复使用。

公开(公告)号：EP1724251B1

公开(公告)日：2015-09-16

申请号：EP05704190.7

申请日：2005-01-27

Applicant: Japan Science and Technology Agency

Inventor： KOBAYASHI, Shu ,  MANABE, Kei

IPC: C07C45/00 ,  B01J31/14 ,  C07C45/75 ,  C07C49/497 ,  C07C49/733 ,  C07C49/82 ,  C07C327/22

CPC classification number: C07C327/22 ,  C07B53/00 ,  C07C45/512 ,  C07C2601/08 ,  C07C2601/14 ,  C07C2601/18 ,  C07C2602/08 ,  C07C2602/10 ,  C07C49/747 ,  C07C49/82 ,  C07C49/717 ,  C07C49/713 ,  C07C49/707 ,  C07C49/248

公开(公告)号：EP2258477B1

公开(公告)日：2015-03-25

申请号：EP09705661.8

申请日：2009-01-28

Applicant: Japan Science and Technology Agency

Inventor： KOBAYASHI, Shu ,  AGOSTINHO, Magno ,  SCHNEIDER, Uwe ,  YAMAGUCHI, Miyuki

IPC: B01J31/02 ,  C07C67/347 ,  C07C69/738 ,  C07C201/12 ,  C07C205/56 ,  C07B53/00 ,  C07B61/00 ,  C07D207/325 ,  C07D307/54 ,  C07D333/24 ,  B01J31/18

CPC classification number: C07C311/16 ,  B01J31/0212 ,  B01J31/1805 ,  B01J2231/348 ,  B01J2531/21 ,  B01J2531/22 ,  B01J2531/23 ,  B01J2531/24 ,  B01J2531/25 ,  C07B53/00 ,  C07B2200/07 ,  C07C67/347 ,  C07C201/12 ,  C07C2602/10 ,  C07D207/325 ,  C07D307/54 ,  C07D333/24 ,  C07C69/738 ,  C07C205/56

公开(公告)号：EP1726577B1

公开(公告)日：2012-11-14

申请号：EP05704332.5

申请日：2005-01-26

Applicant: Japan Science and Technology Agency

Inventor： KOBAYASHI, Shu ,  MORI, Yuichiro ,  KITAMORI, Takehiko ,  UENO, Masaharu ,  OKAMOTO, Kuniaki

IPC: C07B35/02 ,  C07B41/12 ,  C07C15/12 ,  C07C15/18 ,  C07C13/28 ,  C07C5/03 ,  C07C5/08 ,  C07C45/62 ,  C07C49/213 ,  C07C49/403 ,  C07C29/17 ,  C07C33/20 ,  C07C67/00 ,  C07C69/618 ,  C07C211/46 ,  C07C209/36 ,  B01J31/28 ,  C07B61/00

CPC classification number: C07C5/03 ,  B01J19/0093 ,  B01J23/44 ,  B01J31/1633 ,  B01J35/0013 ,  B01J37/0219 ,  B01J2219/00831 ,  B01J2219/00835 ,  B01J2231/641 ,  B01J2231/643 ,  B01J2231/645 ,  B01J2531/62 ,  B01J2531/64 ,  B01J2531/66 ,  B01J2531/72 ,  B01J2531/821 ,  B01J2531/822 ,  B01J2531/824 ,  B01J2531/825 ,  B01J2531/827 ,  C07C5/08 ,  C07C29/175 ,  C07C45/62 ,  C07C209/36 ,  C07C2601/14 ,  Y02P20/588 ,  C07C15/12 ,  C07C15/18 ,  C07C33/20 ,  C07C211/46