公开(公告)号：AU3232701A

公开(公告)日：2001-08-27

申请号：AU3232701

申请日：2001-02-16

Applicant: KANEKA CORP

Inventor： SUGAWARA MASANOBU ,  FUJII AKIO ,  OKURO KAZUMI ,  SAKA YASUHIRO ,  NAGASHIMA NOBUO ,  INOUE KENJI ,  TAKEDA TOSHIHIRO ,  KINOSHITA KOICHI ,  MOROSHIMA TADASHI ,  FUSE YOSHIHIDE ,  UEDA YASUYOSHI

IPC: C07C227/10 ,  C07C227/32 ,  C07C227/42 ,  C07C229/26 ,  C07C229/30 ,  C07C303/36 ,  C07C311/19 ,  C07D203/08 ,  C07D203/20 ,  C07D203/24 ,  C07C227/04 ,  C07B53/00

Abstract: An optically active amino acid derivative is produced by N-protecting an optically active 3-haloalanine derivative followed by cyclization, or cyclizing this derivative followed by N-protection to thereby give an optically active N-protected-aziridine-2-carboxylic acid derivative which is protected by a benzenesulfonyl group substituted by nitro at the 2- and/or 4-positions and then treating this product with an organic metal reagent, or by N-protecting an optically active 3-haloalanine derivative to thereby give N-protected-aziridine-2-carboxylic acid which is protected by a benzenesulfonyl group substituted by nitro at the 2- and/or 4-positions and then treating this product with an organic metal reagent. According to this process, natural and unnatural optically active amino acids can be produced from inexpensive materials by using simple procedures.

公开(公告)号：NO20015042D0

公开(公告)日：2001-10-16

申请号：NO20015042

申请日：2001-10-16

Applicant: KANEKA CORP

Inventor： SUGAWARA MASANOBU ,  FUJII AKIO ,  OKURO KAZUMI ,  SAKA YASUHIRO ,  NAGASHIMA NOBUO ,  INOUE KENJI ,  TAKEDA TOSHIHIRO ,  KINOSHITA KOICHI ,  MOROSHIMA TADASHI ,  FUSE YOSHIHIDE ,  UEDA YASUYOSHI

IPC: C07C227/10 ,  C07C227/32 ,  C07C227/42 ,  C07C229/26 ,  C07C229/30 ,  C07C303/36 ,  C07C311/19 ,  C07D203/08 ,  C07D203/20 ,  C07D203/24 ,  G01N

Abstract: An optically active amino acid derivative is produced by N-protecting an optically active 3-haloalanine derivative followed by cyclization, or cyclizing this derivative followed by N-protection to thereby give an optically active N-protected-aziridine-2-carboxylic acid derivative which is protected by a benzenesulfonyl group substituted by nitro at the 2- and/or 4-positions and then treating this product with an organic metal reagent, or by N-protecting an optically active 3-haloalanine derivative to thereby give N-protected-aziridine-2-carboxylic acid which is protected by a benzenesulfonyl group substituted by nitro at the 2- and/or 4-positions and then treating this product with an organic metal reagent. According to this process, natural and unnatural optically active amino acids can be produced from inexpensive materials by using simple procedures.

公开(公告)号：DK2639216T3

公开(公告)日：2018-09-24

申请号：DK11839101

申请日：2011-11-08

Applicant: KANEKA CORP

Inventor： YAMAMOTO SHOHEI ,  NISHIHACHIJO MASAKATSU ,  TANAKA RIE ,  KAWANO SHIGERU ,  FUJII AKIO

IPC: C07C29/17 ,  C07B53/00 ,  C07C45/62 ,  C07C45/63 ,  C07C45/65 ,  C07D241/04 ,  C12P7/22 ,  C12P7/38

公开(公告)号：ES3012790T3

公开(公告)日：2025-04-10

申请号：ES16835083

申请日：2016-08-05

Applicant: KANEKA CORP

Inventor： TANAKA TATSUYOSHI ,  MIZUTANI MASAYA ,  OGINO HIROYUKI ,  AKAZAWA MITSUJI ,  FUJII AKIO ,  IMAI NAOHIRO

IPC: A61K9/70 ,  A61K31/167 ,  A61P23/02

Abstract: La presente invención aborda el problema de proporcionar un parche con una adhesividad y fuerza cohesiva prácticas para uso medicinal, que proporcione un efecto anestésico inmediato. Se proporciona un parche formado por una capa adhesiva que contiene una mezcla de lidocaína con otro anestésico local en una cantidad de entre el 5 % en peso y el 20 % en peso. La capa adhesiva contiene al menos un adhesivo a base de caucho y parafina líquida, y el contenido de un agente de pegajosidad en la capa adhesiva no supera el 10 % en peso. (Traducción automática con Google Translate, sin valor legal)

公开(公告)号：PL350362A1

公开(公告)日：2002-12-02

申请号：PL35036201

申请日：2001-02-16

Applicant: KANEKA CORP

Inventor： SUGAWARA MASANOBU ,  FUJII AKIO ,  OKURO KAZUMI ,  SAKA YASUHIRO ,  NAGASHIMA NOBUO ,  INOUE KENJI ,  TAKEDA TOSHIHIRO ,  KINOSHITA KOICHI ,  MOROSHIMA TADASHI ,  FUSE YOSHIHIDE ,  UEDA YASUYOSHI

IPC: C07C227/10 ,  C07C227/32 ,  C07C227/42 ,  C07C229/26 ,  C07C229/30 ,  C07C303/36 ,  C07C311/19 ,  C07D203/08 ,  C07D203/20 ,  C07D203/24 ,  C07C227/04 ,  C07B53/00

Abstract: An optically active amino acid derivative is produced by N-protecting an optically active 3-haloalanine derivative followed by cyclization, or cyclizing this derivative followed by N-protection to thereby give an optically active N-protected-aziridine-2-carboxylic acid derivative which is protected by a benzenesulfonyl group substituted by nitro at the 2- and/or 4-positions and then treating this product with an organic metal reagent, or by N-protecting an optically active 3-haloalanine derivative to thereby give N-protected-aziridine-2-carboxylic acid which is protected by a benzenesulfonyl group substituted by nitro at the 2- and/or 4-positions and then treating this product with an organic metal reagent. According to this process, natural and unnatural optically active amino acids can be produced from inexpensive materials by using simple procedures.

公开(公告)号：CA2369678A1

公开(公告)日：2001-08-23

申请号：CA2369678

申请日：2001-02-16

Applicant: KANEKA CORP

Inventor： SUGAWARA MASANOBU ,  FUJII AKIO ,  KINOSHITA KOICHI ,  TAKEDA TOSHIHIRO ,  FUSE YOSHIHIDE ,  UEDA YASUYOSHI ,  OKURO KAZUMI ,  INOUE KENJI ,  MOROSHIMA TADASHI ,  NAGASHIMA NOBUO ,  SAKA YASUHIRO

IPC: C07C227/10 ,  C07C227/32 ,  C07C227/42 ,  C07C229/26 ,  C07C229/30 ,  C07C303/36 ,  C07C311/19 ,  C07D203/08 ,  C07D203/20 ,  C07D203/24 ,  C07B53/00 ,  C07C227/04

Abstract: An optically active amino acid derivative is prepared either by subjecting a n optically active 3-haloalanine derivative (1) to N-protection followed by cyclization or cyclization followed by N-protection to prepare an optically active aziridinecarboxylic acid derivative (3) whose imino group is protecte d with 2- and/or 4-nitrated benzenesulfonyl and treating this derivative (3) with an organometallic reagent or by subjecting an optically active 3- haloalanine derivative to N-protection to obtain an optically active 3- haloalanine derivative (4) whose amino group is protected with 2- and/or 4- nitrated benzenesulfonyl and treating this derivative (4) with an organometallic reagent. According to such processes, natural and nonnatural optically active amino acids can be prepared from inexpensive raw materials through simple and easy operation. In said derivatives, X is halogen; R1 and R2 are each hydrogen or the like; * represents an asymmetric carbon atom; an d P1 is 2- and/ or 4- nitrated benzenesulfonyl.

公开(公告)号：CZ20014121A3

公开(公告)日：2002-10-16

申请号：CZ20014121

申请日：2001-02-16

Applicant: KANEKA CORP

Inventor： SUGAWARA MASANOBU ,  FUJII AKIO ,  OKURO KAZUMI ,  SAKA YASUHIRO ,  NAGASHIMA NOBUO ,  INOUE KENJI ,  TAKEDA TOSHIHIRO ,  KINOSHITA KOICHI ,  MOROSHIMA TADASHI ,  FUSE YOSHIHIDE ,  UEDA YASUYOSHI

IPC: C07C227/10 ,  C07C227/32 ,  C07C227/42 ,  C07C229/26 ,  C07C229/30 ,  C07C303/36 ,  C07C311/19 ,  C07D203/08 ,  C07D203/20 ,  C07D203/24 ,  C07C227/04 ,  C07C227/26 ,  C07B53/00

Abstract: An optically active amino acid derivative is produced by N-protecting an optically active 3-haloalanine derivative followed by cyclization, or cyclizing this derivative followed by N-protection to thereby give an optically active N-protected-aziridine-2-carboxylic acid derivative which is protected by a benzenesulfonyl group substituted by nitro at the 2- and/or 4-positions and then treating this product with an organic metal reagent, or by N-protecting an optically active 3-haloalanine derivative to thereby give N-protected-aziridine-2-carboxylic acid which is protected by a benzenesulfonyl group substituted by nitro at the 2- and/or 4-positions and then treating this product with an organic metal reagent. According to this process, natural and unnatural optically active amino acids can be produced from inexpensive materials by using simple procedures.

公开(公告)号：HU0201353A2

公开(公告)日：2002-08-28

申请号：HU0201353

申请日：2001-02-16

Applicant: KANEKA CORP

Inventor： FUJII AKIO ,  FUSE YOSHIHIDE ,  INOUE KENJI ,  KINOSHITA KOICHI ,  MOROSHIMA TADASHI ,  NAGASHIMA NOBUO ,  OKURO KAZUMI ,  SAKA YASUHIRO ,  SUGAWARA MASANOBU ,  TAKEDA TOSHIHIRO ,  UEDA YASUYOSHI

IPC: C07C227/10 ,  C07C227/32 ,  C07C227/42 ,  C07C229/26 ,  C07C229/30 ,  C07C303/36 ,  C07C311/19 ,  C07D203/08 ,  C07D203/20 ,  C07D203/24

Abstract: An optically active amino acid derivative is produced by N-protecting an optically active 3-haloalanine derivative followed by cyclization, or cyclizing this derivative followed by N-protection to thereby give an optically active N-protected-aziridine-2-carboxylic acid derivative which is protected by a benzenesulfonyl group substituted by nitro at the 2- and/or 4-positions and then treating this product with an organic metal reagent, or by N-protecting an optically active 3-haloalanine derivative to thereby give N-protected-aziridine-2-carboxylic acid which is protected by a benzenesulfonyl group substituted by nitro at the 2- and/or 4-positions and then treating this product with an organic metal reagent. According to this process, natural and unnatural optically active amino acids can be produced from inexpensive materials by using simple procedures.

公开(公告)号：CA2309530A1

公开(公告)日：2000-11-28

申请号：CA2309530

申请日：2000-05-25

Applicant: KANEKA CORP

Inventor： INOUE KENJI ,  FUJII AKIO ,  SUGAWARA MASANOBU

IPC: C07B53/00 ,  C07C227/02 ,  C07C227/16 ,  C07C227/18 ,  C07C227/32 ,  C07C229/22 ,  C07C229/34 ,  C07C315/04 ,  C07C317/28

Abstract: This invention to provide a process for producing an optically active threo-phenylnorstatin derivative which does not require a toxic cyanating agent or a costly reagent, or a complicated procedure, and can be practiced on a commercial scale. This invention is directed to a process for producing a .beta.-amino-.alpha.-hydroxy acid derivative which comprises treating either a .gamma.-amino- .beta.-keto sulfoxide derivative with a halogenating agent to produce a .gamma.-amino-.alpha.-halo-.beta.-keto sulfoxide derivative, treating the same with an acid and an alcohol to produce a .beta. -amino- .alpha. -keto ester derivative or .beta.-amino- .alpha.-keto acid derivative, and followed by reducing.

公开(公告)号：JP2010254616A

公开(公告)日：2010-11-11

申请号：JP2009106184

申请日：2009-04-24

Applicant: Kaneka Corp ,  株式会社カネカ

Inventor： MAEDA HIROBUMI ,  TANI HISAKO ,  FUJII AKIO

IPC: C07H21/02

CPC classification number: Y02P20/55

Abstract: PROBLEM TO BE SOLVED: To provide a method of selectively and efficiently removing the substituted carbamoyl group from the 2'-hydroxy group in a ribonucleoside derivative and/or an oligonucleic acid derivative including this ribonucleoside derivative as a constituting unit. SOLUTION: The method for efficiently producing a high purity oligonucleic acid comprises reacting a ribonucleoside derivative having a carbamoyl protective group for the 2'-hydroxy group and/or an oligonucleic acid derivative including this ribonucleoside derivative as a constituting unit with R 4 NF and removing the carbamoyl protective group from the 2'-hydroxy group. COPYRIGHT: (C)2011,JPO&INPIT

Abstract translation: 解决问题的方法：提供一种选择性且有效地从包含该核糖核苷衍生物的核糖核苷衍生物和/或低聚核酸衍生物作为构成单位从2'-羟基除去取代氨基甲酰基的方法。 解决方案：用于高效制备高纯度寡核酸的方法包括使含有这种核糖核苷衍生物的含有2'-羟基的氨基甲酰保护基的核糖核苷衍生物和/或包含该核糖核苷衍生物的寡核酸衍生物作为构成单元， SB> 4 NF，并从2'-羟基除去氨基甲酰保护基。 版权所有（C）2011，JPO＆INPIT