公开(公告)号：AT468069T

公开(公告)日：2010-06-15

申请号：AT03755595

申请日：2003-07-11

Applicant: MAUNA KEA TECHNOLOGIES

Inventor： GENET MAGALIE ,  VIELLEROBE BERTRAND ,  BERIER FREDERIC ,  CLADE SOPHIE

IPC: A61B5/00 ,  G01N21/64 ,  A61B1/00 ,  A61B1/04 ,  G02B21/00 ,  G02B23/24 ,  G02B23/26 ,  G02B26/10 ,  H04N1/028

Abstract: The method consists in deflecting the excitation signal at a speed corresponding to acquisition of a number of images per second sufficient for real time use and in detecting the fluorescence signal at a detecting frequency corresponding to a minimum frequency for sampling the fibers one by one. The method uses an image guide consisting of several thousands of optical fibers, an excitation signal being emitted by a source, deflected and injected by turns into the optical fibers of the guide, each excitation point of the tissue in the fiber output emitting in return a fluorescence signal collected by the fiber, then detected and digitized to form an image element. The method also provides for the focussing of the beam in the fiber output to excite a subsurface plane to produce a confocal image. The method also provides for the production of a divergent beam in the fiber output capable of exciting a micro-volume of the tissue from the surface.

公开(公告)号：DE602004020113D1

公开(公告)日：2009-04-30

申请号：DE602004020113

申请日：2004-12-29

Applicant: MAUNA KEA TECHNOLOGIES

Inventor： MATHIEU GILLES ,  GENET MAGALIE ,  VIELLEROBE BERTRAND ,  BERIER FREDERIC

IPC: A61B1/005 ,  A61B1/00 ,  A61B1/04 ,  A61B1/05 ,  A61B5/00 ,  G02B6/26 ,  G02B6/35 ,  G02B7/02 ,  G02B21/00 ,  G02B26/10

Abstract: The head has a laser source to produce a light beam (13), and a ball lens (12), with a large numerical aperture, disposed at the end of the head to converge the beam at an excitation point (19). The point is located in an observed sub-surface field (14) of a sample (15). A scanning unit (10) displaces the source in rotation such that the point scans the field. An independent claim is also included for a confocal imaging system.

公开(公告)号：AT425696T

公开(公告)日：2009-04-15

申请号：AT04817613

申请日：2004-12-29

Applicant: MAUNA KEA TECHNOLOGIES

Inventor： MATHIEU GILLES ,  GENET MAGALIE ,  VIELLEROBE BERTRAND ,  BERIER FREDERIC

IPC: A61B1/005 ,  A61B1/00 ,  A61B1/04 ,  A61B1/05 ,  A61B5/00 ,  G02B6/26 ,  G02B6/35 ,  G02B7/02 ,  G02B21/00 ,  G02B26/10

Abstract: The head has a laser source to produce a light beam (13), and a ball lens (12), with a large numerical aperture, disposed at the end of the head to converge the beam at an excitation point (19). The point is located in an observed sub-surface field (14) of a sample (15). A scanning unit (10) displaces the source in rotation such that the point scans the field. An independent claim is also included for a confocal imaging system.

公开(公告)号：BRPI0418235A

公开(公告)日：2007-04-17

申请号：BRPI0418235

申请日：2004-12-29

Applicant: MAUNA KEA TECHNOLOGIES

Inventor： BERIER FREDERIC ,  PERCHANT AYMERIC

IPC: G06T5/50

Abstract: The method involves performing a set of acquisitions across an image guide (1). Each acquisition is performed for a given spatial offset at a distal end of the guide with respect to an optical head. Each acquired data is transformed in a scatter diagram and each diagram is readjusted with respect to a reference scatter diagram. A final image is reconstructed by superimposing readjusted diagram. Independent claims are also included for the following: (A) a device for enhancing resolution of confocal image acquired across an image guide (B) a system implementing confocal image resolution enhancing method.

公开(公告)号：CA2550305A1

公开(公告)日：2005-08-11

申请号：CA2550305

申请日：2004-12-29

Applicant: MAUNA KEA TECHNOLOGIES

Inventor： BERIER FREDERIC ,  PERCHANT AYMERIC

IPC: G06T5/50

Abstract: L~invention concerne un procédé pour augmenter la résolution d~images confocales acquises à travers un guide d~image dont l~extrémité distale est associée à une tête optique pour focaliser le faisceau laser émis par le gui de d~image dans un objet d~observation. Selon l~invention, pour une position donnée de la tête optique, ce procédé comprend les étapes de : réalisation d~une pluralité d~acquisitions à travers le guide d~image, chaque acquisitio n étant réalisée pour un décalage spatial donné de ladite extrémité distale du guide d~image par rapport à la tête optique qui reste fixe ; transformation des données de chaque acquisition en un nuage de points ; recalage de chaque nuage de points par rapport à un nuage de points pris comme référence ; superposition des nuages de points ainsi recalés ; et reconstruction d~une image finale à partir de cette superposition. Avantageusement, on utilise un tube piézoélectrique commandé disposé autour de l~extrémité distale du guide d~image pour déplacer ce dernier.

公开(公告)号：AU2004314774A1

公开(公告)日：2005-08-11

申请号：AU2004314774

申请日：2004-12-29

Applicant: MAUNA KEA TECHNOLOGIES

Inventor： BERIER FREDERIC ,  PERCHANT AYMERIC

IPC: G06T5/50

Abstract: The method involves performing a set of acquisitions across an image guide (1). Each acquisition is performed for a given spatial offset at a distal end of the guide with respect to an optical head. Each acquired data is transformed in a scatter diagram and each diagram is readjusted with respect to a reference scatter diagram. A final image is reconstructed by superimposing readjusted diagram. Independent claims are also included for the following: (A) a device for enhancing resolution of confocal image acquired across an image guide (B) a system implementing confocal image resolution enhancing method.

公开(公告)号：BR0215371A

公开(公告)日：2004-12-07

申请号：BR0215371

申请日：2002-12-20

Applicant: MAUNA KEA TECHNOLOGIES

Inventor： VIELLEROBE BERTRAND ,  GENET MAGALIE ,  BERIER FREDERIC ,  LACOMBE FRANCOIS ,  PERCHANT AYMERIC ,  GOUALHER GEORGES LE ,  MARTI SANDRA ,  BOURRIAUX STEPHANE

IPC: G02B23/26 ,  A61B1/00 ,  A61B1/04 ,  A61B1/07 ,  G02B21/00 ,  G02B23/24

Abstract: Equipment includes an image guide ( 1 ) consisting of flexible optical fibers with: on the proximal end side: a source ( 2 ), angular scanning elements ( 3 ), injection elements ( 4 ) in one of the fibers, elements for splitting ( 5 ) the illuminating beam and the backscattered signal, elements for spatial filtering ( 6 ), elements for detecting ( 7 ) the signal, electronic elements ( 8 ) for controlling, analyzing and digital processing of the detected signal and display; and on the distal end side: an optical head ( 9 ) for focusing the illuminating beam exiting from the illuminated fiber. The scanning elements include a resonant line mirror (M 1 ) and a galvanometric field mirror (M 2 ) with a variable frequency and two afocal optical systems adapted to conjugate the two mirrors (M 1 , M 2 ) firstly in the field mirror (M 2 ) and the injection elements ( 4 ) in the image guide in a second step.

公开(公告)号：BR0215370A

公开(公告)日：2004-12-07

申请号：BR0215370

申请日：2002-12-20

Applicant: MAUNA KEA TECHNOLOGIES

Inventor： BERIER FREDERIC ,  BOURRIAUX STEPHANE ,  GENET MAGALIE ,  VIELLEROBE BERTRAND ,  LOISEAU ALEXANDRE ,  ABRAT BENJAMIN

IPC: G02B23/26 ,  A61B1/00 ,  G02B21/02 ,  G02B23/24 ,  A61B1/07

Abstract: An optical head for equipping the distal end of a flexible optical fiber bundle, designed to be urged into contact with an analyzing surface and including optical elements for focusing an excitation signal into a so-called excitation focal point located at a specific depth beneath the analyzing surface and for sampling a signal backscattered by the excitation focal point which is carried back by the fiber bundle. The head includes an optics-holder tube wherein are inserted on one side the distal end portion of the fiber bundle and on the other optical elements, the latter including a plate placed in contact with the end of the fiber bundle whereof the index is close to that of the fiber core and a focusing optical block, an output window being further provided adapted to provide index adaptation so as to eliminate parasitic reflection occurring on the analyzing surface.

公开(公告)号：AU2003296825A1

公开(公告)日：2004-08-13

申请号：AU2003296825

申请日：2003-12-12

Applicant: MAUNA KEA TECHNOLOGIES

Inventor： BERIER FREDERIC ,  VIELLEROBE BERTRAND ,  GENET MAGALIE ,  LACOMBE FRANCOIS ,  SANTOS PEDRO

IPC: G02B21/00 ,  G02B23/24 ,  G02B26/08 ,  G02B26/10

Abstract: The confocal optical miniature head has optical convergers (12,13) to an excitation point (S) on a subsurface. There is a sweep system around the observation point. There is a mechanical microsystem (14a,14b) moving one of the lenses following an offset (DC) in two planes to obtain the sweep.

公开(公告)号：FR2849218A1

公开(公告)日：2004-06-25

申请号：FR0216279

申请日：2002-12-20

Applicant: MAUNA KEA TECHNOLOGIES

Inventor： BERIER FREDERIC ,  VIELLEROBE BERTRAND ,  GENET MAGALIE ,  LACOMBE FRANCOIS ,  SANTOS PEDRO

IPC: G02B21/00 ,  G02B23/24 ,  G02B26/08 ,  G02B26/10 ,  G02B6/35

Abstract: The confocal optical miniature head has optical convergers (12,13) to an excitation point (S) on a subsurface. There is a sweep system around the observation point. There is a mechanical microsystem (14a,14b) moving one of the lenses following an offset (DC) in two planes to obtain the sweep.