公开(公告)号：CA2754863A1

公开(公告)日：2010-09-16

申请号：CA2754863

申请日：2010-03-12

Applicant: MAUNA KEA TECHNOLOGIES

Inventor： ROCHER ALEXANDRA ,  DOUSSOUX FRANCOIS ,  CLADE SOPHIE ,  PETIT SYLVAIN ,  BOULAROT NICOLAS

IPC: G02B6/42 ,  A61B1/07 ,  G02B6/38 ,  G02B6/40 ,  G02B23/26

Abstract: A connector to connect a fiber bundle probe to a light injection module including a tightening cam having an opening of a specified shape adapted to receive the fiber bundle probe, a cam driving coupled to the tightening cam, wherein the tightening cam is configured to translate in response to rotation of the cam driving until the tightening cam is blocked, at least one spring extending between the tightening cam and the cam driving, wherein the at least one spring is configured to resist when the cam driving is actuated by rotation and the tightening cam is blocked, and a locking mechanism to lock the cam driving into a selected position.

公开(公告)号：FR2842407A1

公开(公告)日：2004-01-23

申请号：FR0209099

申请日：2002-07-18

Applicant: MAUNA KEA TECHNOLOGIES

Inventor： GENET MAGALIE ,  VIELLEROBE BERTRAND ,  BERIER FREDERIC ,  CLADE SOPHIE

IPC: A61B1/00 ,  G01N21/64 ,  A61B1/04 ,  A61B5/00 ,  G02B21/00 ,  G02B23/24 ,  G02B23/26 ,  G02B26/10 ,  H04N1/028

Abstract: The method consists in deflecting the excitation signal at a speed corresponding to acquisition of a number of images per second sufficient for real time use and in detecting the fluorescence signal at a detecting frequency corresponding to a minimum frequency for sampling the fibers one by one. The method uses an image guide consisting of several thousands of optical fibers, an excitation signal being emitted by a source, deflected and injected by turns into the optical fibers of the guide, each excitation point of the tissue in the fiber output emitting in return a fluorescence signal collected by the fiber, then detected and digitized to form an image element. The method also provides for the focussing of the beam in the fiber output to excite a subsurface plane to produce a confocal image. The method also provides for the production of a divergent beam in the fiber output capable of exciting a micro-volume of the tissue from the surface.

公开(公告)号：CA2754863C

公开(公告)日：2015-11-17

申请号：CA2754863

申请日：2010-03-12

Applicant: MAUNA KEA TECHNOLOGIES

Inventor： ROCHER ALEXANDRA ,  DOUSSOUX FRANCOIS ,  CLADE SOPHIE ,  PETIT SYLVAIN ,  BOULAROT NICOLAS

IPC: G02B6/42 ,  A61B1/07 ,  G02B6/38 ,  G02B6/40 ,  G02B23/26

Abstract: A connector to connect a fiber bundle probe to a light injection module including a tightening cam having an opening of a specified shape adapted to receive the fiber bundle probe, a cam driving coupled to the tightening cam, wherein the tightening cam is configured to translate in response to rotation of the cam driving until the tightening cam is blocked, at least one spring extending between the tightening cam and the cam driving, wherein the at least one spring is configured to resist when the cam driving is actuated by rotation and the tightening cam is blocked, and a locking mechanism to lock the cam driving into a selected position.

公开(公告)号：AU2003273437A1

公开(公告)日：2004-02-09

申请号：AU2003273437

申请日：2003-07-11

Applicant: MAUNA KEA TECHNOLOGIES

Inventor： CLADE SOPHIE ,  GENET MAGALIE ,  VIELLEROBE BERTRAND ,  BERIER FREDERIC

IPC: G01N21/64 ,  A61B1/00 ,  A61B1/04 ,  A61B5/00 ,  G02B21/00 ,  G02B23/24 ,  G02B23/26 ,  G02B26/10 ,  H04N1/028

Abstract: The method consists in deflecting the excitation signal at a speed corresponding to acquisition of a number of images per second sufficient for real time use and in detecting the fluorescence signal at a detecting frequency corresponding to a minimum frequency for sampling the fibers one by one. The method uses an image guide consisting of several thousands of optical fibers, an excitation signal being emitted by a source, deflected and injected by turns into the optical fibers of the guide, each excitation point of the tissue in the fiber output emitting in return a fluorescence signal collected by the fiber, then detected and digitized to form an image element. The method also provides for the focussing of the beam in the fiber output to excite a subsurface plane to produce a confocal image. The method also provides for the production of a divergent beam in the fiber output capable of exciting a micro-volume of the tissue from the surface.

公开(公告)号：ES2347871T3

公开(公告)日：2010-11-24

申请号：ES03755595

申请日：2003-07-11

Applicant: MAUNA KEA TECHNOLOGIES

Inventor： CLADE SOPHIE ,  BERIER FREDERIC ,  VIELLEROBE BERTRAND ,  GENET MAGALIE

IPC: A61B5/00 ,  G01N21/64 ,  A61B1/00 ,  A61B1/04 ,  G02B21/00 ,  G02B23/24 ,  G02B23/26 ,  G02B26/10 ,  H04N1/028

Abstract: Procedimiento para realizar una imagen confocal de fluorescencia in vivo in situ, el procedimiento utiliza una guía de imagen hecha de varios millares de fibras ópticas y consiste en barrer punto por punto un tejido en un plano subsuperficial, cada punto correspondiente a una señal de excitación emitida por una fuente continua, desviada e inyectada en una de las fibras ópticas de dicho haz luego enfocada a la salida de dicha fibra en dicho plano, cada punto emitiendo de vuelta una señal de fluorescencia recogida por dicha fibra óptica, luego detectada y digital izada para formar un elemento de imagen, el procedimiento comporta las siguientes etapas: - se desvía la señal de excitación a una velocidad que corresponde a la adquisición de un mínimo de 12 imágenes por segundo en el caso de un modo de visualización máxima de 640 x 640 píxeles, - se detecta la señal de fluorescencia a una frecuencia de detección superior o igual a una frecuencia mínima de preparación de muestreo de las fibras una por una que es sensiblemente igual a 1,5 MHz para dicho mínimo de 12 imágenes por segundo en el caso de un modo de visualización de 640 x 640 píxeles.

公开(公告)号：DE60332630D1

公开(公告)日：2010-07-01

申请号：DE60332630

申请日：2003-07-11

Applicant: MAUNA KEA TECHNOLOGIES

Inventor： GENET MAGALIE ,  VIELLEROBE BERTRAND ,  BERIER FREDERIC ,  CLADE SOPHIE

IPC: A61B5/00 ,  G01N21/64 ,  A61B1/00 ,  A61B1/04 ,  G02B21/00 ,  G02B23/24 ,  G02B23/26 ,  G02B26/10 ,  H04N1/028

公开(公告)号：AT468069T

公开(公告)日：2010-06-15

申请号：AT03755595

申请日：2003-07-11

Applicant: MAUNA KEA TECHNOLOGIES

Inventor： GENET MAGALIE ,  VIELLEROBE BERTRAND ,  BERIER FREDERIC ,  CLADE SOPHIE

IPC: A61B5/00 ,  G01N21/64 ,  A61B1/00 ,  A61B1/04 ,  G02B21/00 ,  G02B23/24 ,  G02B23/26 ,  G02B26/10 ,  H04N1/028

Abstract: The method consists in deflecting the excitation signal at a speed corresponding to acquisition of a number of images per second sufficient for real time use and in detecting the fluorescence signal at a detecting frequency corresponding to a minimum frequency for sampling the fibers one by one. The method uses an image guide consisting of several thousands of optical fibers, an excitation signal being emitted by a source, deflected and injected by turns into the optical fibers of the guide, each excitation point of the tissue in the fiber output emitting in return a fluorescence signal collected by the fiber, then detected and digitized to form an image element. The method also provides for the focussing of the beam in the fiber output to excite a subsurface plane to produce a confocal image. The method also provides for the production of a divergent beam in the fiber output capable of exciting a micro-volume of the tissue from the surface.

公开(公告)号：FR2842407B1

公开(公告)日：2005-05-06

申请号：FR0209099

申请日：2002-07-18

Applicant: MAUNA KEA TECHNOLOGIES

Inventor： GENET MAGALIE ,  VIELLEROBE BERTRAND ,  BERIER FREDERIC ,  CLADE SOPHIE

IPC: G01N21/64 ,  A61B1/00 ,  A61B1/04 ,  A61B5/00 ,  G02B21/00 ,  G02B23/24 ,  G02B23/26 ,  G02B26/10 ,  H04N1/028

Abstract: The method consists in deflecting the excitation signal at a speed corresponding to acquisition of a number of images per second sufficient for real time use and in detecting the fluorescence signal at a detecting frequency corresponding to a minimum frequency for sampling the fibers one by one. The method uses an image guide consisting of several thousands of optical fibers, an excitation signal being emitted by a source, deflected and injected by turns into the optical fibers of the guide, each excitation point of the tissue in the fiber output emitting in return a fluorescence signal collected by the fiber, then detected and digitized to form an image element. The method also provides for the focussing of the beam in the fiber output to excite a subsurface plane to produce a confocal image. The method also provides for the production of a divergent beam in the fiber output capable of exciting a micro-volume of the tissue from the surface.

公开(公告)号：CA2491748C

公开(公告)日：2012-10-23

申请号：CA2491748

申请日：2003-07-11

Applicant: MAUNA KEA TECHNOLOGIES

Inventor： GENET MAGALIE ,  VIELLEROBE BERTRAND ,  BERIER FREDERIC ,  CLADE SOPHIE

IPC: G01N21/64 ,  A61B1/00 ,  A61B1/04 ,  A61B5/00 ,  G02B21/00 ,  G02B23/24 ,  G02B23/26 ,  G02B26/10 ,  H04N1/028

Abstract: Le procédé utilise un guide d'image fait de plusieurs milliers de fibres optiques, un signal d'excitation étant émis par une source, dévié et injecté tout à tour dans l'une des fibres dudit guide, chaque point d'excitation du tissu en sortie de fibre émettant en retour un signal de fluorescence collecté par ladite fibre, puis détecté et numérisé pour former un élément d'image. Selon un premier aspect, le procédé prévoit la focalisation du faisceau en sortie de fibre pour exciter un plant subsurfacique et réaliser une image confocale. Selon un second aspect le procédé prévoit de produire un faisceau divergent en sortie de fibre susceptible d'exciter un microvolume du tissu depuis la surface. Selon l'invention, le procédé est caractérisé en ce que l'on dévie le signal d'excitation à une vitesse correspondant à l'acquisition d'un nombre d'images par seconde suffisant pour une utilisation en temps réel et en ce que l'on détecte le signal de fluorescence à une fréquence de détection correspondant à une fréquence minimale d'échantillonnage des fibres une à une. Grâce à l'invention, on peut réaliser une image in vivo in situ et en temps réel.

公开(公告)号：FR2852394A1

公开(公告)日：2004-09-17

申请号：FR0302972

申请日：2003-03-11

Applicant: MAUNA KEA TECHNOLOGIES

Inventor： GENET MAGALIE ,  VIELLEROBE BERTRAND ,  BERIER FREDERIC ,  CLADE SOPHIE

IPC: A61B5/00 ,  G02B21/00 ,  G01N21/64 ,  G01N33/483

Abstract: The method consists in deflecting the excitation signal at a speed corresponding to acquisition of a number of images per second sufficient for real time use and in detecting the fluorescence signal at a detecting frequency corresponding to a minimum frequency for sampling the fibers one by one. The method uses an image guide consisting of several thousands of optical fibers, an excitation signal being emitted by a source, deflected and injected by turns into the optical fibers of the guide, each excitation point of the tissue in the fiber output emitting in return a fluorescence signal collected by the fiber, then detected and digitized to form an image element. The method also provides for the focussing of the beam in the fiber output to excite a subsurface plane to produce a confocal image. The method also provides for the production of a divergent beam in the fiber output capable of exciting a micro-volume of the tissue from the surface.