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    INTEGRATED SCANNING MINIATURE OPTICAL HEAD FOR PRODUCING A HOMOGENEOUS CONFOCAL IMAGE, AND CONFOCAL IMAGING SYSTEM USING SAME
    1.
    发明申请
    INTEGRATED SCANNING MINIATURE OPTICAL HEAD FOR PRODUCING A HOMOGENEOUS CONFOCAL IMAGE, AND CONFOCAL IMAGING SYSTEM USING SAME 审中-公开
    用于生成均匀共焦图像的集成扫描微型光学头和使用相同的共焦成像系统

    公开(公告)号：WO2005072597A2

    公开(公告)日：2005-08-11

    申请号：PCT/FR2004003402

    申请日：2004-12-29

    Applicant: MAUNA KEA TECHNOLOGIES ,  MATHIEU GILLES ,  GENET MAGALIE ,  VIELLEROBE BERTRAND ,  BERIER FREDERIC

    Inventor： MATHIEU GILLES ,  GENET MAGALIE ,  VIELLEROBE BERTRAND ,  BERIER FREDERIC

    IPC: A61B1/00 ,  A61B1/005 ,  A61B1/04 ,  A61B1/05 ,  A61B5/00 ,  G02B6/26 ,  G02B6/35 ,  G02B7/02 ,  G02B21/00 ,  G02B26/10

    CPC classification number: G02B21/0036 ,  A61B1/00188 ,  A61B1/05 ,  G02B7/027 ,  G02B21/0032

    Abstract: The invention concerns a miniature confocal optical head (4) for a confocal imaging system, in particular endoscopic, said head comprising a point source (2a) for producing a light beam (13); a ball lens (12) arranged at the tip of the optical head, partly outside, to cause said light beam to converge in an excitation point (19) located in a subsurface field under observation (14) of a sample (15), the digital aperture of said lens and the dimension of the point source being adapted to ensure confocality of the assembly; and scanning means (10, 211, 22) for rotating the point source so that the excitation point (19) scans said field under observation. The inventive system produces a real-time confocal image (about 10 images/sec.) of very high quality and homogeneous in the entire field (the optical aberrations are constant in the entire field due to the spherical symmetry of the ball lens), and this is achieved through a miniature head.

    Abstract translation: 本发明涉及一种用于共焦成像系统，特别是内窥镜的微型共焦光学头（4），所述头部包括用于产生光束（13）的点光源（2a）。 布置在光学头的尖端部分外部的球透镜（12），以使所述光束会聚在位于样品（15）的观察（14）下的地下场中的激发点（19）处， 所述透镜的数字孔径和点源的尺寸适于确保组件的共焦; 以及用于旋转点源的扫描装置（10,211,22），使得激发点（19）在观察下扫描所述场。 本发明的系统在整个领域中产生非常高质量和均匀的实时共焦图像（约10个图像/秒）（由于球透镜的球形对称性，光学像差在整个场中是恒定的），并且 这是通过微型头实现的。

    APPAREILLAGE D'IMAGERIE CONFOCALE NOTAMMENT POUR ENDOSCOPE
    2.
    发明专利
    APPAREILLAGE D'IMAGERIE CONFOCALE NOTAMMENT POUR ENDOSCOPE 未知

    公开(公告)号：CA2471721C

    公开(公告)日：2012-03-13

    申请号：CA2471721

    申请日：2002-12-20

    Applicant: MAUNA KEA TECHNOLOGIES

    Inventor： VIELLEROBE BERTRAND ,  GENET MAGALIE ,  BERIER FREDERIC ,  LACOMBE FRANCOIS ,  PERCHANT AYMERIC ,  LE GOUALHER GEORGES ,  MARTI SANDRA ,  BOURRIAUX STEPHANE

    IPC: G02B23/24 ,  G02B23/26 ,  A61B1/00 ,  A61B1/04 ,  A61B1/07 ,  G02B21/00

    Abstract: Il comporte un guide d'image (1) constitué de fibres optiques souples avec : du côté de l'extrémité proximale : une source (2), des moyens de balayage angulaire (3), des moyens d'injection (4) dans l'une des fibres, des moyens de séparation (5) du faisceau d'illumination et du signal rétroémis, des moyens de filtrage spatial (6), des moyens de détection (7) dudit signal, des moyens électroniques (8) de commande, d'analyse et de traitement numérique du signal détecté et de visualisation ; et du côté de l'extrémité distale : une tête optique (9) adaptée à focaliser le faisceau d'illumination sortant de la fibre illuminée. Selon l'invention, les moyens (3) comprennent un miroir ligne résonnant (Ml) et un miroir trame (M2) galvanométrique avec une fréquence variable et deux systèmes optiques d'afocaux adaptés à conjuguer les deux miroirs (Ml, M2) dams un premier temps puis le miroir trame (M2) et le moyen d'injection (4) dans le guide d'image dans un deuxième temps.

    3.
    发明专利
    未知

    公开(公告)号：DE60205408T2

    公开(公告)日：2006-06-01

    申请号：DE60205408

    申请日：2002-12-20

    Applicant: MAUNA KEA TECHNOLOGIES

    Inventor： VIELLEROBE BERTRAND ,  GENET MAGALIE ,  BERIER FREDERIC ,  LACOMBE FRANCOIS ,  PERCHANT AYMERIC ,  LE GOUALHER GEORGES ,  MARTI SANDRA ,  BOURRIAUX STEPHANE

    IPC: G02B23/24 ,  G02B23/26 ,  A61B1/00 ,  A61B1/04 ,  A61B1/07 ,  G02B21/00

    Abstract: Equipment includes an image guide ( 1 ) consisting of flexible optical fibers with: on the proximal end side: a source ( 2 ), angular scanning elements ( 3 ), injection elements ( 4 ) in one of the fibers, elements for splitting ( 5 ) the illuminating beam and the backscattered signal, elements for spatial filtering ( 6 ), elements for detecting ( 7 ) the signal, electronic elements ( 8 ) for controlling, analyzing and digital processing of the detected signal and display; and on the distal end side: an optical head ( 9 ) for focusing the illuminating beam exiting from the illuminated fiber. The scanning elements include a resonant line mirror (M 1 ) and a galvanometric field mirror (M 2 ) with a variable frequency and two afocal optical systems adapted to conjugate the two mirrors (M 1 , M 2 ) firstly in the field mirror (M 2 ) and the injection elements ( 4 ) in the image guide in a second step.

    4.
    发明专利
    未知

    公开(公告)号：AT320614T

    公开(公告)日：2006-04-15

    申请号：AT02801158

    申请日：2002-12-20

    Applicant: MAUNA KEA TECHNOLOGIES

    Inventor： BERIER FREDERIC ,  BOURRIAUX STEPHANE ,  GENET MAGALIE ,  VIELLEROBE BERTRAND ,  LOISEAU ALEXANDRE ,  ABRAT BENJAMIN

    IPC: G02B23/26 ,  A61B1/00 ,  G02B21/02 ,  G02B23/24 ,  A61B1/07

    Abstract: An optical head for equipping the distal end of a flexible optical fiber bundle, designed to be urged into contact with an analyzing surface and including optical elements for focusing an excitation signal into a so-called excitation focal point located at a specific depth beneath the analyzing surface and for sampling a signal backscattered by the excitation focal point which is carried back by the fiber bundle. The head includes an optics-holder tube wherein are inserted on one side the distal end portion of the fiber bundle and on the other optical elements, the latter including a plate placed in contact with the end of the fiber bundle whereof the index is close to that of the fiber core and a focusing optical block, an output window being further provided adapted to provide index adaptation so as to eliminate parasitic reflection occurring on the analyzing surface.

    METHOD AND EQUIPMENT FOR FIBER OPTIC HIGH-RESOLUTION, IN PARTICULAR CONFOCAL, FLUORESCENCE IMAGING
    6.
    发明专利
    METHOD AND EQUIPMENT FOR FIBER OPTIC HIGH-RESOLUTION, IN PARTICULAR CONFOCAL, FLUORESCENCE IMAGING 未知

    公开(公告)号：AU2003273437A1

    公开(公告)日：2004-02-09

    申请号：AU2003273437

    申请日：2003-07-11

    Applicant: MAUNA KEA TECHNOLOGIES

    Inventor： CLADE SOPHIE ,  GENET MAGALIE ,  VIELLEROBE BERTRAND ,  BERIER FREDERIC

    IPC: G01N21/64 ,  A61B1/00 ,  A61B1/04 ,  A61B5/00 ,  G02B21/00 ,  G02B23/24 ,  G02B23/26 ,  G02B26/10 ,  H04N1/028

    Abstract: The method consists in deflecting the excitation signal at a speed corresponding to acquisition of a number of images per second sufficient for real time use and in detecting the fluorescence signal at a detecting frequency corresponding to a minimum frequency for sampling the fibers one by one. The method uses an image guide consisting of several thousands of optical fibers, an excitation signal being emitted by a source, deflected and injected by turns into the optical fibers of the guide, each excitation point of the tissue in the fiber output emitting in return a fluorescence signal collected by the fiber, then detected and digitized to form an image element. The method also provides for the focussing of the beam in the fiber output to excite a subsurface plane to produce a confocal image. The method also provides for the production of a divergent beam in the fiber output capable of exciting a micro-volume of the tissue from the surface.

    7.
    发明专利
    未知

    公开(公告)号：FR2834349A1

    公开(公告)日：2003-07-04

    申请号：FR0116980

    申请日：2001-12-28

    Applicant: MAUNA KEA TECHNOLOGIES

    Inventor： VIELLEROBE BERTRAND ,  GENET MAGALIE ,  BERIER FREDERIC ,  LACOMBE FRANCOIS ,  PERCHANT AYMERIC ,  LE GOUALHER GEORGES ,  MARTI SANDRA ,  BOURRIAUX STEPHANE

    IPC: G02B23/26 ,  A61B1/00 ,  A61B1/04 ,  A61B1/07 ,  G02B21/00 ,  G02B23/24 ,  G02B26/10 ,  G06F19/00

    Abstract: Equipment includes an image guide ( 1 ) consisting of flexible optical fibers with: on the proximal end side: a source ( 2 ), angular scanning elements ( 3 ), injection elements ( 4 ) in one of the fibers, elements for splitting ( 5 ) the illuminating beam and the backscattered signal, elements for spatial filtering ( 6 ), elements for detecting ( 7 ) the signal, electronic elements ( 8 ) for controlling, analyzing and digital processing of the detected signal and display; and on the distal end side: an optical head ( 9 ) for focusing the illuminating beam exiting from the illuminated fiber. The scanning elements include a resonant line mirror (M 1 ) and a galvanometric field mirror (M 2 ) with a variable frequency and two afocal optical systems adapted to conjugate the two mirrors (M 1 , M 2 ) firstly in the field mirror (M 2 ) and the injection elements ( 4 ) in the image guide in a second step.

    8.
    发明专利
    未知

    公开(公告)号：FR2834348A1

    公开(公告)日：2003-07-04

    申请号：FR0116979

    申请日：2001-12-28

    Applicant: MAUNA KEA TECHNOLOGIES

    Inventor： BERIER FREDERIC ,  BOURRIAUX STEPHANE ,  GENET MAGALIE ,  VIELLEROBE BERTRAND ,  LOISEAU ALEXANDRE ,  ABRAT BENJAMIN

    IPC: G02B23/26 ,  A61B1/00 ,  G02B21/02 ,  A61B1/07

    Abstract: An optical head for equipping the distal end of a flexible optical fiber bundle, designed to be urged into contact with an analyzing surface and including optical elements for focusing an excitation signal into a so-called excitation focal point located at a specific depth beneath the analyzing surface and for sampling a signal backscattered by the excitation focal point which is carried back by the fiber bundle. The head includes an optics-holder tube wherein are inserted on one side the distal end portion of the fiber bundle and on the other optical elements, the latter including a plate placed in contact with the end of the fiber bundle whereof the index is close to that of the fiber core and a focusing optical block, an output window being further provided adapted to provide index adaptation so as to eliminate parasitic reflection occurring on the analyzing surface.

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