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    INTEGRATED SCANNING MINIATURE OPTICAL HEAD FOR PRODUCING A HOMOGENEOUS CONFOCAL IMAGE, AND CONFOCAL IMAGING SYSTEM USING SAME
    2.
    发明申请
    INTEGRATED SCANNING MINIATURE OPTICAL HEAD FOR PRODUCING A HOMOGENEOUS CONFOCAL IMAGE, AND CONFOCAL IMAGING SYSTEM USING SAME 审中-公开
    用于生成均匀共焦图像的集成扫描微型光学头和使用相同的共焦成像系统

    公开(公告)号：WO2005072597A2

    公开(公告)日：2005-08-11

    申请号：PCT/FR2004003402

    申请日：2004-12-29

    Applicant: MAUNA KEA TECHNOLOGIES ,  MATHIEU GILLES ,  GENET MAGALIE ,  VIELLEROBE BERTRAND ,  BERIER FREDERIC

    Inventor： MATHIEU GILLES ,  GENET MAGALIE ,  VIELLEROBE BERTRAND ,  BERIER FREDERIC

    IPC: A61B1/00 ,  A61B1/005 ,  A61B1/04 ,  A61B1/05 ,  A61B5/00 ,  G02B6/26 ,  G02B6/35 ,  G02B7/02 ,  G02B21/00 ,  G02B26/10

    CPC classification number: G02B21/0036 ,  A61B1/00188 ,  A61B1/05 ,  G02B7/027 ,  G02B21/0032

    Abstract: The invention concerns a miniature confocal optical head (4) for a confocal imaging system, in particular endoscopic, said head comprising a point source (2a) for producing a light beam (13); a ball lens (12) arranged at the tip of the optical head, partly outside, to cause said light beam to converge in an excitation point (19) located in a subsurface field under observation (14) of a sample (15), the digital aperture of said lens and the dimension of the point source being adapted to ensure confocality of the assembly; and scanning means (10, 211, 22) for rotating the point source so that the excitation point (19) scans said field under observation. The inventive system produces a real-time confocal image (about 10 images/sec.) of very high quality and homogeneous in the entire field (the optical aberrations are constant in the entire field due to the spherical symmetry of the ball lens), and this is achieved through a miniature head.

    Abstract translation: 本发明涉及一种用于共焦成像系统，特别是内窥镜的微型共焦光学头（4），所述头部包括用于产生光束（13）的点光源（2a）。 布置在光学头的尖端部分外部的球透镜（12），以使所述光束会聚在位于样品（15）的观察（14）下的地下场中的激发点（19）处， 所述透镜的数字孔径和点源的尺寸适于确保组件的共焦; 以及用于旋转点源的扫描装置（10,211,22），使得激发点（19）在观察下扫描所述场。 本发明的系统在整个领域中产生非常高质量和均匀的实时共焦图像（约10个图像/秒）（由于球透镜的球形对称性，光学像差在整个场中是恒定的），并且 这是通过微型头实现的。

    MODULAR IMAGING DEVICE, MODULE FOR THIS DEVICE, AND METHOD OF IMPLEMENTATION BY THIS DEVICE
    4.
    发明申请
    MODULAR IMAGING DEVICE, MODULE FOR THIS DEVICE, AND METHOD OF IMPLEMENTATION BY THIS DEVICE 审中-公开
    模块化成像装置，用于该装置的模块以及由该装置执行的方法

    公开(公告)号：WO2009053632A3

    公开(公告)日：2009-06-25

    申请号：PCT/FR2008051845

    申请日：2008-10-10

    Applicant: MAUNA KEA TECHNOLOGIES

    Inventor： VIELLEROBE BERTRAND ,  LACOMBE FRANCOIS ,  BOULAROT NICOLAS ,  DOUSSOUX FRANCOIS ,  LAVILLONNIERE NICOLAS

    IPC: G01N21/64 ,  A61B1/00 ,  A61B1/07 ,  G02B21/00

    CPC classification number: G01N21/6458 ,  A61B1/00165 ,  A61B1/00186 ,  A61B1/043 ,  A61B1/0638 ,  A61B1/07 ,  A61B5/0068 ,  A61B5/0071 ,  A61B5/0084 ,  G01N2021/6419 ,  G01N2021/6421 ,  G01N2201/024 ,  G01N2201/0846 ,  G01N2201/086

    Abstract: The present invention relates to an imaging device comprising: an illumination module (1) comprising means for emitting at least one excitation beam; a scanning/injection module (2) comprising an image waveguide (3), the two ends of which, the proximal end (3a) and the distal end (3b) respectively, are connected via a plurality of optical fibres, and scanning/injection means (6) designed to inject the at least one excitation beam in turn into a fibre of the image waveguide (3) and then into the proximal side (3a) of said waveguide and a detection module (4) comprising means for detecting a light flux (14) collected at the distal end (3b) of the waveguide. At least either the illumination module (1) or the detection module (4) is optically conjugate with the scanning/injection module (2) via a conjugating optical fibre (5, 7). The use of conjugating fibres (5, 7) enables the maintenance, repair and updating of the device to be improved. It also enables modal filtering of the excitation beam to be carried out and ensures that the device is confocal.

    Abstract translation: 本发明涉及一种成像装置，其包括：照明模块（1），其包括用于发射至少一个激发光束的装置; 包括图像波导（3）的扫描/注射模块（2），所述图像波导（3）的两端分别通过多根光纤连接所述近端（3a）和所述远端（3b），并且扫描/注入 被设计成将所述至少一个激励光束依次注入到所述图像波导（3）的光纤中并且然后注入到所述波导的近侧（3a）中的装置（6）;以及检测模块（4），其包括用于检测光 通量（14）收集在波导的远端（3b）处。 照明模块（1）或检测模块（4）中的至少一个经由共轭光纤（5,7）与扫描/注射模块（2）光学共轭。 共轭纤维（5,7）的使用使得设备的维护，修理和更新得以改善。 它还可以对激发光束进行模态滤波，确保设备共焦。

    7.
    发明专利
    未知

    公开(公告)号：AT468069T

    公开(公告)日：2010-06-15

    申请号：AT03755595

    申请日：2003-07-11

    Applicant: MAUNA KEA TECHNOLOGIES

    Inventor： GENET MAGALIE ,  VIELLEROBE BERTRAND ,  BERIER FREDERIC ,  CLADE SOPHIE

    IPC: A61B5/00 ,  G01N21/64 ,  A61B1/00 ,  A61B1/04 ,  G02B21/00 ,  G02B23/24 ,  G02B23/26 ,  G02B26/10 ,  H04N1/028

    Abstract: The method consists in deflecting the excitation signal at a speed corresponding to acquisition of a number of images per second sufficient for real time use and in detecting the fluorescence signal at a detecting frequency corresponding to a minimum frequency for sampling the fibers one by one. The method uses an image guide consisting of several thousands of optical fibers, an excitation signal being emitted by a source, deflected and injected by turns into the optical fibers of the guide, each excitation point of the tissue in the fiber output emitting in return a fluorescence signal collected by the fiber, then detected and digitized to form an image element. The method also provides for the focussing of the beam in the fiber output to excite a subsurface plane to produce a confocal image. The method also provides for the production of a divergent beam in the fiber output capable of exciting a micro-volume of the tissue from the surface.

    DISPOSITIF D' IMAGERIE MODULAIRE, MODULE POUR CE DISPOSITIF ET PROCEDE MIS EN OEUVRE PAR CE DISPOSITIF
    9.
    发明专利
    DISPOSITIF D' IMAGERIE MODULAIRE, MODULE POUR CE DISPOSITIF ET PROCEDE MIS EN OEUVRE PAR CE DISPOSITIF 未知

    公开(公告)号：CA2701993A1

    公开(公告)日：2009-04-30

    申请号：CA2701993

    申请日：2008-10-10

    Applicant: MAUNA KEA TECHNOLOGIES

    Inventor： VIELLEROBE BERTRAND ,  LACOMBE FRANCOIS ,  BOULAROT NICOLAS ,  DOUSSOUX FRANCOIS ,  LAVILLONNIERE NICOLAS

    IPC: G01N21/64 ,  A61B1/00 ,  A61B1/07 ,  A61B5/00 ,  G01N21/63 ,  G02B21/00 ,  G02B23/14 ,  G02B26/10

    Abstract: La présente invention concerne un dispositif d'imagerie, comprenant: un module d'illumination (1) comprenant des moyens pour émettre au moins un faisceau d'excitation; un module de balayage et d'injection (2) comprenant un guide d'image (3) dont deux extrémités respectivement proximale (3a) et distale (3b) sont reliées par une pluralité de fibres optiques, et des moyens (6) de balayage et d'injection agencés pour injecter l'au moins un faisceau d'excitation tour à tour dans une fibre du guide d'image (3) et du côté proximal (3a) du guide; un module de détection (4) comprenant des moyens pour détecter un flux lumineux (14) collecté à l'extrémité distale (3b) du guide. Au moins un parmi le module d'illumination (1) et le module de détection (4) est conjugué optiquement au module de balayage et d'injection (2) par une fibre optique de conjugaison (5, 7). L'utilisation de fibres de conjugaison (5, 7) permet d'améliorer la maintenance, la réparation et la mise à jour du dispositif, et peut en outre permettre de réaliser un filtrage modal du faisceau d'excitation et d'assurer la confocalité du dispositif.

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