公开(公告)号：WO2005072597A2

公开(公告)日：2005-08-11

申请号：PCT/FR2004003402

申请日：2004-12-29

Applicant: MAUNA KEA TECHNOLOGIES ,  MATHIEU GILLES ,  GENET MAGALIE ,  VIELLEROBE BERTRAND ,  BERIER FREDERIC

Inventor： MATHIEU GILLES ,  GENET MAGALIE ,  VIELLEROBE BERTRAND ,  BERIER FREDERIC

IPC: A61B1/00 ,  A61B1/005 ,  A61B1/04 ,  A61B1/05 ,  A61B5/00 ,  G02B6/26 ,  G02B6/35 ,  G02B7/02 ,  G02B21/00 ,  G02B26/10

CPC classification number: G02B21/0036 ,  A61B1/00188 ,  A61B1/05 ,  G02B7/027 ,  G02B21/0032

Abstract: The invention concerns a miniature confocal optical head (4) for a confocal imaging system, in particular endoscopic, said head comprising a point source (2a) for producing a light beam (13); a ball lens (12) arranged at the tip of the optical head, partly outside, to cause said light beam to converge in an excitation point (19) located in a subsurface field under observation (14) of a sample (15), the digital aperture of said lens and the dimension of the point source being adapted to ensure confocality of the assembly; and scanning means (10, 211, 22) for rotating the point source so that the excitation point (19) scans said field under observation. The inventive system produces a real-time confocal image (about 10 images/sec.) of very high quality and homogeneous in the entire field (the optical aberrations are constant in the entire field due to the spherical symmetry of the ball lens), and this is achieved through a miniature head.

Abstract translation: 本发明涉及一种用于共焦成像系统，特别是内窥镜的微型共焦光学头（4），所述头部包括用于产生光束（13）的点光源（2a）。 布置在光学头的尖端部分外部的球透镜（12），以使所述光束会聚在位于样品（15）的观察（14）下的地下场中的激发点（19）处， 所述透镜的数字孔径和点源的尺寸适于确保组件的共焦; 以及用于旋转点源的扫描装置（10,211,22），使得激发点（19）在观察下扫描所述场。 本发明的系统在整个领域中产生非常高质量和均匀的实时共焦图像（约10个图像/秒）（由于球透镜的球形对称性，光学像差在整个场中是恒定的），并且 这是通过微型头实现的。

公开(公告)号：CA2471721C

公开(公告)日：2012-03-13

申请号：CA2471721

申请日：2002-12-20

Applicant: MAUNA KEA TECHNOLOGIES

Inventor： VIELLEROBE BERTRAND ,  GENET MAGALIE ,  BERIER FREDERIC ,  LACOMBE FRANCOIS ,  PERCHANT AYMERIC ,  LE GOUALHER GEORGES ,  MARTI SANDRA ,  BOURRIAUX STEPHANE

IPC: G02B23/24 ,  G02B23/26 ,  A61B1/00 ,  A61B1/04 ,  A61B1/07 ,  G02B21/00

Abstract: Il comporte un guide d'image (1) constitué de fibres optiques souples avec : du côté de l'extrémité proximale : une source (2), des moyens de balayage angulaire (3), des moyens d'injection (4) dans l'une des fibres, des moyens de séparation (5) du faisceau d'illumination et du signal rétroémis, des moyens de filtrage spatial (6), des moyens de détection (7) dudit signal, des moyens électroniques (8) de commande, d'analyse et de traitement numérique du signal détecté et de visualisation ; et du côté de l'extrémité distale : une tête optique (9) adaptée à focaliser le faisceau d'illumination sortant de la fibre illuminée. Selon l'invention, les moyens (3) comprennent un miroir ligne résonnant (Ml) et un miroir trame (M2) galvanométrique avec une fréquence variable et deux systèmes optiques d'afocaux adaptés à conjuguer les deux miroirs (Ml, M2) dams un premier temps puis le miroir trame (M2) et le moyen d'injection (4) dans le guide d'image dans un deuxième temps.

公开(公告)号：CA2774621A1

公开(公告)日：2011-03-24

申请号：CA2774621

申请日：2010-09-17

Applicant: MAUNA KEA TECHNOLOGIES

Inventor： BOULAROT NICOLAS ,  GENET MAGALIE ,  SCHWARZ FRANCE

IPC: A61B1/04

Abstract: A method to inspect a solid organ in a subject includes introducing a needle in a predetermined area of the solid organ, inserting an optical probe through a lumen of the needle, and imaging the predetermined area using the optical probe. An optical probe to inspect a solid organ in a subject, the optical probe being intended to be positioned in the solid organ through a needle, the optical probe includes an optical fiber bundle, a ferule to protect the distal tip of the optical fiber bundle, the ferule comprising a shank and a head, and a sheath wrapping the fiber bundle and the shank, wherein the head of the ferule has a length adapted for the optical probe to image the solid organ while keeping the sheath inside the needle.

公开(公告)号：FR2900741B1

公开(公告)日：2008-07-18

申请号：FR0604019

申请日：2006-05-05

Applicant: MAUNA KEA TECHNOLOGIES SOC PAR

Inventor： GENET MAGALIE ,  MATHIEU GILLES ,  VIELLEROBE BERTRAND ,  DOUSSOUX FRANCOIS ,  BOULAROT NICOLAS ,  LAVILLONNIERE NICOLAS

IPC: G02B23/24 ,  A61B1/00

Abstract: A miniaturized optical head provided to equip the distal end of a beam of flexible optical fibers scanned by a laser beam, is designed to come in contact with a sample and to excite the sample confocally. This optical head includes elements for correcting spherical aberrations and focusing members. The focusing members include: at least a first lens (L4) of high convergence associated with a spherical or hemispherical lens (L5) arranged at the distal end of the optical head, and elements for correcting the axial and lateral chromatic aberration provided with a single divergent lens (3b) whose curvature is substantially centered on the pupil of the optical fiber beam and arranged at the exact distance for this pupil for which the conditions of lateral achromatization coincide with the conditions of axial achromatization; this divergent lens being associated with a second convergent lens (L3a) in the form of a doublet (L3).

公开(公告)号：DE60205408T2

公开(公告)日：2006-06-01

申请号：DE60205408

申请日：2002-12-20

Applicant: MAUNA KEA TECHNOLOGIES

Inventor： VIELLEROBE BERTRAND ,  GENET MAGALIE ,  BERIER FREDERIC ,  LACOMBE FRANCOIS ,  PERCHANT AYMERIC ,  LE GOUALHER GEORGES ,  MARTI SANDRA ,  BOURRIAUX STEPHANE

IPC: G02B23/24 ,  G02B23/26 ,  A61B1/00 ,  A61B1/04 ,  A61B1/07 ,  G02B21/00

Abstract: Equipment includes an image guide ( 1 ) consisting of flexible optical fibers with: on the proximal end side: a source ( 2 ), angular scanning elements ( 3 ), injection elements ( 4 ) in one of the fibers, elements for splitting ( 5 ) the illuminating beam and the backscattered signal, elements for spatial filtering ( 6 ), elements for detecting ( 7 ) the signal, electronic elements ( 8 ) for controlling, analyzing and digital processing of the detected signal and display; and on the distal end side: an optical head ( 9 ) for focusing the illuminating beam exiting from the illuminated fiber. The scanning elements include a resonant line mirror (M 1 ) and a galvanometric field mirror (M 2 ) with a variable frequency and two afocal optical systems adapted to conjugate the two mirrors (M 1 , M 2 ) firstly in the field mirror (M 2 ) and the injection elements ( 4 ) in the image guide in a second step.

公开(公告)号：AT320614T

公开(公告)日：2006-04-15

申请号：AT02801158

申请日：2002-12-20

Applicant: MAUNA KEA TECHNOLOGIES

Inventor： BERIER FREDERIC ,  BOURRIAUX STEPHANE ,  GENET MAGALIE ,  VIELLEROBE BERTRAND ,  LOISEAU ALEXANDRE ,  ABRAT BENJAMIN

IPC: G02B23/26 ,  A61B1/00 ,  G02B21/02 ,  G02B23/24 ,  A61B1/07

Abstract: An optical head for equipping the distal end of a flexible optical fiber bundle, designed to be urged into contact with an analyzing surface and including optical elements for focusing an excitation signal into a so-called excitation focal point located at a specific depth beneath the analyzing surface and for sampling a signal backscattered by the excitation focal point which is carried back by the fiber bundle. The head includes an optics-holder tube wherein are inserted on one side the distal end portion of the fiber bundle and on the other optical elements, the latter including a plate placed in contact with the end of the fiber bundle whereof the index is close to that of the fiber core and a focusing optical block, an output window being further provided adapted to provide index adaptation so as to eliminate parasitic reflection occurring on the analyzing surface.

公开(公告)号：FR2864438A1

公开(公告)日：2005-07-01

申请号：FR0315627

申请日：2003-12-31

Applicant: MAUNA KEA TECHNOLOGIES

Inventor： MATHIEU GILLES ,  GENET MAGALIE ,  VIELLEROBE BERTRAND ,  BERIER FREDERIC

IPC: A61B1/00 ,  A61B1/005 ,  A61B1/04 ,  A61B1/05 ,  A61B5/00 ,  G02B6/26 ,  G02B6/35 ,  G02B7/02 ,  G02B21/00 ,  G02B26/10 ,  A61B1/07 ,  G02B6/06 ,  G02B26/08 ,  H01J3/14

Abstract: The head has a laser source to produce a light beam (13), and a ball lens (12), with a large numerical aperture, disposed at the end of the head to converge the beam at an excitation point (19). The point is located in an observed sub-surface field (14) of a sample (15). A scanning unit (10) displaces the source in rotation such that the point scans the field. An independent claim is also included for a confocal imaging system.

公开(公告)号：AU2003273437A1

公开(公告)日：2004-02-09

申请号：AU2003273437

申请日：2003-07-11

Applicant: MAUNA KEA TECHNOLOGIES

Inventor： CLADE SOPHIE ,  GENET MAGALIE ,  VIELLEROBE BERTRAND ,  BERIER FREDERIC

IPC: G01N21/64 ,  A61B1/00 ,  A61B1/04 ,  A61B5/00 ,  G02B21/00 ,  G02B23/24 ,  G02B23/26 ,  G02B26/10 ,  H04N1/028

Abstract: The method consists in deflecting the excitation signal at a speed corresponding to acquisition of a number of images per second sufficient for real time use and in detecting the fluorescence signal at a detecting frequency corresponding to a minimum frequency for sampling the fibers one by one. The method uses an image guide consisting of several thousands of optical fibers, an excitation signal being emitted by a source, deflected and injected by turns into the optical fibers of the guide, each excitation point of the tissue in the fiber output emitting in return a fluorescence signal collected by the fiber, then detected and digitized to form an image element. The method also provides for the focussing of the beam in the fiber output to excite a subsurface plane to produce a confocal image. The method also provides for the production of a divergent beam in the fiber output capable of exciting a micro-volume of the tissue from the surface.

公开(公告)号：FR2834349A1

公开(公告)日：2003-07-04

申请号：FR0116980

申请日：2001-12-28

Applicant: MAUNA KEA TECHNOLOGIES

Inventor： VIELLEROBE BERTRAND ,  GENET MAGALIE ,  BERIER FREDERIC ,  LACOMBE FRANCOIS ,  PERCHANT AYMERIC ,  LE GOUALHER GEORGES ,  MARTI SANDRA ,  BOURRIAUX STEPHANE

IPC: G02B23/26 ,  A61B1/00 ,  A61B1/04 ,  A61B1/07 ,  G02B21/00 ,  G02B23/24 ,  G02B26/10 ,  G06F19/00

Abstract: Equipment includes an image guide ( 1 ) consisting of flexible optical fibers with: on the proximal end side: a source ( 2 ), angular scanning elements ( 3 ), injection elements ( 4 ) in one of the fibers, elements for splitting ( 5 ) the illuminating beam and the backscattered signal, elements for spatial filtering ( 6 ), elements for detecting ( 7 ) the signal, electronic elements ( 8 ) for controlling, analyzing and digital processing of the detected signal and display; and on the distal end side: an optical head ( 9 ) for focusing the illuminating beam exiting from the illuminated fiber. The scanning elements include a resonant line mirror (M 1 ) and a galvanometric field mirror (M 2 ) with a variable frequency and two afocal optical systems adapted to conjugate the two mirrors (M 1 , M 2 ) firstly in the field mirror (M 2 ) and the injection elements ( 4 ) in the image guide in a second step.

公开(公告)号：FR2834348A1

公开(公告)日：2003-07-04

申请号：FR0116979

申请日：2001-12-28

Applicant: MAUNA KEA TECHNOLOGIES

Inventor： BERIER FREDERIC ,  BOURRIAUX STEPHANE ,  GENET MAGALIE ,  VIELLEROBE BERTRAND ,  LOISEAU ALEXANDRE ,  ABRAT BENJAMIN

IPC: G02B23/26 ,  A61B1/00 ,  G02B21/02 ,  A61B1/07

Abstract: An optical head for equipping the distal end of a flexible optical fiber bundle, designed to be urged into contact with an analyzing surface and including optical elements for focusing an excitation signal into a so-called excitation focal point located at a specific depth beneath the analyzing surface and for sampling a signal backscattered by the excitation focal point which is carried back by the fiber bundle. The head includes an optics-holder tube wherein are inserted on one side the distal end portion of the fiber bundle and on the other optical elements, the latter including a plate placed in contact with the end of the fiber bundle whereof the index is close to that of the fiber core and a focusing optical block, an output window being further provided adapted to provide index adaptation so as to eliminate parasitic reflection occurring on the analyzing surface.