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公开(公告)号：FR2834340A1
公开(公告)日：2003-07-04
申请号：FR0116981
申请日：2001-12-28
Applicant: MAUNA KEA TECHNOLOGIES
Inventor： GENET MAGALIE , BOURG HECKLY GENEVIEVE , VILETTE SANDRINE , LACOMBE FRANCOIS , LOISEAU ALEXANDRE , ABRAT BENJAMIN
IPC: A61B1/00 , A61B5/00 , G01N21/64 , G01N33/483 , A61B1/07
Abstract: An equipment includes an excitation source ( 1 ), elements for injecting ( 2 ) an excitation signal produced by the source in an ordered bundle ( 3 ) of flexible optical fibers, elements for analyzing ( 21, 22 ) an emitted autofluorescence signal. The equipment also includes at the output of the optical fiber bundle ( 3 ) an optical head ( 4 ) designed to be placed in contact with the biological tissue ( 6 ), the optical head being equipped with optical elements adapted to cause the excitation signal output from the bundle ( 3 ) to converge into a subsurface analyzing zone ( 5 ), the same optical fiber(s) used for excitation of the bundle ( 3 ) being used for detecting the signal emitted by the subsurface analyzing zone, elements (D) placed upstream of the injection elements ( 2 ) being further provided to separate the wavelength of the excitation signal and the wavelength of the autofluorescence signal.
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公开(公告)号：ES2347871T3
公开(公告)日：2010-11-24
申请号：ES03755595
申请日：2003-07-11
Applicant: MAUNA KEA TECHNOLOGIES
Inventor： CLADE SOPHIE , BERIER FREDERIC , VIELLEROBE BERTRAND , GENET MAGALIE
IPC: A61B5/00 , G01N21/64 , A61B1/00 , A61B1/04 , G02B21/00 , G02B23/24 , G02B23/26 , G02B26/10 , H04N1/028
Abstract: Procedimiento para realizar una imagen confocal de fluorescencia in vivo in situ, el procedimiento utiliza una guía de imagen hecha de varios millares de fibras ópticas y consiste en barrer punto por punto un tejido en un plano subsuperficial, cada punto correspondiente a una señal de excitación emitida por una fuente continua, desviada e inyectada en una de las fibras ópticas de dicho haz luego enfocada a la salida de dicha fibra en dicho plano, cada punto emitiendo de vuelta una señal de fluorescencia recogida por dicha fibra óptica, luego detectada y digital izada para formar un elemento de imagen, el procedimiento comporta las siguientes etapas: - se desvía la señal de excitación a una velocidad que corresponde a la adquisición de un mínimo de 12 imágenes por segundo en el caso de un modo de visualización máxima de 640 x 640 píxeles, - se detecta la señal de fluorescencia a una frecuencia de detección superior o igual a una frecuencia mínima de preparación de muestreo de las fibras una por una que es sensiblemente igual a 1,5 MHz para dicho mínimo de 12 imágenes por segundo en el caso de un modo de visualización de 640 x 640 píxeles.
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公开(公告)号：DE60332630D1
公开(公告)日：2010-07-01
申请号：DE60332630
申请日：2003-07-11
Applicant: MAUNA KEA TECHNOLOGIES
Inventor： GENET MAGALIE , VIELLEROBE BERTRAND , BERIER FREDERIC , CLADE SOPHIE
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公开(公告)号：AT468069T
公开(公告)日：2010-06-15
申请号：AT03755595
申请日：2003-07-11
Applicant: MAUNA KEA TECHNOLOGIES
Inventor： GENET MAGALIE , VIELLEROBE BERTRAND , BERIER FREDERIC , CLADE SOPHIE
IPC: A61B5/00 , G01N21/64 , A61B1/00 , A61B1/04 , G02B21/00 , G02B23/24 , G02B23/26 , G02B26/10 , H04N1/028
Abstract: The method consists in deflecting the excitation signal at a speed corresponding to acquisition of a number of images per second sufficient for real time use and in detecting the fluorescence signal at a detecting frequency corresponding to a minimum frequency for sampling the fibers one by one. The method uses an image guide consisting of several thousands of optical fibers, an excitation signal being emitted by a source, deflected and injected by turns into the optical fibers of the guide, each excitation point of the tissue in the fiber output emitting in return a fluorescence signal collected by the fiber, then detected and digitized to form an image element. The method also provides for the focussing of the beam in the fiber output to excite a subsurface plane to produce a confocal image. The method also provides for the production of a divergent beam in the fiber output capable of exciting a micro-volume of the tissue from the surface.
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公开(公告)号：DE602004020113D1
公开(公告)日：2009-04-30
申请号：DE602004020113
申请日：2004-12-29
Applicant: MAUNA KEA TECHNOLOGIES
Inventor： MATHIEU GILLES , GENET MAGALIE , VIELLEROBE BERTRAND , BERIER FREDERIC
IPC: A61B1/005 , A61B1/00 , A61B1/04 , A61B1/05 , A61B5/00 , G02B6/26 , G02B6/35 , G02B7/02 , G02B21/00 , G02B26/10
Abstract: The head has a laser source to produce a light beam (13), and a ball lens (12), with a large numerical aperture, disposed at the end of the head to converge the beam at an excitation point (19). The point is located in an observed sub-surface field (14) of a sample (15). A scanning unit (10) displaces the source in rotation such that the point scans the field. An independent claim is also included for a confocal imaging system.
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Patent Agency Ranking
公开(公告)号：AT425696T
公开(公告)日：2009-04-15
申请号：AT04817613
申请日：2004-12-29
Applicant: MAUNA KEA TECHNOLOGIES
Inventor： MATHIEU GILLES , GENET MAGALIE , VIELLEROBE BERTRAND , BERIER FREDERIC
IPC: A61B1/005 , A61B1/00 , A61B1/04 , A61B1/05 , A61B5/00 , G02B6/26 , G02B6/35 , G02B7/02 , G02B21/00 , G02B26/10
Abstract: The head has a laser source to produce a light beam (13), and a ball lens (12), with a large numerical aperture, disposed at the end of the head to converge the beam at an excitation point (19). The point is located in an observed sub-surface field (14) of a sample (15). A scanning unit (10) displaces the source in rotation such that the point scans the field. An independent claim is also included for a confocal imaging system.
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公开(公告)号：FR2900741A1
公开(公告)日：2007-11-09
申请号：FR0604019
申请日：2006-05-05
Applicant: MAUNA KEA TECHNOLOGIES SOC PAR
Inventor： GENET MAGALIE , MATHIEU GILLES , VIELLEROBE BERTRAND , DOUSSOUX FRANCOIS , BOULAROT NICOLAS , LAVILLONNIERE NICOLAS
Abstract: L'invention concerne une tête optique miniaturisée prévue pour équiper l'extrémité distale d'un faisceau de fibres optiques souples balayé par un faisceau laser, ladite tête optique étant destinée à venir au contact d'un échantillon et exciter ledit échantillon de manière confocale ; cette tête optique comprenant des moyens de correction des aberrations sphériques et des moyens de focalisation. Selon l'invention, les moyens de focalisation comprennent :- au moins une première lentille (L4) de forte convergence associée à une lentille (L5) boule ou demi-boule disposée à l'extrémité distale de la tête optique, et- des moyens de correction du chromatisme axial et latéral pourvus d'une unique lentille divergente (3b) dont la courbure est sensiblement centrée sur la pupille du faisceau de fibres optiques et disposée à la juste distance de cette pupille pour laquelle les conditions d'achromatisation latérale coïncident avec les conditions d'achromatisation axiale; cette lentille divergente étant associée à une seconde lentille convergente (L3a) sous forme d'un doublet (L3).
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公开(公告)号：BR0215371A
公开(公告)日：2004-12-07
申请号：BR0215371
申请日：2002-12-20
Applicant: MAUNA KEA TECHNOLOGIES
Inventor： VIELLEROBE BERTRAND , GENET MAGALIE , BERIER FREDERIC , LACOMBE FRANCOIS , PERCHANT AYMERIC , GOUALHER GEORGES LE , MARTI SANDRA , BOURRIAUX STEPHANE
Abstract: Equipment includes an image guide ( 1 ) consisting of flexible optical fibers with: on the proximal end side: a source ( 2 ), angular scanning elements ( 3 ), injection elements ( 4 ) in one of the fibers, elements for splitting ( 5 ) the illuminating beam and the backscattered signal, elements for spatial filtering ( 6 ), elements for detecting ( 7 ) the signal, electronic elements ( 8 ) for controlling, analyzing and digital processing of the detected signal and display; and on the distal end side: an optical head ( 9 ) for focusing the illuminating beam exiting from the illuminated fiber. The scanning elements include a resonant line mirror (M 1 ) and a galvanometric field mirror (M 2 ) with a variable frequency and two afocal optical systems adapted to conjugate the two mirrors (M 1 , M 2 ) firstly in the field mirror (M 2 ) and the injection elements ( 4 ) in the image guide in a second step.
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公开(公告)号：BR0215370A
公开(公告)日：2004-12-07
申请号：BR0215370
申请日：2002-12-20
Applicant: MAUNA KEA TECHNOLOGIES
Inventor： BERIER FREDERIC , BOURRIAUX STEPHANE , GENET MAGALIE , VIELLEROBE BERTRAND , LOISEAU ALEXANDRE , ABRAT BENJAMIN
Abstract: An optical head for equipping the distal end of a flexible optical fiber bundle, designed to be urged into contact with an analyzing surface and including optical elements for focusing an excitation signal into a so-called excitation focal point located at a specific depth beneath the analyzing surface and for sampling a signal backscattered by the excitation focal point which is carried back by the fiber bundle. The head includes an optics-holder tube wherein are inserted on one side the distal end portion of the fiber bundle and on the other optical elements, the latter including a plate placed in contact with the end of the fiber bundle whereof the index is close to that of the fiber core and a focusing optical block, an output window being further provided adapted to provide index adaptation so as to eliminate parasitic reflection occurring on the analyzing surface.
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20.发明专利
公开(公告)号：AU2003296825A1
公开(公告)日：2004-08-13
申请号：AU2003296825
申请日：2003-12-12
Applicant: MAUNA KEA TECHNOLOGIES
Inventor： BERIER FREDERIC , VIELLEROBE BERTRAND , GENET MAGALIE , LACOMBE FRANCOIS , SANTOS PEDRO
Abstract: The confocal optical miniature head has optical convergers (12,13) to an excitation point (S) on a subsurface. There is a sweep system around the observation point. There is a mechanical microsystem (14a,14b) moving one of the lenses following an offset (DC) in two planes to obtain the sweep.
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