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公开(公告)号：AU2006320414A1
公开(公告)日：2007-06-07
申请号：AU2006320414
申请日：2006-12-01
Applicant: PACIFIC BIOSCIENCES CALIFORNIA
Inventor： OTTO GEOFFREY , TURNER STEPHEN , EID JOHN , MURPHY DEVON
Abstract: Compositions, devices, systems and methods for reducing and/or preventing photodamage of one or more reactants in illuminated analytical reactions by one or more of incorporating photodamage mitigating agents within the reaction mixture and/or interrogating different observation regions of the reaction mixture for a period that is less than a photodamage threshold period.
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公开(公告)号：WO2007075987A3
公开(公告)日：2009-01-29
申请号：PCT/US2006048973
申请日：2006-12-21
Applicant: PACIFIC BIOSCIENCES CALIFORNIA , HANZEL DAVID , KORLACH JONAS , PELUSO PAUL , OTTO GEOFFREY , PHAM THANG , RANK DAVID , TURNER STEPHEN
Inventor： HANZEL DAVID , KORLACH JONAS , PELUSO PAUL , OTTO GEOFFREY , PHAM THANG , RANK DAVID , TURNER STEPHEN
CPC classification number: C12Q1/6837 , C07K2319/23 , C12N9/1252 , C12Q1/6844 , C12Q2521/101 , C12Q2565/531
Abstract: Active surface coupled polymerases, surfaces that include such polymerases, and methods of making and using surface-attached polymerases are provided.
Abstract translation: 提供活性表面偶联的聚合酶，包括这种聚合酶的表面，以及制备和使用表面连接的聚合酶的方法。
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公开(公告)号：WO2007149724A3
公开(公告)日：2008-07-31
申请号：PCT/US2007070901
申请日：2007-06-11
Applicant: PACIFIC BIOSCIENCES CALIFORNIA , FOQUET MATHIEU , PELUSO PAUL , TURNER STEPHEN , ROITMAN DANIEL BERNARDO , OTTO GEOFFREY
Inventor： FOQUET MATHIEU , PELUSO PAUL , TURNER STEPHEN , ROITMAN DANIEL BERNARDO , OTTO GEOFFREY
IPC: G02B6/10
CPC classification number: G02B6/10 , G01N21/648 , G01N2021/7713
Abstract: Substrates, including zero mode waveguide substrates that have been fabricated to provide additional f?pclionai elements and/or components including increased volumes for positioning of active surfaces and or components for the mitigation of negative electrochemical properties of the underlying substrates.
Abstract translation: 衬底，包括零模式波导衬底，其已经被制造以提供额外的光伏元件和/或组件，包括用于定位有源表面的增加的体积和/或用于减轻下面衬底的负电化学性质的组件。
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公开(公告)号：CA2654470C
公开(公告)日：2015-02-03
申请号：CA2654470
申请日：2007-06-11
Applicant: PACIFIC BIOSCIENCES CALIFORNIA
Inventor： FOQUET MATHIEU , PELUSO PAUL , TURNER STEPHEN , ROITMAN DANIEL BERNARDO , OTTO GEOFFREY
Abstract: Substrates, including zero mode waveguide substrates that have been fabricated to provide additional f.upsilon..pi.clionai elements and/or components including increased volumes for positioning of active surfaces and or components for the mitigation of negative electrochemical properties of the underlying substrates.
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公开(公告)号：AU2009212165A1
公开(公告)日：2009-08-13
申请号：AU2009212165
申请日：2009-02-06
Applicant: PACIFIC BIOSCIENCES CALIFORNIA INC
Inventor： SHEN GENE , KONG XIANGXU , EMIG ROBIN , OTTO GEOFFREY
IPC: C07H21/00
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Patent Agency Ranking
公开(公告)号：AU2006331512A1
公开(公告)日：2007-07-05
申请号：AU2006331512
申请日：2006-12-21
Applicant: PACIFIC BIOSCIENCES CALIFORNIA
Inventor： KORLACH JONAS , OTTO GEOFFREY , HANZEL DAVID , PELUSO PAUL , TURNER STEPHEN , RANK DAVID , PHAM THANG
Abstract: Active surface coupled polymerases, surfaces that include such polymerases, and methods of making and using surface-attached polymerases are provided.
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公开(公告)号：CA2642937A1
公开(公告)日：2007-06-07
申请号：CA2642937
申请日：2006-12-01
Applicant: PACIFIC BIOSCIENCES CALIFORNIA
Inventor： EID JOHN , OTTO GEOFFREY , MURPHY DEVON , TURNER STEPHEN
Abstract: Compositions, devices, systems and methods for reducing and/or preventing photodamage of one or more reactants in illuminated analytical reactions by one or more of incorporating photodamage mitigating agents within the reaction mixture and/or interrogating different observation regions of the reaction mixture for a period that is less than a photodamage threshold period.
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公开(公告)号：EP1963530A4
公开(公告)日：2009-08-05
申请号：EP06848008
申请日：2006-12-21
Applicant: PACIFIC BIOSCIENCES CALIFORNIA
Inventor： HANZEL DAVID , KORLACH JONAS , PELUSO PAUL , OTTO GEOFFREY , PHAM THANG , RANK DAVID , TURNER STEPHEN
CPC classification number: C12Q1/6837 , C07K2319/23 , C12N9/1252 , C12Q1/6844 , C12Q2521/101 , C12Q2565/531
Abstract: Active surface coupled polymerases, surfaces that include such polymerases, and methods of making and using surface-attached polymerases are provided.
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公开(公告)号：EP2252625A4
公开(公告)日：2014-07-02
申请号：EP09707425
申请日：2009-02-06
Applicant: PACIFIC BIOSCIENCES CALIFORNIA
Inventor： OTTO GEOFFREY , SHEN GENE , KONG XIANGXU , EMIG ROBIN
Abstract: The present invention provides methods and compositions for performing illuminated reactions, particularly sequencing reactions, while mitigating and/or preventing photodamage to reactants that can result from prolonged illumination. In particular, the invention provides methods and compositions for incorporating photoprotective agents into conjugates comprising reporter molecules and nucleoside polyphosphates.
Abstract translation: 本发明提供用于进行照明反应，特别是测序反应的方法和组合物，同时减轻和/或防止可能由长时间照射引起的对反应物的光损伤。 特别地，本发明提供了将光保护剂掺入包含报道分子和核苷多磷酸的缀合物中的方法和组合物。
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公开(公告)号：EP2027253A4
公开(公告)日：2014-04-30
申请号：EP07845184
申请日：2007-06-11
Applicant: PACIFIC BIOSCIENCES CALIFORNIA
Inventor： FOQUET MATHIEU , PELUSO PAUL , TURNER STEPHEN , ROITMAN DANIEL BERNARDO , OTTO GEOFFREY
IPC: C12M3/00
CPC classification number: G02B6/10 , G01N21/648 , G01N2021/7713
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