公开(公告)号：EP2863905A4

公开(公告)日：2015-12-16

申请号：EP13807089

申请日：2013-06-14

Applicant: PORTOLA PHARM INC

Inventor： SONG YONGHONG ,  XU QING ,  SRAN ARVINDER ,  BAUER SHAWN M ,  JIA ZHAOZHONG J ,  KANE BRIAN ,  PANDEY ANJALI

IPC: C07D401/12 ,  A61K31/4439 ,  A61K31/444 ,  A61P9/10 ,  A61P29/00 ,  A61P35/00 ,  A61P37/00 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  C07D417/14 ,  C07D471/04

CPC classification number: C07D417/12 ,  C07D401/12 ,  C07D413/12 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04

公开(公告)号：EP2863748A4

公开(公告)日：2015-12-09

申请号：EP13807456

申请日：2013-06-14

Applicant: PORTOLA PHARM INC

Inventor： JIA ZHAOZHONG J ,  KANE BRIAN ,  ROSE JACK ,  BAUER SHAWN M ,  SONG YONGHONG ,  XU QING ,  PANDEY ANJALI

IPC: A01N43/64 ,  A01N43/707 ,  A61K31/53 ,  C07D253/075 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D403/14 ,  C07D405/12 ,  C07D405/14 ,  C07D409/12 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  C07D471/04 ,  C07D495/04

CPC classification number: C07D253/075 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D403/14 ,  C07D405/12 ,  C07D405/14 ,  C07D409/12 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  C07D471/04 ,  C07D495/04

Abstract: Provided are triazine compounds for inhibiting of Syk kinase, intermediates used in making such compounds, methods for their preparation, pharmaceutical compositions thereof, methods for inhibiting Syk kinase activity, and methods for treating conditions mediated at least in part by Syk kinase activity.

Abstract translation: 提供用于抑制Syk激酶的三嗪化合物，用于制备这种化合物的中间体，其制备方法，其药物组合物，抑制Syk激酶活性的方法，以及至少部分地通过Syk激酶活性介导的病症的治疗方法。

公开(公告)号：EP2900243A4

公开(公告)日：2016-04-13

申请号：EP13840922

申请日：2013-09-27

Applicant: PORTOLA PHARM INC

Inventor： PANDEY ANJALI ,  SONG YONGHONG ,  XU QING

IPC: A61K31/5365 ,  A61P11/00 ,  C07D498/04

CPC classification number: C07D498/04

公开(公告)号：EP2782579A4

公开(公告)日：2015-08-26

申请号：EP12852197

申请日：2012-11-23

Applicant: PORTOLA PHARM INC

Inventor： SONG YONGHONG ,  XU QING ,  JIA ZHAOZHONG J ,  KANE BRIAN ,  BAUER SHAWN M ,  PANDEY ANJALI

IPC: C07D403/12 ,  A61K31/4965 ,  A61P7/00 ,  A61P9/00 ,  A61P31/00 ,  A61P33/00 ,  A61P37/00 ,  C07D401/12 ,  C07D417/12

CPC classification number: C07D241/28 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D403/14 ,  C07D405/12 ,  C07D405/14 ,  C07D409/14 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  C07D417/14 ,  C07D471/04 ,  C07D495/04 ,  C07D513/04

Abstract: Provided are substituted pyrazine-2-carboxamide compounds of Formula I: useful for inhibiting of Syk kinase, intermediates used in making such compounds, methods for their preparation, pharmaceutical compositions thereof, methods for inhibition Syk kinase activity, and methods for treating conditions mediated at least in part by Syk kinase activity.

Abstract translation: 提供式I的取代吡嗪-2-甲酰胺化合物：可用于抑制Syk激酶，用于制备此类化合物的中间体，其制备方法，其药物组合物，抑制Syk激酶活性的方法和用于治疗在 至少部分由Syk激酶活性。

公开(公告)号：CA2960692C

公开(公告)日：2019-09-24

申请号：CA2960692

申请日：2009-04-16

Applicant: PORTOLA PHARM INC

Inventor： BAUER SHAWN M ,  JIA ZHAOZHONG J ,  SONG YONGHONG ,  XU QING ,  MEHROTRA MUKUND ,  ROSE JACK W ,  HUANG WOLIN ,  VENKATARAMANI CHANDRASEKAR ,  PANDEY ANJALI

IPC: C07D239/48 ,  A61K31/505 ,  A61K31/506 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D417/12

Abstract: The present specification is directed to compounds of formula I-II and pharmaceutically acceptable tautomers, salts, or stereoisomers thereof which are inhibitors of syk and/or JAK kinase. The present specification is also directed to intermediates used in making such compounds, the preparation of such a compound, methods for inhibition of syk and/or JAK kinase activity, methods for inhibition of the platelet aggregation, and methods to prevent or treat a number of conditions mediated at least in part by syk and/or JAK kinase activity, such as undesired thrombosis and Non Hodgkin's Lymphoma. The present specification is also directed to pharmaceutical compositions containing such a compound and which are formulated for topical administration.

公开(公告)号：CY1118559T1

公开(公告)日：2017-07-12

申请号：CY161101026

申请日：2016-10-13

Applicant: PORTOLA PHARM INC

Inventor： BAUER SHAWN M ,  JIA ZHAOZHONG J ,  SONG YONGHONG ,  XU QING ,  MEHROTRA MUKUND ,  ROSE JACK W ,  HUANG WOLIN ,  VENKATARAMANI CHANDRASEKAR ,  PANDEY ANJALI

IPC: C07D239/48 ,  A61K31/506 ,  A61P9/00 ,  A61P35/00 ,  C07D401/12 ,  C07D403/12 ,  C07D413/12 ,  C07D417/12

Abstract: ΗπαρούσαεφεύρεσηαναφέρεταισεενώσειςτουτύπουΙ-ΙΙκαιταφαρμακευτικάαποδεκτάταυτομερή, άλατα, ήταστερεοϊσομερήαυτών, ταοποίαείναιαναστολείςτηςκινάσης Syk και/ή JAK. Ηπαρούσαεφεύρεσηεπίσηςαναφέρεταισεενδιάμεσαπουχρησιμοποιούνταιστηνσύνθεσητέτοιωνενώσεων, τηνπαρασκευήμίαςτέτοιαςένωσης, τιςφαρμακευτικέςσυνθέσειςπουπεριέχουνμίατέτοιαένωση, τιςμεθόδουςαναστολήςτηςδραστικότηταςτηςκινάσης Syk και/ή JAK, τιςμεθόδουςαναστολήςτηςσυσσωμάτωσηςτωναιμοπεταλίων, καιτιςμεθόδουςγιατηνπρόληψηή τηθεραπείαενόςαριθμούπαθήσεωνπουπροκαλούνταιτουλάχιστονενμέρειαπότηνδραστικότητατηςκινάσης Syk και/ή JAK, όπωςη καρδιαγγειακήνόσος, ηφλεγμονώδηςνόσος, ηαυτοάνοσηνόσοςκαιη πολλαπλασιαστικήδιαταραχήκυττάρων, ηθρόμβωση, ηαλλεργία, τοάσθμα, ηρευματοειδήςαρθρίτιδα, ηλευχαιμία, ήτολέμφωμαμη-Hodgkin.

公开(公告)号：CA2723205C

公开(公告)日：2017-03-14

申请号：CA2723205

申请日：2009-04-16

Applicant: PORTOLA PHARM INC

Inventor： BAUER SHAWN M ,  JIA ZHAOZHONG J ,  SONG YONGHONG ,  XU QING ,  MEHROTRA MUKUND ,  ROSE JACK W ,  HUANG WOLIN ,  VENKATARAMANI CHANDRASEKAR ,  PANDEY ANJALI

IPC: C07D239/48 ,  A61K31/506 ,  A61P9/00 ,  A61P35/00 ,  C07D401/12 ,  C07D403/12 ,  C07D413/12 ,  C07D417/12

Abstract: The present invention is directed to compounds of formula I-II and pharmaceutically acceptable tautomers, salts, or stereoisomers thereof which are inhibitors of syk and/or JAK kinase. The present invention is also directed to intermediates used in making such compounds, the preparation of such a compound, pharmaceutical compositions containing such a compound, methods of inhibition syk and/or JAK kinase activity, methods of inhibition the platelet aggregation,and methods to prevent or treat a number of conditions mediated at least in part by syk and/or JAK kinase activity, such as cardiovascular disease, inflammatory disease, autoimmune disease and cell proliferative disorder, thrombosis, allergy, asthma, rheumatoid arthritis, leukemia, or non-Hodgkin's lymphoma.

公开(公告)号：LT2321283T

公开(公告)日：2016-12-12

申请号：LT09755219

申请日：2009-04-16

Applicant: PORTOLA PHARM INC

Inventor： BAUER SHAWN M ,  JIA ZHAOZHONG J ,  SONG YONGHONG ,  XU QING ,  MEHROTRA MUKUND ,  ROSE JACK W ,  HUANG WOLIN ,  VENKATARAMANI CHANDRASEKAR ,  PANDEY ANJALI

IPC: C07D239/48 ,  A61K31/506 ,  A61P9/00 ,  A61P35/00 ,  C07D401/12 ,  C07D403/12 ,  C07D413/12 ,  C07D417/12

公开(公告)号：HK1213252A1

公开(公告)日：2016-06-30

申请号：HK16101133

申请日：2016-02-01

Applicant: PORTOLA PHARM INC

Inventor： PANDEY ANJALI ,  SONG YONGHONG ,  XU QING

IPC: C07D20060101

公开(公告)号：NZ625114A

公开(公告)日：2016-02-26

申请号：NZ62511412

申请日：2012-11-23

Applicant: PORTOLA PHARM INC

Inventor： PANDEY ANJALI ,  SONG YONGHONG ,  XU QING ,  JIA ZHAOZHONG J ,  KANE BRIAN ,  BAUER SHAWN M

IPC: A61K31/4965 ,  C07D241/20 ,  C07D241/28

Abstract: Provided are pyrazine compounds for inhibiting of Syk kinase, intermediates used in making such compounds, methods for their preparation, pharmaceutical compositions thereof, methods for inhibition Syk kinase activity, and methods for treating conditions mediated at least in part by Syk kinase activity.