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公开(公告)号：FR2853649A1
公开(公告)日：2004-10-15
申请号：FR0304381
申请日：2003-04-09
Applicant: SERVIER LAB
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公开(公告)号：NO20041313L
公开(公告)日：2004-10-11
申请号：NO20041313
申请日：2004-03-30
Applicant: SERVIER LAB
Inventor： LESIEUR DANIEL , AUDINOT VALERIE , BENNEJEAN CAROLINE , WALLEZ VALERIE , RENARD PIERRE , YOUS SAID , DELAGRANGE PHILIPPE , POISSONNIER-DURIEUX SOPHIE , GASNEREAU ANNE , BOUTON JEAN ALBERT
IPC: C07D217/14 , A61K31/472 , A61P1/00 , A61P3/02 , A61P3/04 , A61P3/10 , A61P9/00 , A61P15/00 , A61P25/00 , A61P25/02 , A61P25/06 , A61P25/08 , A61P25/16 , A61P25/20 , A61P25/22 , A61P25/24 , A61P25/28 , A61P35/00 , A61P37/02 , A61P43/00 , C07D217/16 , C07D217/24 , C07D217/22 , A61K31/4353
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公开(公告)号：PT867436E
公开(公告)日：2004-09-30
申请号：PT98400711
申请日：1998-03-26
Applicant: SERVIER LAB
Inventor： PEGLION JEAN-LOUIS , MILLAN MARK , AUDINOT VALERIE , GOBERT ALAIN , GOUMENT BERTRAND
IPC: A61K31/443 , A61K31/4433 , A61K31/445 , A61P3/00 , A61P9/00 , A61P25/04 , A61P25/18 , A61P25/30 , C07D405/04 , C07D409/04 , C07D411/04 , C07D471/04 , A61K31/40
Abstract: N-Aryl piperidine derivatives of formula (I), their racemic mixtures, optical isomers and acid addition salts are new. m = 1-5; n = 1 or 2; R = H, 1-5C alkyl or aryl(1-5C) alkyl; E = H or Me; Ar = bicyclic heteroaryl (optionally substituted by halo); and A = adamantyl or bicyclic aryl or tricyclic heteroaryl (both optionally substituted).
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公开(公告)号：DE69631104D1
公开(公告)日：2004-01-29
申请号：DE69631104
申请日：1996-09-26
Applicant: SERVIER LAB
Inventor： PEGLION JEAN-LOUIS , VIAN JOEL , DESSINGES AIMEE , MILLAN MARK , AUDINOT VALERIE
IPC: C07D307/77 , A61K31/34 , A61K31/343 , A61K31/40 , A61P25/00 , A61P25/18 , A61P25/24 , A61P25/26 , A61P25/28 , C07D307/92 , C07D405/12
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公开(公告)号：FI111948B
公开(公告)日：2003-10-15
申请号：FI952802
申请日：1995-06-07
Applicant: INST NAT SANTE RECH MED , SERVIER LAB
Inventor： PEGLION JEAN-LOUIS , VIAN JOEL , GOUMENT BERTRAND , MILLAN MARK , AUDINOT VALERIE , SCHWARTZ JEAN-CHARLES , SOKOLOFF PIERRE
IPC: A61K31/435 , A61K31/4741 , A61K31/535 , A61K31/5383 , A61P25/00 , A61P25/16 , A61P25/18 , A61P25/24 , A61P25/26 , A61P25/28 , A61P25/30 , C07D491/04 , C07D491/048 , C07D491/153 , C07D498/04 , C07D498/14 , A61K31/34
Abstract: 1,4-Oxazine tetracyclic derivatives of formula (I) and their acid addition salts in racemic, optically active or enantiomeric forms are new. X, Y = O or CH2; A-B = -(CH2)2- or -HC=CH-, and when Y = O, then A-B may also be -(CH2)3-, when Y = CH2 then A-B may also be -H2C-CO- or -H2C-CHOH-; R = H, 1-10C alkyl, 3-10C alkenyl, 3-10C alkynyl, all of which opt. substd. by 3-8C cycloalkyl, or by phenyl, thienyl, and pyridyl, each of which may be substd. by one or more halogens, OH, or 1-6C alkyl or alkoxy; n = 0 or 1 when X = CH2, or is 1 when X = O.
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Patent Agency Ranking
公开(公告)号：HK1014954A1
公开(公告)日：1999-10-08
申请号：HK99100194
申请日：1999-01-14
Applicant: SERVIER LAB
Inventor： PEGLION JEAN-LOUIS , GOUMENT BERTRAND , MILLAN MARK , GOBERT ALAIN , AUDINOT VALERIE
IPC: A61K31/443 , A61K31/4433 , A61K31/445 , A61P3/00 , A61P9/00 , A61P25/04 , A61P25/18 , A61P25/30 , C07D405/04 , C07D409/04 , C07D411/04 , C07D471/04 , C07D , A61K
Abstract: N-Aryl piperidine derivatives of formula (I), their racemic mixtures, optical isomers and acid addition salts are new. m = 1-5; n = 1 or 2; R = H, 1-5C alkyl or aryl(1-5C) alkyl; E = H or Me; Ar = bicyclic heteroaryl (optionally substituted by halo); and A = adamantyl or bicyclic aryl or tricyclic heteroaryl (both optionally substituted).
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公开(公告)号：AU5967798A
公开(公告)日：1998-10-01
申请号：AU5967798
申请日：1998-03-27
Applicant: SERVIER LAB
Inventor： PEGLION JEAN-LOUIS , GOUMENT BERTRAND , MILLAN MARK , GOBERT ALAIN , AUDINOT VALERIE
IPC: A61K31/443 , A61K31/4433 , A61K31/445 , A61P3/00 , A61P9/00 , A61P25/04 , A61P25/18 , A61P25/30 , C07D405/04 , C07D409/04 , C07D411/04 , C07D471/04 , A61K31/47 , A61K31/455 , C07D405/10
Abstract: N-Aryl piperidine derivatives of formula (I), their racemic mixtures, optical isomers and acid addition salts are new. m = 1-5; n = 1 or 2; R = H, 1-5C alkyl or aryl(1-5C) alkyl; E = H or Me; Ar = bicyclic heteroaryl (optionally substituted by halo); and A = adamantyl or bicyclic aryl or tricyclic heteroaryl (both optionally substituted).
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18.发明专利
公开(公告)号：GEP20115240B
公开(公告)日：2011-06-10
申请号：GEAP2007011251
申请日：2007-10-17
Applicant: SERVIER LAB
Inventor： MARCHAND PASCAL , BABONNEAU VINCENT , PIESSARD SYLVIE , DUFLOS MURIEL , BOUTIN JEAN ALBERT , AUDINOT VALERIE , DELAGRANGE PHILIPPE , CAIGNARD DANIEL-HENRI
IPC: C07D209/32 , A61K31/4045
Abstract: An invention refers to compounds of formula (I) in which R1 is an alkyl, cycloalkyl or cycloalkylalkyl group, R2 and R3 form, together with the nitrogen atom which bears them, a heterocycle comprising from 5 to 8 ring members, and n is 2 to 6; also the use of compositions thereof for preparation of medicaments for treatment of melatoninergic system.
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公开(公告)号：GEP20115192B
公开(公告)日：2011-03-25
申请号：GEAP2007011252
申请日：2007-10-17
Applicant: SERVIER LAB
Inventor： MARCHAND PASCAL , BABONNEAU VINCENT , PIESSARD SYLVIE , DUFLOS MURIEL , BOUTIN JEAN ALBERT , AUDINOT VALERIE , DELAGRANGE PHILIPPE , CAIGNARD DANIEL-HENRI
IPC: C07D209/42 , A61K31/404 , A61P1/00 , A61P9/00 , A61P15/00 , A61P25/00 , A61P35/00
Abstract: The invention relates to compounds of formula in which R1 is an alkyl, cycloalkyl or cycloalkylalkyl group, R2 is a linear or branched (C1-C6) alkyl group, and n is 1 to 6, their compositions and use thereof for treatment of disorders in the melatoninergic system.
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公开(公告)号：MA30797B1
公开(公告)日：2009-10-01
申请号：MA31793
申请日：2009-04-16
Applicant: SERVIER LAB
Inventor： MARCHAND PASCAL , BABONNEAU VINCENT , PIESSARD SYLVIE , DUFLOS MURIEL , BOUTIN JEAN ALBERT , AUDINOT VALERIE , DELAGRANGE PHILIPPE , CAIGNARD DANIEL-HENRI
IPC: C07D209/32 , A61K31/4045
Abstract: COMPOSÉS DE FORMULE (I) : DANS LAQUELLE : R1 REPRÉSENTE UN GROUPEMENT ALKYLE, CYCLOALKYLE OU CYCLOALKYLALKYLE, R2 ET R3 FORMENT ENSEMBLE AVEC L'ATOME D'AZOTE QUI LES PORTE UN HÉTÉROCYCLE COMPORTANT DE 5 À 8 CHAÎNONS, ET N REPRÉSENTE 2 À 6, MÉDICAMENTS.
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