-
公开(公告)号：GB2485729B
公开(公告)日：2012-07-25
申请号：GB201203865
申请日：2008-12-19
Applicant: SINGULEX INC
Inventor： LIVINGSTON RICHARD A
Abstract: The invention encompasses analyzers and analyzer systems that include a single molecule analyzer, methods of using the analyzer and analyzer systems to analyze samples, either for single molecules or for molecular complexes. The single molecule uses electromagnetic radiation that is translated through the sample to detect the presence or absence of a single molecule. The single molecule analyzer provided herein is useful for diagnostics because the analyzer detects single molecules with zero carryover between samples.
-
公开(公告)号：GB2485729A
公开(公告)日：2012-05-23
申请号：GB201203865
申请日：2008-12-19
Applicant: SINGULEX INC
Inventor： LIVINGSTON RICHARD A
Abstract: A single molecule analyser comprises an electromagnetic radiation source for providing radiation to a substantially transparent sample container holding one or more samples, a system for directing radiation to an interrogation space in a sample such that the sample emits radiation from a single type of label attached to a single molecule, a translating system for translating the sample container to form a movable interrogation space in a sample, a microscope objective to define the interrogation space, a detector for detecting radiation from the label attached to the molecule, and analysis means to determine presence of the single molecule. The single molecule analyzer is useful for diagnostics as the analyzer detects single molecules with zero carryover between samples.
-
公开(公告)号：AU2009234106A1
公开(公告)日：2009-10-15
申请号：AU2009234106
申请日：2009-03-04
Applicant: SINGULEX INC
Inventor： GOIX PHILIPPE J , HELD DOUGLAS , PUSKAS ROBERT , TODD JOHN , AGEE SARA , LIVINGSTON RICHARD A
Abstract: The present invention discloses methods for the detection and monitoring of a condition in a subject using highly sensitive detection of molecules. The invention provides a method for detecting or monitoring a condition in a subject, comprising detecting a first marker in a first sample from the subject and detecting a second marker, wherein the first marker comprises a biomarker, e.g., Cardiac Troponin-I (cTnI) or Vascular Endothelial Growth Factor (VEGF), and wherein the limit of detection of the first marker is less than about 10 pg/ml. The second marker can be a biomarker, physiological marker, a molecular marker or a genetic marker.
-
公开(公告)号：GB2458025A
公开(公告)日：2009-09-09
申请号：GB0903848
申请日：2009-03-05
Applicant: SINGULEX INC
Inventor： GOIX PHILIPPE J , PUSKAS ROBERT , TODD JOHN , LIVINGSTON RICHARD A , HELD DOUGLAS , AGEE SARA
Abstract: A method for detecting and monitoring a condition in a subject using a single molecule detector is disclosed comprising detecting a first marker in a first sample from the subject, wherein the first marker comprises a biomarker such as Cardiac Troponin-I (cTnI), and wherein the limit of detection of the first marker is less than 20 pg/ml, and further comprising the detection of a second marker as a further indication of the condition to be detected. The second marker can be a biomarker, physiological marker, a molecular marker or a genetic marker. Also claimed are similar methods involving the detection of Vascular Endothelial Growth Factor (VEGF), pro B-type Natriuretic Peptide (proBNP), TREM-1, Interleukin 1 Alpha (IL-1 a ), IL- 1 b , IL-4, IL-6, IL-8, IL-10, Interferon gamma (IFN- q ), Tumour Necrosis Factor alpha (TNF- a ), Glucagon-like peptide-1 (GLP-1), Leukotriene E4 (LTE4), Transforming Growth Factor Beta (TGF- b ), Akt1, A b -40, A b -42, and Fas ligand (FasL). The markers may be detected using fluorescent labels.
-
公开(公告)号：AU2005290314A1
公开(公告)日：2006-04-06
申请号：AU2005290314
申请日：2005-01-28
Applicant: SINGULEX INC
Inventor： URDEA MICKEY , FREESE ROBERT , PUSKAS ROBERT , LIVINGSTON RICHARD A , KLEIN BARBARA , GIOX PHILIPPE , DAVID PETER , FUKUSHIMA NOELLE , HELD DOUGLAS D
Abstract: The invention encompasses analyzers and analyzer systems that include a single particle analyzer, methods of using the analyzers and analyzers systems to analyze samples, either for single particles or for multiple particles (multiplexing), methods of doing business based on the use of the analyzers or analyzer systems of the system, and electronic media for storing parameters useful in the analyzers and analyzer systems of the invention.
-
Patent Agency Ranking
公开(公告)号：WO2009126380A3
公开(公告)日：2009-12-03
申请号：PCT/US2009036086
申请日：2009-03-04
Applicant: SINGULEX INC , GOIX PHILIPPE J , PUSKAS ROBERT , TODD JOHN , LIVINGSTON RICHARD A , HELD DOUGLAS , AGEE SARA
Inventor： GOIX PHILIPPE J , PUSKAS ROBERT , TODD JOHN , LIVINGSTON RICHARD A , HELD DOUGLAS , AGEE SARA
IPC: G01N33/53
CPC classification number: G01N33/577 , A61B5/00 , A61B5/0402 , A61B5/412 , A61B5/415 , A61B5/418 , A61B5/7264 , A61B5/7275 , G01N21/6428 , G01N33/582 , G01N33/6863 , G01N33/6869 , G01N33/6872 , G01N33/6887 , G01N33/6896 , G01N33/74 , G01N33/92 , G01N2333/4712 , G01N2333/475 , Y02A90/26 , Y10T436/143333
Abstract: The present invention discloses methods for the detection and monitoring of a condition in a subject using highly sensitive detection of molecules. The invention provides a method for detecting or monitoring a condition in a subject, comprising detecting a first marker in a first sample from the subject and detecting a second marker, wherein the first marker comprises a biomarker, e.g., Cardiac Troponin-I (cTnl) or Vascular Endothelial Growth Factor (VEGF), and wherein the limit of detection of the first marker is less than about 10 pg/ml. The second marker can be a biomarker, physiological marker, a molecular marker or a genetic marker.
Abstract translation: 本发明公开了使用分子的高灵敏度检测来检测和监测受试者状况的方法。 本发明提供了用于检测或监测受试者状况的方法，包括检测来自受试者的第一样品中的第一标志物和检测第二标志物，其中第一标志物包含生物标志物，例如心脏肌钙蛋白-I（cTnI） 或血管内皮生长因子（VEGF），并且其中第一标记的检测极限小于约10pg / ml。 第二个标记可以是生物标记，生理标记，分子标记或遗传标记。
-
公开(公告)号：WO2006036182A2
公开(公告)日：2006-04-06
申请号：PCT/US2005003524
申请日：2005-01-28
Applicant: SINGULEX INC , PUSKAS ROBERT , GIOX PHILIPPE , LIVINGSTON RICHARD A , HELD DOUGLAS D , KLEIN BARBARA , FUKUSHIMA NOELLE , FREESE ROBERT , DAVID PETER , URDEA MICKEY
Inventor： PUSKAS ROBERT , GIOX PHILIPPE , LIVINGSTON RICHARD A , HELD DOUGLAS D , KLEIN BARBARA , FUKUSHIMA NOELLE , FREESE ROBERT , DAVID PETER , URDEA MICKEY
IPC: G01N24/00
CPC classification number: G01N35/1095 , G01N1/28 , G01N15/1459 , G01N21/6428 , G01N27/447 , G01N33/68 , G01N33/6803 , G01N33/6845 , G01N2015/1438 , G01N2035/1034
Abstract: The invention encompasses analyzers and analyzer systems that include a single particle analyzer, methods of using the analyzers and analyzers systems to analyze samples, either for single particles of for multiple particles (multiplexing), methods of doing business based on the use of the analyzers or analyzer systems of the system, and electronic media for storing parameters useful in the analyzers and analyzer systems of the invention.
Abstract translation: 本发明包括分析器和分析器系统，其包括单个粒子分析器，使用分析器和分析器系统分析样品的方法，用于多个粒子的单个粒子（复用），基于使用分析器的业务方法或 系统的分析器系统和用于存储在本发明的分析器和分析器系统中有用的参数的电子介质。
-
公开(公告)号：EP2263085A4
公开(公告)日：2011-07-06
申请号：EP09731410
申请日：2009-03-04
Applicant: SINGULEX INC
Inventor： GOIX PHILIPPE J , PUSKAS ROBERT , TODD JOHN , LIVINGSTON RICHARD A , HELD DOUGLAS , LE SARA
IPC: G01N33/53
CPC classification number: G01N33/577 , A61B5/00 , A61B5/0402 , A61B5/412 , A61B5/415 , A61B5/418 , A61B5/7264 , A61B5/7275 , G01N21/6428 , G01N33/582 , G01N33/6863 , G01N33/6869 , G01N33/6872 , G01N33/6887 , G01N33/6896 , G01N33/74 , G01N33/92 , G01N2333/4712 , G01N2333/475 , Y02A90/26 , Y10T436/143333
Abstract: The present invention discloses methods for the detection and monitoring of a condition in a subject using highly sensitive detection of molecules. The invention provides a method for detecting or monitoring a condition in a subject, comprising detecting a first marker in a first sample from the subject and detecting a second marker, wherein the first marker comprises a biomarker, e.g., Cardiac Troponin-I (cTnI) or Vascular Endothelial Growth Factor (VEGF), and wherein the limit of detection of the first marker is less than about 10 pg/ml. The second marker can be a biomarker, physiological marker, a molecular marker or a genetic marker.
-
19.发明公开SCANNING ANALYZER FOR SINGLE MOLECULE DETECTION AND METHODS OF USE 审中-公开扫描分析仪ZUREINZELMOLEKÜLERKENNUNGUND VERFAHREN ZU SEINER ANWENDUNG
公开(公告)号：EP2232271A4
公开(公告)日：2014-12-10
申请号：EP08873367
申请日：2008-12-18
Applicant: SINGULEX INC
Inventor： LIVINGSTON RICHARD A
CPC classification number: G01N21/6428 , B01L3/5085 , B01L2300/0654 , B01L2300/0829 , G01N15/14 , G01N15/1434 , G01N15/1456 , G01N15/1463 , G01N21/00 , G01N21/01 , G01N21/64 , G01N21/645 , G01N33/53 , G01N2015/0038 , G01N2015/1447 , G01N2015/1452 , G01N2201/02 , G01N2201/06113 , G01N2201/062 , G01N2201/0697
Abstract: The invention encompasses analyzers and analyzer systems that include a single molecule analyzer, methods of using the analyzer and analyzer systems to analyze samples, either for single molecules or for molecular complexes. The single molecule uses electromagnetic radiation that is translated through the sample to detect the presence or absence of a single molecule. The single molecule analyzer provided herein is useful for diagnostics because the analyzer detects single molecules with zero carryover between samples.
Abstract translation: 本发明包括分析仪和分析仪系统，其包括单分子分析仪，使用分析仪和分析仪系统分析样品的单分子或分子复合物的方法。 单分子使用通过样品翻译的电磁辐射来检测单个分子的存在或不存在。 本文提供的单分子分析仪可用于诊断，因为分析仪检测到样品之间具有零携带的单分子。
-
公开(公告)号：EP1805500A4
公开(公告)日：2008-05-07
申请号：EP05757239
申请日：2005-01-28
Applicant: SINGULEX INC
Inventor： PUSKAS ROBERT , GOIX PHILIPPE , LIVINGSTON RICHARD A , HELD DOUGLAS D , KLEIN BARBARA , FUKUSHIMA NOELLE , FREESE ROBERT , DAVID PETER , URDEA MICKEY
CPC classification number: G01N35/1095 , G01N1/28 , G01N15/1459 , G01N21/6428 , G01N27/447 , G01N33/68 , G01N33/6803 , G01N33/6845 , G01N2015/1438 , G01N2035/1034
Abstract: The invention encompasses analyzers and analyzer systems that include a single particle analyzer, methods of using the analyzers and analyzers systems to analyze samples, either for single particles of for multiple particles (multiplexing), methods of doing business based on the use of the analyzers or analyzer systems of the system, and electronic media for storing parameters useful in the analyzers and analyzer systems of the invention.
-
-
-
-
-
-
-
-
-
Search Results
20
records
(took 0.023 seconds)
