公开(公告)号：AU2007299010A1

公开(公告)日：2008-03-27

申请号：AU2007299010

申请日：2007-09-17

Applicant: SOLVAY PHARM GMBH

Inventor： SCHOEN UWE ,  HUSEN BETTINA ,  MESSINGER JOSEF ,  KOSKIMIES PASI ,  KALLIO LILA ,  THOLE HEINRICH-HUBERT

IPC: A61K31/58 ,  A61P5/32 ,  A61P13/00 ,  A61P35/00 ,  C07J43/00

公开(公告)号：HK1096105A1

公开(公告)日：2007-05-25

申请号：HK07103455

申请日：2007-03-30

Applicant: SOLVAY PHARM GMBH

Inventor： HOELTJE DAGMAR ,  FISCHER YVAN ,  ZIEGLER DIETER ,  WESKE MICHAEL ,  MICHAELIS KATHRIN ,  KARIMI-NEJAD YASMIN ,  MESSINGER JOSEF ,  PAHL AXEL ,  HOEFER CONSTANZE ,  IKONOMIDOU HRISSANTHI ,  TURSKI LECHOSLAW

IPC: A61K20090101 ,  A61K38/00 ,  A61P20090101 ,  A61P9/12 ,  C07K20090101 ,  C07K5/02 ,  C07K5/078

Abstract: Described are novel compounds with neutral endopeptidase (NEP) and/or human soluble endopeptidase (hSEP) inhibitory activity of the general formula (I), wherein the substituents R , R , R and R have the meanings given in the description and also medicaments containing these compounds, in particular medicaments suitable for treating or preventing cardiovascular diseases, sexual dysfunction and/or adverse conditions associated with apoptosis.

公开(公告)号：CA2624015A1

公开(公告)日：2007-04-12

申请号：CA2624015

申请日：2006-09-28

Applicant: SOLVAY PHARM GMBH

Inventor： HINAJE MARIA ,  KLINGER-DABRAL VIBHUTI ,  BOECKER CHRISTIANE ,  THOLE HEINRICH-HUBERT ,  MESSINGER JOSEF ,  HUSEN BETTINA ,  MARK CHRISTOPH ,  BUCHHOLZ MONIKA

IPC: C07J15/00 ,  A61K31/57 ,  A61P5/34 ,  A61P5/36

Abstract: Described herein are new retrosteroidal compounds of general formula (I), representing progesterone receptor modulators, and their production, and pharmaceutical preparations containing these compounds. Said compounds are preferably used for the treatment of benign gynecological disorders such as endometriosis and uterine fibroids, as well as for female birth control and for HRT.

公开(公告)号：NO20061821A

公开(公告)日：2006-06-22

申请号：NO20061821

申请日：2006-04-25

Applicant: SOLVAY PHARM GMBH

Inventor： TURSKI LECHOSLAW ,  ZIEGLER DIETER ,  MESSINGER JOSEF ,  WESKE MICHAEL ,  PAHL AXEL ,  HOELTJE DAGMAR ,  FISCHER YVAN ,  MICHAELIS KATHRIN ,  KARIMI-NEJAD YASMIN ,  HOEFER CONSTANZE ,  IKONOMIDOU HRISSANTHI

IPC: C07K5/06 ,  A61K38/00 ,  A61K38/05 ,  A61P9/12 ,  C07K5/02 ,  C07K5/078

CPC classification number: C07K5/06139 ,  A61K38/00 ,  C07K5/0222 ,  Y02A50/409

Abstract: Described are novel compounds with neutral endopeptidase (NEP) and/or human soluble endopeptidase (hSEP) inhibitory activity of the general formula (I), wherein the substituents R , R , R and R have the meanings given in the description and also medicaments containing these compounds, in particular medicaments suitable for treating or preventing cardiovascular diseases, sexual dysfunction and/or adverse conditions associated with apoptosis.

公开(公告)号：AU2004325692A1

公开(公告)日：2006-06-22

申请号：AU2004325692

申请日：2004-12-13

Applicant: SOLVAY PHARM GMBH

Inventor： HIRVELA LEENA ,  KOSKIMIES PASI ,  MESSINGER JOSEF ,  LEHTOVUORI PEKKA ,  THOLE HEINRICH-HUBERT ,  SAARENKETO PAULI ,  HUSEN BETTINA ,  STEEN BARTHOLOMEUS JOHANNES VA ,  PIRKKALA LILA ,  KIVINIEMI JOHANNA ,  PENTIKAINEN OLLI TANELI ,  UNKILA MIKKO

IPC: C07D495/04 ,  A61K31/519

公开(公告)号：AU2004289459A1

公开(公告)日：2005-05-26

申请号：AU2004289459

申请日：2004-11-11

Applicant: SOLVAY PHARM GMBH

Inventor： THOLE HEINRICH-HUBERT ,  KOSKIMIES PASI ,  SCHNEIDER GYULA ,  JOHANSSON NINA ,  HUSEN BETTINA ,  STEEN BARTHOLOMEUS JOHANNES VA ,  ADAMSKI JERZY ,  HULSHOF JOHANNES BERNARDUS EVE ,  MESSINGER JOSEF

IPC: A61K31/565 ,  C07J1/00

Abstract: The present invention relates to novel 3, 15 substituted estrone derivatives which represent inhibitory compounds of the 17beta-hydroxysteroid dehydrogenase type I (17beta-HSD1), to their salts, to pharmaceutical preparations containing these compounds and to processes for the preparation of these compounds. Furthermore, the invention concerns the therapeutic use of said novel 3, 15 substituted estrone derivatives, particularly their use in the treatment or prevention of steroid hor­mone dependent diseases or disorders, such as steroid hormone dependent diseases or disorders requiring the inhibition of 17beta-hydroxysteroid dehydrogenase type I enzymes and/or requiring the lowering of the endogenous 17beta-estradiol concentration. In addition, the present invention relates to the general use of selective 17beta-hydroxysteroid dehydrogenase type 1 inhibitors which possess in addition no or only pure antagonistic binding affinities to the estrogen receptor for the treatment and prevention of benign gynaecological disorders, in particular endometriosis.

公开(公告)号：CA2539895A1

公开(公告)日：2005-04-07

申请号：CA2539895

申请日：2004-09-23

Applicant: SOLVAY PHARM GMBH

Inventor： FISCHER YVAN ,  MICHAELIS KATHRIN ,  TURSKI LECHOSLAW ,  IKONOMIDOU HRISSANTHI ,  HOELTJE DAGMAR ,  PAHL AXEL ,  MESSINGER JOSEF ,  KARIMI-NEJAD YASMIN ,  HOEFER CONSTANZE ,  WESKE MICHAEL ,  ZIEGLER DIETER

IPC: C07K5/06 ,  A61K38/00 ,  A61K38/05 ,  A61P9/12 ,  C07K5/02 ,  C07K5/078

Abstract: Described are novel compounds with neutral endopeptidase (NEP) and/or human soluble endopeptidase (hSEP) inhibitory activity of the general formula (I), wherein the substituents R , R , R and R have the meanings given in the description and also medicaments containing these compounds, in particular medicaments suitable for treating or preventing cardiovascular diseases, sexual dysfunction and/or adverse conditions associated with apoptosis.

公开(公告)号：SI1270576T1

公开(公告)日：2005-02-28

申请号：SI200230027

申请日：2002-06-22

Applicant: SOLVAY PHARM GMBH

Inventor： SCHOEN UWE ,  MESSINGER JOSEF ,  BRUECKNER REINHARD ,  ZIEGLER DIETER

IPC: A61K31/435 ,  A61K31/439 ,  A61P9/00 ,  A61P9/06 ,  C07D221/00 ,  C07D471/08 ,  C07D471/10

Abstract: 7-Alkyl-3-(substituted phenyl)-9,9-(dialkyl or alkylene)-3,7-diazabicyclo (3.3.1) nonane derivatives (I) are new. Diazabicyclononane derivatives of formula (I) and their acid addition salts are new. R1 = 1-6C alkyl or 4-7C cycloalkylalkyl; R2, R3 = 1-4C alkyl; or R2 + R3 = 3-6C alkylene; and R4 = phenyl (monosubstituted in the ortho- or para-position by NO2, CN or 2-5C alkanoyl) or 2,4-dinitrophenyl. An Independent claim is also included for the preparation of (I).

公开(公告)号：TR200402391T4

公开(公告)日：2004-12-21

申请号：TR200402391

申请日：2002-06-22

Applicant: SOLVAY PHARM GMBH

Inventor： SCHOEN UWE ,  MESSINGER JOSEF ,  BRUECKNER REINHARD ,  ZIEGLER DIETER

IPC: A61K31/435 ,  A61K31/439 ,  A61P9/00 ,  A61P9/06 ,  C07D221/00 ,  C07D471/08 ,  C07D471/10

Abstract: 7-Alkyl-3-(substituted phenyl)-9,9-(dialkyl or alkylene)-3,7-diazabicyclo (3.3.1) nonane derivatives (I) are new. Diazabicyclononane derivatives of formula (I) and their acid addition salts are new. R1 = 1-6C alkyl or 4-7C cycloalkylalkyl; R2, R3 = 1-4C alkyl; or R2 + R3 = 3-6C alkylene; and R4 = phenyl (monosubstituted in the ortho- or para-position by NO2, CN or 2-5C alkanoyl) or 2,4-dinitrophenyl. An Independent claim is also included for the preparation of (I).

公开(公告)号：BR0202419A

公开(公告)日：2003-04-29

申请号：BR0202419

申请日：2002-06-26

Applicant: SOLVAY PHARM GMBH

Inventor： SCHOEN UWE ,  MESSINGER JOSEF ,  BRUECKNER REINHARD ,  ZIEGLER DIETER

IPC: A61K31/435 ,  A61K31/439 ,  A61P9/00 ,  A61P9/06 ,  C07D221/00 ,  C07D471/08 ,  C07D471/10 ,  C07D471/06 ,  A61K31/4353

Abstract: 7-Alkyl-3-(substituted phenyl)-9,9-(dialkyl or alkylene)-3,7-diazabicyclo (3.3.1) nonane derivatives (I) are new. Diazabicyclononane derivatives of formula (I) and their acid addition salts are new. R1 = 1-6C alkyl or 4-7C cycloalkylalkyl; R2, R3 = 1-4C alkyl; or R2 + R3 = 3-6C alkylene; and R4 = phenyl (monosubstituted in the ortho- or para-position by NO2, CN or 2-5C alkanoyl) or 2,4-dinitrophenyl. An Independent claim is also included for the preparation of (I).