公开(公告)号：CA2499298A1

公开(公告)日：2004-04-29

申请号：CA2499298

申请日：2003-10-17

Applicant: SYMYX TECHNOLOGIES INC

Inventor： PINKAS DANIEL M ,  MATSIEV LEONID ,  BENNETT JAMES ,  SPITKOVSKY MIKHAIL ,  KOLOSOV OLEG ,  GUAN SHENHENG

IPC: G01F23/296 ,  G01N9/00 ,  G01N11/16 ,  G01N29/036 ,  G01N29/34 ,  G01N29/02

Abstract: A method for analyzing a fluid contained within a machine, comprising the steps of providing a machine system (100) including a passage (104) for containing a fluid; placing a sensor (106) including a mechanical resonator in the passage; operating the resonator to have a portion thereof translate through the fluid; and monitoring the response of the resonator to the fluid in the passage. One specific sensor includes a tuning fork resonator.

公开(公告)号：DE69814035D1

公开(公告)日：2003-06-05

申请号：DE69814035

申请日：1998-10-02

Applicant: SYMYX TECHNOLOGIES INC

Inventor： MATSIEV LEONID ,  BENNETT JAMES ,  MCFARLAND ERIC

IPC: G01H13/00 ,  G01N5/04 ,  G01N9/00 ,  G01N29/02 ,  G01N29/036 ,  G01N29/34 ,  G01N29/42 ,  G01N29/44 ,  H03H9/19

Abstract: A method and apparatus for measuring properties of a liquid composition includes a mechanical resonator, such as a thickness shear mode resonator or a tuning fork resonator, connected to a measurement circuit. The measurement circuit provides a variable frequency input signal to the tuning fork, causing the mechanical resonator to oscillate. To test the properties of a liquid composition, the mechanical resonator is placed inside a sample well containing a small amount of the liquid. The input signal is then sent to the mechanical resonator and swept over a selected frequency range, preferably less than 1 MHz to prevent the liquid being tested from exhibiting gel-like characteristics and causing false readings. The mechanical resonator's response over the frequency range depends on various characteristics of the liquid being tested, such as the temperature, viscosity, and other physical properties. Particular mechanical resonators, such as tuning fork resonators, can also be used to measure a liquid composition's electrical properties, such as the dielectric constant and conductivity, because the tuning fork's structure allows a high degree of electrical coupling between the tuning fork and the surrounding liquid. The mechanical resonator can be covered with a coating to impart additional special detection properties to the resonator, and multiple resonators can be attached together as a single sensor to obtain multiple frequency responses. The invention is particularly suitable for combinatorial chemistry applications, which require rapid analysis of chemical properties for screening.

公开(公告)号：CA2290394A1

公开(公告)日：1999-10-14

申请号：CA2290394

申请日：1999-04-02

Applicant: SYMYX TECHNOLOGIES INC

Inventor： PETRO MIROSLAV ,  CARLSON ERIC ,  SAFIR ADAM ,  KUEBLER SIGRID C ,  NIELSEN RALPH B ,  DALES G CAMERON ,  LEE THOMAS S ,  BENNETT JAMES ,  FRECHET JEAN M J

IPC: G01N37/00 ,  B01D15/08 ,  B01D15/26 ,  B01D15/32 ,  B01D15/34 ,  B01J19/00 ,  B01J19/26 ,  C40B40/14 ,  C40B40/18 ,  G01N1/00 ,  G01N15/02 ,  G01N30/02 ,  G01N30/16 ,  G01N30/24 ,  G01N30/30 ,  G01N30/32 ,  G01N30/46 ,  G01N30/54 ,  G01N30/60 ,  G01N30/88 ,  G01N30/90 ,  G01N33/44 ,  G01N35/08 ,  G01N1/14 ,  G01N21/53 ,  G01N30/74

Abstract: Rapid characterization and screening of polymer samples to determine average molecular weight, molecular weight distribution and other properties is disclosed. Rapid flow characterization systems and methods, including liquid chromatography and flow-injection analysis systems and methods are preferably employed. High throughput, automated sampling systems and methods, hightemperature characterization systems and methods, and rapid, indirect calibration compositions and methods are also disclosed. The described methods, systems, and devices have primary applications in combinatorial polymer research and in industrial process control.

公开(公告)号：WO2006107900A2

公开(公告)日：2006-10-12

申请号：PCT/US2006012374

申请日：2006-03-31

Applicant: SYMYX TECHNOLOGIES INC ,  CYPES STEPHEN ,  UHRICH MARK ,  CARLSON ERIC D ,  KOLOSOV OLEG ,  PADOWITZ DAVID ,  BENNETT JAMES ,  MATSIEV LEONID

Inventor： CYPES STEPHEN ,  UHRICH MARK ,  CARLSON ERIC D ,  KOLOSOV OLEG ,  PADOWITZ DAVID ,  BENNETT JAMES ,  MATSIEV LEONID

IPC: G01N29/02 ,  G01N9/00 ,  G01N11/10 ,  G01N27/00 ,  G01N29/036 ,  G01N29/22

CPC classification number: B01D5/009 ,  B01D3/00 ,  B01D3/06 ,  B01D3/14 ,  B01D3/22 ,  B01D3/322 ,  B01J19/0006 ,  B01J2219/00191 ,  G01N9/002 ,  G01N29/022 ,  G01N29/036 ,  G01N29/222 ,  G01N2291/0226 ,  G01N2291/0253 ,  G01N2291/0254 ,  G01N2291/0255 ,  G01N2291/0256 ,  G01N2291/02818 ,  G01N2291/0426 ,  G01N2291/0427 ,  G01N2291/101 ,  G01N2291/106

Abstract: Fluid sensor methods and systems adapted for monitoring and/or controlling distillation operations in fluidic systems, such as batch distillation operations or continuous distillation operations, are disclosed. Preferred embodiments are directed to process monitoring and/or process control for unit operations involving endpoint determination of a distillation, for example, as applied to a liquid-component-switching operation (e.g., a solvent switching operation), a liquid-liquid separation operation, a solute concentration operation, a dispersed-phase concentration operation, among others.

Abstract translation: 公开了用于监测和/或控制流体系统中的蒸馏操作的流体传感器方法和系统，例如间歇式蒸馏操作或连续蒸馏操作。 优选的实施方案涉及涉及终点确定蒸馏的单元操作的过程监控和/或过程控制，例如应用于液体成分切换操作（例如，溶剂切换操作），液 - 液分离操作 溶质浓缩操作，分散相浓缩操作等。

公开(公告)号：WO2005103674A3

公开(公告)日：2006-06-01

申请号：PCT/US2005013642

申请日：2005-04-20

Applicant: SYMYX TECHNOLOGIES INC ,  KOLOSOV OLEG ,  BENNETT JAMES ,  DALES CAMERON G ,  FEELAND JOHN M III ,  LOW ERIC ,  MATSEIV LEONID ,  RUST WILLIAM C ,  SPITKOVSKY MIKHAIL ,  UHRICH MARK

Inventor： KOLOSOV OLEG ,  BENNETT JAMES ,  DALES CAMERON G ,  FEELAND JOHN M III ,  LOW ERIC ,  MATSEIV LEONID ,  RUST WILLIAM C ,  SPITKOVSKY MIKHAIL ,  UHRICH MARK

IPC: G01H13/00 ,  G01F23/296 ,  G01N9/00 ,  G01N11/16 ,  G01N29/02 ,  G01N29/22

CPC classification number: G01F23/2967 ,  G01N9/002 ,  G01N11/16 ,  G01N29/022 ,  G01N29/222 ,  G01N2291/02818 ,  G01N2291/02836 ,  G01N2291/0422 ,  G01N2291/0423 ,  G01N2291/0426 ,  G01N2291/0427

Abstract: In the methods, systems and apparatus of the present invention, a property of a fluid in a fluidic system is monitored using a sensor interfaced with the fluidic system. In some embodiments, the interfaced sensor is formed from and includes at least one sensor subassembly interfaced with an installed unit that is either a sensor or another sensor subassembly. Likewise, the systems and apparatus of the present invention comprise a sensor or a sensor subassembly. In each case, the sensor is a flexural resonator sensor. In preferred embodiments, a flexural resonator sensor comprises a flexural resonator sensing element having a sensing surface for contacting the fluid being sensed. In operation during a sensing period, the sensing surface of a flexural resonator displaces or is displaced by at least a portion of the fluid being sensed.

Abstract translation: 在本发明的方法，系统和装置中，使用与流体系统接口的传感器监测流体系统中的流体的性质。 在一些实施例中，接口传感器由与包括传感器或另一个传感器子组件的安装单元相连接的至少一个传感器子组件形成并且包括至少一个传感器子组件。 同样，本发明的系统和装置包括传感器或传感器子组件。 在每种情况下，传感器是弯曲谐振器传感器。 在优选实施例中，弯曲谐振器传感器包括弯曲谐振器感测元件，其具有用于接触被感测的流体的感测表面。 在感测周期期间的操作中，弯曲谐振器的感测表面被待感测的流体的至少一部分置换或移位。

公开(公告)号：CA2290394C

公开(公告)日：2006-02-28

申请号：CA2290394

申请日：1999-04-02

Applicant: SYMYX TECHNOLOGIES INC

Inventor： LEE THOMAS S ,  NIELSEN RALPH B ,  FRECHET JEAN M J ,  SAFIR ADAM ,  BENNETT JAMES ,  CARLSON ERIC ,  DALES G CAMERON ,  KUEBLER SIGRID C ,  PETRO MIROSLAV

IPC: G01N30/02 ,  G01N37/00 ,  B01D15/08 ,  B01D15/26 ,  B01D15/32 ,  B01D15/34 ,  B01J19/00 ,  B01J19/26 ,  C40B40/14 ,  C40B40/18 ,  G01N1/00 ,  G01N1/14 ,  G01N15/02 ,  G01N21/53 ,  G01N30/16 ,  G01N30/24 ,  G01N30/30 ,  G01N30/32 ,  G01N30/46 ,  G01N30/54 ,  G01N30/60 ,  G01N30/74 ,  G01N30/88 ,  G01N30/90 ,  G01N33/44 ,  G01N35/08

Abstract: Rapid characterization and screening of polymer samples to determine average molecular weight, molecular weight distribution and other properties is disclosed. Rapid flow characterization systems and methods, including liquid chromatography and flow-injection analysis systems and methods are preferably employed. High throughput, automated sampling systems and methods, high-temperature characterization systems and methods, and rapid, indirect calibration compositions and methods are also disclosed. The described methods, systems, and devices have primary applications in combinatorial polymer research and in industrial process control.

公开(公告)号：ES2199467T3

公开(公告)日：2004-02-16

申请号：ES98949736

申请日：1998-10-02

Applicant: SYMYX TECHNOLOGIES INC

Inventor： MATSIEV LEONID ,  BENNETT JAMES ,  MCFARLAND ERIC

IPC: G01H13/00 ,  G01N5/04 ,  G01N9/00 ,  G01N29/02 ,  G01N29/036 ,  G01N29/34 ,  G01N29/42 ,  G01N29/44 ,  H03H9/19

Abstract: A method and apparatus for measuring properties of a liquid composition includes a mechanical resonator, such as a thickness shear mode resonator or a tuning fork resonator, connected to a measurement circuit. The measurement circuit provides a variable frequency input signal to the tuning fork, causing the mechanical resonator to oscillate. To test the properties of a liquid composition, the mechanical resonator is placed inside a sample well containing a small amount of the liquid. The input signal is then sent to the mechanical resonator and swept over a selected frequency range, preferably less than 1 MHz to prevent the liquid being tested from exhibiting gel-like characteristics and causing false readings. The mechanical resonator's response over the frequency range depends on various characteristics of the liquid being tested, such as the temperature, viscosity, and other physical properties. Particular mechanical resonators, such as tuning fork resonators, can also be used to measure a liquid composition's electrical properties, such as the dielectric constant and conductivity, because the tuning fork's structure allows a high degree of electrical coupling between the tuning fork and the surrounding liquid. The mechanical resonator can be covered with a coating to impart additional special detection properties to the resonator, and multiple resonators can be attached together as a single sensor to obtain multiple frequency responses. The invention is particularly suitable for combinatorial chemistry applications, which require rapid analysis of chemical properties for screening.

公开(公告)号：AU3691700A

公开(公告)日：2000-07-03

申请号：AU3691700

申请日：1999-12-10

Applicant: SYMYX TECHNOLOGIES INC

Inventor： MANSKY PAUL ,  BENNETT JAMES

IPC: B01J19/00 ,  C40B30/08 ,  C40B40/18 ,  G01N9/00 ,  G01N11/00 ,  G01N25/00 ,  G01N25/18 ,  G01N25/20 ,  G01N27/72 ,  G01N37/00 ,  G01N31/00

公开(公告)号：WO0036410A9

公开(公告)日：2001-05-25

申请号：PCT/US9930008

申请日：1999-12-10

Applicant: SYMYX TECHNOLOGIES INC ,  MANSKY PAUL ,  BENNETT JAMES

Inventor： MANSKY PAUL ,  BENNETT JAMES

IPC: B01J19/00 ,  C40B30/08 ,  C40B40/18 ,  G01N9/00 ,  G01N11/00 ,  G01N25/00 ,  G01N25/18 ,  G01N25/20 ,  G01N27/72 ,  G01N37/00 ,  G01N31/00

CPC classification number: G01N25/005 ,  B01J19/0046 ,  B01J2219/00605 ,  B01J2219/00612 ,  B01J2219/00621 ,  B01J2219/00637 ,  B01J2219/00653 ,  B01J2219/00659 ,  B01J2219/00707 ,  B01J2219/00745 ,  B01J2219/00747 ,  C40B30/08 ,  C40B40/18 ,  G01N25/18 ,  G01N27/72

Abstract: A modular materials characterization apparatus includes a sensor array (10) disposed on a substrate (16), with a standardized array and contact pad (14) format; electronic test and measurement apparatus (54) for sending electrical signals to and receiving electrical signals from the sensor array (10); an apparatus for making electrical contact (50) to the sensors in the standardized array format; an apparatus for routing signals (129) between one or more selected sensors and the electronic test and measurement apparatus and a computer (52) with a computer program recorded therein for controlling the operation of the apparatus. The sensor array (10) is preferably arranged in a standardized format used in combinatorial chemistry applications for rapid deposition of sample materials on the sensor array. An interconnection apparatus (40) and sensor array (10) and contact pad (32) allow measurement of many different material properties by using substrates carrying different sensor types.

Abstract translation: 模块化材料表征装置包括设置在基板（16）上的传感器阵列（10），具有标准化阵列和接触垫（14）格式; 用于向所述传感器阵列（10）发送电信号并接收电信号的电子测试和测量装置（54）。 用于以标准化阵列格式向所述传感器电接触（50）的装置; 用于在一个或多个选择的传感器与电子测试和测量设备之间路由信号（129）的设备和具有记录在其中的计算机程序的计算机（52），用于控制设备的操作。 传感器阵列（10）优选地以用于组合化学应用中的标准化格式布置，用于将样品材料快速沉积在传感器阵列上。 互连装置（40）和传感器阵列（10）和接触垫（32）允许通过使用携带不同传感器类型的基板来测量许多不同的材料特性。

公开(公告)号：WO2006084263A3

公开(公告)日：2006-11-23

申请号：PCT/US2006004231

申请日：2006-02-03

Applicant: SYMYX TECHNOLOGIES INC ,  KOLOSOV OLEG ,  SPITKOVSKY MIKHAIL ,  BENNETT JAMES ,  MATSEIV LEONID ,  GAMMER VLADIMIR

Inventor： KOLOSOV OLEG ,  SPITKOVSKY MIKHAIL ,  BENNETT JAMES ,  MATSEIV LEONID ,  GAMMER VLADIMIR

IPC: G01N29/02 ,  G01F23/296 ,  G01H13/00 ,  G01N29/036 ,  G01N29/22

CPC classification number: G01F23/2967 ,  G01F23/2966 ,  G01H13/00 ,  G01N29/022 ,  G01N29/036 ,  G01N29/22 ,  G01N2291/0226 ,  G01N2291/02818 ,  G01N2291/02836 ,  G01N2291/0422 ,  G01N2291/0423 ,  G01N2291/0426 ,  G01N2291/0427 ,  G01N2291/106 ,  H01R13/65807

Abstract: Fluid monitoring methods, sensors and systems are disclosed. Preferred embodiments comprise two or more mechanical resonators, preferably two or more flexural resonators configured for sensing, monitoring or evaluating one or more fluids at multiple positions within one or more fluidic systems. In the methods, sensors and systems of the invention, signals generated in response to stimulation of the mechanical resonators are communicated by multiplexing over a common communication path, and then deconvoluted with respect to the position of the resonators.

Abstract translation: 公开了流体监测方法，传感器和系统。 优选实施例包括两个或更多个机械谐振器，优选地，两个或更多个弯曲谐振器被配置为感测，监测或评估一个或多个流体系统内的多个位置处的一个或多个流体。 在这些方法中，本发明的传感器和系统响应于机械谐振器的刺激而产生的信号通过在公共通信路径上进行复用来传送，然后相对于谐振器的位置解卷积。