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    IMMUNOPARTICLES AND PROCESS FOR PREPARING THE SAME
    11.
    发明专利
    IMMUNOPARTICLES AND PROCESS FOR PREPARING THE SAME 未知

    公开(公告)号：DE3171273D1

    公开(公告)日：1985-08-08

    申请号：DE3171273

    申请日：1981-12-08

    Applicant: TORAY INDUSTRIES

    Inventor： HOSAKA SHUNTARO ,  MURAO YASUO

    IPC: A61K39/385 ,  A61K39/44 ,  C08F220/32 ,  G01N33/543 ,  G01N33/546

    Abstract: Immunochemicals having an amino group are immobilized by covalent bonding on fine particles having an average diameter of 0.03 to 10 mu m, the fine particles comprising a polymer having the repeating unit of glycidyl acrylate or glycidyl methacrylate and the fine particles not having on the surface thereof a hydrophobic component other than the above unit, whereby there are obtained immunoparticles effective as a diagnostic reagent for immunological tests for detecting or measuring a component in human or animal body fluids or for labeling cells.

    IMMUNOPARTICLES AND PROCESS FOR PREPARING SAME
    13.
    发明专利
    IMMUNOPARTICLES AND PROCESS FOR PREPARING SAME 未知

    公开(公告)号：CA1177751A

    公开(公告)日：1984-11-13

    申请号：CA391753

    申请日：1981-12-08

    Applicant: TORAY INDUSTRIES

    Inventor： HOSAKA SHUNTARO ,  MURAO YASUO

    IPC: A61K39/385 ,  A61K39/44 ,  C08F220/32 ,  G01N33/543 ,  G01N33/54

    Abstract: Immunochemicals haying an amino group are immobilized by covalent bonding on fine particles having an average diameter of 0.03 to 10 .mu.m, the fine particles comprising a polymer having the repeating unit of glycidyl acrylate or glycidyl methacrylate and the fine particles not having on the surface thereof a hydrophobic component other than the above unit, whereby there are obtained immunoparticles effective as a diagnostic reagent for immunological tests for detecting or measuring a component in human or animal body fluids or for labeling cells.

    COLUMN FOR ENTERITIS
    15.
    发明专利
    COLUMN FOR ENTERITIS 失效

    公开(公告)号：JP2000053583A

    公开(公告)日：2000-02-22

    申请号：JP22794398

    申请日：1998-08-12

    Applicant: TORAY INDUSTRIES

    Inventor： YOKOYAMA AKIRA ,  MURAO YASUO ,  HOKARI NAOTO ,  KOUGO YUTAKA ,  AYABE TOKIYOSHI

    IPC: A61M1/36 ,  A61K38/00 ,  A61P1/00

    Abstract: PROBLEM TO BE SOLVED: To obtain the subject column capable of performing extracorporeal circulation of blood and improving enteritis by using a polymyxin immobilized carrier. SOLUTION: This column for enteritis is obtained by using a polymyxin immobilized carrier. Preferably, the carrier is a fibrous carrier and its component is a polymer such as a (crosslinked) polystyrene fiber or an acrylic acid.acrylonitrile copolymer fiber and preferably is a sea-island fiber reinforced with the island component. Preferably, a surface area of the carrier is 0.1-100 m2/g. An amount of an immobilized antibiotic substance, polymyxin is pref. >=1 mg/g carrier, further pref. 6-20 mg/g carrier. The column is obtained by mixing the carrier with the polymyxin, and further adding a peptide condensing agent, or the like. By the process, sufficient treatment of inflammable intestinal diseases such as colitis ulcerosa or Crohn's disease can be expected.

    PREPARATION OF SINGLE STRANDED DNA
    17.
    发明专利
    PREPARATION OF SINGLE STRANDED DNA 失效

    公开(公告)号：JPS6420088A

    公开(公告)日：1989-01-24

    申请号：JP2956688

    申请日：1988-02-10

    Applicant: TORAY INDUSTRIES

    Inventor： MURAO YASUO ,  HOSAKA SHUNTARO

    IPC: G01N33/50 ,  C07H21/04 ,  C07K14/02 ,  C12N15/09 ,  C12N15/10 ,  C12Q1/68

    Abstract: PURPOSE:To obtain high-sensitivity DNA having a little back ground free from false positive, by setting part to stop elongation of DNA in single stranded DNA integrated with template DNA, hybridizing the template DNA with a primer, elongating the primer and separating the formed DNA from the template DNA. CONSTITUTION:A vector A, a cyclic DNA, is cleft and opened B, with a proper restriction enzyme, DNA fragment C obtained by cleaving DNA of a sample to be tested with the same restriction enzyme is inserted into the cleft and opened vector, which is subjected to ring formation and the prepared recombinant DNA:D is integrated F into a host cell. DNA is extracted from the prepared phage to give single stranded template DNA:E. Then the DNA is hybridized F with DNA oligomer complementary to restriction enzyme recognition site of vector in the vicinity of 5' end of the template DNA:E and cleft with a restriction enzyme to give part to stop elongation of DNA. DNA is elongated I with four kinds of bases as a substrate, formed DNA is separated from the template DNA by alkaline electrophoresis using a gel membrane and single strand-ed DNA is recovered K.

    FINE PARTICLE JOINED TO COMPLEMENT
    20.
    发明专利
    FINE PARTICLE JOINED TO COMPLEMENT 失效

    公开(公告)号：JPS57175128A

    公开(公告)日：1982-10-28

    申请号：JP5978481

    申请日：1981-04-22

    Applicant: TORAY INDUSTRIES

    Inventor： UCHIDA TAKASHI ,  HOSAKA SHIYUNTAROU ,  MURAO YASUO

    IPC: A61K39/44 ,  A61K39/395

    Abstract: PURPOSE:The titled fine particles, prepared by joining a complementary component to particles obtained by immobilizing an immunoglobulin, e.g. derived from a man, in fine particles of an organic high polymer by the complementary bonds, regarded as useful for immunological functional tests, etc., easily preparable and storable for a long term. CONSTITUTION:A human or animal complementary component is joined to particles, containing immobilized immunoglobulin, and prepared by immobilizing a human or animal immunoglobulin G or immunoglobulin M in fine particles of an organic high polymer, e.g. polystyrene having introduced carboxyl groups, etc. as functional groups with chemical bonds, by complementary bonds to give the aimed fine particles. The complement is usable for a test, diagnosis, etc. by determining the proportion of the B lymphatic corpsucles from the proportion of cells having the complementary receptor, but the fine particles, joined to the complement, and consisting of the organic high polymer have the mechanical strength and improved storage stability without causing hemolysis, and provides easy observation of the rosette formation without causing the nonspecific adsorption on the lymphatic corpuscles.

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