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公开(公告)号：AU2013234046B2
公开(公告)日：2017-09-07
申请号：AU2013234046
申请日：2013-03-14
Applicant: UNIV HEALTH NETWORK
Inventor： TUSCHE MICHAEL W , MAK TAK W , OHASHI PAMELA S , LANG PHILIPP , LANG KARL , BRENNER DIRK , LIN GLORIA
Abstract: The present invention is further directed to methods and compositions for modulating the activity of the Toso protein. The invention further encompasses treatment of disorders associated with inflammation, autoimmune disorders, and cancer using compositions that include a soluble Toso protein.
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公开(公告)号：AU2014286869A1
公开(公告)日：2016-02-11
申请号：AU2014286869
申请日：2014-07-02
Applicant: UNIV HEALTH NETWORK
Inventor： MAK TAK W , LAI XIUQIU , TUSCHE MICHAEL W
Abstract: The present invention provides methods and compositions for modulating Toso activity and treating diseases and disorders in which Toso is implicated. Such methods and compositions include the use of one or more antibodies that bind to a Toso protein or to a ligand of a Toso protein.
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公开(公告)号：AU2017272172B2
公开(公告)日：2019-04-04
申请号：AU2017272172
申请日：2017-12-05
Applicant: UNIV HEALTH NETWORK
Inventor： TUSCHE MICHAEL W , MAK TAK W , OHASHI PAMELA S , LANG PHILIPP , LANG KARL , BRENNER DIRK , LIN GLORIA
Abstract: METHODS AND COMPOSITIONS FOR MODULATING TOSO ACTIVITY The present invention is further directed to methods and compositions for modulating the activity of the Toso protein. The invention further encompasses treatment of disorders associated with inflammation, autoimmune disorders, and cancer using compositions that include a soluble Toso protein.
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公开(公告)号：CA2941691A1
公开(公告)日：2015-09-11
申请号：CA2941691
申请日：2015-03-07
Applicant: UNIV HEALTH NETWORK
Inventor： HERSHENFIELD BRIAN , MAK TAK W
IPC: C04B30/00 , C12N15/113 , C12Q1/00 , C12Q1/68 , C40B30/04 , C40B40/06 , G01N33/48 , G01N33/483
Abstract: The present invention is directed to methods for identifying one or more target genes that modulate the activation state of dendritic cells. The methods are based on transfection of a siRNA library into immature bone marrow-derived dendritic cells and detecting the activation state of said cells. The identified one or more target genes can be further validated as candidate targets for induction of self-tolerance and treatment of autoimmune diseases.
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公开(公告)号：CA2917077A1
公开(公告)日：2015-01-08
申请号：CA2917077
申请日：2014-07-02
Applicant: UNIV HEALTH NETWORK
Inventor： MAK TAK W , LAI XIUQIU , TUSCHE MICHAEL W
IPC: C07K16/28
Abstract: The present invention provides methods and compositions for modulating Toso activity and treating diseases and disorders in which Toso is implicated. Such methods and compositions include the use of one or more antibodies that bind to a Toso protein or to a ligand of a Toso protein.
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Patent Agency Ranking
公开(公告)号：AU2019204594B2
公开(公告)日：2021-05-06
申请号：AU2019204594
申请日：2019-06-28
Applicant: UNIV HEALTH NETWORK
Inventor： TUSCHE MICHAEL W , MAK TAK W , OHASHI PAMELA S , LANG PHILIPP , LANG KARL , BRENNER DIRK , LIN GLORIA
Abstract: METHODS AND COMPOSITIONS FOR MODULATING TOSO ACTIVITY The present invention is further directed to methods and compositions for modulating the activity of the Toso protein. The invention further encompasses treatment of disorders associated with inflammation, autoimmune disorders, and cancer using compositions that include a soluble Toso protein.
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公开(公告)号：AU2015225867A1
公开(公告)日：2016-09-22
申请号：AU2015225867
申请日：2015-03-06
Applicant: UNIV HEALTH NETWORK
Inventor： MAK TAK W
IPC: A61K39/395 , A61K38/17 , A61P35/00 , A61P37/00
Abstract: The present invention is directed to methods and compositions for modulating proteins involved in the immune response, specifically by modulating the expression and/or activity of the Toso protein. The present invention further provides methods and compositions for treatment of autoimmune disease and cancer by modulating the expression and/or activity of the Toso protein.
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公开(公告)号：AU2013234046A1
公开(公告)日：2014-10-09
申请号：AU2013234046
申请日：2013-03-14
Applicant: UNIV HEALTH NETWORK
Inventor： TUSCHE MICHAEL W , MAK TAK W , OHASHI PAMELA S , LANG PHILIPP , LANG KARL , BRENNER DIRK , LIN GLORIA
Abstract: The present invention is further directed to methods and compositions for modulating the activity of the Toso protein. The invention further encompasses treatment of disorders associated with inflammation, autoimmune disorders, and cancer using compositions that include a soluble Toso protein.
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公开(公告)号：CA2680058A1
公开(公告)日：2008-09-12
申请号：CA2680058
申请日：2008-03-07
Applicant: UNIV HEALTH NETWORK
Inventor： ZAUGG KATHRIN , PAN GUOHUA , YAO YI , MAK TAK W
IPC: C07H21/02 , A61K31/7105 , A61K31/713 , A61K48/00 , A61P35/00 , C12N9/10 , C12N15/113 , C12N15/54 , C12Q1/02 , C12Q1/48 , C12Q1/68 , G01N33/53 , G01N33/68
Abstract: This invention relates to compositions and methods for cancer therapeutic s. In particular, the present invention provides compositions and methods fo r treating tumors by inhibiting the activity of CPT1C. The methods and compo sitions can additionally include inhibition of glycolysis.
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公开(公告)号：CA2867444C
公开(公告)日：2021-04-13
申请号：CA2867444
申请日：2013-03-14
Applicant: UNIV HEALTH NETWORK
Inventor： TUSCHE MICHAEL W , MAK TAK W , OHASHI PAMELA S , LANG PHILIPP , LANG KARL , BRENNER DIRK , LIN GLORIA
Abstract: The present invention is further directed to methods and compositions for modulating the activity of the Toso protein. The invention further encompasses treatment of disorders associated with inflammation, autoimmune disorders, and cancer using compositions that include a soluble Toso protein.
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