公开(公告)号：WO2007030618A3

公开(公告)日：2007-05-31

申请号：PCT/US2006034857

申请日：2006-09-08

Applicant: VERTEX PHARMA ,  NEUBERT TIMOTHY ,  ZIMMERMANN NICOLE ,  KAWATKAR ARTIS ,  MARTINBOROUGH ESTHER ,  TERMIN ANDREAS

Inventor： NEUBERT TIMOTHY ,  ZIMMERMANN NICOLE ,  KAWATKAR ARTIS ,  MARTINBOROUGH ESTHER ,  TERMIN ANDREAS

IPC: C07D417/12 ,  A61K31/426 ,  A61K31/427 ,  A61K31/4709 ,  A61P25/00 ,  C07D277/52

CPC classification number: C07D417/12 ,  C07D277/52

Abstract: Bicyclic derivatives useful as ion channel antagonists are disclosed herein. The compositions thereof are useful for treating or relieving pain-related conditions.

Abstract translation: 本文公开了可用作离子通道拮抗剂的双环衍生物。 其组合物可用于治疗或缓解疼痛相关病症。

公开(公告)号：WO2006124865A2

公开(公告)日：2006-11-23

申请号：PCT/US2006018871

申请日：2006-05-15

Applicant: VERTEX PHARMA ,  TERMIN ANDREAS ,  WILSON DEAN ,  JOSHI PRAMOD

Inventor： TERMIN ANDREAS ,  WILSON DEAN ,  JOSHI PRAMOD

IPC: C07D295/14 ,  A61K31/495 ,  C07D295/18

CPC classification number: C07D295/185 ,  C07D295/15

Abstract: The present invention relates to compounds useful as inhibitors of ion channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.

Abstract translation: 本发明涉及可用作离子通道抑制剂的化合物。 本发明还提供包含本发明化合物的药学上可接受的组合物和使用该组合物治疗各种疾病的方法。

公开(公告)号：CO2022002749A2

公开(公告)日：2022-06-21

申请号：CO2022002749

申请日：2022-03-09

Applicant: VERTEX PHARMA

Inventor： ANDERSON COREY DON ,  CLEMENS JEREMY J ,  CLEVELAND THOMAS ,  COON TIMOTHY RICHARD ,  FRIEMAN BRYAN ,  GROOTENHUIS PETER (DECEASED) ,  HADIDA RUAH SARA SABINA ,  MCCARTNEY JASON ,  MILLER MARK THOMAS ,  PARASELLI PRASUNA ,  PIERRE FABRICE ,  SWIFT SARA E ,  ZHOU JINGLAN ,  ABELA ALEXANDER RUSSELL ,  ISHIHARA YOSHIHIRO ,  UY JOHNNY ,  BOOKSER BRETT C ,  BUSCH BRETT B ,  GHIRMAI SENAIT G ,  GULEVICH ANTON V ,  KHATUYA HARIPADA ,  TERMIN ANDREAS ,  VOGEL CARL V

IPC: C07D513/22 ,  A61K31/435 ,  A61P11/00

Abstract: Esta descripción proporciona moduladores del regulador de la conductancia transmembrana de la fibrosis quística (CFTR), composiciones farmacéuticas que contienen al menos un modulador de este tipo, métodos de tratamiento de la fibrosis quística mediante el uso de dichos moduladores y composiciones farmacéuticas, y procesos para fabricar dichos moduladores.

公开(公告)号：LT3519401T

公开(公告)日：2021-11-25

申请号：LT17054611

申请日：2017-09-29

Applicant: VERTEX PHARMA

Inventor： ALCACIO TIMOTHY ,  BAEK MINSON ,  GROOTENHUIS PETER ,  HADIDA RUAH SARA ,  HUGHES ROBERT ,  KESHAVARZ-SHOKRI ALI ,  MCAULEY-AOKI RACHEL ,  MCCARTNEY JASON ,  MILLER MARK ,  VAN GOOR FREDRICK ,  ZHANG BEILI ,  ANDERSON COREY ,  CLEVELAND THOMAS ,  FRIEMAN BRYAN ,  KHATUYA HARIPADA ,  JOSHI PRAMOD ,  KRENITSKY PAUL ,  MELILLO VITO ,  PIERRE FABRICE ,  TERMIN ANDREAS ,  UY JOHNNY ,  ZHOU JINGLAN ,  ABELA ALEXANDER ,  BUSCH BRETT ,  PARASELLI PRASUNA ,  SIESEL DAVID

IPC: C07D401/14 ,  A61K31/4439 ,  A61P1/16 ,  A61P1/18 ,  A61P11/00 ,  A61P11/12 ,  A61P43/00 ,  C07D471/14 ,  C07D498/14

公开(公告)号：NZ715751A

公开(公告)日：2021-09-24

申请号：NZ71575114

申请日：2014-07-18

Applicant: VERTEX PHARMA

Inventor： HADIDA-RUAH SARA ,  ANDERSON COREY ,  ARUMUGAM VIJAYALAKSMI ,  JOHNSON JAMES ,  BEAR BRIAN ,  TERMIN ANDREAS ,  KRENITSKY PAUL

IPC: C07C311/46 ,  A61K31/18

Abstract: The invention relates to compounds of formula I or pharmaceutically acceptable salts thereof, useful as inhibitors of sodium channels: (I). The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders, including pain.

公开(公告)号：HUE053448T2

公开(公告)日：2021-06-28

申请号：HUE17152492

申请日：2014-01-29

Applicant: VERTEX PHARMA

Inventor： HADIDA RUAH SARA ,  ANDERSON COREY ,  ARUMUGAM VIJAYALAKSMI ,  ASGIAN IULIANA ,  BEAR BRIAN ,  TERMIN ANDREAS ,  JOHNSON JAMES

IPC: A61K31/44 ,  A61P29/00

公开(公告)号：LT3239134T

公开(公告)日：2021-02-25

申请号：LT17152492

申请日：2014-01-29

Applicant: VERTEX PHARMA

Inventor： HADIDA RUAH SARA ,  ANDERSON COREY ,  ARUMUGAM VIJAYALAKSMI ,  ASGIAN IULIANA ,  BEAR BRIAN ,  TERMIN ANDREAS ,  JOHNSON JAMES

IPC: C07D213/75 ,  A61K31/44 ,  A61K31/4412 ,  A61P29/00 ,  C07D401/12 ,  C07D405/12

公开(公告)号：MA51828A

公开(公告)日：2020-12-23

申请号：MA51828

申请日：2019-02-14

Applicant: VERTEX PHARMA

Inventor： ABELA ALEXANDER RUSSELL ,  ANDERSON COREY DON ,  BUSCH BRETT B ,  CHEN WEICHAO GEORGE ,  CLEMENS JEREMY J ,  CLEVELAND THOMAS ,  COON TIMOTHY RICHARD ,  FRIEMAN BRYAN ,  GHIRMAI SENAIT G ,  GROOTENHUIS PETER ,  GULEVICH ANTON V ,  HADIDA RUAH SARA SABINA ,  HSIA CLARA KUANG-JU ,  KANG PING ,  KHATUYA HARIPADA ,  MCCARTNEY JASON ,  MILLER MARK THOMAS ,  PARASELLI PRASUNA ,  PIERRE FABRICE ,  SWIFT SARA E ,  TERMIN ANDREAS ,  UY JOHNNY ,  VOGEL CARL V ,  ZHOU JINGLAN

IPC: A61K31/437 ,  A61P11/00 ,  C07D513/22 ,  C07D515/22

公开(公告)号：NZ750187A

公开(公告)日：2020-09-25

申请号：NZ75018714

申请日：2014-01-29

Applicant: VERTEX PHARMA

Inventor： HADIDA-RUAH SARA ,  ANDERSON COREY ,  ARUMUGAM VIJAYALAKSMI ,  JOHNSON JAMES ,  ASGIAN IULIANA ,  BEAR BRIAN ,  TERMIN ANDREAS

IPC: C07D213/75 ,  A61K31/44 ,  A61P29/00 ,  C07D401/12

Abstract: The invention relates to pyridone amide compounds of formula I and I’or pharmaceutically acceptable salts thereof, useful as inhibitors of sodium channels: I, I’, The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders, including pain.

公开(公告)号：NZ710293A

公开(公告)日：2020-09-25

申请号：NZ71029314

申请日：2014-01-29

Applicant: VERTEX PHARMA

Inventor： HADIDA-RUAH SARA ,  ANDERSON COREY ,  ARUMUGAM VIJAYALAKSMI ,  JOHNSON JAMES ,  BEAR BRIAN ,  TERMIN ANDREAS ,  ASGIAN IULIANA

IPC: C07D213/79 ,  A61K31/44 ,  A61P29/00 ,  C07C235/64

Abstract: The invention relates to amide compounds of formula I and For pharmaceutically acceptable salts thereof, useful as inhibitors of sodium channels: (I), (I’) The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders, including pain.