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    METHOD AND APPARATUS FOR INJECTING A CHROMATOGRAPHIC SAMPLE
    12.
    发明申请
    METHOD AND APPARATUS FOR INJECTING A CHROMATOGRAPHIC SAMPLE 审中-公开
    注射色谱样品的方法和设备

    公开(公告)号：WO2017192792A1

    公开(公告)日：2017-11-09

    申请号：PCT/US2017/030950

    申请日：2017-05-04

    Applicant: WATERS TECHNOLOGIES CORPORATION

    Inventor： GILAR, Martin ,  ANDREWS, Richard, W. ,  BEALS, Peyton, C. ,  MCDONALD, Thomas ,  FADGEN, Keith ,  KORNFELD, Jordan ,  GERHARDT, Geoff ,  CORMIER, Sylvain

    IPC: G01N30/20

    Abstract: A method for injecting a diluted sample in a chromatography system includes merging a flow of a sample and a flow of a diluent to form a flow of a diluted sample. A dilution ratio of the diluted sample equals a sum of the volumetric flow rates of the sample and the diluent divided by the volumetric flow rate of the sample. The diluted sample is stored in a holding element before injection into a chromatographic system flow. Sample dilution occurs under low pressure relative to the chromatographic flow thereby allowing lower pressure sample and diluent syringes to be used. Other benefits include reduced compressibility and a reduction in leaks due to the lower pressure operation. The method avoids problems associated with manual techniques which can introduce errors due, for example, to loss of sample, sample precipitation and adsorption of sample to vials.

    Abstract translation: 用于将稀释样品注入色谱系统的方法包括合并样品流和稀释剂流以形成稀释样品流。 稀释样品的稀释比等于样品和稀释剂的体积流量之和除以样品的体积流量。 稀释的样品在注入色谱系统流程之前储存在保持元件中。 在相对于色谱流动的低压下进行样品稀释，从而允许使用较低压力的样品和稀释剂注射器。 其他好处包括压缩性降低和由于较低压力操作导致的泄漏减少。 该方法避免了由于例如样品损失，样品沉淀和样品吸附到样品瓶而可能引入误差的手动技术相关的问题。

    CHROMATOGRAPHY COLUMN ASSEMBLY
    13.
    发明申请
    CHROMATOGRAPHY COLUMN ASSEMBLY 审中-公开
    色谱柱组装

    公开(公告)号：WO2013032832A1

    公开(公告)日：2013-03-07

    申请号：PCT/US2012/051972

    申请日：2012-08-23

    Applicant: WATERS TECHNOLOGIES CORPORATION ,  MICHIENZI, Joseph D. ,  FADGEN, Keith ,  LEVEILLE, SR., Wade P. ,  FISK, Raymond P. ,  MARZALKOWSKI, JR., Frank John

    Inventor： MICHIENZI, Joseph D. ,  FADGEN, Keith ,  LEVEILLE, SR., Wade P. ,  FISK, Raymond P. ,  MARZALKOWSKI, JR., Frank John

    IPC: B01D15/08 ,  B23P19/00

    CPC classification number: B05B5/16 ,  B01D15/10 ,  B01D15/1871 ,  B01D15/22 ,  G01N30/60 ,  G01N30/6004 ,  G01N30/6026 ,  G01N30/603 ,  G01N30/6039 ,  G01N30/6052 ,  G01N30/6095 ,  G01N30/7266 ,  Y10T29/49908

    Abstract: Described is a chromatography column assembly that includes a permanently deformable outer tube, an intermediate tube, an inner tube and a sorbent bed disposed within the inner tube. The sorbent bed may be in the form of packed chromatographic particles or a porous monolithic structure. A radial seal is provided by one or more uniform radial crimps at longitudinal locations on the assembly. The uniform radial crimp compresses the outer tube and underlying intermediate tube onto the inner tube to achieve a high pressure liquid tight seal between the three tubes. The length and depth of each crimp is accurately formed to accommodate the requirements of the particular application. Leakage along the tubing assembly is prevented and void volume is reduced or eliminated. No external ferrule or ferrule swaging mechanism is needed; therefore the chromatography column assembly is easily adapted for use in various chromatographic column configurations.

    Abstract translation: 描述了一种色谱柱组件，其包括永久变形的外管，中间管，内管和设置在内管内的吸附剂床。 吸附剂床可以是填充色谱颗粒或多孔整体结构的形式。 在组件的纵向位置处由一个或多个均匀的径向卷曲提供径向密封。 均匀的径向卷曲将外管和下面的中间管压缩到内管上，以实现三管之间的高压液密封。 精确地形成每个卷曲的长度和深度以适应特定应用的要求。 防止管道组件的泄漏，减少或消除空隙体积。 不需要外部套圈或套圈型锻机构; 因此色谱柱组件易于适用于各种色谱柱配置。

    HIGH PRESSURE FLUIDIC SWITCHING VALVE HAVING VARIABLE PRESSURE LOADING
    16.
    发明申请
    HIGH PRESSURE FLUIDIC SWITCHING VALVE HAVING VARIABLE PRESSURE LOADING 审中-公开
    具有可变压力负载的高压液压开关阀

    公开(公告)号：WO2012151080A1

    公开(公告)日：2012-11-08

    申请号：PCT/US2012/034760

    申请日：2012-04-24

    Applicant: WATERS TECHNOLOGIES CORPORATION ,  BUNNER, Bernard ,  MICHIENZI, Joseph ,  FADGEN, Keith

    Inventor： BUNNER, Bernard ,  MICHIENZI, Joseph ,  FADGEN, Keith

    IPC: F16K31/12

    CPC classification number: F16K3/10 ,  F16K3/18 ,  F16K31/041 ,  G01N35/1097 ,  G01N2030/202 ,  Y10T137/0318

    Abstract: Described are a rotary shear seal valve and a method for switching a high pressure fluid. The method includes applying a fixed force between a planar surface of a rotor and a planar surface of a stator. The planar surface of the rotor includes a fluidic channel and the planar surface of the stator has a pair of ports to receive and provide the fluid. A control signal is applied to a linear actuator coupled to the rotor to generate a controllable force between the planar surfaces of the rotor and stator. The control signal is responsive to a rotational state of the rotor. The total force between the planar surfaces of the rotor and the stator is substantially equal to a sum of the fixed force and the controllable force. The method reduces the wear and extends the lifetime of components in a rotary shear seal valve.

    Abstract translation: 描述了一种旋转剪切密封阀和一种用于切换高压流体的方法。 该方法包括在转子的平坦表面和定子的平坦表面之间施加固定的力。 转子的平面表面包括流体通道，并且定子的平坦表面具有一对接口并提供流体的端口。 控制信号被施加到耦合到转子的线性致动器，以在转子和定子的平面之间产生可控的力。 控制信号响应转子的旋转状态。 转子和定子的平面之间的总的力基本上等于固定力和可控力之和。 该方法减少了磨损并延长了旋转剪切密封阀中部件的使用寿命。

    ELECTROKINETICALLY CONTROLLED CALIBRANT DELIVERY
    17.
    发明申请
    ELECTROKINETICALLY CONTROLLED CALIBRANT DELIVERY 审中-公开
    电子控制校准交付

    公开(公告)号：WO2012125381A1

    公开(公告)日：2012-09-20

    申请号：PCT/US2012/028155

    申请日：2012-03-08

    Applicant: WATERS TECHNOLOGIES CORPORATION ,  GERHARDT, Geoff, C. ,  FADGEN, Keith

    Inventor： GERHARDT, Geoff, C. ,  FADGEN, Keith

    IPC: H01J49/00

    CPC classification number: H01J49/0009 ,  H01J49/00 ,  H01J49/04

    Abstract: An electrokinetic pump can be used to deliver calibrant ("lock mass") ions to a mass spectrometer for calibration of a mass spectrometry system. Electrokinetically controlled calibrant delivery can help to eliminate the need for the more cumbersome mechanisms that are often used for ion delivery. In addition, electrokinetically controlled calibrant delivery can provide for a more user- friendly system in which a calibrant solution can be packaged into a disposable cartridge. Furthermore, when implemented in a microfluidic format, electrokinetically controlled calibrant delivery can be coupled with an electrokinetically controlled separation system, such as capillary electrophoresis (CE), to allow efficient solid-state switching between analytical and calibrant sprays.

    Abstract translation: 可以使用电动泵将校准物（“锁定质量”）离子输送到质谱仪用于校准质谱系统。 电动控制的校准物输送可以帮助消除对经常用于离子传递的更繁琐的机制的需要。 此外，电动控制的校准物输送可以提供更加用户友好的系统，其中校准液可以被包装到一次性盒中。 此外，当以微流体形式实施时，电动控制的校准物输送可与电动控制的分离系统（例如毛细管电泳（CE））结合，以允许分析和校准喷雾之间的有效的固态切换。

    VARIABLE-VOLUME INJECTION VALVE
    18.
    发明申请
    VARIABLE-VOLUME INJECTION VALVE 审中-公开
    可变容积注射阀

    公开(公告)号：WO2012027632A1

    公开(公告)日：2012-03-01

    申请号：PCT/US2011/049275

    申请日：2011-08-26

    Applicant: WATERS TECHNOLOGIES CORPORATION ,  GERHARDT, Geoff, C. ,  FADGEN, Keith

    Inventor： GERHARDT, Geoff, C. ,  FADGEN, Keith

    IPC: F16K11/074

    CPC classification number: F16K11/00 ,  F16K11/0743 ,  Y10T137/0318 ,  Y10T137/86863

    Abstract: Variable- volume injection valves include a stator and a rotor. The stator has a first port, a second port, and a contact surface with a groove therein. The first port opens into the stator groove. The rotor has a contact surface with a groove therein. The contact surface of the rotor is urged against the contact surface of the stator such that the rotor groove opposes the stator groove with one end of the rotor groove overlapping the stator groove and the opposite end of the rotor groove overlapping the second port of the stator. The overlapping grooves of the rotor and stator provide a fluidic channel between the first and second ports of the stator. The rotor is movable with respect to the stator in order to vary a length of overlap between their overlapping grooves.

    Abstract translation: 可变容积喷射阀包括定子和转子。 定子具有第一端口，第二端口和与其中的凹槽的接触表面。 第一端口通向定子槽。 转子具有与其中的凹槽的接触表面。 转子的接触表面被推靠在定子的接触表面上，使得转子槽与定子槽相对，转子槽的一端与定子槽重叠，转子槽的相对端与定子的第二端重叠 。 转子和定子的重叠槽在定子的第一和第二端口之间提供流体通道。 转子可相对于定子移动，以便改变其重叠槽之间的重叠长度。

    HIGH PRESSURE FLUIDIC SWITCHING VALVE HAVING VARIABLE PRESSURE LOADING
    20.
    发明授权
    HIGH PRESSURE FLUIDIC SWITCHING VALVE HAVING VARIABLE PRESSURE LOADING 有权

    公开(公告)号：EP2705286B1

    公开(公告)日：2018-08-08

    申请号：EP12779916.1

    申请日：2012-04-24

    Applicant: Waters Technologies Corporation

    Inventor： BUNNER, Bernard ,  MICHIENZI, Joseph ,  FADGEN, Keith

    IPC: F16K31/12

    CPC classification number: F16K3/10 ,  F16K3/18 ,  F16K31/041 ,  G01N35/1097 ,  G01N2030/202 ,  Y10T137/0318

    Abstract: A method for switching a high pressure fluid includes applying a fixed force between a planar surface of a rotor and a planar surface of a stator. The planar surface of the rotor includes a fluidic channel and the planar surface of the stator has a pair of ports to receive and provide the fluid. A control signal is applied to a linear actuator coupled to the rotor to generate a controllable force between the planar surfaces of the rotor and stator. The control signal is responsive to a rotational state of the rotor. The total force between the planar surfaces of the rotor and the stator is substantially equal to a sum of the fixed force and the controllable force. The method reduces the wear and extends the lifetime of components in a rotary shear seal valve.

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