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公开(公告)号：KR1020110131630A
公开(公告)日：2011-12-07
申请号：KR1020100051165
申请日：2010-05-31
Applicant: 대한민국 (식품의약품안전처장)
CPC classification number: C12Q1/6865 , C12Q2600/156 , C12Q2600/172
Abstract: PURPOSE: A haplotype analysis kit of NAT2 gene promoter and an analysis method using the same are provided to analyze genetic polymorphism of NAT2 and to develop a drug. CONSTITUTION: A method for analyzing haplotype of human NAT2 gene comprises: a step of performing PCR of genome DNA of a test person using a primer set for amplifying the human NAT2 gene promoter or fragment of the fragment; a step of analyzing base sequence of DNA product prepared by PCR; a step of determining SNP presence of -10818 T>C(2942th base of sequence number 8), -10065 A>G(3695th base of sequence number 8), -9905 T>C(3855th base of sequence number 8), -9601 A>G(4159th base of sequence number 8), -9246 G>C(4514th base of sequence number 8), or -8853 A>G(4907th base of sequence number 8).
Abstract translation: 目的：提供NAT2基因启动子的单倍型分析试剂盒及其分析方法，分析NAT2的遗传多态性，开发药物。 构成：用于分析人类NAT2基因单倍型的方法包括：使用引物组进行测试人基因组DNA的PCR扩增步骤，以扩增人类NAT2基因启动子或片段片段; 分析通过PCR制备的DNA产物碱基序列的步骤; 确定天然存在的步骤（序列号8的第2942个碱基），-10065A> G（序列号8的第3695位），-9905T> C（序列号8的第3855位）的SNP存在的步骤， （序列号815的第4159位），-9246G> C（序列号845的第4514位）或-8853A> G（序列号890的第497位）。
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公开(公告)号：KR101035574B1
公开(公告)日：2011-05-23
申请号：KR1020090030892
申请日：2009-04-09
Applicant: 대한민국 (식품의약품안전처장)
IPC: G01N33/15 , G01N33/493
Abstract: 본 발명은 제 2형 당뇨병 치료제 후보약물을 제 2형 당뇨병을 수반하는 실험동물에 투여하고, 뇨에 포함된 특정 대사체의 농도를 측정하는 단계를 포함하는, 제 2형 당뇨병 치료효과를 판정하는 방법에 관한 것이다. 본 발명의 제 2형 당뇨병 치료효과를 판정하는 방법은, (ⅰ) 제 2형 당뇨병 치료제 후보약물을 제 2형 당뇨병을 수반하는 실험동물에 투여하고, 이로부터 뇨를 수집하여 뇨에 포함된 혈당수준 강하효과와 관련된 대사체의 농도를 측정하는 단계; 및, (ⅱ) 상기 뇨에 포함된 대사체의 농도를 약물을 주사하지 않은 대조군의 뇨에 포함된 대사체의 농도와 비교하여, 상기 후보약물이 제 2형 당뇨병 치료효과가 있는지의 여부를 판단하는 단계를 포함한다. 본 발명의 방법을 이용하면, 신약개발 단계에 있어서 제 2형 당뇨병 치료제 후보약물이 제 2형 당뇨병의 치료효과를 나타내는 지의 여부를 간편하게 판단할 수 있으므로, 제 2형 당뇨병의 치료제를 보다 효과적으로 개발할 수 있을 것이다.
제 2형 당뇨병 치료제, 후보약물, 뇨, 대사체-
公开(公告)号：KR1020100112396A
公开(公告)日：2010-10-19
申请号：KR1020090030892
申请日：2009-04-09
Applicant: 대한민국 (식품의약품안전처장)
IPC: G01N33/15 , G01N33/493
Abstract: PURPOSE: A method for determining an effect for type 2 diabetes is provided to simply know treatment effect of therapeutic candidate drug for type 2 diabetes. CONSTITUTION: A method for determining an effect for type 2 diabetes comprises: a step of administering therapeutic agent candidate drug for type 2 diabetes to an experimental animal; a step of collecting urine; a step of measuring the concentration of metabolite related to blood glucose reduction; and a step of comparing with the concentration of control group. The metabolite is glucose, succinate, 2-oxoglutarate, or taurine.
Abstract translation: 目的：提供一种确定2型糖尿病影响的方法，以简单了解治疗性候选药物治疗2型糖尿病的治疗效果。 构成：确定2型糖尿病效果的方法，包括：向实验动物施用2型糖尿病候补药物的步骤; 收集尿液的一个步骤; 衡量与血糖降低相关的代谢物浓度的步骤; 并与对照组的浓度进行比较。 代谢物是葡萄糖，琥珀酸，2-氧戊二酸或牛磺酸。
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公开(公告)号：KR100973775B1
公开(公告)日：2010-08-04
申请号：KR1020080066591
申请日：2008-07-09
Applicant: 대한민국 (식품의약품안전처장)
Abstract: 본 발명은 인공 고관절 마모시험기에 관한 것으로, 그 목적은 골두 시편과 비구컵 시편을 맞물려 하중운동과 회전운동을 동시에 가하여 시편에서 발생하는 마모량을 측정하는 인공 고관절 마모시험기를 제공함에 있다.
상기 목적달성을 위한 본 발명은 골두시편과 비구컵시편을 맞물려 마모도를 측정하는 인공 고관절 마모시험기에 있어서, 골두시편이 설치되는 샤프트가 적어도 두개의 자유도 회전 조인트를 갖으며 일정한 예각의 회전축에 설치되어 4절링크에 의해 회전각을 형성하며 구동되는 각운동 발생장치와; 비구컵시편이 설치되는 고정대가 상하로 움직이며 반복적인 하중을 일으키는 왕복 수직이동체에 설치된 하중 발생장치와; 상기 각운동 발생장치와 하중 발생장치의 구동력을 전달하는 구동부를 포함하는 인공 고관절 마모시험기에 관한 것을 그 기술적 요지로 한다.
인공관절, 고관절, 골두시편, 비구컵시편, 마모시험기, 하중운동, 회전운동.-
公开(公告)号：KR1020100060153A
公开(公告)日：2010-06-07
申请号：KR1020080118623
申请日：2008-11-27
Applicant: 대한민국 (식품의약품안전처장)
IPC: C12Q1/68
CPC classification number: C12Q1/6827 , C12Q2600/156 , C12Q2600/172
Abstract: PURPOSE: A method for analyzing the haplotype of CYP1A2 is provided to analyze genetic SNP of CYP1A2 and to develop a drug related to CYP1A2. CONSTITUTION: A method for analyzing the haplotype of CYP1A2 comprises: a step of obtaining a promoter, intron 4, intron 6, and exon 7 of a gene encoding CYP1A2 from a genome DNA; a step of detecting the presence of SNP(single nucleotide polymorphism); and a step of identifying the detected SNP to a haplotype selected from H1-H11.
Abstract translation: 目的：提供CYP1A2单倍型分析方法，分析CYP1A2基因SNP，开发CYP1A2相关药物。 构成：用于分析CYP1A2的单倍型的方法包括：从基因组DNA获得编码CYP1A2的基因的启动子，内含子4，内含子6和外显子7的步骤; 检测SNP（单核苷酸多态性）的存在的步骤; 以及将检测到的SNP鉴定为选自H1-H11的单倍型。
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Patent Agency Ranking
公开(公告)号：KR1020100060150A
公开(公告)日：2010-06-07
申请号：KR1020080118616
申请日：2008-11-27
Applicant: 대한민국 (식품의약품안전처장)
IPC: C12Q1/68
CPC classification number: C12Q1/6827 , C12Q2600/156 , C12Q2600/172
Abstract: PURPOSE: A method for analyzing the haplotype of a gene encoding CYP2E1 is provided to analyze SNP(single nucleotide polymorphism) and to develop drugs. CONSTITUTION: A method for analyzing CYP2E1 haplotype comprises: a step of obtaining a promoter, intron 5, intron 6, and exon 7 of a gene encoding CYP2E1 and determining nucleotide sequence thereof; a step of detecting presence of SNP; and a step of identifying the detected SNP. The SNP comprises a mutant in which promoter -1295 locus base G is replaced with base C, a mutant in which promoter -333 locus base T is replaced with base A, and a mutant a codon encoding phenylalanine base C is mutated with base T.
Abstract translation: 目的：提供一种分析编码CYP2E1基因单倍型的方法，分析SNP（单核苷酸多态性）和开发药物。 构成：分析CYP2E1单元型的方法，包括：获得编码CYP2E1的基因的启动子，内含子5，内含子6和外显子7的步骤，并确定其核苷酸序列; 检测SNP存在的步骤; 以及识别检测到的SNP的步骤。 SNP包括其中启动子-1295基因座G被碱基C替代的突变体，其中启动子-333基因座T被碱基A替代的突变体，并且编码苯丙氨酸碱基C的突变体编码苯丙氨酸碱基C用碱T突变
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公开(公告)号：KR1020100041018A
公开(公告)日：2010-04-22
申请号：KR1020080099994
申请日：2008-10-13
Applicant: 대한민국 (식품의약품안전처장)
IPC: C12Q1/68
CPC classification number: G01N33/53 , C12Q1/6837 , C12Q2600/142
Abstract: PURPOSE: A method for determining food additive having hepatotoxicity is provided to effectively determine hepatotoxicity and develop safe food additive. CONSTITUTION: A method for determining food additive having hepatotoxicity comprises: a step of treating food additive to liver cell line and culturing; a step of isolating RNA from liver cell line and synthesizing cDNA; and a step of measuring hepatotoxicity-specific gene expression level and comparing with control liver cell line to determine presence of hepatotoxicity. The liver cell line is HepG2. The measurement is performed through Northern blot.
Abstract translation: 目的：提供一种确定具有肝毒性的食品添加剂的方法，以有效确定肝毒性并开发安全的食品添加剂。 构成：一种确定具有肝毒性的食品添加剂的方法，包括：对肝细胞系的食品添加剂进行处理和培养的步骤; 从肝细胞系中分离RNA并合成cDNA的步骤; 测定肝毒性特异性基因表达水平，与对照肝细胞系比较，测定肝毒性的存在。 肝细胞系为HepG2。 通过Northern印迹进行测量。
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公开(公告)号：KR1020100019682A
公开(公告)日：2010-02-19
申请号：KR1020080078369
申请日：2008-08-11
Applicant: 대한민국 (식품의약품안전처장)
IPC: G06Q50/10 , G06F3/0484
CPC classification number: G06Q50/10 , G06F3/04845
Abstract: PURPOSE: A server for food menu preparation and nutrition valuation and a method thereof are provided to make out various menus by preparing a menu for production registered by a user. CONSTITUTION: A detailed item of menu information is inputted(S410), and a menu marking screen is activated(S415). On the menu writing screen, a meal is selected(S420). At least one of a recommended menu and a user menu is displayed(S430). When a specific menu is selected, the selected menu is added to a menu list for the meal(S445,S447). The nutrition for the made menu is evaluated(S455).
Abstract translation: 目的：提供用于食物菜单准备和营养评估的服务器及其方法，以通过准备用户登记的生产菜单来制作各种菜单。 构成：输入菜单信息的详细项目（S410），菜单标记画面被激活（S415）。 在菜单写入屏幕上，选择餐（S420）。 显示推荐菜单和用户菜单中的至少一个（S430）。 当选择特定菜单时，所选择的菜单被添加到菜单菜单中（S445，S447）。 对菜单进行营养评估（S455）。
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公开(公告)号：KR1020090118432A
公开(公告)日：2009-11-18
申请号：KR1020080044204
申请日：2008-05-13
Applicant: 대한민국 (식품의약품안전처장)
IPC: G06F7/08
CPC classification number: G06Q50/22 , G06F17/30342
Abstract: PURPOSE: A human tissue classifying method is provided to visually figure out the common matters required for the human tissue transplant by using the classifying method consisting of contributor information and tissue information. CONSTITUTION: The data about human tissue is inputted(S100). The object information including one or more among tissue kinds, a processing method, and a sterilizing method is extracted from the data(S200). An object code corresponding to the object information is searched from the object code database(S300). The ID code for the human body tissue is generated based on the object code (S400). The tissue information includes one or more among the tissue kinds, the processing method, and the sterilizing method.
Abstract translation: 目的：提供人体组织分类方法，通过使用由贡献者信息和组织信息组成的分类方法来目视确定人体组织移植所需的常见事项。 构成：输入关于人体组织的数据（S100）。 从数据中提取包括组织种类，处理方法和消毒方法中的一个或多个的对象信息（S200）。 从对象代码数据库中搜索与对象信息对应的目标代码（S300）。 基于目标代码生成人体组织的ID码（S400）。 组织信息包括组织种类，处理方法和灭菌方法中的一种或多种。
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公开(公告)号：KR1020090099637A
公开(公告)日：2009-09-23
申请号：KR1020080024745
申请日：2008-03-18
Applicant: 대한민국 (식품의약품안전처장)
CPC classification number: C12Q1/6874 , C12Q1/6827 , C12Q2600/124
Abstract: A method for distinguishing hybridized beef and Korean beef (Hanwoo) using a SNP marker is provided to exactly distinguish the hybridized beef through SNP genotyping. An SNP marker for distinguishing a hybridized beef of Korean beef (Hanwoo)-milk cow comprises 21th mutation site of each sequence numbers 1 (SEQ ID NO:1) to 25. The hybridized beef is distinguished by confirming the heterozygous genotype of SNP marker for detecting the hybridized beef.
Abstract translation: 提供了使用SNP标记区分杂交牛肉和韩国牛肉（Hanwoo）的方法，以通过SNP基因分型准确区分杂交牛肉。 用于区分韩国牛肉（Hanwoo） - 混合牛的杂交牛肉的SNP标记包括每个序列号1（SEQ ID NO：1）至25的第21个突变位点。杂交牛肉通过证实SNP标记的杂合基因型 检测杂交牛肉。
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