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公开(公告)号：KR1020020088181A
公开(公告)日：2002-11-27
申请号：KR1020010027171
申请日：2001-05-18
Applicant: 한국과학기술연구원
IPC: A61K9/00
CPC classification number: A61K9/06 , A61K9/0019 , A61K31/196 , A61K31/65 , A61K47/24 , A61K47/36
Abstract: PURPOSE: A process of preparing a gel type composition containing a specified amount of a biocompatible polymer is provided. Whereby, the composition can be used as a local drug delivery system and formulations thereof and release drug from a local portion for 6 days. CONSTITUTION: This gel type composition comprises a phospholipid-based compound, drug and water, wherein the composition additionally contains 3% by weight of one or more biocompatible polymers selected from the group consisting of hyaluronic acid, chitosan and alginic acid. The phospholipid-based compound is one or more selected from a saturated or unsaturated C6-22 phosphatidylcholine-based compound, phosphatidylethanolamine-based compound, phosphatidylserine-based compound and phosphatidic acid-based compound.
Abstract translation: 目的：提供一种制备含有特定量的生物相容性聚合物的凝胶型组合物的方法。 因此，组合物可以用作局部药物递送系统及其制剂，并从局部部分释放药物6天。 构成：该凝胶型组合物包含基于磷脂的化合物，药物和水，其中该组合物另外含有3重量％的一种或多种选自透明质酸，壳聚糖和海藻酸的生物相容性聚合物。 基于磷脂的化合物是选自饱和或不饱和的C6-22磷脂酰胆碱化合物，基于磷脂酰乙醇胺的化合物，磷脂酰丝氨酸基化合物和磷脂酸类化合物中的一种或多种。
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公开(公告)号：KR1020020066776A
公开(公告)日：2002-08-21
申请号：KR1020010007123
申请日：2001-02-13
Applicant: 한국과학기술연구원
IPC: A61K9/10
CPC classification number: A61K9/0095 , A61K9/1075 , A61K9/4858
Abstract: PURPOSE: A process of preparing a peroral administration form for insulin is provided by using monoglycerides, emulsifiers, organic solvents, insulin and an acidic aqueous solution. Therefore, the formulation is excellent in a filling rate of insulin into the administration form and bioavailability as compared to prior art and has improved convenience. CONSTITUTION: A liquid peroral administration form for insulin comprises 0.01 to 20% by weight of insulin, 9 to 90% by weight of one or more monoglycerides, 0.01 to 90% by weight of one or more emulsifiers, 0.01 to 10% by weight of an acidic aqueous solution, 1 to 90% by weight of an organic solvent and 0 to 5% by weight of an additive, and is prepared by dissolving the emulsifier in the organic solvent, adjusting the solution to acidity, adding and agitating insulin powder, adding one or more monoglycerides and removing a volatile organic solvent from the obtained viscose composition.
Abstract translation: 目的：通过使用单酸甘油酯，乳化剂，有机溶剂，胰岛素和酸性水溶液来提供制备胰岛素口服给药形式的方法。 因此，与现有技术相比，该配方在胰岛素与给药形式的填充率和生物利用度方面是优异的，并且具有改进的便利性。 构成：用于胰岛素的液体口服给药形式包含0.01至20重量％的胰岛素，9至90重量％的一种或多种甘油单酯，0.01至90重量％的一种或多种乳化剂，0.01至10重量％ 酸性水溶液，1〜90重量％的有机溶剂和0〜5重量％的添加剂，通过将乳化剂溶解在有机溶剂中，将溶液调节至酸性，加入并搅拌胰岛素粉末， 加入一种或多种单甘油酯并从所得粘胶组合物中除去挥发性有机溶剂。
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公开(公告)号：KR1020010068458A
公开(公告)日：2001-07-23
申请号：KR1020000000385
申请日：2000-01-06
Applicant: 한국과학기술연구원
IPC: C08J9/00
CPC classification number: C08J3/126 , C08F6/04 , C08F8/12 , C08J2331/04 , C08J2429/04 , Y10S525/902 , Y10S526/909 , C08F118/08
Abstract: PURPOSE: Provided is a preparation method of micro-spherical embolus material with duplex structure of polyvinylacetate (PVAc) core/polyvinyl alcohol (PVA) shell, which is used in the embolus treatment. In this treatment, the material is introduced to the blood vessels near the ailment spot where operation is not possible and it cutoffs the blood flow to cure the ailment such as hyper-vascular tumor, eases the symptoms caused by blood overflow and stops the bleeding by external wound or inflammatory bleeding of tuberculosis. Presently, polyvinyl alcohol is used as the embolus material but it brings side effect of inflammation presumably due to the sharp edges and ununiformity of the granules. CONSTITUTION: The preparation process for separating polyvinylacetate granules with uniform diameter of dispersant index of 1.00-1.6 comprises adding 0.1-100wt. parts (when PVAc wt. parts is 1) inorganic salts as dispersant and anti-static agent, wherein the salt is selected from sodium sulfate, sodium sulfite, sodium chloride, calcium sulfate and magnesium sulfate; milling PVAc granules; separating them to particles with desired size by using a standard sieve; and saponifying these granules only on the surface by suspending them in alkali aqueous solution containing NaOH, NaSO4, NaSO3 and methanol at 0 - 90deg.C so that the granules have double structure of PVAc core and PVA shell.
Abstract translation: 目的：提供一种用于栓塞治疗的聚乙酸乙烯酯（PVAc）芯/聚乙烯醇（PVA）壳双重结构的微球状栓塞材料的制备方法。 在这种治疗中，将材料引入到不可能操作的疾病斑点附近的血管中，并且阻断血流以治愈诸如高血管肿瘤的疾病，从而减轻由血液溢出引起的症状并且通过 外伤或结核病的炎性出血。 目前，使用聚乙烯醇作为栓塞材料，但是由于颗粒的锋利边缘和不均匀性而引起炎症的副作用。 构成：分散指数为1.00-1.6的均匀分散的聚乙酸乙烯酯颗粒的制备方法包括加入0.1-100wt。 部分（PVAc重量份为1）无机盐作为分散剂和抗静电剂，其中盐选自硫酸钠，亚硫酸钠，氯化钠，硫酸钙和硫酸镁; 研磨PVAc颗粒; 通过使用标准筛分成具有所需尺寸的颗粒; 并通过将其悬浮在含有NaOH，NaSO 4，NaSO 3和甲醇的碱性水溶液中，在0-90℃下将表面皂化，使颗粒具有PVAc芯和PVA壳的双重结构。
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公开(公告)号：KR1020010063154A
公开(公告)日：2001-07-09
申请号：KR1019990060034
申请日：1999-12-21
Applicant: 한국과학기술연구원
IPC: C12N1/00
CPC classification number: C08J9/28 , C08B37/003 , C08J2201/0484 , C08J2305/08 , C08L5/08 , C12N5/0075 , C12N2533/72
Abstract: PURPOSE: Provided are multi-porous chitosan bead whose pores are big and relatively constant in size and a preparation method thereof. The bead is used as a matrix for cell cultivation and for the study of alternative metabolic organ, bone and cartilage and protein, antibiotics, anti-cancer medicine, polysaccharide, biological active material, animal hormone, and plant hormone. CONSTITUTION: A multi-porous chitosan bead has a pore being 5-20 micrometer in a size at its inside and outside. It is prepared by the following steps of: (a) preparing chitosan solution by dissolving chitosan in acetic acid aqueous solution, water-soluble chitosan solution by dissolving water-soluble chitosan in deionized solution or mixed solution thereof; (b) making it in bead form by adding organic solvent of low temperature or liquid nitrogen; and (c) freeze-drying the resultant bead.
Abstract translation: 目的：提供孔径大且尺寸相对恒定的多孔壳聚糖珠及其制备方法。 该珠被用作细胞培养的基质和用于替代代谢器官，骨和软骨和蛋白质，抗生素，抗癌药物，多糖，生物活性物质，动物激素和植物激素的研究。 构成：多孔壳聚糖珠的内部和外部具有5-20微米的孔径。 通过以下步骤制备：（a）通过将水溶性壳聚糖溶解在去离子溶液或其混合溶液中，通过将壳聚糖溶解在乙酸水溶液，水溶性壳聚糖溶液中制备壳聚糖溶液; （b）通过加入低温或液氮的有机溶剂使其呈珠粒形式; 和（c）冷冻干燥所得的珠粒。
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Patent Agency Ranking
公开(公告)号：KR1020000069800A
公开(公告)日：2000-11-25
申请号：KR1019997005944
申请日：1997-12-31
Applicant: 한국과학기술연구원
IPC: A61K9/19
CPC classification number: A61K9/7007 , Y10S514/953 , Y10S514/964 , Y10S514/975
Abstract: PURPOSE: A method of preparing a porous matrix-type drug delivery system by dispersing a drug-containing aqueous solution in an organic solvent in which a polymer compound and a surfactant are dissolved and forming the obtained emulsion into a desirable matrix shape is provided which can produce the titled system capable of being widely used for a therapeutic agent CONSTITUTION: The method for producing a porous matrix-type drug delivery system comprises the steps of: dispersing, stirring, and emulsifying an aqueous solution of a drug in an organic solvent having a polymer compound and a surface active agent solved therein; thereafter forming it into a desirable matrix shape; lyophilizing or drying it at a low temperature or room temperature until the matrix surface is hardened; and drying it again in order to remove the water and the organic solvent.
Abstract translation: 目的：提供一种通过将含药水溶液分散在其中溶解高分子化合物和表面活性剂的有机溶剂中并将所得乳液形成为期望的基质形状来制备多孔基质型药物递送系统的方法，其可以 制备能够广泛用于治疗剂的标题系统构成：多孔基质型药物递送系统的制备方法包括以下步骤：将药物的水溶液分散，搅拌和乳化在具有 高分子化合物和其中溶解的表面活性剂; 然后将其形成为期望的矩阵形状; 在低温或室温下冻干或干燥，直到基质表面硬化; 并再次干燥以除去水和有机溶剂。
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公开(公告)号：KR100181252B1
公开(公告)日：1999-03-20
申请号：KR1019960082443
申请日：1996-12-31
Applicant: 한국과학기술연구원
IPC: A61K9/10
CPC classification number: A61K9/7007 , Y10S514/953 , Y10S514/964 , Y10S514/975
Abstract: 약물이 포함된 수용액을 고분자화합물과 계면활성제가 유기용매에 용해된 유기용액에 분산 교반시켜 에멀젼으로 만든 다음, 원하는 매트릭스 형태로 만들어 즉시 동결건조하거나 상온에서 일정시간 즉 매트릭스 표면이 경화되기 시작할 때까지 건조시킨 후 다시 진공건조하여 다공성 매트릭스를 제조하는 것을 특징으로 함.
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公开(公告)号：KR100164462B1
公开(公告)日：1999-01-15
申请号：KR1019950050632
申请日：1995-12-15
Applicant: 한국과학기술연구원
Abstract: 본 발명은 알긴산염으로 이루어진, 입자 직경이 나노미터 내지 수 마이크로미터인 알긴산염 초미세구립자 및 그의 제조방법을 제공한다. 본 발명의 알긴산염 초미세구립자의 제조방법은 알긴산염 수용액을 계면활성제가 첨가된 유기용매에 분산, 교반시켜 에멀젼을 만든 다음, 칼슘 용액을 이 에멀젼에 첨가하여 겔화하고, 탈수 용매를 가해 탈수시키고 경화시키는 것으로 이루어진다. 본 발명의 알긴산염 초미세구립자는 비경구 투여에 의한 약물의 표적 지향, 펩타이드 약물의 경구 흡수, 또는 경구용 백신 개발 등 폭넓게 응용될 수 있다.
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198.发明授权용매추출법을 이용한 생분해성 고분자 미립구의 개선된 제조방법 및 이를 이용한 국소염증 질환 치료용 미립구의 제조방법 失效使用溶剂萃取的生物可降解聚合物微球的改进制备方法和用于处理本发明的局部炎症的微球的制备方法
公开(公告)号：KR100162872B1
公开(公告)日：1998-12-01
申请号：KR1019960009755
申请日：1996-04-01
Applicant: 한국과학기술연구원
IPC: A61K9/50
CPC classification number: A61K9/1694 , A61K9/1647 , C08J3/16
Abstract: 용매추출법을 이용한 생분해성 고분자 미립구의 개선된 제조방법 및 이를 이용한 국소염증 질환 치료용 미립구의 제조방법이 제공된다. 본 발명의 방법에서는 외부수상에 고분자의 불용매를 미리 첨가시킴으로써 단시간 내에 고분자의 고형화를 달성할 수 있어 결과적으로 약물의 봉입율을 향상시킬 수 있다.
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公开(公告)号：KR1019980067137A
公开(公告)日：1998-10-15
申请号：KR1019970003021
申请日：1997-01-31
Applicant: 한국과학기술연구원
Abstract: 본 발명은 공유결합된 또는 단순혼합된 폐렴구균의 캡슐 다당체와 콜레라 독소 B 서브유니트 및 알긴산을 함유하는 수상에, 염화칼슘을 용해시키는 유기용매로 이루어지는 유상을 첨가하여 에멀젼화시킨 후, 여기에 염화칼슘을 용해시킨 상기 유기용매를 첨가하여 상기 폐렴구균의 캡슐 다당체와 콜레라 독소 B 서브유니트를 미세과립구 형태로 고형화시키는 것으로 이루어지는, 폐렴 구균 감염증에 대한 경구 또는 비강 투여용 백신의 제조방법에 관한 것이다. 또한 본 발명은 폐렴구균의 캡슐 다당체와 콜레라 독소 B 서브유니트를 함유하며 미세과립구 형태인, 면역성이 증가된 폐렴구균 감염증에 대한 경구 또는 비강 투여용 백신에 관한 것이다.
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